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Here is a list of papers introduced in the recent seminar of our laboratory.
The lab undergraduate/graduate students choose from Alzheimer's disease-related and recently published papers with high impact.

・Apr. 1, 2016 - Mar. 31, 2017 
・Apr. 1, 2015 - Mar. 31, 2016 
・Apr. 1, 2014 - Mar. 31, 2015 
・Apr. 1, 2013 - Mar. 31, 2014 
・Apr. 1, 2012 - Mar. 31, 2013 

*, corresponding author; #, equal contribution

#27 (2017/12/14; by YK)

Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A*
Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease
Proc Natl Acad Sci U S A 2017;114(45):E9645-E9654
PMID: 29042514

#26 (2017/12/14; by KK)

Li C, Götz J*
Somatodendritic accumulation of tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation
EMBO J 2017;36(21):3120-3138
PMID: 28864542

#21 (2017/11/10; by YH)

Zhang Y, Kim MS, Jia B, Yan J, Zuniga-Hertz JP, Han C, Cai D*
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Nature 2017;548(7665):52-57
PMID: 28746310

#20 (2017/11/01; by DH)

Kim J, Kim Y, Nakajima R, Shin A, Jeong M, Park AH, Jeong Y, Jo S, Yang S, Park H, Cho SH, Cho KH, Shim I, Chung JH, Paik SB, Augustine GJ, Kim D*
Inhibitory basal ganglia inputs induce excitatory motor signals in the thalamus
Neuron 2017;95(5):1181-1196.e8
PMID: 28858620

#19 (2017/10/26; by YO)

Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trumbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C*
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
EMBO Rep 2017;18(7):1186-1198
PMID: 28483841

#18 (2017/10/26; by KN)

George C, Gontier G, Lacube P, Francois JC, Holzenberger M,* Aïd S
The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons
Brain 2017;140(7):2012-2027
PMID: 28595357

#17 (2017/10/19; by KO)

Paolicelli RC,* Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L*
TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss
Neuron 2017;95(2):297-308
PMID: 28669544

#15 (2017/10/13; by ST)

Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M*
Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice
Proc Natl Acad Sci U S A (in press)
PMID: 28874550

#16 (2017/10/19; by SU)

Branca C, Shaw DM, Belfiore R, Gokhale V, Shaw AY, Foley C, Smith B, Hulme C, Dunckley T, Meechoovet B, Caccamo A, Oddo S*
Dyrk1 inhibition improves Alzheimer's disease-like pathology
Aging Cell 2017;16(5):1146-1154
PMID: 28779511

#14 (2017/10/13; by MK)

Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L,* De Strooper B*
Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration
EMBO Mol Med 2017;9(8):1088-1099
PMID: 28588032

#13 (2017/10/06; by YK)

Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biferi MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C*
β-Amyloid precursor protein intracellular domain controls mitochondrial function by modulating phosphatase and tensin homolog-induced kinase 1 transcription in cells and in Alzheimer mice models
Biol Psychiatry (in press)
PMID: 28587718

#12 (2017/10/06; by KK)

Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C*
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
EMBO Mol Med (in press)
PMID: 28855300

#11 (2017/06/23; by YH)

Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T*
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
Nature 2017;544(7651):488-492
PMID: 28424512

#10 (2017/06/23; by KF)

Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D*
Neuroprotective functions for the histone deacetylase SIRT6
Cell Rep 2017;7:18(13):3052-3062
PMID: 28355558

#09 (2017/06/01; by DH)

Wu D, Bacaj T, Morishita W, Goswami D, Arendt KL, Xu W, Chen L, Malenka RC,* Sudhof TC*
Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
Nature (in press)
PMID: 28355182

#07 (2017/05/18; by YO)

Zhong L,# Chen XF,# Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer JD, Xu H, Bu G*
Soluble TREM2 induces inflammatory responses and enhances microglial survival
J Exp Med 2017;214(3):597-607
PMID: 28209725

#06 (2017/05/11; by SY)

Calafate S, Flavin W, Verstreken P,* Moechars D*
Loss of Bin1 promotes the propagation of Tau pathology.
Cell Rep 2016;17(4):931-940
PMID: 27760323

#05 (2017/05/11; by AS)

Liu Q, Tang Y, Chen L, Liu N, Lang F, Liu H, Wang P, Sun X*
E3 ligase SCFβTrCP-induced DYRK1A protein degradation is essential for cell cycle progression in HEK293 cells
J Biol Chem 2016;291(51):26399-26409
PMID: 27807027

#04 (2017/04/20; by KN)

Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P*
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein
Biochim Biophys Acta 20171864(1):217-230
PMID: 27818272

#03 (2017/04/20; by DN)

Chen C, Arai I, Satterfield R, Young SM Jr, Jonas P*
Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse
Cell Rep 2017;18(3):723-736
PMID: 28099850

#02 (2017/04/07; by RS)

Junker M, Rapoport TA*
Involvement of VAT-1 in phosphatidylserine transfer from the endoplasmic reticulum to mitochondria
Traffic 2015;16(12):1306-1317
PMID: 26394711

#01 (2017/04/07; by SU)

Kim H,# Lee KS,# Kim AK, Choi M, Choi K, Kang M, Chi SW, Lee MS, Lee JS, Lee SY, Song WJ, Yu K, Cho S*
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition
Dis Model Mech 2016;9(8):839-848
PMID: 27483355


Department of Genome-based Drug Discovery
Graduate School of Biomedical Sciences
Nagasaki University

 1-14 Bunkyo-machi,
 Nagasaki 852-8521, Japan