2017年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌の中から最近公表されたアルツハイマー病に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
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Borreca A, Valeri F, De Luca M, Ernst L, Russo A, Nobili A, Cordella A, Corsetti V, Amadoro G, Mercuri NB, D'Amelio M, Ammassari-Teule M.
Transient upregulation of translational efficiency in prodromal and early symptomatic Tg2576 mice contributes to Aβ pathology.
Neurobiol Dis 2020;139:104787
PMID: 32032729
Bagalkot TR, Block ER, Bucchin K, Balcita-Pedicino JJ, Calderon M, Sesack SR, Sorkin A.
Dopamine Transporter Localization in Medial Forebrain Bundle Axons Indicates Its Long-Range Transport Primarily by Membrane Diffusion with a Limited Contribution of Vesicular Traffic on Retromer-Positive Compartments.
J Neurosci 2020; 41(2):234-250
PMID: 33234607
Xia Y, Wang ZH, Zhang J, Liu X, Yu SP, Ye KX, Wang JZ, Ye K, Wang XC.
C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease.
Mol psychiatry 2020; Online ahead of print
PMID: 33339957
Prager EM, Dorman DB, Hobel ZB, Malgady JM, Blackwell KT, Plotkin JL.
Dopamine oppositely modulates state transitions in striosome and matrix direct pathway striatal spiny neurons.
Neuron 2020; 108(6):1091-1102.e5
PMID: 33080228
Ledo JH, Liebmann T, Zhang R, Chang JC, Azevedo EP, Wong E, Silva HM, Troyanskaya OG, Bustos V, Greengard P.
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.
Mol Psychiatry 2020; Online ahead of print
PMID: 32792660
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA.
Endosomal dysfunction induced by directly overactivating Rab5 recapitulates prodromal and neurodegenerative features of Alzheimer’s disease.
Cell Rep 2020;33(8):108420
PMID: 33238112
Fitz NF, Wolfe CM , Playso BE , Biedrzycki RJ , Lu Y , Nam KN , Lefterov L , Koldamova R.
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice.
Mol Neurodegener 2020;15(1):41
PMID: 32703241
Abd-Elrahman KS, Albaker A, de Souza JM, Ribeiro FM, Schlossmacher MG, Tiberi M, Hamilton A, Ferguson SSG.
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner.
Sci Signal 2020;13(662):eabd2494
PMID: 33323410
Shen R, Zhao X, He L, Ding Y, Xu W, Lin S, Fang S, Yang W, Sung K, Spencer B, Rissman RA, Lei M, Ding J, Wu C.
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease.
Transl Neurodegener 2020;9(1):26
PMID: 32552912
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, Q Do K, Halliez S, Bezzi P, Buée L, Leuba G, Colin M, Toni N, Déglon N.
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Nat Neurosci 2020;23(12):1567-1579
PMID: 33169029
Dastidar SG, Pham MT, Mitchell MB, Yeom SG, Jordan S, Chang A, Sopher BL, La Spada AR.
4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response.
J Neurosci 2020;40(45):8734-8745
PMID: 33046555
Batool A, Majeed ST, Aashaq S, Majeed R, Bhat NN, Andrabi KI.
Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.
Mol Cell Biochem 2020;465(1-2):13-26
PMID: 31782083
Rahman K, Coomer CA, Majdoul S, Ding SY, Padilla-Parra S, Compton AA.
Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state.
Elife 2020;9:e58537
PMID: 33112230
Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR.
Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell-autonomous neuronal degeneration.
Neuron 2020;105(5):855-866
PMID: 31924446
Savino E, Cervigni RI, Povolo M, Stefanetti A, Ferrante D, Valente P, Corradi A, Benfenati F, Guarnieri FC, Valtorta F.
Proline-rich transmembrane protein 2 (PRRT2) regulates the actin cytoskeleton during synaptogenesis.
Cell Death Dis 2020;11(10): 856
PMID: 33056987
McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith L, Davtyan H, Cahalan.
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
Nat Commun 2020;11(1):5370
PMID: 33097708
Liu Z, Ning J, Zheng X, Meng J, Han L, Zheng H, Zhong L, Chen XF, Zhang X, Luo H, Can D, Xu H, Zhang YW.
TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities.
Cell Death Dis 2020;11(8):678
PMID: 32826884
Zhou Y, Zhu F, Liu Y, Zheng M, Wang Y, Zhang D, Anraku Y, Zou Y, Li J, Wu H, Pang X, Tao W, Shimoni O, Bush AI, Xue X, Shi B.
Blood-brain barrier-penetrating siRNA nanomedicine for Alzheimer's disease therapy.
