2017年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌の中から最近公表されたアルツハイマー病に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
・2017年度に紹介された文献一覧 □
・2016年度に紹介された文献一覧 □
・2015年度に紹介された文献一覧 □
・2014年度に紹介された文献一覧 □
・2013年度に紹介された文献一覧 □
・2012年度に紹介された文献一覧 □
Nomura H, Mizuta H, Norimoto H, Masuda F, Miura Y, Kubo A, Kojima H, Ashizuka A, Matsukawa N, Baraki Z, Hitora IN, Nakayama D, Ishikawa T, Okada M, Orita K, Saito R, Yamauchi N, Sano Y, Kusuhara H, Minami M, Takahashi H, Ikegaya Y.
Central histamine boosts perirhinal cortex activity and restores forgotten object memories.
Biol Psychiatry 2018 Dec 19; S0006-3223(18): 32021-32034
PMID: 30635130
Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT.
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.
Nat Neurosci 2019 Jan;22(1):57-64
PMID: 30559471
Klein HU, McCabe C, Gjoneska E, Sullivan SE, Kaskow BJ, Tang A, Smith RV, Xu J, Pfenning AR, Bernstein BE, Meissner A, Schneider JA, Mostafavi S, Tsai LH, Young-Pearse TL, Bennett DA, De Jager PL.
Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.
Nat Neurosci 2019 Jan;22(1):37-46
PMID: 30559478
Mo J, Wang B, Zhu X, Wu X, Liu Y.
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
Neurobiol Dis 2019 Jan;121:274-285
PMID: 30347267
Shentu YP, Hu WT, Zhang Q, Huo Y, Liang JW, Liuyang ZY, Zhou H, Wei H, Ke D, Wang XC, Wang JZ, Man HY, Westermarck J, Liu R.
CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.
Neurobiol Aging 2018 Dec 6; 75: 198-208
PMID: 30504047
Tsutsui M, Hirase R, Miyamura S, Nagayasu K, Nakagawa T, Mori Y, Shirakawa H, Kaneko S.
TRPM2 exacerbates central nervous system inflammation in experimental autoimmune encephalomyelitis by increasing production of CXCL2 chemokines.
J Neurosci 2018 Sep 26; 38(39):8484-8495
PMID: 30201769
Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K.
Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory.
Proc Natl Acad Sci USA 2018 Jul 31; 115(31):E7408-E7417
PMID: 30012602
Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH.
APOE4 causes widespread molecular and cellular alterations associated with Alzheimer's disease phenotypes in human iPSC-derived brain cell types.
Neuron 2018 Jun 27; 98(6):1141-1154.e7
PMID: 29861287
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT.
Tau protein disrupts nucleocytoplasmic transport in Alzheimer's disease.
Neuron 2018 Sep; 99:925-940.e7
PMID: 30189209
Chinchalongporn V, Shukla M, Govitrapong P.
Melatonin ameliorates Aβ42-induced alteration of βAPP-processing secretases via the melatonin receptor through the Pin1/GSK3β/NF-κB pathway in SH-SY5Y cells.
J Pineal Res 2018 Feb 8;64(4):e12470
PMID: 29352484
Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ.
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Nature 2018 Oct; 562(7728):578-582
PMID: 30232451
Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu S, Fujita K, Okazawa H
The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology
Mol Psychiatry 2018 Oct 03 [Epub ahead of print]
PMID: 30283027
McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P.
Synaptogyrin-3 mediates presynaptic dysfunction induced by tau.
Neuron 2018 Feb 21; 97(4):823-835
PMID: 29398363
Dunn M, Henke A, Clark S, Kovalyova Y, Kempadoo KA, Karpowicz RJ Jr, Kandel ER, Sulzer D, Sames D
Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo
Nat Commun 2018 Jul 19; 9(1):2838
PMID: 30026491
Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY, Liu R.
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease.
Cell Rep 2018; Jul 17;24(3):713-723
PMID: 30021167
Inês S. Amorim, Sonal Kedia, Stella Kouloulia, Konstanze Simbriger, Ilse Gantois, Seyed Mehdi Jafarnejad, Yupeng Li, Agniete Kampaite, Tine Pooters, Nicola Romanò and Christos G. Gkogkas
Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation
J Neurosci 2018; Feb 21;38 (8): 2118-2133
PMID: 29367404
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Nat Commun 2018; 9(1):3421
PMID: 30143604
Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
Nature 2018; 560(7717):185-191
PMID: 30046111
Leino S, Koski SK, Hänninen R, Tapanainen T, Rannanpää S, Salminen O
Attenuated dopaminergic neurodegeneration and motor dysfunction in hemiparkinsonian mice lacking the α5 nicotinic acetylcholine receptor subunit.
Neuropharmacology 2018; 138:371-380
PMID: 29940207
Petkovic M, Jemaiel A, Daste F, Specht CG, Izeddin I, Vorkel D, Verbavatz JM, Darzacq X, Triller A, Pfenninger KH, Tareste D, Jackson CL, Galli T
The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion
Nat Cell Biol 2014;16(5):434-444
PMID: 24705552
Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze JL, Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ
Innate immune memory in the brain shapes neurological disease hallmarks
Nature 2018;556(7701):332-338
PMID: 29643512
Devi L, Ohno M
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease
Neurobiol Aging 2014;35(10):2272-2281
PMID: 24889041
Moy JK, Khoutorsky A, Asiedu MN, Dussor G, Price TJ
eIF4E phosphorylation influences Bdnf mRNA translation in mouse dorsal root ganglion neurons
Front Cell Neurosci 2018;12:29
PMID: 29467623
Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R
Genetic inhibition of Phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer’s disease
PLOS one 2014;9(7) :e101643
PMID: 24992504
Cheng W, Wang S, Mestre AA, Fu C, Makarem A, Xian F, Hayes LR, Lopez-Gonzalez R, Drenner K, Jiang J, Cleveland DW, Sun S
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
Nat Commun 2018;9(1):51
PMID: 29302060
Fruscione F, Valente P, Sterlini B, Romei A, Baldassari S, Fadda M, Prestigio C, Giansante G, Sartorelli J, Rossi P, Rubio A, Gambardella A, Nieus T, Broccoli V, Fassio A, Baldelli P, Corradi A, Zara F, Benfenati F
PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity
Brain 2018;141(4):1000-1016
PMID: 29554219
Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
Brain 2017;140(12):3252-3268
PMID: 29155979
〒852-8521
長崎県長崎市文教町1-14
Tel・Fax:
095-819-2437
E-mail:
*****