Research
Department of Pharmacology and Therapeutic Innovation
Teaching staffs
| Name, Position | Email *convert [a] to @ |
Tel | Fax |
|---|---|---|---|
|
Masayuki Kaneko, Ph. D. Professor |
m-kaneko[a]nagasaki-u.ac.jp | +81-95-819-2421 | +81-95-819-2420 |
| Tamotsu Tsuakahara,
Ph. D. Associate Professor |
ttamotsu[a]nagasaki-u.ac.jp | +81-95-819-2473 | +81-95-819-2420 |
| Takumi Okamoto,
Ph. D. Assistant Professor |
toka[a]nagasaki-u.ac.jp | +81-95-819-2422 | +81-95-819-2420 |
Research interests
- Physiological roles and drug discovery of ubiquitin ligase
- Analysis of gene function and drug discovery using genome editing
- Biological effects of lysophospholipids on vascular disease
- LC-MS-based lipidomics and its application to vascular disease
- Identification of cellular and molecular mechanisms of vascular disease
Selected publications
- Maeoka Y, Wu Y, Okamoto T, Kanemoto S, Guo XP, Saito A, Asada R, Matsuhisa K, Masaki T, Imaizumi K, Kaneko M: NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells. J Biol Chem 294: 101-115, 2019
- Kaneko M, Iwase I, Yamasaki Y, Takai T, Wu Y, Kanemoto S, Matsuhisa K, Asada R, Okuma Y, Watanabe T, Imaizumi K, Nomura Y: Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation. Sci Rep 6: 30955, 2016
- Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, Nomura Y: Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. J Neurosci 30: 3924-3932, 2010
- Tsukahara T, Haniu H, Uemura T, Matsuda Y: Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro. Sci Rep 10: 3748, 2020
- Tsukahara T, Tsukahara R, Fujiwara Y, Yue J, Cheng Y, Guo H, Bolen A, Zhang C, Balazs L, Re F, Du G, Frohman MA, Baker DL, Parrill AL, Uchiyama A, Kobayashi T, Murakami-Murofushi K, Tigyi G: Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARγ by cyclic phosphatidic acid. Mol Cell 39: 421-432, 2010
Works
Please find latest works in their website.
