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2017年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌の中から最近公表されたアルツハイマー病に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。

・2016年度に紹介された文献一覧 
・2015年度に紹介された文献一覧 
・2014年度に紹介された文献一覧 
・2013年度に紹介された文献一覧 
・2012年度に紹介された文献一覧 

*, corresponding author; #, equal contribution

#35 (2018/01/29; by SY)

Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Stiller B, Mandelkow EM, Mandelkow E,* Cuervo AM*
Interplay of pathogenic forms of human tau with different autophagic pathways
Aging Cell (in press)
PMID: 29024336

#34 (2018/01/29; by AS)

Rasmussen J,# Mahler J,# Beschorner N,# Kaeser SA, Hasler LM, Baumann F, Nystrom S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarstrom P, Staufenbiel M, Walker LC, Jucker M*
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease
Proc Natl Acad Sci U S A 2017;114(49):13018-13023
PMID: 29158413

#33 (2018/01/25; by KF)

Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen ?, Gubert Olive M, Shakirzyanova A, Leskela S, Sarajarvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hamalainen RH, Koistinaho J*
PSEN1 mutant iPSC-derived model reveals severe astrocyte pathology in Alzheimer's disease
Stem Cell Reports (in press)
PMID: 29153989

#32 (2018/01/25; by KO)

He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, Trojanowski JQ, Lee VM*
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Nat Med (in press)
PMID: 29200205

#31 (2018/01/19; by RS)

Netzer WJ,* Bettayeb K, Sinha SC, Flajolet M, Greengard P,* Bustos V
Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage
Proc Natl Acad Sci U S A 2017;114(6):1389-1394
PMID: 28115709

#30 (2018/01/19; by SU)

Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, aertig MA, Abdullatif AA, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B* *
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
Nat Neurosci (in press)
PMID: xxxxxxxx

#29 (2017/12/25; by ST)

Xiang J, Yang S, Xin N, Gaertig MA, Reeves RH, Li S,* Li XJ*
DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome
Proc Natl Acad Sci U S A 2017;114(7):E1224-E1233
PMID: 28137862

#28 (2017/12/25; by MK)

Andrew RJ,# Fernandez CG,# Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prevot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G*
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease
Proc Natl Acad Sci U S A 2017;114(45):E9665-E9674
PMID: 29078331

#27 (2017/12/14; by YK)

Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A*
Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease
Proc Natl Acad Sci U S A 2017;114(45):E9645-E9654
PMID: 29042514

#26 (2017/12/14; by KK)

Li C, Götz J*
Somatodendritic accumulation of tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation
EMBO J 2017;36(21):3120-3138
PMID: 28864542

#25 (2017/12/08; by SY)

Siegel G,* Gerber H, Koch P, Bruestle O, Fraering PC, Rajendran L*
The Alzheimer's disease γ-secretase generates higher 42:40 ratios for β-amyloid than for p3 peptides
Cell Rep 19(10):1967-1976
PMID: 28591569

#24 (2017/12/08; by AS)

Sun M, Zhang H*
Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1
Neurobiol Aging 2017;60:129-140
PMID: 28946017

#23 (2017/11/22; by KF)

Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B,* Chávez-Gutiérrez L*
Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions
Cell 2017;170(3):443-456.e14
PMID: 28753424

#22 (2017/11/22; by RS)

Kim NY, Cho MH, Won SH, Kang HJ, Yoon SY, Kim DH*
Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1
Alzheimers Res Ther 2017;9(1):4
PMID: 28109317

#21 (2017/11/17; by YH)

Zhang Y, Kim MS, Jia B, Yan J, Zuniga-Hertz JP, Han C, Cai D*
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Nature 2017;548(7665):52-57
PMID: 28746310

#20 (2017/11/10; by DH)

Kim J, Kim Y, Nakajima R, Shin A, Jeong M, Park AH, Jeong Y, Jo S, Yang S, Park H, Cho SH, Cho KH, Shim I, Chung JH, Paik SB, Augustine GJ, Kim D*
Inhibitory basal ganglia inputs induce excitatory motor signals in the thalamus
Neuron 2017;95(5):1181-1196.e8
PMID: 28858620

#19 (2017/10/26; by YO)

Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trumbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C*
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
EMBO Rep 2017;18(7):1186-1198
PMID: 28483841

#18 (2017/10/26; by KN)

George C, Gontier G, Lacube P, Francois JC, Holzenberger M,* Aïd S
The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons
Brain 2017;140(7):2012-2027
PMID: 28595357

#17 (2017/10/19; by KO)

Paolicelli RC,* Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L*
TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss
Neuron 2017;95(2):297-308
PMID: 28669544

#16 (2017/10/19; by SU)

Branca C, Shaw DM, Belfiore R, Gokhale V, Shaw AY, Foley C, Smith B, Hulme C, Dunckley T, Meechoovet B, Caccamo A, Oddo S*
Dyrk1 inhibition improves Alzheimer's disease-like pathology
Aging Cell 2017;16(5):1146-1154
PMID: 28779511

#15 (2017/10/13; by ST)

Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M*
Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice
Proc Natl Acad Sci U S A (in press)
PMID: 28874550

#14 (2017/10/13; by MK)

Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L,* De Strooper B*
Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration
EMBO Mol Med 2017;9(8):1088-1099
PMID: 28588032

#13 (2017/10/06; by YK)

Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biferi MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C*
β-Amyloid precursor protein intracellular domain controls mitochondrial function by modulating phosphatase and tensin homolog-induced kinase 1 transcription in cells and in Alzheimer mice models
Biol Psychiatry (in press)
PMID: 28587718

#12 (2017/10/06; by KK)

Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C*
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
EMBO Mol Med (in press)
PMID: 28855300

#11 (2017/06/23; by YH)

Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T*
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
Nature 2017;544(7651):488-492
PMID: 28424512

#10 (2017/06/23; by KF)

Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D*
Neuroprotective functions for the histone deacetylase SIRT6
Cell Rep 2017;7:18(13):3052-3062
PMID: 28355558

#09 (2017/06/01; by DH)

Wu D, Bacaj T, Morishita W, Goswami D, Arendt KL, Xu W, Chen L, Malenka RC,* Sudhof TC*
Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
Nature (in press)
PMID: 28355182

#08 (2017/05/18; by KO)

Yang YR,# Song S,# Hwang H, Jung JH, Kim SJ, Yoon S, Hur JH, Park JI, Lee C, Nam D, Seo YK, Kim JH, Rhim H,* Suh PG*
Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
Sic Rep 2017;7:44921
PMID: 28368052

#07 (2017/05/18; by YO)

Zhong L,# Chen XF,# Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer JD, Xu H, Bu G*
Soluble TREM2 induces inflammatory responses and enhances microglial survival
J Exp Med 2017;214(3):597-607
PMID: 28209725

#06 (2017/05/11; by SY)

Calafate S, Flavin W, Verstreken P,* Moechars D*
Loss of Bin1 promotes the propagation of Tau pathology.
Cell Rep 2016;17(4):931-940
PMID: 27760323

#05 (2017/05/11; by AS)

Liu Q, Tang Y, Chen L, Liu N, Lang F, Liu H, Wang P, Sun X*
E3 ligase SCFβTrCP-induced DYRK1A protein degradation is essential for cell cycle progression in HEK293 cells
J Biol Chem 2016;291(51):26399-26409
PMID: 27807027

#04 (2017/04/20; by KN)

Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P*
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein
Biochim Biophys Acta 20171864(1):217-230
PMID: 27818272

#03 (2017/04/20; by DN)

Chen C, Arai I, Satterfield R, Young SM Jr, Jonas P*
Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse
Cell Rep 2017;18(3):723-736
PMID: 28099850

#02 (2017/04/07; by RS)

Junker M, Rapoport TA*
Involvement of VAT-1 in phosphatidylserine transfer from the endoplasmic reticulum to mitochondria
Traffic 2015;16(12):1306-1317
PMID: 26394711

#01 (2017/04/07; by SU)

Kim H,# Lee KS,# Kim AK, Choi M, Choi K, Kang M, Chi SW, Lee MS, Lee JS, Lee SY, Song WJ, Yu K, Cho S*
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition
Dis Model Mech 2016;9(8):839-848
PMID: 27483355



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長崎大学大学院 医歯薬学総合研究科
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