Research

Genome-based Drug Discovery
Genome-based Drug Discover
Department of
Genome-based Drug Discovery
Course of Pharmaceutical Sciences
http://www.ph.nagasaki-u.ac.jp/lab/biotech/index-e.html
Teaching Staff
Name Position E-mail Tel Fax
Nobuhisa Iwata, Ph.D.
Professor
iwata-n@nagasaki-u.ac.jp
Keiro Shirotani, Ph.D.
Associate Professor
keiroshiro@nagasaki-u.ac.jp
Masashi Asai, Ph.D.
Assistant Professor
asai@nagasaki-u.ac.jp
Kaori Watanabe, M.S.
Technical Staff
kaori-wi@nagasaki-u.ac.jp
Yuka Jiuchi, B.S.
Technical Staff
jiuchi@nagasaki-u.ac.jp
Research
  • Analysis of molecular mechanism for the pathogenesis of Alzheimer's disease
  • Development of disease-modifying therapy and biomarker of Alzheimer's disease
  • Searching for molecules that modulate activities of secretases and neprilysin
  • Molecular analysis of the Down syndrome-related genes in the pathogenesis of Alzheimer's diseases
  • Molecular analysis of PRRT2 in synaptic functions
Selected Publications
  1. Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC, Single App knock-in mouse models of Alzheimer's disease, Nat. Neurosci. 17: 661-663 (2014)
  2. Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC, Aβ secretion and plaque formation depend on autophagy, Cell Rep. 5: 61-69 (2013)
  3. Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC, Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice, Sci. Rep. 3: 1472 (2013)
  4. Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H, Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness, Cell Stem Cell 12: 487-496 (2013)
  5. Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC, Potent amyloidogenicity and pathogenicity of Aβ43, Nat. Neurosci. 14: 1023-1032 (2011)
Research Paper List