2012年度にゲノム創薬学研究室(旧 薬品生物工学研究室)のセミナー時に紹介された文献の一覧です。
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*, corresponding author; #, equal contribution
Liu L,* Hamre KM, Goldowitz D*
Kainic acid-induced neuronal degeneration in hippocampal pyramidal neurons is driven by both intrinsic and extrinsic factors: analysis of FVB/N↔C57BL/6 chimeras
J Neurosci 2012;32(35):12093-12101
PMID: 22933793
Govindarajan N, Rao P, Burkhardt S, Sananbenesi F, Schluter OM, Bradke F, Lu J, Fischer A*
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
EMBO Mol Med 2013;5(1):52-63
PMID: 23184605
Kaufmann MR, Barth S, Konietzko U, Wu B, Egger S, Kunze R, Marti HH, Hick M, Muller U, Camenisch G, Wenger RH*
Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations
J Neurosci 2013;33(5):1915-1926
PMID: 23365231
Michaud JP, Hallé M, Lampron A, Thériault P, Préfontaine P, Filali M, Tribout-Jover P, Lanteigne AM, Jodoin R, Cluff C, Brichard V, Palmantier R, Pilorget A, Larocque D,* Rivest S*
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology
Proc Natl Acad Sci U S A 2013;10(5):1941-1946
PMID: 23322736
Yao J,* Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF*
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease
J Exp Med 2012;209(13):2501-2513
PMID: 23209315
Vom Berg J,# Prokop S,# Miller KR, Obst J, Kalin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B,* Heppner FL*
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline
Nat Med 2012;18(12):1812-1819
PMID: 23178247
Okochi M,* Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M
γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
Cell Rep 2013;3(1):42-51
PMID: 23291095
Thathiah A,* Horré K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, De Kloe G, Munck S, De Strooper B*
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
Nat Med 2013;19(1):43-49
PMID: 23202293
Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK, Wong BX, Adlard PA, Cherny RA, Lam LQ, Roberts BR, Volitakis I, Egan GF, McLean CA, Cappai R, Duce JA, Bush AI*
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
Nat Med 2012;18(2):291-295
PMID: 22286308
Heneka MT,#,* Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E,#,* Golenbock DT#,*
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
Nature 2013;493(7434):674-678
PMID: 23254930
Ly PT,# Wu Y,# Zou H, Wang R, Zhou W, Kinoshita A, Zhang M, Yang Y, Cai F, Woodgett J, Song W*
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes
J Clin Invest 2013;123(1):224-235
PMID: 23202730
Rudinskiy N, Hawkes JM, Betensky RA, Eguchi M, Yamaguchi S, Spires-Jones TL, Hyman BT*
Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease
Nat Neurosci 2012;15(10):1422-1429
PMID: 22922786
Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS, Bhattacharya S*
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Nat Med 2012;18(8):1279-1285
PMID: 22842477
Andreyeva A, Nieweg K, Horstmann K, Klapper S, Muller-Schiffmann A, Korth C, Gottmann K*
C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β
Brain 2012;135(Pt 7):2140-2154
PMID: 22637581
Tamayev R, Matsuda S, Arancio O, D'Adamio L*
β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
EMBO Mol Med 2012;4(3):171-179
PMID: 22170863
Yoon SO,* Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K
JNK3 perpetuates metabolic stress induced by Aβ peptides
Neuron 2012;75(5):824-837
PMID: 22958823
Wang HY,* Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah SM, Burns LH
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A
J Neurosci 2012;32(29):9773-9784
PMID: 22815492
Mandrekar-Colucci S, Karlo JC, Landreth GE*
Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
J Neurosci 2012;32(30):10117-10128
PMID: 22836247
Lehmann SM, Kruger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kalin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S*
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
Nat Neurosci 2012;15(6):827-835
PMID: 22610069
Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jonsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K*
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
Nature 2012;488(7409):96-99
PMID: 22801501
Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Brase S, Lichtenthaler SF*
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
EMBO J 2012;31(14):3157-3168
PMID: 22728825
Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE*
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
Science 2012;335(6075):1503-1506
PMID: 22323736
Oulès B,# Del Prete D,# Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Brechot P, Trebak M, Checler F,* Benfenati F, Chami M*
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease
J Neurosci 2012;32(34):11820-11834
PMID: 22915123
Chen Y,# Huang X,# Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H*
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid
J Neurosci 2012;32(33):11390-11395
PMID: 22895721
Park JH, Jung MS, Kim YS, Song WJ,* Chung SH*
Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α
J Neurochem 2012;122(5):1081-1091
PMID: 22765017
Lefort R, Pozueta J, Shelanski M*
Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease
J Neurosci 2012;32(31):10674-10685
PMID: 22855816
Brouillette J, Caillierez R, Zommer N, Alves-Pires C, Benilova I, Blum D, De Strooper B, Buée L*
Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model
J Neurosci 2012;32(23):7852-7861
PMID: 22674261
Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, Nagaike K, Ihara Y,* Japanese Alzheimer's Disease Neuroimaging Initiative
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease
EMBO Mol Med 2012;4(4):344-352
PMID: 22354516
Nussbaum JM,# Schilling S,# Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Ronicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU,* Bloom GS*
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
Nature 2012;485(7400):651-655
PMID: 22660329
Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rubsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU,* von Hörsten S*
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation
J Neurosci 2011;31(36):12790-12801
PMID: 21900558
Sadleir KR, Vassar R*
Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease
J Biol Chem 2012;287(10):7224-7235
PMID: 22223639
Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda GA, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon JE, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon RA, Pasinetti GM*
Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment
J Neurosci 2012;32(15):5144-5150
PMID: 22496560
Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L*
Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation
J Biol Chem 2012;287(11):8424-8433
PMID: 22267734
Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ*
Reducing amyloid plaque burden via ex vivo gene delivery of an Aβ-degrading protease: a novel therapeutic approach to Alzheimer disease
PLoS Med 2007;4(8):e262
PMID: 17760499
Ma SL, Pastorino L, Zhou XZ, Lu KP*
Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease
J Biol Chem 2012;287(10):6969-6973
PMID: 22184106
Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W*
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
Proc Natl Acad Sci U S A 2011;108(34):E559-E568
PMID: 21825135
Jung MS, Park JH, Ryu YS, Choi SH, Yoon SH, Kwen MY, Oh JY, Song WJ, Chung SH*
Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation
J Biol Chem 2011;286(46):40401-40412
PMID: 21965663
Nakamura K, Greenwood A, Binder L, Bigio EH, Denial S, Nicholson L, Zhou XZ,* Lu KP*
Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease
Cell 2012;149(1):232-244
PMID: 22464332
Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK*
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging
Neurobiol Aging 2012;33(4):828.e31-e44
PMID: 21843906
Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N*
Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with Homer1a
J Neurosci 2011;31(31):11100-11109
PMID: 21813671
Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ*
A human stem cell model of early Alzheimer's disease pathology in Down syndrome
Sci Transl Med 2012;4(124):124ra29
PMID: 22344463
Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T,* Iwatsubo T*
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1
EMBO J 2011;30(23)4815-4824
PMID: 22002539
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