* * * * *                                                            問い合わせ サイトマップ English


文献紹介 (2016/04/01 - 2017/03/31)



*, corresponding author; #, equal contribution

#39 (2017/02/23; by MK)

Kuhn PH,* Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Muller U, Schweizer M, Saftig P, Brase S, Lichtenthaler SF*
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
Elife 2016;5:e12748
PMID: 26802628

#38 (2017/02/23; by KF)

Barr RK,# Verdile G,# Wijaya LK, Morici M, Taddei K, Gupta VB, Pedrini S, Jin L, Nicolazzo JA, Knock E, Fraser PE, Martins RN*
Validation and characterization of a novel peptide that binds monomeric and aggregated β-amyloid and inhibits the formation of neurotoxic oligomers
J Biol Chem 2016;291(2):547-559
PMID: 26538562

#37 (2017/02/23; by KO)

Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, Figueroa HY, Goldberg E, Hussaini SA, Duff KE*
Tau pathology induces excitatory neuron loss, grid cell dysfunction, and spatial memory deficits reminiscent of early Alzheimer's disease
Neuron 2017;93(3):533-541
PMID: 28111080

#36 (2017/02/17; by YK)

Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH*
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Nature 2016;540(7632):230-235
PMID: 27929004

#35 (2017/02/17; by DN)

Michetti C, Castroflorio E, Marchionni I, Forte N, Sterlini B, Binda F, Fruscione F, Baldelli P, Valtorta F, Zara F, Corradi A, Benfenati F*
The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations
Neurobiol Dis 2016;99:66-83
PMID: 28007585

#34 (2017/01/27; by KK)

Jay TR, Hirsch AM, Broihier ML, Miller CM, Neilson LE, Ransohoff RM, Lamb BT, Landreth GE*
Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease
J Neurosci 2017;37(3):637-647
PMID: 28100745

#33 (2017/01/06; by MK)

Chen PT, Chen ZT, Hou WC, Yu LC, Chen RP*
Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease
Sci Rep 2016;6:29760
PMID: 27407064

#32 (2017/01/06; by ST)

Li T,* Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C, Wong PC
The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model
Nat Commun 2016;7:12082
PMID: 27373369

#31 (2016/12/28; by RY)

Kobayashi M, Konishi H, Sayo A, Takai T, Kiyama H*
TREM2/DAP12 signal elicits proinflammatory response in microglia and exacerbates neuropathic pain
J Neurosci 21016;36(43):11138-11150
PMID: 27798193

#30 (2016/12/28; by RM)

Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay J, Poljak A, Delerue F, Ke YD, Ittner LM*
Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice
Science 2016;354(6314):904-908
PMID: 27856911

#29 (2016/12/22; by KM)

Zuhl AM,* Nolan CE, Brodney MA, Niessen S, Atchison K, Houle C, Karanian DA, Ambroise C, Brulet JW, Beck EM, Doran SD, O'Neill BT, Am Ende CW, Chang C, Geoghegan KF, West GM, Judkins JC, Hou X, Riddell DR, Johnson DS*
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors
Nat Commun 2016;7:13042
PMID: 27727204

#28 (2016/12/15; by YK)

Katsouri L, Lim YM, Blondrath K, Eleftheriadou I, Lombardero L, Birch AM, Mirzaei N, Irvine EE, Mazarakis ND,* Sastre M*
PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model
Proc Natl Acad Sci U S A 2016;113(43):12292-12297
PMID: 27791018

#27 (2016/12/15; by KK)

Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, Hansen DV, Atwal J, Lu Y, Bumbaca D, Pfeifer A, Watts RJ, Muhs A,* Scearce-Levie K,* Ayalon G*
Antibody-mediated targeting of tau in vivo does not require effector function and microglial engagement
Cell Rep 2016;16(6):1690-1700
PMID: 27475227

#26 (2016/12/09; by TK)

Brill MS,* Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T*
Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination
Neuron 2016;92(4):845-856
PMID: 27773584

#25 (2016/12/09; by ST)

Zhao X, Kotilinek LA, Smith B, Hlynialuk C, Zahs K, Ramsden M, Cleary J, Ashe KH*
Caspase-2 cleavage of tau reversibly impairs memory
Nat Med 2016;22(11):1268-1276
PMID: 27723722

#24 (2016/11/25; by YH)

Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, Fuhrmann M*
Dysfunction of somatostatin-positive interneurons associated with memory deficits in an Alzheimer's disease model
Neuron 2016;92(1):114-125
PMID: 27641495

#23 (2016/11/17; by DN)

Astorga C, Jorquera RA, Ramirez M, Kohler A, Lopez E, Delgado R, Cordova A, Olguin P, Sierralta J*
Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca2+ channels
Sci Rep 2016;6:32132
PMID: 27573697

#22 (2016/11/17; by DH)

Jackman SL, Turecek J, Belinsky JE, Regehr WG*
The calcium sensor synaptotagmin 7 is required for synaptic facilitation
Nature 2016;529(7584):88-91
PMID: 26738595

#21 (2016/11/17; by KO)

Sekine Y,* Zyryanova A, Crespillo-Casado A, Fischer PM, Harding HP, Ron D*
Mutations in a translation initiation factor identify the target of a memory-enhancing compound
Science 2015;348(6238):1027-1030
PMID: 25858979

#20 (2016/11/11; by RY)

Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM Jr, Dickey CA*
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins
EMBO J 2016;35(14):1537-1549
PMID: 27261198

#19 (2016/11/11; by KF)