Sci Adv 2020;6(41):eabc7031
PMID: 33036977
Yan T, Liang J, Gao J, Wang L, Fujioka H; Alzheimer Disease Neuroimaging Initiative, Zhu X, Wang X.
FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.
Nat Commun 2020;11(1):411
PMID: 31964863
Najm R, Zalocusky KA, Zilberter M, Yoon SY, Hao Y, Koutsodendris N, Nelson M, Rao A, Taubes A, Jones EA, Huang Y.
In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons.
Cell Rep 2020;32(4):107962
PMID: 32726626
Meilandt WJ, Ngu H, Gogineni A, Lalehzadeh G, Lee SH, Srinivasan K, Imperio J, Wu T, Weber M, Kruse AJ, Stark KL, Chan P, Kwong M, Modrusan Z, Friedman BA, Elstrott J, Foreman O, Easton A, Sheng M, Hansen DV.
Trem2 deletion reduces late-Stage amyloid plaque accumulation, elevates the Aβ42:Aβ40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the PS2APP Alzheimer's mouse model.
J Neurosci 2020;40(9)1956-1974
PMID: 31980586
Zhou X, Brooks M, Jiang P, Koga S, Zuberi AR, Baker MC, Parsons TM, Castanedes-Casey M, Phillips V, Librero AL, Kurti A, Fryer JD, Bu G, Lutz C, Dickson DW, Rademakers R.
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice.
EMBO Rep 2020;21(10):e50197
PMID: 32761777
Calame D, Xiao J, Khan M M, Hollingsworth T J, Xue Y, Person A, LeDoux S.
Presynaptic PRRT2 Deficiency Causes Cerebellar Dysfunction and Paroxysmal Kinesigenic Dyskinesia.
Neuroscience 2020;448:272-286
PMID: 32891704
Suire CN, Abdul-Hay SO, Sahara T, Kang D, Brizuela MK, Saftig P, Dickson DW, Rosenberry TL, Leissring MA.
Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40.
Alzheimers Res Ther 2020;12(1):80
PMID: 32631408
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT.
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Nature 2020;579(7799):433-437
PMID: 32132706
Alarcón-Arís D, Pavia-Collado R, Miquel-Rio L, Coppola-Segovia V, Ferrés-Coy A, Ruiz-Bronchal E, Galofré M, Paz V, Campa L, Revilla R, Montefeltro A, Kordower JH, Vila M, Artigas F, Bortolozzi A.
Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.
EBioMedicine 2020;59:102944
PMID: 32810825
Wang J, Sun BL, Xiang Y, Tian DY, Zhu C, Li WW, Liu YH, Bu XL, Shen LL, Jin WS, Wang Z, Zeng GH, Xu W, Chen LY, Chen XW, Hu Z, Zhu ZM, Song W, Zhou HD, Yu JT, Wang YJ.
Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice.
Transl Psychiatry 2020;10: 230
PMID: 32661266
Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, Shi J, Dugas JC, Andreone BJ, Logan T, Solanoy HO, Chen H, Srivastava A, Poda SB, Sanchez PE, Watts RJ, Sandmann T, Astarita G, Lewcock JW, Monroe KM, Di Paolo G.
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge.
Neuron 2020;105(5):837-854
PMID: 31902528
Suzuki K, Elegheert J, Song I, Sasakura H, Senkov O, Matsuda K, Kakegawa W, Clayton AJ, Chang VT, Ferrer-Ferrer M, Miura E, Kaushik R, Ikeno M, Morioka Y, Takeuchi Y, Shimada T, Otsuka S, Stoyanov S, Watanabe M, Takeuchi K, Dityatev A, Aricescu AR, Yuzaki M.
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.
Science 2020; 369(6507):eabb4853
PMID: 32855309
Andreone BJ, Przybyla L, Llapashtica C, Rana A, Davis SS, van Lengerich B, Lin K, Shi J, Mei Y, Astarita G, Di Paolo G, Sandmann T, Monroe KM, Lewcock JW.
Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Nat Neurosci 2020; 23(8):927-938
PMID: 32514138
Rush T, Roth RJ, Thompson JS, Aldaher RA, Cochran NJ, Roberson DE.
A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity.
Neurobiol Dis 2020; 1134:104668
PMID: 31698056
Ando K, De Decker R, Vergara C, Yilmaz Z, Mansour S, Suain V, Sleegers K, de Fisenne MA, Houben S, Potier MC, Duyckaerts C, Watanabe T, Buée L, Leroy K, Brion JP.
Picalm reduction exacerbates tau pathology in a murine tauopathy model.
Acta Neuropathol 2020; 139(4):773-789
PMID: 31925534
Eom TY, Han SB, Kim J, Blundon JA, Wang YD, Yu J, Anderson K, Damian BK, Miki SS, Pruett-Miller SM, Linda H, Ben W, Robinson CG, Eicholtz M, Rose DC, Zakharenko SS.
Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice.
Nat Commun 2020; 11(1):912
PMID: 32060266
Wei H、Xu Y、Chen Q、Chen H、Zhu X、Li Y.
Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis.
Cell Death Dis 2020; 11(4):290
PMID: 32341353
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS.
LRP1 is a master regulator of tau uptake and spread.
Nature 2020; 580(7803):381-385
PMID: 32296178
Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin G, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VMY, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, Cao W.
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.
J Clin Invest 2020; 130(4):1912-1930
PMID: 31917687
Wu Y, Gong Y, Luan Y, Li Y, Liu J, Yue Z, Yuan B, Sun J, Xie C, Li L, Zhen J, Jin X, Zheng Y, Wang X, Xie L, Wang W.
BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease.
FASEB J 2020; 34(1):1412-1429
PMID: 31914599
He Z, Yang Y, Xing Z, Zuo Z, Wang R, Gu H, Qi F, Yao Z.
Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice.
Cell Death Dis 2020; 11(6):440
PMID: 32514180
Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T.
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
Proc Natl Acad Sci USA 2019; 116 (47) 23790-23796
PMID: 31690660
Welikovitch LA, Do Carmo S, Maglóczky Z, Malcolm JC, Lőke J, Klein WL, Freund T, Cuello AC.
Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain.
Proc Natl Acad Sci USA 2020; 117(12):6844-6854
PMID: 32144141
Condon MD, Platt NJ, Zhang YZ, Roberts BM, Clements MA, Michelina SV, Tseu MY, Brimblecombe KR, Sarah T, Mann EO, Cragg SJ.
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
Nat Commun 2019; 10(1):4263
PMID: 32154671
Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, Tahirovic S, Park JI, Prorok R, Mahon C, Liang CC, Shi J, Kim DJ, Sabelström H, Huang F, Di Paolo G, Simons M, Lewcock JW, Haass C.
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
EMBO Molecular Medicine 2020; 12(4):e11227
PMID: 32154671
Kwak SS, Kevin JW, Emma B, Djuna vM, Jenna A, Susan K, Diane EC, Murat C, Ruslan S, Shen N, Enjana B, Weiming X, Steven LW, Se HC, Rudolph ET, Doo YK.
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.
Nat Commun 2020; 11(1):1377
PMID: 32170138
Woo JA, Liu T, Fang CC, Castaño MA, Kee T, Yrigoin K, Yan Y, Cazzaro S, Matlack J, Wang X, Zhao X, Kang DE, Liggett SB.
β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates
Proc Natl Acad Sci USA 2020; 117(9):5006-5015
PMID: 32071246
Fan Q, He W, Gayen M, Benoit MR, Luo X, Hu X, Yan R.
Activated CX3CL1/Smad2 signals prevent neuronal loss and Alzheimer's tau pathology-mediated cognitive dysfunction.
J Neurosci 2020; 40(5):1133–1144
PMID: 31822518
Menon PK, Koistinen NA, Iverfeldt K, Ström AL.
Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β
J Biol Chem 2019; 294(47):17768-17776
PMID: 31604820
Ricke KM, Cruz SA, Qin Z, Farrokhi K, Sharmin F, Zhang L, Zasloff MA, Stewart AFR, Chen H.
Neuronal protein tyrosine phosphatase 1B hastens amyloid β-associated Alzheimer’s disease in mice
Neurobiol. Dis. 2020; 40(7): 1581-1593
PMID: 31915254
Arboleda-Velasquez JF, Lopera F, O'Hare M, Delgado-Tirado S, Marino C, Chmielewska N, Saez-Torres KL, Amarnani D, Schultz AP, Sperling RA, Leyton-Cifuentes D, Chen K, Baena A, Aguillon D, Rios-Romenets S, Giraldo M, Guzmán-Vélez E, Norton DJ, Pardilla-Delgado E, Artola A, Sanchez JS, Acosta-Uribe J, Lalli M, Kosik KS, Huentelman MJ, Zetterberg H, Blennow K, Reiman RA, Luo J, Chen Y, Thiyyagura P, Su Y, Jun GR, Naymik M, Gai X, Bootwalla M, Ji J, Shen L, Miller JB, Kim LA, Tariot PN, Johnson KA, Reiman EM, Quiroz YT.
Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report
Nat Med 2019; 25(11):1680-1683
PMID: 31686034
Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene CD, Kamboh MI, Kofler JK, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Dickson DW, Frosch MP, Ghetti BF, Lunetta KL, Wang LS, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg GD, Beecham GW, Montine TJ, Jun GR; Alzheimer’s Disease Genetics Consortium
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
Nat Commun 2020; 11(1):667
PMID: 32015339
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