Research
Department of Pharmaceutical Chemistry
Course of Pharmaceutical Sciences
Website
Teaching staffs
| Name, Position | Email *convert [a] to @ |
Tel | Fax |
|---|---|---|---|
| Masakazu Tanaka, Ph. D. Professor | matanaka[a]nagasaki-u.ac.jp | +81-95-819-2423 | +81-95-819-2423 |
| Atsushi Ueda, Ph. D. Associate Professor | aueda[a]nagasaki-u.ac.jp | +81-95-819-2425 | +81-95-819-2423 |
Research interests
- Synthesis of non-natural type amino acids and its application to medicinal chemistry
- Development of helical peptides as an asymmetric organocatalyst
- Design of cell-penetrating foldamers and their application to drug delivery system
Selected publications
- Ueda A, Makura Y, Kakazu S, Kato T, Umeno T, Hirayama K, Doi M, Oba M, Tanaka M: E-Selective ring-closing metathesis in α-helical stapled peptides using carbocyclic α,α-disubstituted α-amino acids. Org Lett 24: 1049-1054, 2022
- Sato K, Umeno T, Ueda A, Kato T, Doi M, Tanaka M: Asymmetric 1,4-addition reactions catalyzed by N-terminal thiourea-modified helical L-Leu-peptide with cyclic amino acids. Chem-Eur J 27: 11216-11220, 2021
- Yamaberi Y, Eto R, Umeno T, Kato T, Doi M, Yokoo H, Oba M, Tanaka M: Synthesis of (S)-(-)-Cucurbitine and Conformation of Its Homopeptides. Org Lett 23: 4358-4362, 2021
- Uchida S, Yamaberi Y, Tanaka M, Oba M: A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of delivered mRNA. Nanoscale 13: 18941, 2021
- Furukawa K, Tanaka M, Oba M: siRNA delivery using amphipathic cell-penetrating peptides into human hepatoma cells. Bioorg Med Chem 28: 115402, 2020
Works
Please find latest works in their website.
