機能性分子化学研究室

研究業績Publications

原著論文

2023年 2022年 2021年 2020年 2019年 2018年 2017年以前

2023年

Recent Advancements in Genome-Targeting Nucleic Acids and Their Potential for Therapeutic Applications
Yu Mikame, Asako Yamayoshi*
Pharmaceutics, 15(10), 2515 (2023). DOI:10.3390/pharmaceutics15102515

Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA
Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano and Asako Yamayoshi*
ChemMedChem, e202300348. DOI:10.1002/cmdc.202300348

Exosome-hijacking drug delivery system with branched arginine linker effectively deliver antisense oligonucleotides into lung adeno-carcinoma cells.
Shota Oyama, Mao Tomita, Moeka Hata, Yu Mikame, Tsuyoshi Yamamoto, Eishi Ashihara and Asako Yamayoshi*
Chem. Pharm. Bull., 71(11), , (2023); DOI:10.1248/cpb.c23-00430
Selected as a "Front Cover"
Selected as a "Highlighted paper selected by Editor-in-Chief" and "Featured Article"

核酸医薬とゲノム編集技術
三瓶悠山本剛史山吉麻子
CLINICAL NEUROSCIENCE, Vol.41 (23年) 05月号 核酸医薬と神経疾患

Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives
Yuri Sugimoto, Tadaharu Suga, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai and Shigeru Kawakami*
Drug Delivery, 3, 2191891 (2023)

Unique Crosslinking Properties of Psoralen-conjugated Oligonucleotides developed by Novel Psoralen N-Hydroxysuccinimide Esters
Juki Nakao, Yu Mikame, Honoka Eshima, Tsuyoshi Yamamoto, Chikara Dohno, Takehiko Wada and Asako Yamayoshi*
ChemBioChem., e202200789. http://dx.doi.org/10.1002/cbic.202200789
Selected as a "Front Cover" Selected as a "ChemBioTalents 2022/23"

2022年

Microfluidic Post-Insertion Method for the Efficient Preparation of PEGylated Liposomes Using High Functionality and Quality Lipids
Yuri Sugimoto, Tadaharu Suga, Naoya Kato, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai and Shigeru Kawakami*
Int. J. Nanomedicine, 17, 6675-6686, (2022);

Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules
Chisato Terada, Seiya Kawamoto, Asako Yamayoshi and Tsuyoshi Yamamoto*
Pharmaceutics, 14(12), 2647, (2022); https://doi.org/10.3390/pharmaceutics14122647

Synthesis and Evaluation of Oligonucleotide-Containing 2’-O-{[(4,5’,8-trimethylpsoralen)-4’-ylmethoxy]ethylaminocarb-onyl}adenosine as Photo-crosslinkable Gene Targeting Tools
Yu Mikame, Yui Sakai, Ryo Tahara, Kinuka Doi, Tsuyoshi Yamamoto, Chikara Dohno, Takayuki Shibata and Asako Yamayoshi*
Chem. Pharm. Bull., Advance online publication (2022); https://doi.org/10.1248/cpb.c22-00333

Selective Photo-Cross-Linking Detection of Methylated Cytosine in DNA Duplex Aided by a Cationic Comb-Type Copolymer
Atsuhiro Kojima, Juki Nakao, Naohiko Shimada, Naoki Yoshida, Yota Abe, Yu Mikame, Tsuyoshi Yamamoto, Takehiko Wada, Atsushi Maruyama and Asako Yamayoshi*
ACS Biomaterials Science & Engineering, in press; https://doi.org/10.1021/acsbiomaterials.2c00048
Selected as a "Front Cover"

Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts
Emi Soma , Asako Yamayoshi, Yuki Toda, Yuji Mishima, Shigekuni Hosogi and Eishi Ashihara*
Cancers, 4(3), 566, (2022); https://doi.org/10.3390/cancers14030566

Therapeutic application of sequence-specific binding molecules for novel genome editing tools
Juki Nakao, Tsuyoshi Yamamoto and Asako Yamayoshi*
Drug Metabolism and Pharmacokinetics, 47, 42, 100427 (2022).

