2021年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌の中から最近公表されたアルツハイマー病に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
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Brelstaff JH, Mason M, Katsinelos T, McEwan WA, Ghetti B, Tolkovsky AM, Spillantini MG.
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.
Sci Adv 2021; 7(43):eabg4980
PMID: 34537209
Fernández G, Krapacher F, Ferreras S, Quassollo G, Mari MM, Pisano MV, Montemerlo A, Rubianes MD, Bregonzio C, Arias C, Paglini MG.
Lack of Cdk5 activity is involved on dopamine transporter expression and function: Evidences from an animal model of Attention-Deficit Hyperactivity Disorder.
Exp Neurol 2021; 346:113866
PMID: 34537209
Bampton A, Gatt A, Humphrey J, Cappelli S, Bhattacharya D, Foti S, Brown AL, Asi Y, Low YH, Foiani M, Raj T, Buratti E, Fratta P, Lashley T.
hnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing.
Acta Neuropathol 2021; 142(4):609-627
PMID: 34274995
Jayaram DR, Frost S, Argov C, Liju VB, Anto NP, Muraleedharan A, Ben-Ari A, Sinay R, Smoly I, Novoplansky O, Isakov N, Toiber D, Keasar C, Elkabets M, Yeger-Lotem E, Livneh E.
Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.
Proc Natl Acad Sci USA 2021; 118(40):e2018899118
PMID: 34593629
Brodovskaya A, Shiono S, Kapur J.
Activation of the basal ganglia and indirect pathway neurons during frontal lobe seizures.
Brain 2021; 144(7):2074-2091
PMID: 33730155
Malave L, Zuelke DR, Uribe-Cano S, Starikov L, Rebholz H, Friedman E, Qin C, Li Q, Bezard E, Kottmann AH.
Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia.
Commun Biol 2021; 4(1):1071
PMID: 34552196
Watamura N, Kakiya N, Nilsson P, Tsubuki S, Kamano N, Takahashi M, Hashimoto S, Sasaguri H, Saito T, Saido TC.
Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-K ATP channel pathway.
Mol Psychiatry 2021; Nov 4. doi: 10.1038/s41380-021-01368-8
PMID: 34737456
Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ.
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Nat Neurosci 2021; 25(1):26-38
PMID: 34916658
Vautheny A, Duwat C, Aurégan G, Joséphine C, Hérard AS, Jan C, Mitja J, Gipchtein P, Gaillard MC, Buée L, Blum D, Hantraye P, Bonvento G, Brouillet E, Cambon K, Bemelmans AP.
THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency.
Neurobiol Dis 2021; 155:105398
PMID: 34019997
Di Lauro C, Bianchi C, Sebastián-Serrano Á, Soria-Tobar L, Alvarez-Castelao B, Nicke A, Díaz-Hernández M.
P2X7 receptor blockade reduces tau induced toxicity, therapeutic implications in tauopathies.
Prog Neurobiol 2021; 102173
PMID: 34516970
Joshi P, Riffel F, Kumar S, Villacampa N, Theil S, Parhizkar S, Haass C, Colonna M, Heneka MT, Arzberger T, Herms J, Walter J.
Differential interaction with TREM2 modulates microglial uptake of modified Aβ species.
Glia 2021; 69(12):2917-2932
PMID: 34427354
Joshi P, Riffel F, Kumar S, Villacampa N, Theil S, Parhizkar S, Haass C, Colonna M, Heneka MT, Arzberger T, Herms J, Walter J.
TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits.
Acta Neuropathol Commun 2021; 9(1):168
PMID: 34663480
Stepchenko AG, Portseva TN, Glukhov IA, Kotnova AP, Lyanova BM, Georgieva SG, Pankratova EV.
Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress.
Sci Rep 2021; 11(1):18808
PMID: 34552146
Streubel-Gallasch L, Giusti V, Sandre M, Tessari I, Plotegher N, Giusto E, Masato A, Iovino L, Battisti I, Arrigoni G, Shimshek D, Greggio E, Tremblay ME, Bubacco L, Erlandsson A, Civiero L.
Parkinson’s disease–associated LRRK2 interferes with astrocyte-mediated alpha-synuclein clearance.
Mol Neurobiol 2021; 58:3119–3140
PMID: 33629273
Xie J, Gorlé N, Vandendriessche C, Van Imschoot G, Van Wonterghem E, Van Cauwenberghe C, Parthoens E, Van Hamme E, Lippens S, Van Hoecke L, Vandenbroucke RE.
Low-grade peripheral inflammation affects brain pathology in the App NL-G-F mouse model of Alzheimer's disease.
Acta Neuropathol Commun 2021; 9(1):163
PMID: 34620254
Binda F, Valente P, Marte A, Baldelli P, Benfenati F.
Increased responsiveness at the cerebellar input stage in the PRRT2 knockout model of paroxysmal kinesigenic dyskinesia.
Neurobiol Dis 2021; 152:105275
PMID: 33515674
Savino E, Guarnieri FC, Tsai JW, Corradi A, Benfenati F, Valtorta F.
