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文献紹介 (2013/04/01 - 2014/03/31)

2013年度にゲノム創薬学研究室(旧 薬品生物工学研究室)のセミナー時に紹介された文献の一覧です。


*, corresponding author; #, equal contribution

#40 (2014/03/17; by RK)

Xu PX,# Wang SW,# Yu XL, Su YJ, Wang T, Zhou WW, Zhang H, Wang YJ,* Liu RT*
Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation
Behav Brain Res 2014;264:173-180
PMID: 24512768

#39 (2014/03/17; by RK)

Currais A, Prior M, Dargusch R, Armando A, Ehren J, Schubert D, Quehenberger O, Maher P*
Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice
Aging Cell 2014;13(2):379-390
PMID: 24341874

#38 (2014/03/07; by AK)

Adorno M, Sikandar S, Mitra SS, Kuo A, Nicolis Di Robilant B, Haro-Acosta V, Ouadah Y, Quarta M, Rodriguez J, Qian D, Reddy VM, Cheshier S, Garner CC, Clarke MF*
Usp16 contributes to somatic stem-cell defects in Down's syndrome
Nature 2013;501(7467):380-384
PMID: 24025767

#37 (2014/03/07; by MH)

Heilbronner G1, Eisele YS, Langer F, Kaeser SA, Novotny R, Nagarathinam A, Aslund A, Hammarstrom P, Nilsson KP, Jucker M*
Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice
EMBO Rep 2013;14(11):1017-1022
PMID: 23999102

#36 (2014/02/28; by TM)

Kühn S,* Gleich T, Lorenz RC, Lindenberger U, Gallinat J
Playing Super Mario induces structural brain plasticity: gray matter changes resulting from training with a commercial video game
Mol Psychiatry 2014;19(2):265-271
PMID: 24166407

#35 (2014/02/28; by TM)

Theendakara V,#1 Patent A,#1 Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV,#2,* Bredesen DE#2,*
Neuroprotective Sirtuin ratio reversed by ApoE4
Proc Natl Acad Sci U S A 2013;110(45):18303-18308
PMID: 24145446

#34 (2014/01/24; by YK)

Donnelly CJ, Zhang PW, Pham JT, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R,* Rothstein JD*
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
Neuron 2013;80(2):415-428
PMID: 24139042

#33 (2014/01/24; by EK)

Cruchaga C,* Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, Hsu S, Choi J, Ryten M; UK Brain Expression Consortium (UKBEC), Hardy J, Ryten M, Trabzuni D, Weale ME, Ramasamy A, Smith C, Sassi C, Bras J, Gibbs JR, Hernandez DG, Lupton MK, Powell J, Forabosco P, Ridge PG, Corcoran CD, Tschanz JT, Norton MC, Munger RG, Schmutz C, Leary M, Demirci FY, Bamne MN, Wang X, Lopez OL, Ganguli M, Medway C, Turton J, Lord J, Braae A, Barber I, Brown K; The Alzheimer’s Research UK (ARUK) Consortium, Passmore P, Craig D, Johnston J, McGuinness B, Todd S, Heun R, Kolsch H, Kehoe PG, Hooper NM, Vardy ER, Mann DM, Pickering-Brown S, Brown K, Kalsheker N, Lowe J, Morgan K, David Smith A, Wilcock G, Warden D, Holmes C, Pastor P, Lorenzo-Betancor O, Brkanac Z, Scott E, Topol E, Morgan K, Rogaeva E, Singleton AB, Hardy J, Kamboh MI, St George-Hyslop P, Cairns N, Morris JC, Kauwe JS, Goate AM
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease
Nature 2014;505(7484):550-554
PMID: 24336208

#32 (2013/12/27; by AT)

Kim T,* Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, Hyman BT, Shatz CJ*
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model
Science 2013;341(6152):1399-1404
PMID: 24052308

#31 (2013/12/20; by TM)