Manocha GD, Floden AM, Rausch K, Kulas JA, McGregor BA, Rojanathammanee L, Puig KR, Puig KL, Karki S, Nichols MR, Darland DC, Porter JE, Combs CK*
APP regulates microglial phenotype in a mouse model of Alzheimer's disease
J Neurosci 2016;36(32):84718486
PMID: 27511018

#18 (2016/10/14; by RM)

Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E*
Reducing endogenous α-synuclein mitigates the degeneration of selective neuronal populations in an Alzheimer's disease transgenic mouse model
J Neurosci 2016;36(30):7971-7984
PMID: 27466341

#17 (2016/10/14; by EH)

Yeh FL, Wang Y, Tom I, Gonzalez LC,* Sheng M*
TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia
Neuron 2016;91(2):328-340
PMID: 27477018

#16 (2016/10/07; by KM)

Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, Clelland CL, Wray S, Duff KE*
Neuronal activity enhances tau propagation and tau pathology in vivo
Nat Neurosci 2016;19(8):1085-1092
PMID: 27322420

#15 (2016/10/07; by SK)

Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ*
Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis
J Cell Biol 2015;211(6):1157-1176
PMID: 26694839

#14 (2016/07/28; by EH)

Umeda T, Ono K, Sakai A, Yamashita M, Mizuguchi M, Klein WL, Yamada M, Mori H, Tomiyama T*
Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers
Brain 2016;139(Pt 5):1568-1586
PMID: 27020329

#13 (2016/07/28; by ST)

Schoch KM, DeVos SL, Miller RL, Chun SJ, Norrbom M, Wozniak DF, Dawson HN, Bennett CF, Rigo F, Miller TM*
Increased 4R-tau induces pathological changes in a human-tau mouse model
Neuron 2016;90(5):941-947
PMID: 27210553

#12 (2016/07/14; by YK)

Beglopoulos V, Tulloch J, Roe AD, Daumas S, Ferrington L, Watson R, Fan Z, Hyman BT, Kelly PA, Bard F, Morris RG*
Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice
Nat Commun 2016;7:11761
PMID: 27249364

#11 (2016/07/14; by JF)

Toledo JB,* Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, Adler CH, Beach TG, Trojanowski JQ
Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology
Acta Neuropathol 2016;131(3):393-409
PMID: 26721587

#10 (2016/06/10; by MK)

Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B*
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Science 2016;352(6286):712-716
PMID: 27033548

#09 (2016/06/10; by KK)

Nicholls RE,* Sontag JM, Zhang H, Staniszewski A, Yan S, Kim CY, Yim M, Woodruff CM, Arning E, Wasek B, Yin D, Bottiglieri T, Sontag E, Kandel ER,* Arancio O
PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments
Proc Natl Acad Sci U S A 2016;113(12):3347-3352
PMID: 26951658

#08 (2016/05/19; by YH)

Roy DS, Arons A, Mitchell TI, Pignatelli M, Ryan TJ, Tonegawa S*
Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease
Nature 2016;531(7595):508-512
PMID: 26982728

#07 (2016/05/19; by SK)

Ben Halima S, Mishra S, Raja KM, Willem M, Baici A, Simons K, Brustle O, Koch P, Haass C, Caflisch A, Rajendran L*
Specific inhibition of β-secretase processing of the Alzheimer disease amyloid precursor protein
Cell Rep 2016;14(9):2127-2141
PMID: 26923602

#06 (2016/04/28; by TK)

Olmos-Serrano JL,# Kang HJ,# Tyler WA,# Silbereis JC,# Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF,* Sestan N*
Down syndrome developmental brain transcriptome reveals defective oligodendrocyte differentiation and myelination
Neuron 2016;89(6):1208-1222
PMID: 26924435

#05 (2016/04/28; by KO)

Djelti F, Braudeau J,# Hudry E,# Dhenain M, Varin J, Bieche I, Marquer C, Chali F, Ayciriex S, Auzeil N, Alves S, Langui D, Potier MC, Laprevote O, Vidaud M, Duyckaerts C, Miles R, Aubourg P,# Cartier N*,#
CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease
Brain 2015;138(Pt 8):2383-2398
PMID: 26141492

#04 (2016/04/15; by LL)

Suarez-Calvet M, Kleinberger G, Araque Caballero MA, Brendel M, Rominger A, Alcolea D, Fortea J, Lleo A, Blesa R, Gispert JD, Sanchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, Traschutz A, Heneka MT, Struyfs H, Engelborghs S, Sleegers K, Van Broeckhoven C, Zetterberg H, Nellgard B, Blennow K, Crispin A, Ewers M,*,# Haass C*,#
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
EMBO Mol Med 2016;8(5):466-476
PMID: 26941262

#03 (2016/04/15; by DH)

Mei Y,# Monteiro P,# Zhou Y, Kim JA, Gao X, Fu Z, Feng G*
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes
Nature 2016;530(7591):481-484
PMID: 26886798

#02 (2016/04/08; by KF)

Yamamoto N,* Fujii Y, Kasahara R, Tanida M, Ohora K, Ono Y, Suzuki K, Sobue K
Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways
Glia 2016;64(6):952-962
PMID: 26875818

#01 (2016/04/08; by DN)

Moore KM, Girens RE, Larson SK, Jones MR, Restivo JL, Holtzman DM, Cirrito JR, Yuede CM, Zimmerman SD, Timson BF*
A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease
Neurobiol Dis 2016;85:218-224
PMID: 26563933


長崎大学大学院 医歯薬学総合研究科
生命薬科学専攻 分子創薬科学講座