Dept Chemical Biology and Medicinal Chemistry

Research

Course of Pharmaceutical Sciences

http://www.ph.nagasaki-u.ac.jp/lab/chembio/index-e.html

Name, Position	Email *convert [a] to @	Tel
Fumika Yakushiji, Ph.D. Professor	fyakushiji[a]nagasaki-u.ac.jp	+81-95-819-2432
Yoshinori Saito, Ph.D. Associate Professor	saiyoshi[a]nagasaki-u.ac.jp	+81-95-819-2433
Koji Yamada, Ph.D. Associate Professor	kyamada[a]nagasaki-u.ac.jp	+81-95-819-2462
Yosuke Matsuo, Ph.D. Assistant Professor	y-matsuo[a]nagasaki-u.ac.jp	+81-95-819-2434

Chemical biology and medicinal chemistry research related to histone modifications
Chemical biology and medicinal chemistry research related to natural product synthesis
Screening and identification of novel bioactive compounds from our original compound library
Research related to natural products isolated from plants and microbial sources; isolation/structural determination/metabolism/function

Matsuo Y, Iki M, Okubo C, Saito Y, Tanaka T: Conformationally flexible ellagitannins: Conformational analysis of davidiin and punicafolin by DFT-based ¹H–¹H coupling constant calculations. New J Chem, 2025, DOI: 10.1039/D5NJ01278C
Hu Y, Saito Y, Okamoto Y, Matsuo Y, Gong X, Tanaka T: Chemical diversity of Eupatorium heterophyllum leaves collected in Yunnan and Sichuan Provinces of China—Isolation of 13 new sesquiterpene lactones. Molecules 28: 5107, 2023
Toyobe M, Yakushiji F: Synthetic modifications of histones and their functional evaluation. Chem Asian J 17: e202200197, 2022
Abdelhameed RFA, Habib ES, Ibrahim AK, Yamada K, Abdel-Kader MS, Ibrahim AK, Ahmed SA, Badr JM, Nafie MS: Chemical profiling, cytotoxic activities through apoptosis induction in MCF-7 cells and molecular docking of Phyllostachys heterocycla bark nonpolar extract. J Biomol Struct Dyn 40: 9636-9647, 2022
Hirabayashi J, Yakushiji F, Katsuyama A, Ichikawa S: Total synthesis of acaulide and acaulone A. Org Lett 22: 5545–5549, 2020

Please find latest works in their website.