An Emerging Role of PRRT2 in Regulating Growth Cone Morphology.
Cells 2021; 10(10):2666
PMID: 34685646
Subramanian VS, Teafatiller T, Vidal J, Gunaratne GS, Rodriguez-Ortiz CJ, Kitazawa M, Marchant JS.
Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake.
Int J Biol Macromol 2021; 192:1178-1184
PMID: 34673103
Ferrante D, Sterlini B, Prestigio C, Marte A, Corradi A, Onofri F, Tortarolo G, Vicidomini G, Petretto A, Muià J, Thalhammer A, Valente P, Cingolani LA, Benfenati F, Baldelli P.
PRRT2 modulates presynaptic Ca2+ influx by interacting with P/Q-type channels.
Cell Rep 2021; 35(11):109248
PMID: 34133925
Jin JW, Fan X, Del Cid-Pellitero E, Liu XX, Zhou L, Dai C, Gibbs E, He W, Li H, Wu X, Hill A, Leavitt BR, Cashman N, Liu L, Lu J, Durcan TM, Dong Z, Fon EA, Wang YT.
Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.
Commun Biol 2021; 4(1):232
PMID: 33608634
Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU.
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Nat Commun 2021; 12(1):4863
PMID: 34381050
Lu B, Lou SS, Xu RS, Kong DL, Wu RJ, Zhang J, Zhuang L, Wu XM, He JY, Wu ZY, Xiong ZQ.
Cerebellar spreading depolarization mediates paroxysmal movement disorder.
Cell Rep 2021; 36(12):109743
PMID: 34551285
Ibach M, Mathews M, Linnartz-Gerlach B, Theil S, Kumar S, Feederle R, Brüstle O, Neumann H, Walter J.
A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region.
Glia 2021; 69(5):1126-1139
PMID: 33314333
Delizannis AT, Nonneman A, Tsering W, De Bondt A, Van den Wyngaert I, Zhang B, Meymand E, Olufemi MF, Koivula P, Maimaiti S, Trojanowski JQ, Lee VM, Brunden KR.
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice.
Acta Neuropathol Commun 2021; 9(1):150
PMID: 34503586
Lee SH, Meilandt WJ, Xie L, Gandham VD, Ngu H, Barck KH, Rezzonico MG, Imperio J, Lalehzadeh G, Huntley MA, Stark KL, Foreman O, Carano RAD, Friedman BA, Sheng M, Easton A, Bohlen CJ, Hansen DV.
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Neuron 2021; 109(8):1283-1301
PMID: 33675684
Xu H, Bensalel J, Capobianco E, Lu ML, Wei J.
Impaired restoration of global protein synthesis contributes to increased vulnerability to acute ER stress recovery in Huntington’s disease.
Cell Mol Neurobiol. 2021; in press
PMID: 34347195
Diaz-Lucena D, Kruse N, Thüne K, Schmitz M, Villar-Piqué A, da Cunha JEG, Hermann P, López-Pérez Ó, Andrés-Benito P, Ladogana A, Calero M, Vidal E, Riggert J, Pineau H, Sim V, Zetterberg H, Blennow K, Del Río JA, Marín-Moreno A, Espinosa JC, Torres JM, Sánchez-Valle R, Mollenhauer B, Ferrer I, Zerr I, Llorens F.
TREM2 expression in the brain and biological fluids in prion diseases.
Acta Neuropathologica. 2021; 141(6):841-859
PMID: 33881612
Thom T, Schmitz M, Fischer AL, Correia A, Correia S, Llorens F, Pique AV, Möbius W, Domingues R, Zafar S, Stoops E, Silva CJ, Fischer A, Outeiro TF, Zerr I.
Cellular prion protein mediates α-synuclein uptake, localization, and toxicity in vitro and in vivo.
Mov Disord. 2021; in press
PMID: 34448510
Lee DSM, Park J, Kromer A, Baras A, Rader DJ, Ritchie MD, Ghanem LR, Barash Y.
Disrupting upstream translation in mRNAs is associated with human disease.
Nat Commun. 2021; 12(1):1515
PMID: 33750777
Benitez D, Jiang S, Wood J, Wang R, Hall C, Peerboom C, Wong N, Stringer K, Vitanova K, Smith V, Joshi D, Saito T, Saido T, Salih D, Tripathi T, Edwards F, Cummings D.
Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.
Mol Neurodegener. 2021; 16(1):47
PMID: 34266459
Fay AJ, McMahon T, Im C, Bair-Marshall C, Niesner KJ, Li H, Nelson A, Voglmaier
SM, Fu Y-H & Ptáček LJ.
Age-dependent neurological phenotypes in a mouse model of PRRT2-related diseases.