2021年

第3章 生体反応を利用したDDS
3節 エクソソームの特性に基づく DDS 技術の開発と展望

大山将大, 相馬瑛美, 芦原英司, 山吉麻子*
医薬品におけるDDS技術開発と製剤への応用, (株式会社 情報機構) (2021)

ゲノム編集技術と核酸医薬
中尾樹希, 山本剛史, 山吉麻子*
実験医学増刊, Vol.39 No.17「核酸医薬 本領を発揮する創薬モダリティ」(横田隆徳 監修)(2021)

Drug Discovery and Development Scheme for Liver-targeting Bridged Nucleic Acid Antisense Oligonucleotides
Fumito Wada, Tsuyoshi Yamamoto, Tadayuki Kobayashi, Keisuke Tachibana, Kosuke Ramon Ito, Mayumi Hamasaki, Yukina Kayaba, Chisato Terada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba*
Molecular Therapy - Nucleic Acids, 26, 957-969, (2021)

Recent Advances in the Delivery Carriers and Chemical Conjugation Strategies for Nucleic Acid Drugs
Shota Oyama, Tsuyoshi Yamamoto and Asako Yamayoshi*
Cancers, 13(15), 3881; https://www.mdpi.com/2072-6694/13/15/3881 (2021)

Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides
Chisato Terada, Fumito Wada, Mei Uchida, Yukari Yasutomi, Kaho Oh, Seiya Kawamoto, Yukina Kayaba, Asako Yamayoshi, Satoshi Obika, Mariko Harada–Shiba and Tsuyoshi Yamamoto*
Nucleic Acid Therapeutics, 31(6), 404-416; https://doi.org/10.1089/nat.2021.0036 (2021)

Development of 7SK snRNA mimics that inhibit HIV transcription
Asako Yamayoshi*, Hiroyuki Fukumoto, Rie Hayashi, Kyosuke Kishimoto, Akio Kobori, Yoshio Koyanagi, Jun A. Komano and Akira Murakami
ChemMedChem, 16, 1-5; https://doi.org/10.1002/cmdc.202100422 (2021)

Highly Potent GalNAc-conjugated tiny LNA anti-miRNA-122 antisense oligonucleotides
Tsuyoshi Yamamoto*, Yahiro Mukai, Fumito Wada, Chisato Terada, Asako Yamayoshi, Satoshi Obika and Mariko Harada–Shiba
Pharmaceutics, 13(6), 817; https://doi.org/10.3390/pharmaceutics13060817 (2021)

A facile method for the quantification of urinary uracil concentration by a uracil-specific fluorescence derivatization reaction
Takayuki Shibata*, Ryosuke Shimamura, Yuji Yamamoto, Hiroki Sakurai, Junya Fujita, Asako Yamayoshi, Toshimitsu Nemoto and Tsutomu Kabashima
Chem. Pharm. Bull., 69(8), 768-772; https://doi.org/10.1248/cpb.c21-00221 (2021)

エクソソーム表面抗原に着目した新たな創薬モダリティの探索
大山将大, 山吉麻子*
Drug Delivery System, 36, 108-116; https://https://doi.org/10.2745/dds.36.108 (2021)

2020年

miRNA (microRNA)
山本剛史, 山吉麻子*
核酸化学ハンドブック, 講談社サイエンティフィック(日本核酸化学会・監 杉本直己・編)(2020)

Development of Antibody-Oligonucleotide Complexes for targeting Exosomal microRNA
Asako Yamayoshi*, Shota Oyama, Yusuke Kishimoto, Ryo Konishi, Tsuyoshi Yamamoto, Akio Kobori, Hiroshi Harada, Eishi Ashihara, Hiroshi Sugiyama and Akira Murakami
Pharmaceutics, 12(6), 545; https://doi.org/10.3390/pharmaceutics12060545 (2020)

エクソソーム随伴導入型薬物送達システムの開発
山吉麻子*
YAKUGAKU ZASSHI, 140, 625-631 (2020)

