Dept Pharmacotherapeutics

Research

Course of Medical and Dental Sciences

http://www.ph.nagasaki-u.ac.jp/lab/treat/index-e.html

Name, Position	Email *convert [a] to @	Tel	Fax
Kazuhiro Tsukamoto, M.D. & Ph. D. Professor	ktsuka[a]nagasaki-u.ac.jp	+81-95-819-8573	+81-95-819-8575
Tatsuro Hirayama, M.D. & Ph. D. Associate Professor	tatsuro_h_20[a]nagasaki-u.ac.jp	+81-95-819-8574	+81-95-819-8575

Association studies on susceptibility genes for diseases, progression, drug effectiveness, adverse effects, and prognosis using genetic polymorphic markers
Research of DNA-based diagnostic methods for personalized medicine
Research into antifungal drug-resistance mechanisms of pathogenic fungi

Ohishi Y, Nakamura M, Iio N, Higa S, Inayoshi M, Aiba Y, Komori A, Omagari K, Ishibashi H, Tsukamoto K. Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis. Hepatology 48:853-862, 2008.
Nanashima K, Mawatari T, Tahara N, Higuchi N, Nakaura A, Inamine T, Kondo S, Yanagihara K, Fukushima K, Suyama N, Kohno S, Tsukamoto K. Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients. Tuberculosis 92:253-259, 2012.
Yamashita A, Inamine T, Suzuki S, Fukuda S, Unoike M, Kawafuchi Y, Machida H, Isomoto H, Nakao K, Tsukamoto K. Genetic variants of SMAD2/3/4/7 are associated with susceptibility to ulcerative colitis in a Japanese genetic background. Immunol Lett 207:64-72, 2019.
Yamaguchi N, Sakaguchi T, Isomoto H, Inamine T, Ueda H, Fukuda D, Ohnita K, Kanda T, Kurumi H, Matsushima K, Hirayama T, Yashima K, Tsukamoto K. ATG16L1 and ATG12 gene polymorphisms are involved in the progression of atrophic gastritis. J Clin Med 12(16):5384, 2023.
Hirayama H, Miyazaki T, Tanaka R, Kitahori N, Yoshida M, Takeda K, Ide S, Iwanaga N, Tashiro M, Takazono T, Izumikawa K, Yanagihara K, Makimura K, Tsukamoto K, Mukae H. TAC1b mutation in Candida auris decreases manogepix susceptibility owing to increased CDR1expression. Antimicrob Agents Chemother 69(2): e0150824, 2025.

Please find latest works in their website.