Research
Department of Pharmaceutical Chemistry
Course of Pharmaceutical Sciences
Website
Teaching staffs
| Name, Position | Email *convert [a] to @ |
Tel | Fax |
|---|---|---|---|
| Masakazu Tanaka, Ph. D. Professor | matanaka[a]nagasaki-u.ac.jp | +81-95-819-2423 | +81-95-819-2423 |
| Atsushi Ueda, Ph. D. Associate Professor | aueda[a]nagasaki-u.ac.jp | +81-95-819-2425 | +81-95-819-2423 |
Research interests
- Synthesis of non-natural type amino acids and its application to medicinal chemistry
- Development of helical peptides as an asymmetric organocatalyst
- Design of cell-penetrating foldamers and their application to drug delivery system
Selected publications
- Oba M, Nonaka H, Umeno T, Kato T, Doi M, Ueda A, Tanaka M: Redox-responsive side chain structural changes in a seven-membered cyclic α,α-disubstituted α-amino acid with a disulfide bond enable reversible conformational changes in peptides. ChemPlusChem 90: e202400772, 2025
- Iyoshi A, Ueda A, Umeno T, Kato T, Hirayama K, Doi M, Tanaka M: Conformational analysis and organocatalytic activity of helical stapled peptides containing α-carbocyclic α,α-disubstituted α-amino acids. Molecules 29: 4340, 2024
- Oba M, Nakajima S, Misao K, Yokoo H, Tanaka M: Effect of helicity and hydrophobicity on cell-penetrating ability of arginine-rich peptides. Bioorg Med Chem 91: 117409, 2023
- Ueda A, Makura Y, Kakazu S, Kato T, Umeno T, Hirayama K, Doi M, Oba M, Tanaka M: E-Selective ring-closing metathesis in α-helical stapled peptides using carbocyclic α,α-disubstituted α-amino acids. Org Lett 24: 1049-1054, 2022
- Sato K, Umeno T, Ueda A, Kato T, Doi M, Tanaka M: Asymmetric 1,4-addition reactions catalyzed by N-terminal thiourea-modified helical L-Leu peptide with cyclic amino acids. Chem-Eur J 27: 11216-11220, 2021
Works
Please find latest works in their website.
