Research
Department of Pharmacology and Therapeutic Innovation
Course of Pharmaceutical Sciences
https://www.ph.nagasaki-u.ac.jp/lab/soyakuri/index-e.html/
Teaching staffs
| Name, Position | Email *convert [a] to @ |
Tel | Fax |
|---|---|---|---|
|
Masayuki Kaneko, Ph. D. Professor |
m-kaneko[a]nagasaki-u.ac.jp | +81-95-819-2421 | +81-95-819-2420 |
Koji Matsuhisa, Ph. D. Associate Professor |
matsuhisa[a]nagasaki-u.ac.jp | +81-95-819-2473 | +81-95-819-2420 |
|
Shinya Sato, M. S. Assistant Professor |
shin-sato[a]nagasaki-u.ac.jp | +81-95-819-2422 | +81-95-819-2420 |
Research interests
- Physiological roles and drug discovery of ubiquitin ligase
- Drug discovery using proteolysis-inducing drugs
- Analysis of gene function and drug discovery using genome editing
Selected publications
- Sato S, Matsukawa M, Takemoto M, Okamoto T, Saito A, Omura I, Matsuhisa K, Ikeda H, Imaizumi K, and Kaneko M: Development of a versatile system for evaluating the target protein degradation activity of novel ubiquitin ligases utilizing existing PROTACs. Biochem Biophys Res Commun 749:151370 (2025) DOI: 10.1016/j.bbrc.2025.151370.
- Matsuhisa K, Sato S, and Kaneko M: Identification of E3 Ubiquitin Ligase Substrates Using Biotin Ligase-Based Proximity Labeling Approaches. Biomedicines, 13, 854 (2025) DOI: 10.3390/biomedicines13040854
- Maeoka Y, Wu Y, Okamoto T, Kanemoto S, Guo XP, Saito A, Asada R, Matsuhisa K, Masaki T, Imaizumi K, Kaneko M: NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells. J Biol Chem 294: 101-115 (2019) DOI: 10.1074/jbc.RA118.002896
- Wu Y, Kimura Y, Okamoto T, Matsuhisa K, Asada R, Saito A, Sakaue F, Imaizumi K, Kaneko M: Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Sci Rep 9: 20301 (2019) DOI: 10.1038/s41598-019-56748-6
- Kaneko M, Iwase I, Yamasaki Y, Takai T, Wu Y, Kanemoto S, Matsuhisa K, Asada R, Okuma Y, Watanabe T, Imaizumi K, Nomura Y: Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation. Sci Rep 6: 30955 (2016) DOI: 10.1038/srep30955
Works
Please find latest works in their website.
