Research

Department of Chemistry of Biofunctional Molecules

Chemistry of Biofunctional Molecules

Course of Pharmaceutical Sciences


Teaching staffs

Name, Position Email
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Tel Fax

Rui Kamada,

Ph. D.
Professor

rkamada[a]nagasaki-u.ac.jp +81-95-819-2438 +81-95-819-2479

Research interests

  • Elucidation of cancer immune regulation by innate immune cells
  • Investigation of the mechanisms of cellular oncogenic transformation and differentiation, and development of inhibitory compounds
  • Elucidation of the formation of cellular memory in response to external stimuli and its regulatory mechanisms
  • 4. Elucidation of innate immune and cellular stress responses mediated by PPM phosphatases

Selected publications

  • Kozakai, Y.*, Kamada, R.*, Furuta, J., Kiyota, Y., Chuman, Y., and Sakaguchi, K., PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin., Sci. Rep. 6:33272, 2016
  • Kamada, R., Yang, W., Zhang, Y., Patel, M.C., Yang, Y., Ouda, R., Dey, A., Wakabayashi, Y., Sakaguchi, K., Fujita, T., Tamura, T., Zhu, J., and Ozato, K., Interferon stimulation creates chromatin marks and establishes transcriptional memory., Proc. Natl. Acad. Sci. U.S.A. 115: E9162-E9171, 2018
  • Kamada, R., Kimura, N., Yoshimura, F., Tanino, K., and Sakaguchi, K., Inhibition of lipid droplet formation by Ser/Thr phosphatase PPM1D inhibitor, SL-176., PLoS One, 14: e0212682, 2019
  • Kamada, R., Uno, S., Kimura, N., Yoshimura, F., Tanino, K., Sakaguchi, K., Lipid droplet formation is regulated by Ser/Thr phosphatase PPM1D via dephosphorylation of perilipin 1., Int. J. Mol. Sci., 23: 12046, 2022

Works

Please find latest works in their website.

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