Research

Chemistry of Biofunctional Molecules
Course of Pharmaceutical Sciences Department of Environmental and Pharmaceutical SciencesCourse of Pharmaceutical Sciences Department of Environmental and Pharmaceutical Sciences
Department of
Chemistry of Biofunctional Molecules
Course of Pharmaceutical Sciences
Web Site
Teaching Staff
Name Position E-mail Tel Fax
Asako YAMAYOSHI, Ph. D.
Professor
asakoy@nagasaki-u.ac.jp +81-95-819-2438 +81-95-819-2479
Research
  • Development of nucleic acid drugs for functional regulation of non-coding RNAs
  • Novel drug delivery system using circulating extracellular vehicles
  • Development of novel photodynamic regulation system for regulation of epigenetic gene expression
Selected Publications
  1. Ariyoshi J, Matsuyama Y, Kobori A, Murakami A, Sugiyama H, Yamayoshi A, Effective anti-miRNA oligonucleotides show high releasing rate of microRNA from RNA-induced silencing complex (RISC), Nucleic Acid Ther. 27: 303-308 (2017)
  2. Yamayoshi A, Miyoshi D, Zouzumi Y, Matsuyama Y, Ariyoshi J, Shimada N, Murakami A, Wada T, Maruyama A, Selective and robust stabilization of triplex DNA structures using cationic Comb-type Copolymers, J. Phys. Chem. B 121: 4015-4022 (2017)
  3. Ariyoshi J, Momokawa D, Eimori N, Kobori A, Murakami A, Yamayoshi A, Development of novel antisense oligonucleotides for the functional regulation of RNA-induced silencing complex (RISC) by promoting the release of microRNA from RISC, Bioconjugate Chem. 26: 2454-2460 (2015)
  4. Yamayoshi A, Matsuyama Y, Kushida M, Kobori A, Murakami A, Novel photodynamic effect of psoralen-conjugated oligonucleotides for discrimination of methylation of cytosine in DNA, Photochem. Photobiol. 90: 716-722 (2014)
  5. Matsuyama Y, Yamayoshi A, Kobori A, Murakami A, Functional regulation of RNA-induced silencing complex by photoreactive oligonucleotides, Bioorg. Med. Chem. 22: 1003-1007 (2014)
Research Paper List