Dept Pharmacy Practice

Research

Course of Medical and Dental Sciences

http://www.ph.nagasaki-u.ac.jp/lab/hospital/index-e.html

Name, Position	Email *convert [a] to @	Tel	Fax
Takeshi Hirota, Ph. D. Professor	t-hirota[a]nagasaki-u.ac.jp	+81-95-819-8570	+81-95-819-8572
Nozomi Aibara, Ph. D. Assistant Professor	nozomi-ai[a]nagasaki-u.ac.jp	+81-95-819-8569
Yuki Kutsuna, Ph. D. Assistant Professor	jim_kutsuna[a]nagasaki-u.ac.jp	+81-95-819-8569

Elucidating mechanisms of interindividual variability in pharmacokinetics and drug response for personalized pharmacotherapy
Development of liquid biomarkers using miRNAs, epigenetic markers, and extracellular vesicles
Pharmacometric approaches for predicting drug response and optimizing dosage
Comprehensive profiling of antigen–antibody complexes to elucidate disease pathophysiology and to identify novel diagnostic and therapeutic targets

Aibara N, Kutsuna JY, Ohyama K, Identification of Disease Characteristic Immune Complex Antigens, Methods in molecular biology (Clifton, N.J.), 2980:189-197 (2026).
Tajiri A, Hirota T, Kawano S, Yonamine A, Ieiri I: Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver. Molecular Pharmacology, 17(8):2821-2830, 2020.
Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I: Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy. Journal of Neurochemistry, 148(3):373-385, 2019.
Takechi T, Hirota T, Sakai T, Maeda N, Kobayashi D, Ieiri I: Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene. Drug Metabolism and Disposition, 46(5):628-635, 2018.
Gotanda K, Hirota T, Saito J, Fukae M, Egashira Y, Izumi N, Deguchi M, Kimura M, Matsuki S, Irie S, Ieiri I: Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines. Scientific Reports, 6:32299, 2016.

Please find latest works in their website.