Dept Pharmacy Practice

Research

Course of Medical and Dental Sciences

http://www.ph.nagasaki-u.ac.jp/lab/hospital/index-e.html

Name, Position	Email *convert [a] to @	Tel	Fax
Mikiro Nakashima, Ph. D. Professor	mikirou[a]nagasaki-u.ac.jp	+81-95-819-8570	+81-95-819-8572
Tomoaki Kurosaki, Ph. D. Assistant Professor	kurosaki[a]nagasaki-u.ac.jp
Nozomi Aibara, Ph. D. Assistant Professor	nozomi-ai[a]nagasaki-u.ac.jp	+81-95-819-8569

Propose use of PXB-mice® as a reliable tool for drug repositioning screening against liver disease
Screening disease-specific immune complex antigens for autoimmune diseases and cancers
Measure the concentration of drugs binding to their target

Aizawa R, Nakamura Y, Ikeda T, Aibara N, Kutsuna YJ, Kurosaki T, Aki K, Hashizume J, Nakagawa H, Sato K, Kodama Y, Nakashima MN, Nakashima M, Mukae H, Ohyama K: Immune complexome analysis of serum samples from non-small-cell lung cancer patients identifies predictive biomarkers for nivolumab therapy, Clinica Chimica Acta, 532:84-88, 2022
Aibara N, Ohyama K, Nakamura M, Nakamura H, Tamai M, Kishikawa N, Kawakami A, Tsukamoto K, Nakashima M, Kuroda N: Investigation of immune complexes formed by mitochondrial antigens containing a new lipoylated site in sera of primary biliary cholangitis patients. Clinical & Experimental Immunology, 204:335-343, 2021
Yamane K, Nakamura H, Hamasaki M, Minei Y, Aibara N, Shimizu T, Kawakami A, Nakashima M, Kuroda N, Ohyama K: Immune complexome analysis reveals the presence of immune complexes and identifies disease-specific immune complex antigens in saliva samples from patients with Sjögren’s syndrome, Clinical & Experimental Immunology, 204:212-220, 2021
Aibara N, Aizawa R, Nakashima M, Ohyama K: Optimization of pH elution conditions in immune complexome analysis for comprehensive identification of immune complex antigens, Analytical Sciences, 36:1423-1426, 2020
Kobayashi S, Ishii K, Yamada Y, Ryu E, Hashizume J, Nose S, Hara T, Nakashima M, Ohyama K: Combination index of the concentration and in vivo antagonism activity of racemic warfarin and its metabolistes to assess individual drug responses. J Thromb Thrombolysis 47: 467-472, 2019

Please find latest works in their website.