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文献紹介 (2012/04/01 - 2013/03/31)

2012年度にゲノム創薬学研究室(旧 薬品生物工学研究室)のセミナー時に紹介された文献の一覧です。


・2016年度に紹介された文献一覧 
・2015年度に紹介された文献一覧 
・2014年度に紹介された文献一覧 
・2013年度に紹介された文献一覧 

*, corresponding author; #, equal contribution

#42 (2013/03/18; by TU)

Liu L,* Hamre KM, Goldowitz D*
Kainic acid-induced neuronal degeneration in hippocampal pyramidal neurons is driven by both intrinsic and extrinsic factors: analysis of FVB/N↔C57BL/6 chimeras
J Neurosci 2012;32(35):12093-12101
PMID: 22933793

#41 (2013/03/18; by YK)

Govindarajan N, Rao P, Burkhardt S, Sananbenesi F, Schluter OM, Bradke F, Lu J, Fischer A*
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
EMBO Mol Med 2013;5(1):52-63
PMID: 23184605

#40 (2013/03/18; by YN)

Kaufmann MR, Barth S, Konietzko U, Wu B, Egger S, Kunze R, Marti HH, Hick M, Muller U, Camenisch G, Wenger RH*
Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations
J Neurosci 2013;33(5):1915-1926
PMID: 23365231

#39 (2013/03/01; by HK)

Michaud JP, Hallé M, Lampron A, Thériault P, Préfontaine P, Filali M, Tribout-Jover P, Lanteigne AM, Jodoin R, Cluff C, Brichard V, Palmantier R, Pilorget A, Larocque D,* Rivest S*
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology
Proc Natl Acad Sci U S A 2013;10(5):1941-1946
PMID: 23322736

#38 (2013/03/01; by EK)

Yao J,* Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF*
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease
J Exp Med 2012;209(13):2501-2513
PMID: 23209315

#37 (2013/02/18; by TH)

Vom Berg J,# Prokop S,# Miller KR, Obst J, Kalin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B,* Heppner FL*
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline
Nat Med 2012;18(12):1812-1819
PMID: 23178247

#36 (2013/02/18; by AT)

Okochi M,* Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M
γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
Cell Rep 2013;3(1):42-51
PMID: 23291095

#35 (2013/01/21; by TK)

Thathiah A,* Horré K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, De Kloe G, Munck S, De Strooper B*
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
Nat Med 2013;19(1):43-49
PMID: 23202293

#34 (2013/01/21; by KI)

Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK, Wong BX, Adlard PA, Cherny RA, Lam LQ, Roberts BR, Volitakis I, Egan GF, McLean CA, Cappai R, Duce JA, Bush AI*
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
Nat Med 2012;18(2):291-295
PMID: 22286308

#33 (2013/01/11; by CK)

Heneka MT,#,* Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E,#,* Golenbock DT#,*
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
Nature 2013;493(7434):674-678
PMID: 23254930

#32 (2013/01/11; by RN)

Ly PT,# Wu Y,# Zou H, Wang R, Zhou W, Kinoshita A, Zhang M, Yang Y, Cai F, Woodgett J, Song W*
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes
J Clin Invest 2013;123(1):224-235
PMID: 23202730

#31 (2012/12/21; by CK)

Rudinskiy N, Hawkes JM, Betensky RA, Eguchi M, Yamaguchi S, Spires-Jones TL, Hyman BT*
Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease
Nat Neurosci 2012;15(10):1422-1429
PMID: 22922786

#30 (2012/12/21; by TU)

Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS, Bhattacharya S*
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Nat Med 2012;18(8):1279-1285
PMID: 22842477

#29 (2012/11/30; by RN)

Andreyeva A, Nieweg K, Horstmann K, Klapper S, Muller-Schiffmann A, Korth C, Gottmann K*
C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β
Brain 2012;135(Pt 7):2140-2154
PMID: 22637581

#28 (2012/11/30; by YN)

Tamayev R, Matsuda S, Arancio O, D'Adamio L*
β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
EMBO Mol Med 2012;4(3):171-179
PMID: 22170863

#27 (2012/11/21; by TK)

Yoon SO,* Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K
JNK3 perpetuates metabolic stress induced by Aβ peptides
Neuron 2012;75(5):824-837
PMID: 22958823

#26 (2012/11/21; by AT)

Wang HY,* Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah SM, Burns LH
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A
J Neurosci 2012;32(29):9773-9784
PMID: 22815492

#25 (2012/11/09; by TH)