2019年

Selective cross-linking behavior of oligodeoxyribonucleotides containing 2’-O-[N-(4,5’,8-trimethylpsoralen-4'-ylmethylcarbamoyl)]adenosine to mutant H-ras DNA Nucleosides
Asako Yamayoshi*, Maiko Higuchi, Yui Sakai, Akio Kobori, Tsuyoshi Yamamoto, Takayuki Shibata and Akira Murakami
Nucleotides & Nucleic Acids, Oct 24:1-12. doi: 10.1080/15257770.2019.1677912. [Epub ahead of print] (2019)

Effect of Modular Conjugation Strategy for N-Acetylgalactosamine-targeted Antisense Oligonucleotides Nucleosides
Tsuyoshi Yamamoto*, Chisato Terada, Koki Kashiwada, Fumito Wada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba
Nucleotides & Nucleic Acids, Oct 16:1-10. doi: 10.1080/15257770.2019.1677911. [Epub ahead of print] (2019)

Synthesis of Monovalent N-Acetylgalactosamine Phosphoramidite for Liver-Targeting Oligonucleotides
Tsuyoshi Yamamoto*, Chisato Terada, Koki Kashiwada, Asako Yamayoshi, Mariko Harada-Shiba and Satoshi Obika
Current Protocols in Nucleic Acid Chemistry, 78(1): e99. doi: 10.1002/cpnc.99. (2019)

Hydrazide Derivatives of Luminol for Chemiluminescence-labelling of Macromolecules
Takayuki Shibata, Hiroki Yoshimura, Asako Yamayoshi, Nobuaki Tsuda and Shpend Dragusha
Bulletins of the Pharmaceutical Society of Japan, 67, 772-774 (2019)

核酸医薬の各作用機序と概要 miRNA標的
山吉麻子*
医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略(株式会社情報機構) (2019)

新しい創薬モダリティ:核酸医薬
山吉麻子*
人工臓器, 48, 3, 195-198 (2019)

仕事と私事 〜お母さんとお父さんの狭間で〜
山吉麻子*
高分子学会誌, 11, 612 (2019)

2018年

Photochromic DNA having fluorescent protein-inspired nucleosides
Akio Kobori, Taichiro Arai, Yuya Sakata, Takayuki Sugita, Asako Yamayoshi and Akira Murakami
Tetrahedron Letters, 59, 3690-3693 (2018)

Peptide Ribonucleic Acid (PRNA)Arginine Hybrids. Effects of Arginine Residues Alternatingly Introduced to PRNA Backbone on Aggregation, Cellular Uptake, and Cytotoxicity
Sugai H., Nakase I., Sakamoto S., Nishio A., Inagaki M., Nishijima M., Yamayoshi A., Araki Y., Ishibashi S., Yokota T., Inoue Y. and Wada T.
Chem. Lett., 47, doi:10.1246/cl.171186 (2018)

siRNA、miRNA-mimic、anti-miR核酸の設計指針
山吉麻子*
中分子医薬開発に資するペプチド・核酸・糖鎖の合成・高機能化技術(シーエムシー出版), pp. 189-198 (2018)

エクソソームに随伴し標的細胞へ侵入する抗体結合型核酸ドラッグ
山吉麻子*
Drug Delivery System, 32-2 (2018)

細胞外微粒子を追跡する遺伝子制御分子 ~非コードRNA を操って生命現象を操る~
山吉麻子*
生命科学研究レター, 57, 4-9 (2018)

長崎の中心で核酸化学を叫ぶ
山吉麻子*
日本核酸化学会誌, 2, 31-34 (2018)

2017年以前

Effective anti-miRNA oligonucleotides show high releasing rate of microRNA from RNA-induced silencing complex (RISC)
Jumpei Ariyoshi, Yohei Matsuyama, Akio Kobori, Akira Murakami, Hiroshi Sugiyama and Asako Yamayoshi*
Nucleic Acid Therapeutics, 27(5), 303-308 (2017)

