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2017年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌の中から最近公表されたアルツハイマー病に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。

・2017年度に紹介された文献一覧 
・2016年度に紹介された文献一覧 
・2015年度に紹介された文献一覧 
・2014年度に紹介された文献一覧 
・2013年度に紹介された文献一覧 
・2012年度に紹介された文献一覧 

#17  (2018/11/2; by YH)

Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ.
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Nature 2018 Oct; 562(7728):578-582
PMID: 30232451

#16 (2018/11/2; by AI)

Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu S, Fujita K, Okazawa H
The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology
Mol Psychiatry 2018 Oct 03  [Epub ahead of print]
PMID: 30283027

#15  (2018/10/26; by KN)

McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P.
Synaptogyrin-3 mediates presynaptic dysfunction induced by tau.
Neuron 2018 Feb 21; 97(4):823-835
PMID: 29398363

#14 (2018/10/26; by DH)

Dunn M, Henke A, Clark S, Kovalyova Y, Kempadoo KA, Karpowicz RJ Jr, Kandel ER, Sulzer D, Sames D
Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo
Nat Commun 2018 Jul 19; 9(1):2838
PMID: 30026491

#13 (2018/10/19; by KF)

Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY, Liu R.
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease.
Cell Rep 2018; Jul 17;24(3):713-723
PMID: 30021167

#12 (2018/10/19; by YT)

Inês S. Amorim, Sonal Kedia, Stella Kouloulia, Konstanze Simbriger, Ilse Gantois, Seyed Mehdi Jafarnejad, Yupeng Li, Agniete Kampaite, Tine Pooters, Nicola Romanò and Christos G. Gkogkas
Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation
J Neurosci 2018; Feb 21;38 (8): 2118-2133
PMID: 29367404

#11 (2018/10/5; by YH)

Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Nat Commun 2018; 9(1):3421
PMID: 30143604

#10 (2018/10/05; by KO)

Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
Nature 2018; 560(7717):185-191
PMID: 30046111

#09 (2018/08/17; by DN)

Leino S, Koski SK, Hänninen R, Tapanainen T, Rannanpää S, Salminen O
Attenuated dopaminergic neurodegeneration and motor dysfunction in hemiparkinsonian mice lacking the α5 nicotinic acetylcholine receptor subunit.
Neuropharmacology 2018; 138:371-380
PMID: 29940207

#08 (2018/07/13; by YH)

Petkovic M, Jemaiel A, Daste F, Specht CG, Izeddin I, Vorkel D, Verbavatz JM, Darzacq X, Triller A, Pfenninger KH, Tareste D, Jackson CL, Galli T
The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion
Nat Cell Biol 2014;16(5):434-444
PMID: 24705552

#07 (2018/07/13; by YH)

Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze JL, Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ
Innate immune memory in the brain shapes neurological disease hallmarks
Nature 2018;556(7701):332-338
PMID: 29643512

#06 (2018/06/08; by RS)

Devi L, Ohno M
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease
Neurobiol Aging 2014;35(10):2272-2281
PMID: 24889041

#05 (2018/06/15; by YT)

Moy JK, Khoutorsky A, Asiedu MN, Dussor G, Price TJ
eIF4E phosphorylation influences Bdnf mRNA translation in mouse dorsal root ganglion neurons
Front Cell Neurosci 2018;12:29
PMID: 29467623

#04 (2018/06/08; by AI)

Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R
Genetic inhibition of Phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer’s disease
PLOS one 2014;9(7) :e101643
PMID: 24992504

#03 (2018/05/11; by KN)

Cheng W, Wang S, Mestre AA, Fu C, Makarem A, Xian F, Hayes LR, Lopez-Gonzalez R, Drenner K, Jiang J, Cleveland DW, Sun S
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
Nat Commun 2018;9(1):51
PMID: 29302060

#02 (2018/04/27; by DH)

Fruscione F, Valente P, Sterlini B, Romei A, Baldassari S, Fadda M, Prestigio C, Giansante G, Sartorelli J, Rossi P, Rubio A, Gambardella A, Nieus T, Broccoli V, Fassio A, Baldelli P, Corradi A, Zara F, Benfenati F
PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity
Brain 2018;141(4):1000-1016
PMID: 29554219

#01 (2018/04/27; by KN)

Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
Brain 2017;140(12):3252-3268
PMID: 29155979



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