Neurogenetics 2021; 22(3):171-185
PMID: 34101060
Ellwanger DC, Wang S, Brioschi S, Shao Z, Green L, Case R, Yoo D, Weishuhn D, Rathanaswami P, Bradley J, Rao S, Cha D, Luan P, Sambashivan S, Gilfillan S, Hasson SA, Foltz IN, Campagne MvL, Colonna M
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Proc Natl Acad Sci USA 2021; 118(3):e2017742118
PMID: 33446504
Kang SS, Ahn EH, Liu X, Bryson M, Miller GW, Weinshenker D, Ye K
ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease.
Acta Neuropathol 2021; 142(1):139-158
PMID: 33895869
Lu YN, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, He L, Wang J
MARK2 phosphorylates eIF2α in response to proteotoxic stress.
PLoS Biol 2021; 19(3):e3001096
PMID: 33705388
Ferreira APA, Casamento A, Carrillo Roas S, Halff EF, Panambalana J, Subramaniam S, Schützenhofer K, Chan Wah Hak L, McGourty K, Thalassinos K, Kittler JT, Martinvalet D, Boucrot E.
Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis.
Nat Commun 2021; 12(1):2424.
PMID: 33893293
Liang Y, Ye C, Chen Y, Chen Y, Diao S, Huang M
Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer's Disease via Regulation of β-Amyloid Production and Endoplasmic Reticulum Stress.
ACS Chem Neurosci 2021; 12(11): 1894–1904.
PMID: 33983710
Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Mol Neurodegener 2021; 16(1):18.
PMID: 33853665
Aguilar JI, Cheng MH, Font J, Schwartz AC, Ledwitch K, Duran A, Mabry SJ, Belovich AN, Zhu Y, Carter AM, Shi L, Kurian MA, Ferrer CF, Meiler J, Ryan RM, Mchaourab HS, Bahar I, Matthies HJ, Galli A
Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife 2021; 10:e68039.
PMID: 34002696
Oliveira MM, Lourenco MV, Longo F, Kasica NP, Yang W, Ureta G, Ferreira DDP, Mendonça PHJ, Bernales S, Ma T, De Felice FG, Klann E, Ferreira ST
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease.
Sci Signal 2021; 14(668):eabc5429.
PMID: 33531382
Sterlini B, Romei A, Parodi C, Aprile D, Oneto M, Aperia A, Valente P, Valtorta F, Fassio A, Baldelli P, Corradi A
An interaction between PRRT2 and Na+/K+ ATPase contributes to the control of neuronal excitability
Cell Death Dis 2021; 12(4): 292.
PMID: 33731672
Audrain M, Haure-Mirande JV, Mleczko J, Wang M, Griffin JK, St George-Hyslop PH, Fraser P, Zhang B, Gandy S, Ehrlich ME
Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice.
Alzheimers Dement 2021; 17(2):149-163.
PMID: 33314529
Baxter PS, Márkus NM, Dando O, He X, Al-Mubarak BR, Qiu J, Hardingham GE
Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation.
Cell Death Dis 2021; 12(2):218.
PMID: 33637689
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, Uytterhoeven V, Verstreken P
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Neuron 2021; 109(5):767-777.e5.
PMID: 33472038
Hall-Roberts H, Agarwal D, Obst J, Smith TB, Monzón-Sandoval J, Daniel ED, Webber C, James WS, Mead E, Davis JB, Cowley SA
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Alzheimers Res Ther 2020; 12(1):151
PMID: 33198789
Pons V, Lévesque P, Plante MM, Rivest S.
Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease
Alzheimers Res Ther 2021; 13(1):8.
PMID: 33402196
Jeong SG, Ohn T, Jang CH, Vijayakumar K, Cho GW.
The Role of Stress Granules in the Neuronal Differentiation of Stem Cells.
Mol Cells 2021; 43(10):848-855
PMID: 33028745
Rofo F, Yilmaz CU, Metzendorf N, Gustavsson T, Beretta C, Erlandsson A, Sehlin D, Syvänen S, Nilsson P, Hultqvist G.
Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain.
Theranostics 2021; 11(2):789-804
PMID: 33391505
Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson J, Lee V, Saito T, Saido T, Trojanowski J, Zhang M, Suhara T, Higuchi M, Sahara N.
Distinct microglial response against Alzheimer’s amyloid and tau pathologies characterized by P2Y12 receptor.
Brain Commun 2021; 3(1):fcab011
PMID: 33644757
Schapansky J, Grinberg Y, Osiecki M, Freeman E, Walker S, Karran E, Gopalakrishnan S, Talanian R.
MEK1/2 activity modulates TREM2 cell surface recruitment.
J Biol Chem 2020; 296:100218, Online ahead of print
PMID: 33839686
Jadhav VS, Lin PBC, Pennington T, Prisco GVD, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BTJadhav VS, Lin PBC, Pennington T, Prisco GVD, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BT.
Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.
Mol Neurodegener 2020; 15(1):62
PMID: 33115519
Feng W, Zhang Y, Wang Z, Xu H, Wu T, Marshall C, Gao J, Xiao M.
Microglia prevent β-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance
Alzheimers Res Ther 2020; 12(1):125
PMID: 33008458
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