Mandrekar-Colucci S, Karlo JC, Landreth GE*
Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
J Neurosci 2012;32(30):10117-10128
PMID: 22836247

#24 (2012/11/09; by KI)

Lehmann SM, Kruger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kalin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S*
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
Nat Neurosci 2012;15(6):827-835
PMID: 22610069

#23 (2012/10/22; by HK)

Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jonsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K*
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
Nature 2012;488(7409):96-99
PMID: 22801501

#22 (2012/10/22; by TA)

Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Brase S, Lichtenthaler SF*
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
EMBO J 2012;31(14):3157-3168
PMID: 22728825

#21 (2012/10/05; by YH)

Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE*
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
Science 2012;335(6075):1503-1506
PMID: 22323736

#20 (2012/10/05; by EK)

Oulès B,# Del Prete D,# Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Brechot P, Trebak M, Checler F,* Benfenati F, Chami M*
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease
J Neurosci 2012;32(34):11820-11834
PMID: 22915123

#19 (2012/09/21; by MI)

Chen Y,# Huang X,# Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H*
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid
J Neurosci 2012;32(33):11390-11395
PMID: 22895721

#18 (2012/09/21; by YK)

Park JH, Jung MS, Kim YS, Song WJ,* Chung SH*
Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α
J Neurochem 2012;122(5):1081-1091
PMID: 22765017

#17 (2012/08/31; by IN)

Lefort R, Pozueta J, Shelanski M*
Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease
J Neurosci 2012;32(31):10674-10685
PMID: 22855816

#16 (2012/07/20; by HK)

Brouillette J, Caillierez R, Zommer N, Alves-Pires C, Benilova I, Blum D, De Strooper B, Buée L*
Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model
J Neurosci 2012;32(23):7852-7861
PMID: 22674261

#15 (2012/07/20; by YN)

Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, Nagaike K, Ihara Y,* Japanese Alzheimer's Disease Neuroimaging Initiative
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease
EMBO Mol Med 2012;4(4):344-352
PMID: 22354516

#14 (2012/07/17; by YH)

Nussbaum JM,# Schilling S,# Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Ronicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU,* Bloom GS*
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
Nature 2012;485(7400):651-655
PMID: 22660329

#13 (2012/07/17; by YH)

Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rubsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU,* von Hörsten S*
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation
J Neurosci 2011;31(36):12790-12801
PMID: 21900558

#12 (2012/07/17; by YK)

Sadleir KR, Vassar R*
Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease
J Biol Chem 2012;287(10):7224-7235
PMID: 22223639

#11 (2012/06/22; by IM)

Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda GA, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon JE, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon RA, Pasinetti GM*
Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment
J Neurosci 2012;32(15):5144-5150
PMID: 22496560

#10 (2012/06/22; by EK)

Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L*
Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation
J Biol Chem 2012;287(11):8424-8433
PMID: 22267734

#09 (2012/06/01; by NK)

Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ*
Reducing amyloid plaque burden via ex vivo gene delivery of an Aβ-degrading protease: a novel therapeutic approach to Alzheimer disease
PLoS Med 2007;4(8):e262
PMID: 17760499

#08 (2012/06/01; by AT)

Ma SL, Pastorino L, Zhou XZ, Lu KP*
Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease
J Biol Chem 2012;287(10):6969-6973
PMID: 22184106

#07 (2012/05/18; by RN)

Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W*
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
Proc Natl Acad Sci U S A 2011;108(34):E559-E568
PMID: 21825135

#06 (2012/05/18; by KI)

Jung MS, Park JH, Ryu YS, Choi SH, Yoon SH, Kwen MY, Oh JY, Song WJ, Chung SH*
Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation
J Biol Chem 2011;286(46):40401-40412
PMID: 21965663

#05 (2012/05/10; by IN)

Nakamura K, Greenwood A, Binder L, Bigio EH, Denial S, Nicholson L, Zhou XZ,* Lu KP*
Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease
Cell 2012;149(1):232-244
PMID: 22464332

#04 (2012/05/10; by TK)

Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK*
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging
Neurobiol Aging 2012;33(4):828.e31-e44
PMID: 21843906

#03 (2012/04/13; by TA)

Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N*
Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with Homer1a
J Neurosci 2011;31(31):11100-11109
PMID: 21813671

#02 (2012/04/13; by CK)

Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ*
A human stem cell model of early Alzheimer's disease pathology in Down syndrome
Sci Transl Med 2012;4(124):124ra29
PMID: 22344463

#01 (2012/04/13; by TH)

Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T,* Iwatsubo T*
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1
EMBO J 2011;30(23)4815-4824
PMID: 22002539



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