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文献紹介

2023年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌(可能な限り)の中から最近公表されたアルツハイマー病等の神経変性疾患、痙攣性神経疾患や遺伝子発現機構に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。

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・2012年度に紹介された文献一覧　□

#24　(2023/7/28; by KM)

Greve HJ, Dunbar AL, Lombo CG, Ahmed C, Thang M, Messenger EJ, Mumaw CL, Johnson JA, Kodavanti UP, Oblak AL, Block ML.
The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates　the peri-plaque microenvironment.
Brain 2023; 146(3):991-1005
PMID: 35348636

#23　(2023/7/28; by KK)

Sterlini B, Franchi F, Morinelli L, Corradi B, Parodi C, Albini M, Bianchi A, Marte A.
Missense mutations in the membrane domain of PRRT2 affect its interaction with Nav1.2 voltage-gated sodium channels.
Neurobiol Dis. 2023; 183:106177
PMID: 37271286

#22　(2023/7/21; by MO)

Ennerfelt H, Holliday C, Shapiro DA, Zengeler KE, Bolte AC, Ulland TK, Lukens JR.
CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer's disease mouse model
Proc Natl Acad Sci USA2023; 120(24):e2303760120
PMID: 37276426

#21　(2023/7/21; by MO)

Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE.
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Genome Med 2023; 15 (1): 11
PMID: 36805764

#20　(2023/7/14; by MO)

Firouzi R, Sowalti-Hashjin S, Chávez-García C, Ashouri M, Karimi-Jafari MH, Karttunen M.
Identification of Catechin’s Binding Sites in Monomeric Aβ42 through Ensemble Docking and MD Simulations.
Int J Mol Sci 2023; 24(9):8161
PMID: 37175868

#19　(2023/7/14; by MN)

Jiao L, Yu Z, Zhong X, Zhong X, Xing L, Ma G, Ma G, Shen J, Wu Y, Du K, Liu J, Tong J, Fu J, Wei M, Liu M.
Cordycepin improved neuronal synaptic plasticity through CREB-induced NGF upregulation driven by MG-M2 polarization: a microglia-neuron symphony in AD.
Biomed Pharmacother 2023; 157:114054
PMID: 36462314

#18　(2023/7/7; by AI)

Wang C, Yang Y, Zhang X, Shi Z, Gao H, Zhong M, Fan Y, Zhang H, Liu B, Qing G.
Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer's disease.
Sci Adv. 2023; 9(21):eade0293
PMID: 37235655

#17　(2023/7/7; by DY)

Bohlen J, Roiuk M, Neff M, Teleman AA.
PRRC2 proteins impact translation initiation by promoting leaky scanning.
Nucleic Acids Res 2023; 51(7): 3391–3409
PMID: 36869665

#16　(2023/6/16; by RS)

Fracassi A, Marcatti M, Tumurbaatar B, Woltjer R, Moreno S, Taglialatela G
TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology.
Brain Pathol 2023; 33 (1): e13108
PMID: 35816404

#15　(2023/6/16; by AN)

Gratuze M, Schlachetzki JC, D'Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O'Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, Glass CK, Ulrich JD, Holtzman DM.
TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.
Neuron 2023; 111(2):202-219.e7.
PMID: 36368315

#14　(2023/6/9; by MN)

Seo DC, Ju YH, Seo JJ, Oh SJ, Lee CJ, Lee SE, Nam MH.
DDC-promoter-driven chemogenetic activation of SNpc dopaminergic neurons alleviates parkinsonian motor symptoms.
Int J Mol Sci 2023; 24(3):2491
PMID: 36768816

#13　(2023/6/9; by SM)

Liu K, Song M, Gao S, Yao L, Zhang L, Feng J, Wang L, Gao R, Wang Y.
The dynamics of dopamine D2 receptor-expressing striatal neurons and the downstream circuit underlying L-dopa-induced dyskinesia in rats.
Neurosci Bull 2023; https://doi.org/10.1007/s12264-023-01054-5
PMID: 37022638

#12　(2023/5/26; by KK)

Valente P, Marte A, Franchi F, Sterlini B, Casagrande S, Corradi A, Baldelli P, Benfenati F.
A Push-Pull Mechanism Between PRRT2 and β4-subunit Differentially Regulates Membrane Exposure and Biophysical Properties of NaV1.2 Sodium Channels.
Mol Neurobiol 2023; 60(3):1281-1296
PMID: 36441479

#11　(2023/5/26; by SI)

Amin PH, Carlson KR, Wek RC.
An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response.
J Biol Chem2023; 299(2):102864
PMID: 36596357

#10　(2023/5/12; by AI)

Martínez-Mármol R, Small C, Jiang A, Palliyaguru T, Wallis TP, Gormal RS, Sibarita JB, Götz J, Meunier FA.
Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates.
Mol Psychiatry 2023; 28(2):946-962
PMID: 36258016

#9　(2023/5/12; by RI)

Chun YS, Kim MY, Lee SY, Kim MJ, Hong TJ, Jeon JK, Ganbat D, Kim HT, Kim SS, Kam TI, Han S.
AMEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer's Disease.
Mol Psychiatry 2022; 27(11): 4770–4780
PMID: 35948663

#8　(2023/4/28; by MN)

van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesamaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM.
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Nat Neurosci 2023; 26(3):416-429
PMID: 36635496

#7　(2023/4/28; by HN)

Rofo F, Metzendorf NG, Saubi C, Suominen L, Godec A, Sehlin D, Syvänen S, Hultqvist G.
Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer's diseasebr> Alzheimers Res Ther 2022; 14(1):180
PMID: 36471433

#6　(2023/4/21; by NM)

Franchi F, Marte A, Corradi B, Sterlini B, Alberini G, Romei A, Fusco AD, Vogel A, Maragliano L, Baldelli P, Corradi A, Valente P, Benfenati F.
The intramembrane COOH-terminal domain of PRRT2 regulates voltage-dependent Na+ channels
J Biol Chem 2023; 104632
PMID: 36958475

#5　(2023/4/21; by KM)

Xu QA, Boerkoel P, Hirsch-Reinshagen V, Mackenzie IR, Hsiung GR, Charm G, To EF, Liu AQ, Schwab K, Jiang K, Sarunic M, Beg MF, Pham W, Cui J, To E, Lee S, Matsubara JA
Müller cell degeneration and microglial dysfunction in the Alzheimer's retina.
Acta Neuropathol Commun 2022; 10(1):145
PMID: 36199154

#4　(2023/4/15; by TT)

Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF.
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
PNAS 2023;119(5):e2114486119
PMID: 35082148

#3　(2023/4/14; by MN)

Gomaa AA, Farghaly HSM, Ahmed AM, Hemida FK.
Intermittent treatment with Apremilast, a phosphodiesterase-4 inhibitor, ameliorates Alzheimer's-like pathology and symptoms through multiple targeting actions in aged T2D rats.
Int Immunopharmacol 2023; 117:109927
PMID: 36848793

#2　(2023/4/7; by AI)

Jain N, Lewis CA, Ulrich JD, Holtzman DM.
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading.
J Exp Med 2023; 220(1):e20220654.
PMID: PMC9559604

#1　(2023/4/7; by MO)

Tian Y,　Viles JH.
PH dependence of amyloid-β fibril assembly kinetics: unravelling the microscopic molecular processes.
Angew Chem Int Ed Engl 2022; 61(48):e202210675
PMID: 36197009