Department of Pharmacy Practice

Analytical Chemistry for Pharmaceuticals

Course of Medical and Dental Sciences

Teaching staffs

Name, Position Email
*convert [a] to @
Tel Fax
Mikiro Nakashima, Ph. D. Professor mikirou[a] +81-95-819-8570  +81-95-819-8572 
Tomoaki Kurosaki, Ph. D. Assistant Professor kurosaki[a]

Nozomi Aibara, Ph. D. Assistant Professor nozomi-ai[a] +81-95-819-8569

Research interests

  • Propose use of PXB-mice® as a reliable tool for drug repositioning screening against liver disease
  • Screening disease-specific immune complex antigens for autoimmune diseases and cancers
  • Measure the concentration of drugs binding to their target

Selected publications

  • Aizawa R, Nakamura Y, Ikeda T, Aibara N, Kutsuna YJ, Kurosaki T, Aki K, Hashizume J, Nakagawa H, Sato K, Kodama Y, Nakashima MN, Nakashima M, Mukae H, Ohyama K: Immune complexome analysis of serum samples from non-small-cell lung cancer patients identifies predictive biomarkers for nivolumab therapy, Clinica Chimica Acta, 532:84-88, 2022
  • Aibara N, Ohyama K, Nakamura M, Nakamura H, Tamai M, Kishikawa N, Kawakami A, Tsukamoto K, Nakashima M, Kuroda N: Investigation of immune complexes formed by mitochondrial antigens containing a new lipoylated site in sera of primary biliary cholangitis patients. Clinical & Experimental Immunology, 204:335-343, 2021
  • Yamane K, Nakamura H, Hamasaki M, Minei Y, Aibara N, Shimizu T, Kawakami A, Nakashima M, Kuroda N, Ohyama K: Immune complexome analysis reveals the presence of immune complexes and identifies disease-specific immune complex antigens in saliva samples from patients with Sjögren’s syndrome, Clinical & Experimental Immunology, 204:212-220, 2021
  • Aibara N, Aizawa R, Nakashima M, Ohyama K: Optimization of pH elution conditions in immune complexome analysis for comprehensive identification of immune complex antigens, Analytical Sciences, 36:1423-1426, 2020
  • Kobayashi S, Ishii K, Yamada Y, Ryu E, Hashizume J, Nose S, Hara T, Nakashima M, Ohyama K: Combination index of the concentration and in vivo antagonism activity of racemic warfarin and its metabolistes to assess individual drug responses. J Thromb Thrombolysis 47: 467-472, 2019


Please find latest works in their website.