Lonskaya I, Hebron ML, Desforges NM, Franjie A, Moussa CE*
Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
EMBO Mol Med 2013;5(8):1247-1262
PMID: 23737459

#30 (2013/12/20; by RK)

Singh I, Sagare AP, Coma M, Perlmutter D, Gelein R, Bell RD, Deane RJ, Zhong E, Parisi M, Ciszewski J, Kasper RT, Deane R*
Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance
Proc Natl Acad Sci U S A 2013;110(36):14771-14776
PMID: 23959870

#29 (2013/12/13; by RN)

Mori K,# Arzberger T,# Grässer FA, Gijselinck I, May S, Rentzsch K, Weng SM, Schludi MH, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C,* Edbauer D*
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
Acta Neuropathol 2013;126(6):881-893
PMID: 24132570

#28 (2013/12/13; by CK)

Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB, Strittmatter SM*
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer Aβ oligomer bound to cellular prion protein
Neuron 2013;79(5):887-902
PMID: 24012003

#27 (2013/11/12; by KI)

Lucin KM, O'Brien CE, Bieri G, Czirr E, Mosher KI, Abbey RJ, Mastroeni DF, Rogers J, Spencer B, Masliah E, Wyss-Coray T*
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
Neuron 2013;79(5):873-886
PMID: 24012002

#26 (2013/11/12; by NA)

Rhinn H,# Fujita R,# Qiang L, Cheng R, Lee JH, Abeliovich A*
Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease
Nature 2013;500(7460):45-50
PMID: 23883936

#25 (2013/11/01; by AT)

Bouter Y, Dietrich K, Wittnam JL, Rezaei-Ghaleh N, Pillot T, Papot-Couturier S, Lefebvre T, Sprenger F, Wirths O, Zweckstetter M, Bayer TA*
N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits
Acta Neuropathol 2013;126(2)189-205
PMID: 23685882

#24 (2013/11/01; by YN)

Pietri M, Dakowski C, Hannaoui S, Alleaume-Butaux A, Hernandez-Rapp J, Ragagnin A, Mouillet-Richard S, Haik S, Bailly Y, Peyrin JM, Launay JM,* Kellermann O, Schneider B*
PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases
Nat Med 2013;19(9):1124-1131
PMID: 23955714

#23 (2013/10/18; by KI)

Santuccione AC,#,* Merlini M,# Shetty A,# Tackenberg C, Bali J, Ferretti MT, McAfoose J, Kulic L, Bernreuther C, Welt T, Grimm J, Glatzel M, Rajendran L, Hock C, Nitsch RM*
Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice
Mol Psychiatry 2013;18(3):358-368
PMID: 22688190

#22 (2013/10/18; by MH)

Kam TI,# Song S,# Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, Klein WL, Yuan J, Jung YK*
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease
J Clin Invest 2013;123(7):2791-2802
PMID: 23921129

#21 (2013/10/11; by TH)

Ni R, Gillberg PG, Bergfors A, Marutle A, Nordberg A*
Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue
Brain 2013;136(Pt 7):2217-2227
PMID: 23757761

#20 (2013/10/11; by AK)

Jiang J, Jing Y, Cost GJ, Chiang JC, Kolpa HJ, Cotton AM, Carone DM, Carone BR, Shivak DA, Guschin DY, Pearl JR, Rebar EJ, Byron M, Gregory PD, Brown CJ, Urnov FD, Hall LL, Lawrence JB*
Translating dosage compensation to trisomy 21
Nature 2013;500(7462):296-300
PMID: 23863942

#19 (2013/10/04; by TA)

Rochin L, Hurbain I, Serneels L, Fort C, Watt B, Leblanc P, Marks MS, De Strooper B, Raposo G, van Niel G*
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells
Proc Natl Acad Sci U S A 2013;110(26):10658-10663
PMID: 23754390

#18 (2013/10/04; by TK)

Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E*
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits
Nat Neurosci 2013;16(9):1299-1305
PMID: 23933749

