2023年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌(可能な限り)の中から最近公表されたアルツハイマー病等の神経変性疾患、痙攣性神経疾患や遺伝子発現機構に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
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Dong L, Xie HZ, Jia L, Hong L, Li G.
Inhibition of amyloid β aggregation and cytotoxicity by berbamine hydrochloride.
Chemistry2024;29(56):e202301865
PMID: 37470691
Nesbit MO, Ahn S, Zou H, Floresco SB, Phillips AG.
Potentiation of prefrontal cortex dopamine function by the novel cognitive enhancer d-govadine.
Neuropharmacology2024;109849
PMID: 38244888
Liu XQ, Hu T, Wu GL, Qiao LJ, Cai YF, Wang Q, Zhang SJ.
Tanshinone IIA, the key compound in Salvia miltiorrhiza, improves cognitive impairment by upregulating Aβ-degrading enzymes in APP/PS1 mice.
Int J Biol Macromol2024;254(Pt 2):127923
PMID: 37101380
Gao AX, Xia TC, Lin LS, Dong TT, Tsim KW.
The neurotrophic activities of brain-derived neurotrophic factor are potentiated by binding with apigenin, a common flavone in vegetables, in stimulating the receptor signaling.
CNS Neurosci Ther2023;29(10):2787-27998
PMID: 37101380
Pelosi A, Nakamura Y, Girault JA, Hervé D.
BDNF/TrkB pathway activation in D1 receptor-expressing striatal projection neurons plays a protective role against L-DOPA-induced dyskinesia.
Neurobiol Dis2023;185:106238
PMID: 37495178
Revol RS, Koistinen NA, Menon PK, Chicote-Gonzàlez A, Iverfeldt K, Ström AL.
α-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair.
Mol Cell Neurosci 2023;127:103903
PMID: 37918552
Kim HY, Lee J, Kim HJ, Lee BE, Jeong J, Cho EJ, Jang HJ, Shin KJ, Kim MJ, Chae YC, Lee SE, Myung K, Baik JH, Suh PG, Kim JI.
PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.
Exp Mol Med 2023;Online ahead of print
PMID: 37907739
Hedaya OM, Venkata Subbaiah KC, Jiang F, Xie LH, Wu J, Khor ES, Zhu M, Mathews DH, Proschel C, Yao P.
Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy.
Nat Commun 2023;14(1):6166
PMID: 37789015
Kaplelach AK, Fox SN, Cook AK, Hall JA, Dannemiller RS, Jaunarajs KL, Arrant AE.
Regulation of extracellular progranulin in medial prefrontal cortex.
Neurobiol Dis 2023;188: 106326
PMID: 37838007
Liu CC, Wang N, Chen Y, Inoue Y, Shue F, Ren Y, Wang M, Qiao W, Ikezu TC, Li Z, Zhao J, Martens Y, Doss SV, Rosenberg CL, Jeevaratnam S, Jia L, Raulin AC, Qi F, Zhu Y, Alnobani A, Knight J, Chen Y, Linares C, Kurti A, Fryer JD, Zhang B, Wu LJ, Kim BY, Bu G.
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease.
Nat Immunol 2023;24(11):1854-1866
PMID: 37857825
Du JC, Chang MH, Yeh CJ, Lee MT, Lee HJ, Chuang SH, Chiou LC.
Pivotal role of Slitrk1 in adult striatal cholinergic neurons in mice: implication in Tourette Syndrome.
Ann Neurol 2023; Online ahead of print.
PMID: 37776102
Park JS, Choe K, Lee HJ, Park TJ, Kim MO.
Neuroprotective effects of osmotin in Parkinson’s disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling.
J Biomed Sci 2023;30(1):66
PMID: 37568205
Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu GQ, Yu X, Smith N, Sayed FA, Gan L, Paz JT, Mucke L.
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.
Neurobiol Dis 2023;186:106263
PMID: 37591465
Hu J, Guan X, Zhao M, Xie P, Guo J, Tan J.
Genome-wide CRISPR-Cas9 Knockout Screening Reveals a TSPAN3-mediated Endo-lysosome Pathway Regulating the Degradation of α-Synuclein Oligomers.
Mol Neurobiol 2023;60(11):6731-6747
PMID: 37477766
Ban YH, Park D, Choi EK, Kim TM, Joo SS, Kim YB.
Effectiveness of Combinational Treatments for Alsheimer's Disease with Human Neutral Stem Cells and Microglial Cells Over-Expressing Functional Genes.
