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JOURNAL CLUB (Apr. 1, 2015 - Mar. 31, 2016)

Here is a list of papers introduced in the recent seminar of our laboratory.
The lab undergraduate/graduate students choose from Alzheimer's disease-related and recently published papers with high impact.

・Apr. 1, 2017 - Mar. 31, 2018　□
・Apr. 1, 2016 - Mar. 31, 2017　□
・Apr. 1, 2014 - Mar. 31, 2015　□
・Apr. 1, 2013 - Mar. 31, 2014　□
・Apr. 1, 2012 - Mar. 31, 2013　□

*, corresponding author; ^#, equal contribution

#36　(2016/03/18; by EH)

Cantarella G, Di Benedetto G, Puzzo D, Privitera L, Loreto C, Saccone S, Giunta S, Palmeri A, Bernardini R*
Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer's disease
Brain 2015;138(Pt 1):203-216
PMID: 25472798

#35　(2016/03/18; by YK)

Spangenberg EE, Lee RJ, Najafi AR, Rice RA, Elmore MR, Blurton-Jones M, West BL, Green KN*
Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology
Brain 2016;139(Pt 4):1265-1281
PMID: 26921617

#34　(2016/03/10; by KK)

Kay HY, Greene DL, Kang S, Kosenko A, Hoshi N*
M-current preservation contributes to anticonvulsant effects of valproic acid
J Clin Invest 2015;125(10):3904-3914
PMID: 26348896

#33　(2016/03/10; by YH)

Knafo S,* Sanchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordonez-Gutierrez L, Wandosell F, Vina J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C,* Esteban JA*
PTEN recruitment controls synaptic and cognitive function in Alzheimer's models
Nat Neurosci 2016;19(3):443-4537
PMID: 26780512

#32　(2016/02/26; by RM)

Stefanova NA,* Maksimova KY, Kiseleva E, Rudnitskaya EA, Muraleva NA, Kolosova NG
Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology
J Pineal Res 2015;59(2):163-177
PMID: 25988948

#31　(2016/02/26; by DH)

Marguet SL, Le-Schulte VT, Merseburg A, Neu A, Eichler R, Jakovcevski I, Ivanov A, Hanganu-Opatz IL, Bernard C, Morellini F, Isbrandt D*
Treatment during a vulnerable developmental period rescues a genetic epilepsy
Nat Med 2015;21(12):1436-1444
PMID: 26594844

#30　(2016/02/05; by SK)

Klevanski M,^# Herrmann U,^# Weyer SW,^# Fol R, Cartier N, Wolfer DP, Caldwell JH, Korte M, Muller UC*
The APP intracellular domain is required for normal synaptic morphology, synaptic plasticity, and hippocampus-dependent behavior
J Neurosci 2015;35(49):16018-16033
PMID: 26658856

#29　(2016/01/29; by MK)

Bien-Ly N,* Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, Shihadeh V, Ulufatu S, Foreman O, Lu Y, DeVoss J, van der Brug M,* Watts RJ
Lack of widespread BBB disruption in Alzheimer's disease models: focus on therapeutic antibodies
Neuron 2015;88(2):289-297
PMID: 26494278

#28　(2016/01/29; by ST)

Chu J, Wisniewski T, Praticò D*
GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome
Ann Neurol 2016;79(1):138-143
PMID: 26448035

#27　(2016/01/28; by KM)

Suberbielle E,* Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L*
DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice
Nat Commun 2015;6:8897
PMID: 26615780

#26　(2016/01/28; by RY)

Kwon MJ, Shin HY, Cui Y, Kim H, Thi AH, Choi JY, Kim EY, Hwang DH, Kim BG*
CCL2 mediates neuron-macrophage interactions to drive proregenerative macrophage activation following preconditioning injury
J Neurosci 2015;35(48):15934-15947
PMID: 26631474

#25　(2015/12/25; by TM)

Cho J, Yu NK, Choi JH, Sim SE, Kang SJ, Kwak C, Lee SW, Kim JI, Choi DI, Kim VN,* Kaang BK*
Multiple repressive mechanisms in the hippocampus during memory formation
Science 2015;350(6256):82-87
PMID: 26430118

#24　(2015/12/25; by RY)

Bailey CC,* DeVaux LB, Farzan M
The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E
J Biol Chem 2015;290(43):26033-26042
PMID: 26374897

Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G*
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
J Biol Chem 2015;290(43):26043-26050
PMID: 26374899

#23　(2015/12/18; by DH)

Kang JQ,* Shen W, Zhou C, Xu D, Macdonald RL
The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration
Nat Neurosci 2015;18(7):988-996
PMID: 26005849

#22　(2015/12/18; by YH)

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kugler S, Ikezu T*
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Nat Neurosci 2015;18(11):1584-1593
PMID: 26436904

#21　(2015/12/11; by RM)

Willem M,* Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Muller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Muller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C*
η-Secretase processing of APP inhibits neuronal activity in the hippocampus
Nature 2015;526(7573):443-447
PMID: 26322584

#20　(2015/12/11; by ST)

Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S*
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells
Acta Neuropathol Commun 2015;3:66
PMID: 26531305

