2022年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌(可能な限り)の中から最近公表されたアルツハイマー病等の神経変性疾患、痙攣性神経疾患や遺伝子発現機構に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
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Popescu AS, Butler CA, Allendorf DH, Piers TM, Mallach A, Roewe J, Reinhardt P, Cinti A, Redaelli L, Boudesco C, Pradier L, Pocock JM, Thornton P, Brown GC.
Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Glia 2022;71(4):974-990
PMID: 36480007
Ennerfelt H, Frost EL, Shapiro DA, Holliday C, Zengeler KE, Voithofer G, Bolte AC, Lammert CR, Kulas JA, Ulland TK, Lukens JR.
SYK coordinates neuroprotective microglial responses in neurodegenerative disease.
Cell 2022;185(22):4135-4152.e22
PMID: 36257314
Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, Lei T, Hou J, Cai Z, Cella M, Nguyen K, Poliani PL, Beatty WL, Chen Y, Cao S, Lin K, Rodrigues C, Ellebedy AH, Gilfillan S, Brown GD, Holtzman DM, Brioschi S, Colonna M.
TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.
Cell 2022;185:4153-4169.e19
PMID: 36306735
van der Linden RJ, Gerritsen JS, Liao M, Widomska J, Pearse RV 2nd, White FM, Franke B, Young-Pearse TL, Poelmans G.
RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.
Prog Neurobiol 2022;217:102316
PMID: 35843356
Skovgård K, Barrientos SA, Petersson P, Halje P, Cenci MA.
Distinctive effects of D1 and D2 receptor agonists on cortico-basal ganglia oscillations in a rodent model of L-DOPA-induced dyskinesia.
Neurotherapeutics 2023;20(1):304–324
PMID: 36344723
Han X, Cheng X, Xu J, Liu Y, Zhou J, Jiang L, Gu X, Xia T.
Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice.
Neuropharmacology 2022;219:109231
PMID: 36041498
Shi H, Yin Z, Koronyo Y, Fuchs DT, Sheyn J, Davis MR, Wilson JW, Margeta MA, Pitts KM, Herron S, Ikezu S, Ikezu T, Graham SL, Gupta VK, Black KL, Mirzaei M, Butovsky O, Koronyo-Hamaoui M.
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia.
Acta Neuropathol Commun 2022;10(1):136
PMID: 36076283
Nelson AB, Girasole AE, Lee HY, Ptáček LJ, Kreitzer AC.
Striatal Indirect Pathway Dysfunction Underlies Motor Deficits in a Mouse Model of Paroxysmal Dyskinesia.
J Neurosci 2022;42(13):2835-2848
PMID: 35165171
Ram AK, Mallik M, Reddy RR, Suryawanshi AR, Alone PV.
Altered proteome in translation initiation fidelity defective eIF5G31R mutant causes oxidative stress and DNA damage.
Sci Rep 2022;12(1):50332
PMID: 35322093
Januário YC, Eden J, de Oliveira LS, De Pace R, Tavares LA, da Silva-Januário ME, Apolloni VB, Wilby EL, Altmeyer R, Burgos PV, Corrêa SAL, Gershlick DC, daSilva LLP.
Clathrin adaptor AP-1-mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments.
J Biol Chem 2022;298(8):102172
PMID: 35753347
Han BH, Cofell B, Everhart E, Humpal C, Kang S, Lee SK, Kim-Han JS.
Amentoflavone Promotes Cellular Uptake and Degradation of Amyloid-Beta in Neuronal Cells.
Int J Mol Sci 2022; 23(11):5885
PMID: 35682567
Causier B, Hopes T, McKay M, Paling Z, Davies B.
Plants utilise ancient conserved peptide upstream open reading frames in stress-responsive translational regulation.
Plant Cell Environ 2022; 45(4): 1229–1241
PMID: 35128674
Zych SM, Ford CP.
Divergent properties and independent regulation of striatal dopamine and GABA co-transmission.
Cell Rep 2022; 39(7):110823
PMID: 35584679
Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, Murad R, Piña-Crespo J, Xu H, Huang TY.
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes.
Mol Neurodegener 2022; 17(1):58
PMID: 36056435
Stefanoska K, Gajwani M, Tan ARP, Ahel HI, Asih PR, Volkerling A, Poljak A, Ittner A.
Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation
Sci Adv 2022; 8(27): eabl8809
PMID: 35857446
Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA.
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Nat Neurosci 2022; 25(6):688-701
PMID: 35654956
Ivanov IP, Saba JA, Fan CM, Wang J, Firth AE, Cao C, Green R, Dever TE.
Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency
Proc Natl Acad Sci USA 2022; 119(9)
PMID: 35217614
Oblak AL, Kotredes KP, Pandey RS, Reagan AM, Ingraham C, Perkins B, Lloyd C, Baker D, Lin PB, Soni DM, Tsai AP, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Meyer JA, Peters JS, Figueiredo LL, Sasner M, Territo PR, Sukoff Rizzo SJ, Carter GW, Lamb BT, Howell GR.
Plcg2M28L interacts with high fat/high sugar diet to accelerate Alzheimer's disease-relevant phenotypes in mice
Front Aging Neurosci 2022; 14: 886575
PMID: 35813947
Melani R, Tritsch NX.
Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake
Cell Rep 2022; 39(3):110716
PMID: 35443174
Feng T, Luan L, Katz II, Ullah M, Van Deerlin VM, Trojanowski JQ, Lee EB, Hu F.
