Research
Department of Pharmaceutical Informatics
Teaching staffs
| Name, Position | Email *convert [a] to @ |
Tel | Fax |
|---|---|---|---|
| Shigeru Kawakami, Ph. D., Professor |
skawakam[a]nagasaki-u.ac.jp | +81-95-819-8563 | |
| Hidefumi Mukai, Ph.D., Associate Professor | hmukai[a]nagasaki-u.ac.jp | +81-95-819-8564 | |
| Kohta Mohri, Ph.D., Associate Professor | k.mohri[a]nagasaki-u.ac.jp | +81-95-819-8579 | |
| Shota Warashina, Ph.D., Assistant Professor | shota.warashina[a]nagasaki-u.ac.jp | +81-95-819-8579 | |
| Shoko Nomura, Ph.D., Assistant Professor | shoko.nomura[a]nagasaki-u.ac.jp | +81-95-819-8579 |
Research interests
- Development of cell-selective targeting system using lipid nanoparticles
- Development of drug delivery system for nucleic acid drugs targeting to the brain
- Development of T cell-induced vaccine based on mRNA delivery
- Development of functionalized extracellular vehicles using microfluidic method
- Development of designer bacteria for the treatment of intractable cancer
- Development of companion / precision diagnostics by PET
Selected publications
- Kato N, Moriya N, Matsumoto M, Matsuo A, Yoshida M, Hiu T, Matsuo T, Takashima Y, Kamiya M, Mukai H, Kawakami S: Synthesis of a novel adapter lipid using Fc-region mediated antibody modification for post-insert preparation of transferrin receptor targeted messenger RNA-loaded lipid nanoparticles. Eur J Pharm Biopharm, 203:114468, 2024
- Geng L, Kato N, Kodama Y, Mukai H, Kawakami S: Influence of lipid composition of messenger RNA-loaded lipid nanoparticles on the protein expression via intratracheal administration in mice. Int J Pharm 637: 122896, 2023
- Kato N, Yamada S, Suzuki R, Iida Y, Matsumoto M, Fumoto S, Arima H, Mukai H, Kawakami S: Development of an apolipoprotein E mimetic peptide-lipid conjugate for efficient brain delivery of liposomes. Drug Deliv, 30(1):2173333, 2023
- Sugimoto Y, Suga T, Umino M, Yamayoshi A, Mukai H, Kawakami S: Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives. Drug Delivery 30: 2191891, 2023
- Ogawa K, Kato N, Yoshida M, Hiu T, Matsuo T, Mizukami S, Omata D, Suzuki R, Maruyama K, Mukai H, Kawakami S: Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain. J Controlled Release 348: 34-41, 2022
