2017年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌の中から最近公表されたアルツハイマー病に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
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・2013年度に紹介された文献一覧 □
・2012年度に紹介された文献一覧 □
*, corresponding author; #, equal contribution
Venegas C,# Kumar S,# Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT*
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease
Nature 2017;552(7685):355-361
PMID: 29293211
Coleman J, Jouannot O, Ramakrishnan SK, Zanetti MN, Wang J, Salpietro V, Houlden H, Rothman JE,* Krishnakumar SS*
PRRT2 regulates synaptic fusion by directly modulating SNARE complex assembly
Cell Rep 2018;22(3):820-831
PMID: 29346777
Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, Xu Y, Chan RB, Di Paolo G, Mehler MF, Perumal GS, Macaluso FP, Freyberg ZZ, Acin-Perez R, Enriquez JA, Schon EA, Area-Gomez E*
Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease
EMBO J 2017;36(22):3356-3371
PMID: 29018038
Kidana K,# Tatebe T,# Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T*
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice
EMBO Mol Med (in press)
PMID: 29311134
Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Stiller B, Mandelkow EM,
Mandelkow E,* Cuervo AM*
Interplay of pathogenic forms of human tau with different autophagic pathways
Aging Cell (in press)
PMID: 29024336
Rasmussen J,# Mahler J,# Beschorner N,# Kaeser SA, Hasler LM, Baumann F, Nystrom S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarstrom P, Staufenbiel M, Walker LC, Jucker M*
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease
Proc Natl Acad Sci U S A 2017;114(49):13018-13023
PMID: 29158413
Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen ?, Gubert Olive
M, Shakirzyanova A, Leskela S, Sarajarvi T, Viitanen M, Rinne JO, Hiltunen
M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hamalainen
RH, Koistinaho J*
PSEN1 mutant iPSC-derived model reveals severe astrocyte pathology in Alzheimer's disease
Stem Cell Reports 2017;9(6):1885-1897
PMID: 29153989
He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, Trojanowski JQ, Lee VM*
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Nat Med 2018;24(1):29-38
PMID: 29200205
Netzer WJ,* Bettayeb K, Sinha SC, Flajolet M, Greengard P,* Bustos V
Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage
Proc Natl Acad Sci U S A 2017;114(6):1389-1394
PMID: 28115709
Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, aertig MA, Abdullatif AA, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B* *
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
Nat Neurosci (in press)
PMID: xxxxxxxx
Xiang J, Yang S, Xin N, Gaertig MA, Reeves RH, Li S,* Li XJ*
DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome
Proc Natl Acad Sci U S A 2017;114(7):E1224-E1233
PMID: 28137862
Andrew RJ,# Fernandez CG,# Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prevot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G*
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease
Proc Natl Acad Sci U S A 2017;114(45):E9665-E9674
PMID: 29078331
Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A*
Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease
Proc Natl Acad Sci U S A 2017;114(45):E9645-E9654
PMID: 29042514
Li C, Götz J*
Somatodendritic accumulation of tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation
EMBO J 2017;36(21):3120-3138
PMID: 28864542
Siegel G,* Gerber H, Koch P, Bruestle O, Fraering PC, Rajendran L*
The Alzheimer's disease γ-secretase generates higher 42:40 ratios for β-amyloid than for p3 peptides
Cell Rep 19(10):1967-1976
PMID: 28591569
Sun M, Zhang H*
Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1
Neurobiol Aging 2017;60:129-140
PMID: 28946017
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B,* Chávez-Gutiérrez L*
Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions
Cell 2017;170(3):443-456.e14
PMID: 28753424
Kim NY, Cho MH, Won SH, Kang HJ, Yoon SY, Kim DH*
Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1
Alzheimers Res Ther 2017;9(1):4
PMID: 28109317
