Dept Pharmacotherapeutics

Research

Course of Medical and Dental Sciences

http://www.ph.nagasaki-u.ac.jp/lab/treat/index-e.html

Name, Position	Email *convert [a] to @	Tel	Fax
Kazuhiro Tsukamoto, M.D. & Ph. D. Professor	ktsuka[a]nagasaki-u.ac.jp	+81-95-819-8573	+81-95-819-8575
Kosuke Kosai, M.D. & Ph. D. Associate Professor	k-kosai[a]nagasaki-u.ac.jp	+81-95-819-8574	+81-95-819-8575

Association studies on susceptibility genes for diseases, progression, drug effectiveness, adverse effects, and prognosis using genetic polymorphic markers
Research of DNA-based diagnostic methods for personalized medicine
Research into antibacterial drug-resistance mechanisms of pathogenic bacteria

Ohishi Y, Nakamura M, Iio N, Higa S, Inayoshi M, Aiba Y, Komori A, Omagari K, Ishibashi H, Tsukamoto K. Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis. Hepatology 48:853-862, 2008.
Nanashima K, Mawatari T, Tahara N, Higuchi N, Nakaura A, Inamine T, Kondo S, Yanagihara K, Fukushima K, Suyama N, Kohno S, Tsukamoto K. Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients. Tuberculosis 92:253-259, 2012.
Yamashita A, Inamine T, Suzuki S, Fukuda S, Unoike M, Kawafuchi Y, Machida H, Isomoto H, Nakao K, Tsukamoto K. Genetic variants of SMAD2/3/4/7 are associated with susceptibility to ulcerative colitis in a Japanese genetic background. Immunol Lett 207:64-72, 2019.
Kosai K, Akamatsu N, Ota K, Mitsumoto-Kaseida F, Sakamoto K, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K. BioFire FilmArray Pneumonia Panel enhances detection of pathogens and antimicrobial resistance in lower respiratory tract specimens. Ann Clin Microbiol Antimicrob 21:24, 2022.
Kosai K, Kawamoto Y, Mitsumoto-Kaseida F, Kaku N, Hasegawa H, Takazono T, Izumikawa K, Mukae H, Yanagihara K. Direct detection of Gram-negative bacilli and extended-spectrum β-lactamase producers in positive blood culture specimens using MALDI-TOF MS. Front Cell Infect Microbiol 15:1701423, 2025.

Please find latest works in their website.