#19　(2015/11/06; by KM)

Maia LF,* Kaeser SA, Reichwald J, Lambert M, Obermuller U, Schelle J, Odenthal J, Martus P, Staufenbiel M, Jucker M*
Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models
EMBO Mol Med 2015;7(7):895-903
PMID: 25978969

#18　(2015/11/06; by MK)

Jaunmuktane Z, Mead S, Ellis M, Wadsworth JD, Nicoll AJ, Kenny J, Launchbury F, Linehan J, Richard-Loendt A, Walker AS, Rudge P, Collinge J,* Brandner S*
Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy
Nature 2015;525(7568):247-250
PMID: 26354483

#17　(2015/10/23; by MH)

Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E,* Gan L*
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Nat Med 2015;21(10):1154-1162
PMID: 26390242

#16　(2015/10/23; by YK)

Yang Y, Kim J, Kim HY, Ryoo N, Lee S, Kim Y, Rhim H,* Shin YK*
Amyloid-β oligomers may impair SNARE-mediated exocytosis by direct binding to Syntaxin 1a
Cell Rep 2015;12(8):1244-1251
PMID: 26279571

#15　(2015/10/09; by AK)

Moore S, Evans LD, Andersson T, Portelius E, Smith J, Dias TB, Saurat N, McGlade A, Kirwan P, Blennow K, Hardy J, Zetterberg H, Livesey FJ*
APP metabolism regulates tau proteostasis in human cerebral cortex neurons
Cell Rep 2015;11(5):689-696
PMID: 25921538

#14　(2015/10/09; by KK)

Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y*
APP intracellular domain-WAVE1 pathway reduces amyloid-β production
Nat Med 2015;21(9):1054-1059
PMID: 26280122

#13　(2015/07/24; by RM)

Shukla M, Htoo HH, Wintachai P, Hernandez JF, Dubois C, Postina R, Xu H, Checler F, Smith DR, Govitrapong P, Vincent B*
Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17
J Pineal Res 2015;58(2):151-165
PMID: 25491598

#12　(2015/07/24; by RY)

Savage JC, Jay T, Goduni E, Quigley C, Mariani MM, Malm T, Ransohoff RM, Lamb BT, Landreth GE*
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease
J Neurosci 2015;35(16):6532-6543
PMID: 25904803

#11　(2015/07/16; by YH)

Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV*
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
Nat Neurosci 2015;18(7):978-987
PMID: 26005850

#10　(2015/07/16; by KM)

Ayton S, Faux NG, Bush AI,* Alzheimer's Disease Neuroimaging Initiative
Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
Nat Commun 2015;19;6:6760
PMID: 25988319

#09　(2015/06/23; by MH)

Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Frohlich C, Lange C, Bruning T, von Bohlen Und Halbach O, Pahnke J*
Accumulation of murine amyloid-β mimics early Alzheimer's disease
Brain (in press)
PMID: 25991605

#09　(2015/06/23; by MH)

Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Frohlich C, Lange C, Bruning T, von Bohlen Und Halbach O, Pahnke J*
Accumulation of murine amyloid-β mimics early Alzheimer's disease
Brain 2015;138(Pt 8):2370-2382
PMID: 25991605

#08　(2015/06/23; by YK)

Chang X, Rong C, Chen Y, Yang C, Hu Q, Mo Y, Zhang C, Gu X, Zhang L, He W, Cheng S, Hou X, Su R, Liu S, Dun W, Wang Q,* Fang S*
(-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression
Exp Cell Res 2015;334(1):136-145
PMID: 25882496

#07　(2015/06/23; by DH)

Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S,* Sobue G*
FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization
Nat Commun 2015;6:7098
PMID: 25968143

#06　(2015/05/01; by AK)

Wang P, Alvarez-Perez JC, Felsenfeld DP, Liu H, Sivendran S, Bender A, Kumar A, Sanchez R, Scott DK, Garcia-Ocana A, Stewart AF*
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Nat Med 2015;21(4):383-388
PMID: 25751815

#05　(2015/05/01; by KK)

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT*
TREM2 deficiency eliminates TREM2⁺ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
J Exp Med 2015;212(3):287-295
PMID: 25732305

#04　(2015/04/17; by EH)

Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM, Sudhakar S, Zinselmeyer BH, Holtzman DM, Cirrito JR, Colonna M
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
Cell 2015;160(6):1061-1071
PMID: 25728668

#03　(2015/04/17; by SK)

Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K*
Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in Alzheimer's disease mouse models
Nat Commun 2015;6:6514
PMID: 25751136

#02　(2015/04/10; by ST)

Balducci C, Mancini S, Minniti S, La Vitola P, Zotti M, Sancini G, Mauri M, Cagnotto A, Colombo L, Fiordaliso F, Grigoli E, Salmona M, Snellman A, Haaparanta-Solin M, Forloni G, Masserini M,* Re F
Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in Alzheimer's disease mouse models
J Neurosci 2014;34(42):14022-14031
PMID: 25319699

#01　(2015/04/10; by MK)

Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I*
Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice
Neurobiol Aging 2015;36(1):201-210
PMID: 25179227