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
Acta Neuropathol Commun 2022; 10(1):33
PMID: 35287730
Ren X, Yao L, Wang Y, Mei L, Xiong WC.
Microglial VPS35 defciency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology
J Neuroinflammation 2022; 19:61
PMID: 35236374
Lin T, van Husen LS, Yu Y, Tjernberg LO, Schedin-Weiss S.
Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein
Glycobiology 2022; 32(6):506-517
PMID: 35275192
Perea JR, Bolós M, Cuadros R, García E, García-Escudero V, Hernández F, McManus RM, Heneka MT, Avila J.
p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function
Mol Neurobiol 2022; 59(3):1632-1648
PMID: 35006531
Jairaman A, McQuade A, Granzotto A, Kang YJ, Chadarevian JP, Gandhi S, Parker L, Smith L, Cho H, Sensi SL, Othy S, Blurton-Jones M, Cahalan MD.
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia
Elife 2022; 11:e73021
PMID: 35191835
Smirnova VV, Shestakova ED, Nogina DS, Mishchenko PA, Prikazchikova TA, Zatsepin TS, Kulakovskiy IV, Shatsky IN, Terenin IM.
Ribosomal leaky scanning through a translated uORF requires eIF4G2.
Nucleic Acids Res 2022; 150(2):1111-1127
PMID: 35018467
Zhang J, Wang X, Bernardi RE, Ju J, Wei S, Gong Z
Activation of AMPA receptors in the lateral habenula produces anxiolytic effects in a rat model of Parkinson's disease.
Front Pharmacol 2022; 13: 8321975
PMID: 35145415
Ganz T, Fainstein N, Elad A, Lachish M, Goldfarb S, Einstein O, Ben-Hur T.
Microbial pathogens induce neurodegeneration in Alzheimer's disease mice: protection by microglial regulation.
J Neuroinflammation 2022; 19(1):5
PMID: 34991645
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesämaa I, Haberl S, Nuscher B, Kleinberger G, Klimmt J, Götzl JK, Liesz A, Bürger K, Brendel M, Levin J, Diehl-Schmid J, Suh J, Di Paolo G, Lewcock JW, Monroe KM, Paquet D, Capell A, Haass C.
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
EMBO J 2022; 41(4):e109108
PMID: 35019161
Lizarazo S, Yook Y, Tsai NP.
Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2.
J Cell Physiol 2022;in press
PMID: 35434801
Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS.
Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease.
Brain 2022;145(3):879-886
PMID: 35258081
Morgenstern NA, Isidro AF, Israely I, Costa RM.
Pyramidal tract neurons drive amplification of excitatory inputs to striatum through cholinergic interneurons.
Biomedicines 2022;10(4):881
PMID: 35453631
Domenicale C, Mercatelli D, Albanese F, Novello S, Vincenzi F, Varani K, Morari M.
Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice.
Science Adv 2022; 8(6)
PMID: 35138902
Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson DW, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP.
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Cell 2022;185(8):1346-1355.e15
PMID: 35247328
Peng G, Gu A, Niu H, Chen L, Chen Y, Zhou M, Zhang Y, Liu J, Cai L, Liang D, Liu X, Liu M.
Amyotrophic lateral sclerosis (ALS) linked mutation in ubiquilin 2 affects stress granule assembly via TIA-1.
CNS Neurosci Ther 2022;28(1):105-115
PMID: 34750982
Ogata K, Kadono F, Hirai Y, Inoue K, Takada M, Karube F, Fujiyama F.
Conservation of the direct and indirect pathway dichotomy in mouse caudal striatum with uneven distribution of dopamine receptor D1- and D2-expressing neurons.
Front Neuroanat 2022;16:809446
PMID: 35185482
Bhattacharjee S, Zhao Y, Dua P, Rogaev EI, Lukiw WJ.
microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration.
PLoS One 2016; 11(3):e0150211
PMID: 26949937
Ledo JH, Liebmann T, Zhang R, Chang JC, Azevedo EP, Wong E, Silva HM, Troyanskaya OG, Bustos V, Greengard P.
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.
Mol Psychiatry 2022;26:5620–5635
PMID: 32792660
Sato K, Watamura N, Fujioka R, Mihira N, Sekiguchi M, Nagata K, Ohshima T, Saito T, Saido TC, Sasaguri H.
A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.
J Biol Chem 2021; 297(3): 101004
PMID: 34329683
Kenkhuis B, Somarakis A, Kleindouwel LRT, van Roon-Mom WMC, Höllt T, van der Weerd L.
Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease.
Neurobiol Dis 2022;167:105684
PMID: 35247551
Lloyd JT, Yee AG, Kalligappa PK, Jabed A, Cheung PY, Todd KL, Karunasinghe RN, Vlajkovic SM, Freestone PS, Lipski J.
Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model.
Neuroscience 2022; S0306-4522(22)00135-X
PMID: 35331847
Nelde A, Flötotto L, Jürgens L, Szymik L, Hubert E, Bauer J, Schliemann C, Kessler T, Lenz G, Rammensee HG, Walz JS, Wethmar K.
Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens.
Cell Mol Life Sci 2022;79(3):171
PMID: 34694469
Reinwald JR, Gass N, Mallien AS, Sartorius A, Becker R, Sack M, Falfan-Melgoza C, Clemm von Hohenberg C, Leo D, Pfeiffer N, Middelman A, Meyer-Lindenberg A, Homberg JR, Weber-Fahr W, Gass P.
Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits.
Mol Psychiatry 2022, in press.
PMID: 35239002
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