Research
Department of Pharmacology and Therapeutic Innovation
Teaching staffs
| Name, Position | Email *convert [a] to @ |
Tel | Fax |
|---|---|---|---|
|
Masayuki Kaneko, Ph. D. Professor |
m-kaneko[a]nagasaki-u.ac.jp | +81-95-819-2421 | +81-95-819-2420 |
|
Shinya Sato, M. S. Assistant Professor |
shin-sato[a]nagasaki-u.ac.jp | +81-95-819-2422 | +81-95-819-2420 |
Research interests
- Physiological roles and drug discovery of ubiquitin ligase
- Drug discovery using proteolysis-inducing drugs
- Analysis of gene function and drug discovery using genome editing
Selected publications
- Maeoka Y, Wu Y, Okamoto T, Kanemoto S, Guo XP, Saito A, Asada R, Matsuhisa K, Masaki T, Imaizumi K, Kaneko M: NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells. J Biol Chem 294: 101-115, 2019
- Wu Y, Kimura Y, Okamoto T, Matsuhisa K, Asada R, Saito A, Sakaue F, Imaizumi K, Kaneko M: Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Sci Rep 9: 20301, 2019
- Kaneko M, Iwase I, Yamasaki Y, Takai T, Wu Y, Kanemoto S, Matsuhisa K, Asada R, Okuma Y, Watanabe T, Imaizumi K, Nomura Y: Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation. Sci Rep 6: 30955, 2016
- Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, Nomura Y: Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. J Neurosci 30: 3924-3932, 2010
Works
Please find latest works in their website.
