Research

Genome-based Drug Discovery
Genome-based Drug Discover
Department of
Genome-based Drug Discovery
Course of Pharmaceutical Sciences
http://www.ph.nagasaki-u.ac.jp/lab/biotech/index-e.html
Teaching Staff
Name Position E-mail Tel Fax
Nobuhisa Iwata, Ph.D.
Professor
iwata-n@nagasaki-u.ac.jp
Keiro Shirotani, Ph.D.
Associate Professor
keiroshiro@nagasaki-u.ac.jp
Kaori Watanabe, M.S.
Technical Staff
kaori-wi@nagasaki-u.ac.jp
Yuka Jiuchi, B.S.
Technical Staff
jiuchi@nagasaki-u.ac.jp
Research
  • Analysis of molecular mechanisms underlying the pathogenesis of Alzheimer's disease
  • Development of disease-modifying therapy and biomarker of Alzheimer's disease
  • Analysis of endogenous molecules that modulate activities of neprilysin and secretases
  • Analysis of the Down syndrome-related genes in the pathogenesis of Alzheimer's diseases
  • Analysis of Pathophysiological roles of convulsive neurological disease-causing gene PRRT2 in the synapse
Selected Publications
  1. Kondo T, Imamura K, Funayama M, Tsukita K, Miyake M, Ohta A, Woltjen K, Nakagawa M, Asada T, Arai T, Kawakatsu S, Izumi Y, Kaji R, Iwata N, Inoue H: iPSC-based compound screening and in vitro trials identify a synergistic anti-amyloid β combination for Alzheimer's disease. Cell Rep 21: 2304-2312, 2017
  2. Shirotani K, Asai M, Iwata N: Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease. J Biochem 161: 463-470, 2017
  3. Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC: Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci 17: 661-663, 2014
  4. Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC: Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Sci Rep 3: 1472, 2013
  5. Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H: Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell 12: 487-496, 2013
Research Paper List