#17 (2013/08/08; by YN)

Frenkel D,#,* Wilkinson K,# Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J*
Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
Nat Commun 2013;4:2030
PMID: 23799536

#16 (2013/07/19; by RN)

Lombardo Y,* Filipović A,* Molyneux G, Periyasamy M, Giamas G, Hu Y, Trivedi PS, Wang J, Yague E, Michel L, Coombes RC
Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo
Proc Natl Acad Sci U S A 2012;109(41):16558-16563
PMID: 23012411

#15 (2013/07/12; by TK)

Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A, Polleux F*
The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation
Neuron 2013;78(1):94-108
PMID: 23583109

#14 (2013/07/12; by MH)

Figueiredo CP,# Clarke JR,# Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG,* Ferreira ST*
Memantine rescues transient cognitive impairment caused by high-molecular-weight Aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers
J Neurosci 2013;33(23):9626-9634
PMID: 23739959

#13 (2013/07/10; by TA)

Moreno-Gonzalez I,# Estrada LD,# Sanchez-Mejias E, Soto C*
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease
Nat Commun 2013;4:1495
PMID: 23422663

#12 (2013/06/25; by CK)

Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M,* Haass C*
Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling
J Neurosci 2013;33(18):7856-7869
PMID: 23637177

#11 (2013/06/25; by AK)

Kim WS,# Li H,# Ruberu K, Chan S, Elliott DA, Low JK, Cheng D, Karl T, Garner B*
Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease
J Neurosci 2013;33(10):4387-4394
PMID: 23467355

#10 (2013/06/14; by TU)

Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE*
Alzheimer's Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Neuron 2013;78(4):631-643
PMID: 23623698

#09 (2013/06/14; by TM)

Hedskog L, Pinho CM, Filadi R, Ronnback A, Hertwig L, Wiehager B, Larssen P, Gellhaar S, Sandebring A, Westerlund M, Graff C, Winblad B, Galter D, Behbahani H, Pizzo P, Glaser E, Ankarcrona M*
Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
Proc Natl Acad Sci U S A 2013;110(19):7916-7921
PMID: 23620518

#08 (2013/05/30; by RK)

Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM*
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
Science 2012;338(6109):949-953
PMID: 23161999

#07 (2013/05/17; by TH)

Szatmari EM, Oliveira AF, Sumner EJ, Yasuda R*
Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction
J Neurosci 2013;33(12):5367-5374
PMID: 23516302

#06 (2013/05/17; by NA)

Kessels HW,# Nabavi S,# Malinow R*
Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depressin
Proc Natl Acad Sci U S A 2013;110(10):4033-4038
PMID: 23431156

#05 (2013/05/09; by YK)

Wahlster L,# Arimon M,# Nasser-Ghodsi N, Post KL, Serrano-Pozo A, Uemura K, Berezovska O*
Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease
Acta Neuropathol 2013;125(2):187-199
PMID: 23138650

#04 (2013/05/09; by EK)

Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, Mucke L*
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
Nat Neurosci 2013;16(5):613-621
PMID: 23525040

#03 (2013/04/26; by AT)

Li S,* Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ*
Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers
Neuron 2013;77(5):929-941
PMID: 23473322

#02 (2013/04/26; by KI)

Chen Z, Jalabi W, Shpargel KB, Farabaugh KT, Dutta R, Yin X, Kidd GJ, Bergmann CC, Stohlman SA, Trapp BD*
Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4
J Neurosci 2012;32(34):11706-11715
PMID: 22915113

#01 (2013/04/05; by MA)

Katsuda T, Tsuchiya R, Kosaka N, Yoshioka Y, Takagaki K, Oki K, Takeshita F, Sakai Y, Kuroda M, Ochiya T*
Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes
Sci Rep 2013;3:1197
PMID: 23378928


長崎大学大学院 医歯薬学総合研究科
生命薬科学専攻 分子創薬科学講座