2024年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 5以上の雑誌(可能な限り)の中から最近公表されたアルツハイマー病等の神経変性疾患、痙攣性神経疾患や遺伝子発現機構に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
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Rahman K, Wilt I, Jolley AA, Chowdhury B, Datta SAK, Compton AA.
SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion.
EMBO J 2024; Epub ahead of print.
PMID: 39653855
Kiianitsa K, Lukes ME, Hayes BJ, Brutman JN, Valdmanis PN, Bird TD, Raskind WH, Korvatska O.
TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.
Brain 2024; 147(7):2368-2383.
PMID: 38226698
Stephens GS, Park J, Eagle A, You J, Silva-Pérez M, Fu CH, Choi S, Romain CPS, Sugimoto C, Buffington SA, Zheng Y, Costa-Mattioli M, Liu Y, Robison AJ, Chin J.
Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice.
Prog Neurobiol 2024; 237:102612.
PMID: 38642602
He C, Jiang J, Liu J, Zhou L, Ge Y, Yang Z.
Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology via regulating the microbiota-gut-brain axis in 5 × FAD mice.
Int J Biol Macromol 2024;270(Pt 2):132372.
PMID: 38750854
Kirman DC, Renganathan B, Chui WK, Chen MW, Kaya NA, Ge R.
Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis.
Cell Death Dis 2022; 13(2):172.
PMID: 35197459
Huang X, Fu X, Wu J, Cheng X, Hong X, Li Z, Zheng L, Liu Q, Chen S, Tang B, Zhao Y, Liu X, Li X, Liu X, Zhou Z, Wu L, Fang K, Zhong P, Zhang M, Luan X, Tian W, Tong X, Cao L.
Heterozygous KCNJ10 Variants Affecting Kir4.1 Channel Cause Paroxysmal Kinesigenic Dyskinesia.
Mov Disord 2024; Epub ahead of print.
PMID: 39367724
Zhong R, Xu Y, Williams JW, Li L.
Loss of TREM2 diminishes CAA despite an overall increase of amyloid load in Tg-SwDI mice.
Alzheimers Dement 2024; Epub ahead of print.
PMID: 39308178
Smirnova AM, Hronová V, Mohammad MP, Herrmannová A, Gunišová S, Petráčková D, Halada P, Coufal Š, Świrski M, Rendleman J, Jendruchová K, Hatzoglou M, Beznosková P, Vogel C, Valášek LS.
Stem-loop-induced ribosome queuing in the uORF2/ATF4 overlap fine-tunes stress-induced human ATF4 translational control.
Cell Rep 2024; 43(4):113976
PMID: 38507410
Dogra S, Aguayo C, Xiang Z, Putnam J, Smith J, Johnston C, Foster DJ, Lindsley CW, Niswender CM, Conn PJ.
Activation of metabotropic glutamate receptor 3 modulates thalamo-accumbal transmission and rescues schizophrenia-like physiological and behavioral deficits.
Biol Psychiatry 2024; 96(3):230-242
PMID: 38061467
Bosco DB, Kremen V, Haruwaka K, Zhao S, Wang L, Ebner BA, Zheng J, Xie M, Dheer A, Perry JF, Barath A, Nguyen AT, Worrell GA, Wu LJ.
Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus.
Brain Behav Immun 2024; 123:540-555
PMID: 39353548
Lin M, Xu X, Zhou X, Feng H, Wang R, Yang Y, Li J, Fan N, Jiang Y, Li X, Guan F, Tan Z.
Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells.
Cell Mol Biol Lett 2024; 29(1):46
PMID: 38561669
Zhang D, Zhang W, Ming C, Gao X, Yuan H, Lin X, Mao X, Wang C, Guo X, Du Y, Shao L, Yang R, Lin Z, Wu X, Huang TY, Wang Z, Zhang YW, Xu H, Zhao Y.
P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy.
Cell 2024; 112(10):1676-1693
PMID: 38513667
Terauchi A, Yee P, Johnson-Venkatesh EM, Seiglie MP, Kim L, Pitino JC, Kritzer E, Zhang Q, Zhou J, Li Y, Ginty DD, Lee WA, Umemori H.
The projection-specific signals that establish functionally segregated dopaminergic synapses.
Cell 2023; 186(18):3845-3861.e24
PMID: 37591240
Long DM, Cravetchi O, Chow ES, Allen C, Kretzschmar D.