Int J Mol Sci 2023;24(11):9561
PMID: 37298510
Lee-Gosselin A, Jury-Garfe N, You Y, Dabin L, Jin F, Soni D, Dutta S, Rochet JC, Kim J, Oblak AL, Lasagna-Reeves CA.
TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo.
Cells 2023;12(12):1597
PMID: 37371067
Kim SH, Cho YS, Kim Y, Park J, Yoo SM, Gwak J, Kim Y, Gwon Y, Kam TI, Jung YK.
Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease.
Autophagy 2023;19(8):2318-2337
PMID: 36843263
Kim E, Kim H, Jedrychowski MP, Bakiasi G, Park J, Kruskop J, Choi Y, Kwak SS, Quinti L, Kim DY, Wrann CD, Spiegelman BM, Tanzi RE, Choi SH.
Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.
Neuron 2023;111(22):3619-3633.e8
PMID: 37689059
Ospondpant D, Xia Y, Lai QWS, Yuen GK, Yang M, Chanthanam K, Dong TT, Tsim KWK.
The extracts of Dracaena cochinchinensis stemwood suppress inflammatory response and phagocytosis in lipopolysaccharide-activated microglial cells.
Phytomedicine 2023;118:154936
PMID: 37385071
Gedam M, Comerota MM, Propson NE, Chen T, Jin F, Wang MC, Zheng H.
Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and enhances microglial response to Aβ pathology.
J Clin Invest 2023;133(12):e167501
PMID: 37317973
Ducrot C, Carvalho GD, Delignat-Lavaud B, Delmas CVL, Halder P, Giguère N, Pacelli C, Mukherjee S, Bourque MJ, Parent M, Chen LY, Trudeau LE.
Conditional deletion of neurexins dysregulates neurotransmission from dopamine neurons.
Elife 2023;12: e87902
PMID: 37409563
Yanaizu M, Adachi H, Araki M, Kontani K, Kino Y.
Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2.
Commun Biol 2023;6(1):616
PMID: 37291187
Kim W, Tripathi M, Kim C, Vardhineni S, Cha Y, Kandi SK, Feitosa M, Kholiya R, Sah E, Thakur A, Kim Y, Ko S, Bhatia K, Manohar S, Kong YB, Sindhu G, Kim YS, Cohen B, Rawat DS, Kim KS.
An optimized Nurr1 agonist provides disease-modifying effects in Parkinson's disease models.
Nat Commun 2023;14(1):42835
PMID: 37463889
Xia CX, Gao AX, Dong TT, Tsim KW.
Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons: Signaling via PI3K/Akt and ERK pathways.
Phytomedicine 2023;1115:154832
PMID: 37463889
Greve HJ, Dunbar AL, Lombo CG, Ahmed C, Thang M, Messenger EJ, Mumaw CL, Johnson JA, Kodavanti UP, Oblak AL, Block ML.
The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment.
Brain 2023; 146(3):991-1005
PMID: 35348636
Sterlini B, Franchi F, Morinelli L, Corradi B, Parodi C, Albini M, Bianchi A, Marte A.
Missense mutations in the membrane domain of PRRT2 affect its interaction with Nav1.2 voltage-gated sodium channels.
Neurobiol Dis. 2023; 183:106177
PMID: 37271286
Ennerfelt H, Holliday C, Shapiro DA, Zengeler KE, Bolte AC, Ulland TK, Lukens JR.
CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer's disease mouse model
Proc Natl Acad Sci USA2023; 120(24):e2303760120
PMID: 37276426
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE.
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Genome Med 2023; 15 (1): 11
PMID: 36805764
Firouzi R, Sowalti-Hashjin S, Chávez-García C, Ashouri M, Karimi-Jafari MH, Karttunen M.
Identification of Catechin’s Binding Sites in Monomeric Aβ42 through Ensemble Docking and MD Simulations.
Int J Mol Sci 2023; 24(9):8161
PMID: 37175868
Jiao L, Yu Z, Zhong X, Zhong X, Xing L, Ma G, Ma G, Shen J, Wu Y, Du K, Liu J, Tong J, Fu J, Wei M, Liu M.
Cordycepin improved neuronal synaptic plasticity through CREB-induced NGF upregulation driven by MG-M2 polarization: a microglia-neuron symphony in AD.
Biomed Pharmacother 2023; 157:114054
PMID: 36462314
Wang C, Yang Y, Zhang X, Shi Z, Gao H, Zhong M, Fan Y, Zhang H, Liu B, Qing G.
Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer's disease.
Sci Adv. 2023; 9(21):eade0293
PMID: 37235655
Bohlen J, Roiuk M, Neff M, Teleman AA.
PRRC2 proteins impact translation initiation by promoting leaky scanning.
Nucleic Acids Res 2023; 51(7): 3391–3409
PMID: 36869665
Fracassi A, Marcatti M, Tumurbaatar B, Woltjer R, Moreno S, Taglialatela G
TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology.
Brain Pathol 2023; 33 (1): e13108
PMID: 35816404
Gratuze M, Schlachetzki JC, D'Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O'Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, Glass CK, Ulrich JD, Holtzman DM.
TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.
Neuron 2023; 111(2):202-219.e7.
PMID: 36368315
Seo DC, Ju YH, Seo JJ, Oh SJ, Lee CJ, Lee SE, Nam MH.
DDC-promoter-driven chemogenetic activation of SNpc dopaminergic neurons alleviates parkinsonian motor symptoms.
Int J Mol Sci 2023; 24(3):2491
PMID: 36768816
Liu K, Song M, Gao S, Yao L, Zhang L, Feng J, Wang L, Gao R, Wang Y.
The dynamics of dopamine D2 receptor-expressing striatal neurons and the downstream circuit underlying L-dopa-induced dyskinesia in rats.
Neurosci Bull 2023; https://doi.org/10.1007/s12264-023-01054-5
PMID: 37022638
Valente P, Marte A, Franchi F, Sterlini B, Casagrande S, Corradi A, Baldelli P, Benfenati F.
A Push-Pull Mechanism Between PRRT2 and β4-subunit Differentially Regulates Membrane Exposure and Biophysical Properties of NaV1.2 Sodium Channels.
Mol Neurobiol 2023; 60(3):1281-1296
PMID: 36441479
Amin PH, Carlson KR, Wek RC.
An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response.
J Biol Chem2023; 299(2):102864
PMID: 36596357
Martínez-Mármol R, Small C, Jiang A, Palliyaguru T, Wallis TP, Gormal RS, Sibarita JB, Götz J, Meunier FA.
Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates.
Mol Psychiatry 2023; 28(2):946-962
PMID: 36258016
Chun YS, Kim MY, Lee SY, Kim MJ, Hong TJ, Jeon JK, Ganbat D, Kim HT, Kim SS, Kam TI, Han S.
AMEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer's Disease.
Mol Psychiatry 2022; 27(11): 4770–4780
PMID: 35948663
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesamaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM.
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Nat Neurosci 2023; 26(3):416-429
PMID: 36635496
Rofo F, Metzendorf NG, Saubi C, Suominen L, Godec A, Sehlin D, Syvänen S, Hultqvist G.
Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta
in a mouse model of Alzheimer's diseasebr> Alzheimers Res Ther 2022; 14(1):180
PMID: 36471433
Franchi F, Marte A, Corradi B, Sterlini B, Alberini G, Romei A, Fusco AD, Vogel A, Maragliano L, Baldelli P, Corradi A, Valente P, Benfenati F.
The intramembrane COOH-terminal domain of PRRT2 regulates voltage-dependent Na+ channels
J Biol Chem 2023; 104632
PMID: 36958475
Xu QA, Boerkoel P, Hirsch-Reinshagen V, Mackenzie IR, Hsiung GR, Charm G, To EF, Liu AQ, Schwab K, Jiang K, Sarunic M, Beg MF, Pham W, Cui J, To E, Lee S, Matsubara JA
Müller cell degeneration and microglial dysfunction in the Alzheimer's retina.
Acta Neuropathol Commun 2022; 10(1):145
PMID: 36199154
Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF.
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
PNAS 2023;119(5):e2114486119
PMID: 35082148
Gomaa AA, Farghaly HSM, Ahmed AM, Hemida FK.
Intermittent treatment with Apremilast, a phosphodiesterase-4 inhibitor, ameliorates Alzheimer's-like pathology and symptoms through multiple targeting actions in aged T2D rats.
Int Immunopharmacol 2023; 117:109927
PMID: 36848793
Jain N, Lewis CA, Ulrich JD, Holtzman DM.
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading.
J Exp Med 2023; 220(1):e20220654.
PMID: PMC9559604
Tian Y, Viles JH.
PH dependence of amyloid-β fibril assembly kinetics: unravelling the microscopic molecular processes.
Angew Chem Int Ed Engl 2022; 61(48):e202210675
PMID: 36197009
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