Zhang Y, Kim MS, Jia B, Yan J, Zuniga-Hertz JP, Han C, Cai D*
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Nature 2017;548(7665):52-57
PMID: 28746310
Kim J, Kim Y, Nakajima R, Shin A, Jeong M, Park AH, Jeong Y, Jo S, Yang S, Park H, Cho SH, Cho KH, Shim I, Chung JH, Paik SB, Augustine GJ, Kim D*
Inhibitory basal ganglia inputs induce excitatory motor signals in the thalamus
Neuron 2017;95(5):1181-1196.e8
PMID: 28858620
Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trumbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C*
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
EMBO Rep 2017;18(7):1186-1198
PMID: 28483841
George C, Gontier G, Lacube P, Francois JC, Holzenberger M,* Aïd S
The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons
Brain 2017;140(7):2012-2027
PMID: 28595357
Paolicelli RC,* Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L*
TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss
Neuron 2017;95(2):297-308
PMID: 28669544
Branca C, Shaw DM, Belfiore R, Gokhale V, Shaw AY, Foley C, Smith B, Hulme C, Dunckley T, Meechoovet B, Caccamo A, Oddo S*
Dyrk1 inhibition improves Alzheimer's disease-like pathology
Aging Cell 2017;16(5):1146-1154
PMID: 28779511
Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M*
Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice
Proc Natl Acad Sci U S A (in press)
PMID: 28874550
Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L,* De Strooper B*
Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration
EMBO Mol Med 2017;9(8):1088-1099
PMID: 28588032
Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biferi MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C*
β-Amyloid precursor protein intracellular domain controls mitochondrial function by modulating phosphatase and tensin homolog-induced kinase 1 transcription in cells and in Alzheimer mice models
Biol Psychiatry (in press)
PMID: 28587718
Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C*
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
EMBO Mol Med (in press)
PMID: 28855300
Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T*
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
Nature 2017;544(7651):488-492
PMID: 28424512
Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D*
Neuroprotective functions for the histone deacetylase SIRT6
Cell Rep 2017;7:18(13):3052-3062
PMID: 28355558
Wu D, Bacaj T, Morishita W, Goswami D, Arendt KL, Xu W, Chen L, Malenka RC,* Sudhof TC*
Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
Nature (in press)
PMID: 28355182
Yang YR,# Song S,# Hwang H, Jung JH, Kim SJ, Yoon S, Hur JH, Park JI, Lee C, Nam D, Seo YK, Kim JH, Rhim H,* Suh PG*
Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
Sic Rep 2017;7:44921
PMID: 28368052
Zhong L,# Chen XF,# Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer JD, Xu H, Bu G*
Soluble TREM2 induces inflammatory responses and enhances microglial survival
J Exp Med 2017;214(3):597-607
PMID: 28209725
Calafate S, Flavin W, Verstreken P,* Moechars D*
Loss of Bin1 promotes the propagation of Tau pathology.
Cell Rep 2016;17(4):931-940
PMID: 27760323
Liu Q, Tang Y, Chen L, Liu N, Lang F, Liu H, Wang P, Sun X*
E3 ligase SCFβTrCP-induced DYRK1A protein degradation is essential for cell cycle progression in HEK293 cells
J Biol Chem 2016;291(51):26399-26409
PMID: 27807027
Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P*
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein
Biochim Biophys Acta 20171864(1):217-230
PMID: 27818272
Chen C, Arai I, Satterfield R, Young SM Jr, Jonas P*
Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse
Cell Rep 2017;18(3):723-736
PMID: 28099850
Junker M, Rapoport TA*
Involvement of VAT-1 in phosphatidylserine transfer from the endoplasmic reticulum to mitochondria
Traffic 2015;16(12):1306-1317
PMID: 26394711
Kim H,# Lee KS,# Kim AK, Choi M, Choi K, Kang M, Chi SW, Lee MS, Lee JS, Lee SY, Song WJ, Yu K, Cho S*
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition
Dis Model Mech 2016;9(8):839-848
PMID: 27483355
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