Research

Pharmacotherapeutics
Pharmacotherapeutics
Department of Pharmacotherapeutics
Course of Medical and Dental Sciences
http://www.ph.nagasaki-u.ac.jp/lab/treat/index-e.html
Teaching Staff
Name Position E-mail Tel Fax
Kazuhiro Tsukamoto, M.D. & Ph. D.
Professor
ktsuka@nagasaki-u.ac.jp +81-95-819-8573 +81-95-819-8575
Tatsuo Inamine, Ph.D
Associate Professor
inaminet@nagasaki-u.ac.jp +81-95-819-8574 +81-95-819-8575
Research
  • Research into association studies on susceptibility genes for diseases, progression, drug effectiveness, adverse effects, and prognosis using genetic polymorphic markers
  • Research into DNA-based diagnostic methods for personalized medicine
  • Research investigating interaction between gut microbiome and metabolic diseases
Selected Publications
  1. Ohishi Y, Nakamura M, Iio N, Higa S, Inayoshi M, Aiba Y, Komori A, Omagari K, Ishibashi H, Tsukamoto K. Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis. Hepatology 48:853-862, 2008.
  2. Sato K, Shiota M, Fukuda S, Iwamoto E, Machida H, Inamine T, Kondo S, Yanagihara K, Isomoto H, Mizuta Y, Kohno S, Tsukamoto K. Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn’s disease in the Japanese population. J Clin Immunol 29:815-825, 2009.
  3. Nanashima K, Mawatari T, Tahara N, Higuchi N, Nakaura A, Inamine T, Kondo S, Yanagihara K, Fukushima K, Suyama N, Kohno S, Tsukamoto K. Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients. Tuberculosis 92:253-259, 2012.
  4. Inamine T, Higa S, Noguchi F, Kondo S, Omagari K, Yatsuhashi H, Tsukamoto K, Nakamura M. An association of genes involved in bile acid synthesis with the progression of primary biliary cirrhosis in Japanese patients. J Gastroenterol 48:1160-1170, 2013.
  5. Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Starkel P, Fouts DE, Schnabl B. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest 127:2829-2841, 2017.
Research Paper List