Here is a list of papers introduced in the seminar of our laboratory.
The lab undergraduate/graduate students choose from Alzheimer's disease-related and recently published papers with high impact.
・Apr. 1, 2017 - Mar. 31, 2018 □
・Apr. 1, 2016 - Mar. 31, 2017 □
・Apr. 1, 2015 - Mar. 31, 2016 □
・Apr. 1, 2013 - Mar. 31, 2014 □
・Apr. 1, 2012 - Mar. 31, 2013 □
*, corresponding author; #, equal contribution
Meng L, Ward AJ, Chun S, Bennett CF, Beaudet AL,* Rigo F*
Towards a therapy for Angelman syndrome by targeting a long non-coding RNA
Nature 2015;518(7539):409-412
PMID: 25470045
Zhang M, Cai F, Zhang S, Zhang S, Song W*
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo
Sci Rep 2014;4:7298
PMID: 25466238
Yang DS,* Stavrides P, Saito M, Kumar A, Rodriguez-Navarro JA, Pawlik M, Huo C, Walkley SU, Saito M, Cuervo AM, Nixon RA*
Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits
Brain 2014;137(Pt 12):3300-3318
PMID: 25270989
Chen Y,# Peng Y,# Che P, Gannon M, Liu Y, Li L, Bu G, van Groen T, Jiao K, Wang Q*
α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction
Proc Natl Acad Sci U S A 2014;111(48):17296-17301
PMID: 25404298
Wetzel-Smith MK,# Hunkapiller J,# Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M; Alzheimer's Disease Genetics Consortium, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C,* Watts RJ,* Graham RR*
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Nat Med 2014;20(12):1452-1457
PMID: 25419706
Šišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, von der Kammer H, Remy S*
Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease
Neuron 2014;84(5):1023-1033
PMID: 25456500
Brickman AM, Khan UA, Provenzano FA, Yeung LK, Suzuki W, Schroeter H, Wall M, Sloan RP, Small SA*
Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
Nat Neurosci 2014;17(12):1798-1803
PMID: 25344629
Zhang X, Wu Y, Duan X, Chen W, Zou H, Zhang M, Zhang S, Cai F, Song W*
Upregulation of SET Expression by BACE1 and its Implications in Down Syndrome
Mol Neurobiol 2015;51(2):781-790
PMID: 24935721
Kinoshita C, Aoyama K, Matsumura N, Kikuchi-Utsumi K, Watabe M, Nakaki T*
Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels
Nat Commun 2014;5:3823
PMID: 24804999
Luo HB,# Xia YY,# Shu XJ,# Liu ZC, Feng Y, Liu XH, Yu G, Yin G, Xiong YS, Zeng K, Jiang J, Ye K, Wang XC, Wang JZ*
SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination
Proc Natl Acad Sci U S A 2014;111(46):16586-16591
PMID: 25378699
Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L,* Sun YE, Yu SP, Levey AI, Ye K*
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
Nat Med 2014;20(11):1254-1262
PMID: 25326800
Kang H, Shin JH*
Repression of rRNA transcription by PARIS contributes to Parkinson's disease
Neurobiol Dis 2014;73C:220-228
PMID: 25315684
Liu CC, Tsai CW, Deak F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G*
Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease
Neuron 2014;84(1):63-77
PMID: 25242217
Choi SH,# Kim YH,# Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE,* Kim DY*
A three-dimensional human neural cell culture model of Alzheimer's disease
Nature 2014;515(7526):274-278
PMID: 25307057
Fernandez MA, Klutkowski JA, Freret T, Wolfe MS*
Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ
J Biol Chem 2014;289(45):31043-31052
PMID: 25239621
Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ*
Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease
PLoS Biol 2014;12(8):e1001923
PMID: 25093460
Seo J, Giusti-Rodriguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH*
Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment
Cell 2014;157(2):486-498
PMID: 24725413
Latimer CS, Brewer LD, Searcy JL, Chen KC, Popovi? J, Kraner SD, Thibault O, Blalock EM, Landfield PW, Porter NM*
Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats
Proc Natl Acad Sci U S A 2014;111(41):E4359-E4366
PMID: 25267625
Hamada K,* Terauchi A, Nakamura K, Higo T, Nukina N, Matsumoto N, Hisatsune C, Nakamura T, Mikoshiba K*
Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors
Proc Natl Acad Sci U S A 2014;111(38):E3966-E3975
PMID: 25201980
Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, Kitazawa M, Matusow B, Nguyen H, West BL, Green KN*
Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain
Neuron 2014;82(2):380-397
PMID: 24742461
Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL, Hengst U*
