Research

Department of Chemical Biology and Medicinal Chemistry

Chemical Biology and Medicinal Chemistry for Pharmaceuticals

Course of Pharmaceutical Sciences


Teaching staffs

Name, Position Email
*convert [a] to @
Tel Fax
Fumika Yakushiji, Ph.D. Professor fyakushiji[a]nagasaki-u.ac.jp +81-95-819-2432
Yoshinori Saito, Ph.D. Associate Professor saiyoshi[a]nagasaki-u.ac.jp +81-95-819-2433
Koji Yamada, Ph.D. Associate Professor kyamada[a]nagasaki-u.ac.jp +81-95-819-2462
Yosuke Matsuo, Ph.D. Assistant Professor y-matsuo[a]nagasaki-u.ac.jp +81-95-819-2434

Research interests

  • Chemical biology and medicinal chemistry research related to histone modifications
  • Chemical biology and medicinal chemistry research related to natural product synthesis
  • Screening and identification of novel bioactive compounds from our original compound library
  • Research related to natural products isolated from plants and microbial sources; isolation/structural determination/metabolism/function

Selected publications

  • Hu Y, Saito Y, Okamoto Y, Matsuo Y, Gong X, Tanaka T: Chemical diversity of Eupatorium heterophyllum leaves collected in Yunnan and Sichuan Provinces of China—Isolation of 13 new sesquiterpene lactones. Molecules 28: 5107, 2023
  • Toyobe M, Yakushiji F: Synthetic modifications of histones and their functional evaluation. Chem Asian J 17: e202200197, 2022
  • Abdelhameed RFA, Habib ES, Ibrahim AK, Yamada K, Abdel-Kader MS, Ibrahim AK, Ahmed SA, Badr JM, Nafie MS: Chemical profiling, cytotoxic activities through apoptosis induction in MCF-7 cells and molecular docking of Phyllostachys heterocycla bark nonpolar extract. J Biomol Struct Dyn 40: 9636-9647, 2022
  • Yamashita T, Matsuo Y, Saito Y, Tanaka T: Formation of dehydrohexahydroxydiphenoyl esters by the oxidative coupling of galloyl esters in an aqueous medium involved in ellagitannin biosynthesis. Chem Asian J 16: 1735-1740, 2021
  • Hirabayashi J, Yakushiji F, Katsuyama A, Ichikawa S: Total synthesis of acaulide and acaulone A. Org Lett 22: 5545–5549, 2020

Works

Please find latest works in their website.

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