The amyloid precursor protein intracellular domain induces sleep disruptions and its nuclear localization fluctuates in circadian pacemaker neurons in Drosophila and mice.
Biol Res. 2024; 57(1):56
PMID: 39175009
Alfaro-Ruiz R, Martín-Belmonte A, Aguado C, Moreno-Martínez AE, Fukazawa Y, Luján R.
Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology.
Antioxidants 2024; 13(4):433
PMID: 38671881
Long DM, Cravetchi O, Chow ES, Allen C, Kretzschmar D.
The amyloid precursor protein intracellular domain induces sleep disruptions and its nuclear localization fluctuates in circadian pacemaker neurons in Drosophila and mice.
Neurobiol Dis 2024; 192:106429
PMID: 38309627
Abe Y, Yagishita S, Sano H, Sugiura Y, Dantsuji M, Suzuki T, Mochizuki A, Yoshimaru D, Hata J, Matsumoto M, Taira S, Takeuchi H, Okano H, Ohno N, Suematsu M, Inoue T, Nambu A, Watanabe M, Tanaka KF.
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia.
Cell Rep Med 2023; 4(10):101208
PMID: 37774703
Huang YT, Chen YW, Lin TY, Chen JC.
Suppression of presynaptic corticostriatal glutamate activity attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's disease mice.
Neurobiol Dis 2024; 193:106452
PMID: 38401650
Rachmian N, Medina S, Cherqui U, Akiva H, Deitch D, Edilbi D, Croese T, Salame TM, Ramos JMP, Cahalon L, Krizhanovsky V, Schwartz M.
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain.
Nat Neurosci 2024; 27(6):1116-1124
PMID: 38637622
Leung TCN, Lu SN, Chu CN, Lee J, Liu X, Ngai SM.
Temporal Quantitative Proteomic and Phosphoproteomic Profiling of SH-SY5Y and IMR-32 Neuroblastoma Cells during All-Trans-Retinoic Acid-Induced Neuronal Differentiation.
Int J Mol Sci 2024; 25(2):1047
PMID: 382561210
Wei W, Zhang L, Xin W, Pan Y, Tatenhorst L, Hao Z, Gerner ST, Huber S, Juenemann M, Butz M, Huttner HB, Bähr M, Fitzner D, Jia F, Doeppner TR.
TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury.
Biomed Pharmacother 2024; 170:115962
PMID: 38042110
Wang C, Cui X, Dong Z, Liu Y, Xia P, Wang X, Zhang Z, Yu S, Wu S, Liu H, Zong S, Lu Z.
Attenuated memory impairment and neuroinflammation in Alzheimer’s disease by aucubin via the inhibition of ERK-FOS axis.
Int Immunopharmacol 2024; 126:111312
PMID: 38043266
Medina-Luque J, Piechocinski P, Feyen P, Sgobio C, Herms J.
Striatal dopamine neurotransmission is altered in age-and region-specific manner in a Parkinson’s disease transgenic mouse.
Sci Rep 2024; 14(1):164
PMID: 38167878
Yang L, Jasiqi Y, Lashuel H.
Recombinant full-length TDP-43 oligomers retain their ability to bind RNAs, are not toxic, and do not seed TDP-43 aggregation in vitro.
ACS Chem Neurosci 2024; 15(1):193-204
PMID: 38116987
Yue W, Yiming C, Hongfei H, Yue X, Song C, Xiangdong G.
DHEC mesylate attenuates pathologies and aberrant bisecting N-glycosylation in Alzheimer's disease models.
Neuropharmacology 2024; 248:109863
PMID: 38325771
Zhang X, Tang L, Yang J, Meng L, Chen J, Zhou L, Wang J, Xiong M, Zhang Z.
Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease.
Nat Commun 2023;14(1):6670
PMID: 37865646
Sepulveda J, Kim JY, Binder J, Vicini S, Rebeck GW.
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12.
Mol Neurodegener. 2024;19(1):24.
PMID: 384683084
Maccioni R, Travisan C, Badman J, Zerial S, Wagener A, Andrade-Talavera Y, Picciau F, Grassi C, Chen G, Lemoine L, Fisahn A, Jiang R, Fluhrer R, Mentrup T, Schröder B, Nilsson P, Tambaro S.
Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease.
Prog Neurobiol 2024; 235:102585
PMID: 38367747
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