2017年度にゲノム創薬学研究室のセミナー時に紹介された文献の一覧です。
ゲノム創薬学研究室のセミナーでは、インパクトファクター 7以上の雑誌の中から最近公表されたアルツハイマー病に関わる文献を紹介し、批判的な視点を養うと共に、新しい知見や技術を学び、プレゼンテーション能力や論理的な思考の向上に努めています。
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Bussiere R, Oulès B, Mary A, Vaillant-Beuchot L, Martin C, El Manaa W, Vallée D, Duplan E, Paterlini-Bréchot P, Alves Da Costa C, Checler F, Chami M.
Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer's Disease.
Cells 8(12). pii: E1539. doi: 10.3390/cells8121539
PMID: 31795302
Apicco D, Zhang C, Maziuk B, Ung C, Li H, Wolozin B.
Dysregulation of RNA Splicing in Tauopathies.
Cell Rep 2019; 29 (13) :4377~4388
PMID: 31875547
Aliouat A, Hatin I, Bertin P, François P, Stierlé V, Namy O, Salhi S, Jean-Jean O.
Divergent effects of translation termination factor eRF3A and nonsense-mediated mRNA decay factor UPF1 on the expression of uORF carrying mRNAs and ribosome protein genes.
RNA Biology 2019; 17(2):227-239
PMID: 31619139
Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE.
Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription.
Cell 2019; 178(5):1159-1175.e17
PMID: 31442405
Ioannou MS, Jackson J, Sheu SH, Chang CL, Weigel AV, Liu H, Pasolli HA, Xu CS, Pang S, Matthies D, Hess HF, Lippincott-Schwartz J, Liu Z.
Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity.
Cell 2019; 177(6):1522-1535
PMID: 31130380
Valente P, Romei A, Fadda M, Sterlini B, Lonardoni D, Forte N, Fruscione F, Castroflorio E, Michetti C, Giansante G, Valtorta F, Tsai JW, Zara F, Nieus CT, Corradi A, Fassio A, Baldelli P, Benfenati F.
Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons.
Cereb Cortex 2019; 29(5):2010-2033
PMID: 29912316
Pickett EK, Herrmann AG, McQueen J, Abt K, Dando O, Tulloch J, Jain P, Dunnett S, Sohrabi S, Fjeldstad MP, Calkin W, Murison L, Jackson RJ, Tzioras M, Stevenson A, d'Orange M, Hooley M, Davies C, Colom-Cadena M, Anton-Fernandez A, King D, Oren I, Rose J, McKenzie CA, Allison E, Smith C, Hardt O, Henstridge CM, Hardingham GE, Spires-Jones TL.
Amyloid β and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease.
Cell Rep 2019; 29(11):3592-3604.e5
PMID: 31825838
Guo J, Zhang F, Gao J, Guan X, Liu B, Wang X, Qin Z, Tang K, Liu S.
Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of Saikosaponin A.
J Cell Mol Med 2019; [Epub ahead of print]
PMID: 31762213
Griciuc A, Patel S, Federico AN, Choi SH, Innes BJ, Oram MK, Cereghetti G, McGinty D, Anselmo A, Sadreyev RI, Hickman SE, El Khoury J, Colonna M, Tanzi RE.
TREM2 acts downstream of CD33 in modulating microglial pathology in Alzheimer's disease.
Neuron 2019; 103(5):820-835
PMID: 31301936
Shi Y, Manis M, Long J, Wang K, Sullivan PM, Remolina Serrano J, Hoyle R, Holtzman DM.
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
J Exp Med 2019; 216(11):2546-2561
PMID: 31601677
Zullo JM, Drake D, Aron L, O'Hern P, hamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, Yankner BA.
Regulation of lifespan by neural excitation and REST.
Nature 2019; 574:359–364
PMID: 31619788
Luengo E, Buendia I, Fernández-Mendívil C, Trigo-Alonso P, Negredo P, Michalska P, Hernández-García B, Sánchez-Ramos C, Bernal JA, Ikezu T, León R, López MG.
Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.
J Pineal Res 2019; 67(1):e12578
PMID: 30943316
Tsai MH, Nian FS, Hsu MH, Liu WS, Liu YT, Liu C, Lin PH, Hwang DY, Chuang YC, Tsai JW.
PRRT2 missense mutations cluster near C-terminus and frequently lead to protein mislocalization.
Epilepsia 2019; 60(5):807-817
PMID: 30980674
Ko HJ, Chiou SJ, Wong YH, Wang YH, Lai Y, Chou CH, Wang C, Loh JK, Lieu AS, Cheng JT, Lin YT, Lu PJ, Fann MJ, Huang CF, Hong YR.
GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease.
J Clin Med 2019; 8(10). pii: E1751
PMID: 31640277
Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H.
The Amyloid Precursor Protein C-Terminal Domain alters CA1 neuron firing, modifying hippocampus oscillations and impairing spatial memory encoding.
Cell Rep 2019; 29(2):317-331
PMID: 31597094
Kwart D, Gregg A, Scheckel C, Murphy E, Paquet D, Duffield M, Fak J, Olsen O, Darnell R, Tessier-Lavigne M.
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.
Neuron 2019; 104(2):256-270.e5
PMID: 31416668
Wu T, Dejanovic B, Gandham VD, Gogineni A, Edmonds R, Schauer S, Srinivasan K, Huntley MA, Wang Y, Wang TM, Hedehus M, Barck KH, Stark M, Ngu H, Foreman O, Meilandt WJ, Elstrott J, Chang MC, Hansen DV, Carano RAD, Sheng M and Hanson JE.
Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy.
Cell Rep 2019; 28(8):2111-2123.e6
PMID: 31433986
Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R.
The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.
Neuron 2019; S0896-6273(19)30691-9
PMID: 31522764
Park JS, Lee J, Jung ES, Kim MH, Kim IB, Son H, Kim S, Kim S, Park YM, Mook-Jung I, Yu SJ, Lee JH.
Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation.
Nat Commun 2019; 10(1):3090
PMID: 31300647
Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, Arenkiel BR, Bellen HJ, Shulman JM.
Cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Cell Rep 2019; 28(7):1799-1813
PMID: 31412248
Wang ZH, Xiang J, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Wu S, Wang JZ, Ye K.
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.
Cell Rep 2019; 28(3):655-669.e5
PMID: 31315045
Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P, Poirier J, Saftig P, Bateman RJ, Breitner J, Hock C,, Multhaup G.
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Nat Commun 2019; 10(1):2240
PMID: 31110178
Xiang J, Wang ZH, Ahn EH, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Ju G, Wu S, Ye K.
Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies.
Proc Natl Acad Sci USA 2019; 116(18):9094-9102
PMID: 31004063
Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH.
Single-cell transcriptomic analysis of Alzheimer's disease.
Nature 2019;570(7761):332-337
PMID: 31042697
Bahn G, Park JS, Yun UJ, Lee YJ, Choi Y, Park JS, Baek SH, Choi BY, Cho YS, Kim HK, Han J, Sul JH, Baik SH, Lim J, Wakabayashi N, Bae SH, Han JW, Arumugam TV, Mattson MP, Jo DG.
NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.
Proc Natl Acad Sci USA 2019;116(25):12516-12523
PMID: 31164420
Wahl D, Solon-Biet M.S, Wang Q, Wali A.J, Pulpitel T, Clark X, Raubenheimer D, Senior M.A, Sinclair A.D, Cooney J.G, Cabo de R, Cogger C.V, Simpson J.S, and Le Couteur G.D.
Comparing the effects of low-protein and high-carbohydrate diets and caloric restriction on brain aging in mice.
Cell Rep 2018; 25(8):2234-2243.e6
PMID: 30463018
Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J.
Somatic APP gene recombination in Alzheimer's disease and normal neurons.
Nature 2018; 563(7733):639-645
PMID: 30464338
Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT.
APP-mediated signaling prevents memory decline in Alzheimer's disease mouse model.
Cell Rep 2019; 27(5):1345-1355.e6
PMID: 31042463
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe M, Mattson MP.
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.
Nat Neurosci 2019; 22(5):719-728
PMID: 30936558
Paonessa F, Evans LD, Solanki R, Larrieu D, Wray S, Hardy J, Jackson SP, Livesey FJ.
Microtubules deform the nuclear membrane and disrupt nucleocytoplasmic transport in tau-mediated frontotemporal dementia.
Cell Rep 2019;26(3):582-593.e5
PMID: 30650353
Yang Y, Tian X, Xu D, Zheng F, Lu X, Zhang Y, Ma Y, Li Y1, Xu X, Zhu B, Wang X.
GPR40 modulates epileptic seizure and NMDA receptor function.
Sci Adv 2018; 4(10): eaau2357
PMID: 30345361
Srivastava S, Katorcha E, Makarava N, Barrett JP, Loane DJ, Baskakov IV.
Inflammatory response of microglia to prions is controlled by sialylation of PrPSc.
Sci Rep 2018; 8(1):11326
PMID: 30054538
Kaneko N, Herranz-Pérez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, García-Verdugo JM, Sawamoto K.
New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration.
Sci Adv 2018; 4(12): eaav0618
PMID: 30547091
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, Wang YT, Fischer A, Dean C.
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Science 2019; 363(6422)
PMID: 30545844
Losev Y, Paul A, Frenkel-Pinter M, Abu-Hussein M, Khalaila I, Gazit E, Segal D.
Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity.
Sci Rep 2019;9(1):2254
PMID: 30783169
Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV.
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.
Mol. Neurodegener. 2018, 13: 57
PMID: 30340601
Baker SK, Chen ZL, Norris EH, Revenko AS, MacLeod AR, Strickland S.
Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease
Proc Natl Acad Sci USA 2018: 115(41):E9687-E9696
PMID: 30254165
Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA.
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Nat Neurosci 2019; 22(3):401-412
PMID: 30742114
Mouchard A, Boutonnet MC, Mazzocco C, Biendon N, Macrez N; Neuro-CEB Neuropathology Network.
ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer's disease
Sci Rep 2019; 9(1):3989
PMID: 30850702
Sawangjit A, Oyanedel CN, Niethard N, Salazar C, Born J, Inostroza M.
The hippocampus is crucial for forming non-hippocampal long-term memory during sleep
Nature 2018;9(1):51
PMID: 30429612
Benjamin B. T, Stergios T, Daphney R, Christine F, Thomas C, Frédéric F, Tien P, Marie-Claude G, Eniko K, Marcelle MS, Armand S, Philippe M.
TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer's disease
Neurobiol Dis 2018; 564(7734):109-113
PMID: 30261283
Smith LM, Kostylev MA, Lee S, Strittmatter SM
Systematic and standardized comparison of reported Amyloid-β receptors for sufficiency, affinity, and Alzheimer's disease relevance
J Biol Chem 2019; 294(15):6042-6053
PMID: 30787106
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