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions
Cell 2014;158(5):1159-1172
PMID: 25171414
Yuyama K, Sun H, Sakai S, Mitsutake S, Okada M, Tahara H, Furukawa J, Fujitani N, Shinohara Y, Igarashi Y*
Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice
J Biol Chem 2014;289(35):24488-24498
PMID: 25037226
Jo S,# Yarishkin O,# Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee da Y, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D,* Lee CJ*
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
Nat Med 2014;20(8):886-896
PMID: 24973918
Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SH,* Shi Y*
Three-dimensional structure of human γ-secretase
Nature 2014;512(7513):166-170
PMID: 25043039
Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ, Ladner KJ, Bevan AK, Foust KD, Godbout JP, Popovich PG, Guttridge DC, Kaspar BK*
Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis
Neuron 2014;81(5):1009-1023
PMID: 24607225
Yang G, Lai CS, Cichon J, Ma L, Li W, Gan WB*
Sleep promotes branch-specific formation of dendritic spines after learning
Science 2014;344(6188):1173-1178
PMID: 24904169
Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M*
The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor
Nat Commun 2014;5:3917
PMID: 24894631
Jahrling JB, Hernandez CM, Denner L, Dineley KT*
PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement
J Neurosci 2014;34(11):4054-4063
PMID: 24623782
Boehm-Cagan A, Michaelson DM*
Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene
J Neurosci 2014;34(21):7293-7301
PMID: 24849361
Laurent C, Eddarkaoui S, Derisbourg M, Leboucher A, Demeyer D, Carrier S, Schneider M, Hamdane M, Mϋller CE, Buée L, Blum D*
Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology
Neurobiol Aging 2014;35(9):2079-2090
PMID: 24780254
Zhang J, Zhu Y, Zhan G, Fenik P, Panossian L, Wang MM, Reid S, Lai D, Davis JG, Baur JA, Veasey S*
Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons
J Neurosci 2014;34(12):4418-4431
PMID: 24647961
Villeda SA,* Plambeck KE,# Middeldorp J,# Castellano JM,# Mosher KI,# Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T*
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Nat Med 2014;20(6):659-663
PMID: 24793238
Li JG, Chu J, Barrero C, Merali S, Praticò D*
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles
Ann Neurol 2014;75(6):851-863
PMID: 24644038
Morihara T,* Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M
Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier
Proc Natl Acad Sci U S A 2014;111(7):2638-2643
PMID: 24497505
Dinkins MB, Dasgupta S, Wang G, Zhu G, Bieberich E*
Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
Neurobiol Aging 2014;35(8):1792-17800
PMID: 24650793
Brigidi GS, Sun Y, Beccano-Kelly D, Pitman K, Mobasser M, Borgland SL, Milnerwood AJ, Bamji SX*
Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity
Nat Neurosci 2014;17(4):522-532
PMID: 24562000
Wu Z,* Sun L, Hashioka S, Yu S, Schwab C, Okada R, Hayashi Y, McGeer PL, Nakanishi H*
Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia
Neurobiol Aging 2013;34(12):2715-2725
PMID: 23831373
Zhang J, Malik A, Choi HB, Ko RW, Dissing-Olesen L, MacVicar BA*
Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase
Neuron 2014;82(1):195-207
PMID: 24631344
Begum G, Yan HQ, Li L, Singh A, Dixon CE, Sun D*
Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury
J Neurosci 2014;34(10):3743-3755
PMID: 24599472
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA*
REST and stress resistance in ageing and Alzheimer's disease
Nature 2014;507(7493):448-454
PMID: 24670762
Kurabayashi N, Sanada K*
Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells
Genes Dev 2013;27(24):2708-2721
PMID: 24352425
Frost B, Hemberg M, Lewis J, Feany MB*
Tau promotes neurodegeneration through global chromatin relaxation
Nat Neurosci 2014;17(3):357-366
PMID: 24464041
Brawek B, Schwendele B, Riester K, Kohsaka S, Lerdkrai C, Liang Y, Garaschuk O*
Impairment of in vivo calcium signaling in amyloid plaque-associated microglia
Acta Neuropathol 2014;127(4):495-505
PMID: 24407428
Cheng X, He P, Lee T, Yao H, Li R, Shen Y*
High activities of BACE1 in brains with mild cognitive impairment
Am J Pathol 2014;184(1):141-147
PMID: 24332014
Address:
1-14 Bunkyo-machi,
Nagasaki-shi,
Nagasaki 852-8521, Japan
(〒852-8521
長崎県長崎市文教町1-14)
Tel・Fax:
+81-95-819-2437
E-mail:
****@ml.nagasaki-u.ac.jp