Department of Pharmacotherapeutics


Course of Medical and Dental Sciences

Teaching staffs

Name, Position Email
*convert [a] to @
Tel Fax
Kazuhiro Tsukamoto, M.D. & Ph. D. Professor ktsuka[a] +81-95-819-8573 +81-95-819-8575
Tatsuro Hirayama,
M.D. & Ph. D.
Associate Professor
tatsuro_h_20[a] +81-95-819-8574 +81-95-819-8575

Research interests

  • Association studies on susceptibility genes for diseases, progression, drug effectiveness, adverse effects, and prognosis using genetic polymorphic markers
  • Research of DNA-based diagnostic methods for personalized medicine
  • Research into antifungal drug-resistance mechanisms of pathogenic fungi

Selected publications

  • Ohishi Y, Nakamura M, Iio N, Higa S, Inayoshi M, Aiba Y, Komori A, Omagari K, Ishibashi H, Tsukamoto K. Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis. Hepatology 48:853-862, 2008.
  • Nanashima K, Mawatari T, Tahara N, Higuchi N, Nakaura A, Inamine T, Kondo S, Yanagihara K, Fukushima K, Suyama N, Kohno S, Tsukamoto K. Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients. Tuberculosis 92:253-259, 2012.
  • Hirayama T, Miyazaki T, Yamagishi Y, Mikamo H, Ueda T, Nakajima K, Takesue Y, Higashi Y, Yamamoto Y, Kimura M, Araoka H, Taniguchi S, Fukuda Y, Matsuo Y, Furutani A, Yamashita K, Takazono T, Saijo T, Shimamura S, Yamamoto K, Imamura Y, Izumikawa K, Yanagihara K, Kohno S, Mukae H. Clinical and Microbiological Characteristics of Candida guilliermondii and Candida fermentati.  Antimicrob Agent Chemoth 62:e02528-17, 2018.
  • Yamashita A, Inamine T, Suzuki S, Fukuda S, Unoike M, Kawafuchi Y, Machida H, Isomoto H, Nakao K, Tsukamoto K. Genetic variants of SMAD2/3/4/7 are associated with susceptibility to ulcerative colitis in a Japanese genetic background. Immunol Lett 207:64-72, 2019.
  • Hirayama T, Miyazaki T, Ito Y, Wakayama M, Shibuya K, Yamashita K, Takazono T, Saijo T, Shimamura S, Yamamoto K, Imamura Y, Izumikawa K, Yanagihara K, Kohno S, Mukae H.  Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation.  Sci Rep 10:3814, 2020.


Please find latest works in their website.