2023年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌(可能な限り)の中から最近公表されたアルツハイマー病等の神経変性疾患、痙攣性神経疾患や遺伝子発現機構に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
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Greve HJ, Dunbar AL, Lombo CG, Ahmed C, Thang M, Messenger EJ, Mumaw CL, Johnson JA, Kodavanti UP, Oblak AL, Block ML.
The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment.
Brain 2023; 146(3):991-1005
PMID: 35348636
Sterlini B, Franchi F, Morinelli L, Corradi B, Parodi C, Albini M, Bianchi A, Marte A.
Missense mutations in the membrane domain of PRRT2 affect its interaction with Nav1.2 voltage-gated sodium channels.
Neurobiol Dis. 2023; 183:106177
PMID: 37271286
Ennerfelt H, Holliday C, Shapiro DA, Zengeler KE, Bolte AC, Ulland TK, Lukens JR.
CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer's disease mouse model
Proc Natl Acad Sci USA2023; 120(24):e2303760120
PMID: 37276426
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE.
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Genome Med 2023; 15 (1): 11
PMID: 36805764
Firouzi R, Sowalti-Hashjin S, Chávez-García C, Ashouri M, Karimi-Jafari MH, Karttunen M.
Identification of Catechin’s Binding Sites in Monomeric Aβ42 through Ensemble Docking and MD Simulations.
Int J Mol Sci 2023; 24(9):8161
PMID: 37175868
Jiao L, Yu Z, Zhong X, Zhong X, Xing L, Ma G, Ma G, Shen J, Wu Y, Du K, Liu J, Tong J, Fu J, Wei M, Liu M.
Cordycepin improved neuronal synaptic plasticity through CREB-induced NGF upregulation driven by MG-M2 polarization: a microglia-neuron symphony in AD.
Biomed Pharmacother 2023; 157:114054
PMID: 36462314
Wang C, Yang Y, Zhang X, Shi Z, Gao H, Zhong M, Fan Y, Zhang H, Liu B, Qing G.
Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer's disease.
Sci Adv. 2023; 9(21):eade0293
PMID: 37235655
Bohlen J, Roiuk M, Neff M, Teleman AA.
PRRC2 proteins impact translation initiation by promoting leaky scanning.
Nucleic Acids Res 2023; 51(7): 3391–3409
PMID: 36869665
Fracassi A, Marcatti M, Tumurbaatar B, Woltjer R, Moreno S, Taglialatela G
TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology.
Brain Pathol 2023; 33 (1): e13108
PMID: 35816404
Gratuze M, Schlachetzki JC, D'Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O'Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, Glass CK, Ulrich JD, Holtzman DM.
TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.
Neuron 2023; 111(2):202-219.e7.
PMID: 36368315
Seo DC, Ju YH, Seo JJ, Oh SJ, Lee CJ, Lee SE, Nam MH.
DDC-promoter-driven chemogenetic activation of SNpc dopaminergic neurons alleviates parkinsonian motor symptoms.
Int J Mol Sci 2023; 24(3):2491
PMID: 36768816
Liu K, Song M, Gao S, Yao L, Zhang L, Feng J, Wang L, Gao R, Wang Y.
The dynamics of dopamine D2 receptor-expressing striatal neurons and the downstream circuit underlying L-dopa-induced dyskinesia in rats.
Neurosci Bull 2023; https://doi.org/10.1007/s12264-023-01054-5
PMID: 37022638
Valente P, Marte A, Franchi F, Sterlini B, Casagrande S, Corradi A, Baldelli P, Benfenati F.
A Push-Pull Mechanism Between PRRT2 and β4-subunit Differentially Regulates Membrane Exposure and Biophysical Properties of NaV1.2 Sodium Channels.
Mol Neurobiol 2023; 60(3):1281-1296
PMID: 36441479
Amin PH, Carlson KR, Wek RC.
An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response.
J Biol Chem2023; 299(2):102864
PMID: 36596357
Martínez-Mármol R, Small C, Jiang A, Palliyaguru T, Wallis TP, Gormal RS, Sibarita JB, Götz J, Meunier FA.
Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates.
Mol Psychiatry 2023; 28(2):946-962
PMID: 36258016
Chun YS, Kim MY, Lee SY, Kim MJ, Hong TJ, Jeon JK, Ganbat D, Kim HT, Kim SS, Kam TI, Han S.
AMEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer's Disease.
Mol Psychiatry 2022; 27(11): 4770–4780
PMID: 35948663
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesamaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM.
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Nat Neurosci 2023; 26(3):416-429
PMID: 36635496
Rofo F, Metzendorf NG, Saubi C, Suominen L, Godec A, Sehlin D, Syvänen S, Hultqvist G.
Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta
in a mouse model of Alzheimer's diseasebr> Alzheimers Res Ther 2022; 14(1):180
PMID: 36471433
Franchi F, Marte A, Corradi B, Sterlini B, Alberini G, Romei A, Fusco AD, Vogel A, Maragliano L, Baldelli P, Corradi A, Valente P, Benfenati F.
The intramembrane COOH-terminal domain of PRRT2 regulates voltage-dependent Na+ channels
J Biol Chem 2023; 104632
PMID: 36958475
Xu QA, Boerkoel P, Hirsch-Reinshagen V, Mackenzie IR, Hsiung GR, Charm G, To EF, Liu AQ, Schwab K, Jiang K, Sarunic M, Beg MF, Pham W, Cui J, To E, Lee S, Matsubara JA
Müller cell degeneration and microglial dysfunction in the Alzheimer's retina.
Acta Neuropathol Commun 2022; 10(1):145
PMID: 36199154
Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF.
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
PNAS 2023;119(5):e2114486119
PMID: 35082148
Gomaa AA, Farghaly HSM, Ahmed AM, Hemida FK.
Intermittent treatment with Apremilast, a phosphodiesterase-4 inhibitor, ameliorates Alzheimer's-like pathology and symptoms through multiple targeting actions in aged T2D rats.
Int Immunopharmacol 2023; 117:109927
PMID: 36848793
Jain N, Lewis CA, Ulrich JD, Holtzman DM.
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading.
J Exp Med 2023; 220(1):e20220654.
PMID: PMC9559604
Tian Y, Viles JH.
PH dependence of amyloid-β fibril assembly kinetics: unravelling the microscopic molecular processes.
Angew Chem Int Ed Engl 2022; 61(48):e202210675
PMID: 36197009
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