Inhibition effect of photoresponsive α-haloaldehyde-conjugated oligonucleotides on the gene expression in HeLa cells stably expressing GFP
Yuta Sugihara, Yuki Nakata, Asako Yamayoshi, Akira Murakami and Akio Kobori
Chemistry Letters, 46(8), 1265-1268 (2017)

Selective and robust stabilization of triplex DNA structures using cationic comb-type copolymers
Asako Yamayoshi*, Daisuke Miyoshi*, Yu-ki Zouzumi, Yohei Matsuyama, Jumpei Ariyoshi, Naohiko Shimada, Akira Murakami, Takehiko Wada and Atsushi Maruyama*
Journal of Physical Chemistry, 121(16), 4015-4022 (2017)

Characterization of the releasing profile of microRNA from RISC using anti-miRNA oligonucleotides
Jumpei Ariyoshi, Nao Eimori, Akio Kobori, Akira Murakami, Hiroshi Sugiyama and Asako Yamayoshi*
Chemistry Letters, 46(1), 143-145 (2017)

Cross-linking antisense oligodeoxyribonucleotides with a photoresponsive α-chloroaldehyde moiety for RNA point mutations
Yuta Sugihara, Yuki Nakata, Asako Yamayoshi, Akira Murakami and Akio Kobori*
Journal of Organic Chemistry, 81(3), 981-986 (2016)

Development of novel antisense oligonucleotides for the functional regulation of RNA-induced silencing complex (RISC) by promoting the release of microRNA from RISC
Jumpei Ariyoshi, Daiki Momokawa, Nao Eimori, Akio Kobori, Akira Murakami and Asako Yamayoshi*
Bioconjugate Chemistry, 26(12), 2454-2460 (2015)
selected as "ACS Editors' Choice"

Novel photodynamic effect of psoralen-conjugated oligonucleotides for discrimination of methylation of cytosine in DNA
Asako Yamayoshi*, Yohei Matsuyama, Mikihiko Kushida, Akio Kobori and Akira Murakami
Photochemistry and Photobiology, 90(3), 716-722 (2014)

Functional regulation of RNA-induced silencing complex by photoreactive oligonucleotides
Yohei Matsuyama, Asako Yamayoshi*, Akio Kobori and Akira Murakami
Bioorganic and Medicl Chemistry, 22(3), 1003-1007 (2014)

Rate-adjusted cross-linking reaction by photoresponsive α-bromoaldehyde (PBA)-conjugated ODN
Akio Kobori*, Yuko Nagae, Yuta Sugihara, Asako Yamayoshi and Akira Murakami
Bioorganic and Medicinal Chemistry Letters, 23(21), 5825-5828 (2013)

Dual-fluorescent RNA probes with extremely large Stokes shifts
Akio Kobori*, Takako Ueda, Yuya Sanada, Asako Yamayoshi and Akira Murakami
Bioscience, Biotechnology, and Biochemistry, 77(5), 1117-1119 (2013)

Structural insights for design of inhibitors against RISC function
Asako Yamayoshi*, Yukiko Yamada, Akio Kobori and Akira Murakami
Chemistry Letters, 41(12), 1684-1685 (2012)

RNA-based diagnosis in a multicellular specimen by whole mount in situ hybridization using an RNA-specific probe
Takako Ueda, Akio Kobori, Asako Yamayoshi, Hideki Yoshida, Masamitsu Yamaguchi and Akira Murakami*
Bioorganic and Medicinal Chemistry, 20(20), 6034-6039 (2012)

Synthesis and cross-linking activity of 4-N-(4,5’,8-trimethylpsoralen-4-ylmethyl)- 2’-deoxycytidine-containing oligodeoxyribonucleotides
Akio Kobori*, Khoji Tomita, Yuko Nagae, Asako Yamayoshi and Akira Murakami
Chemistry Letters, 41(8), 804-805 (2012)

Novel photoresponsive cross-linking oligodeoxyribonucleotides having a caged alpha-chloroaldehyde
Akio Kobori*, Takemune Yamauchi, Yuko Nagae, Asako Yamayoshi and Akira Murakami
Bioorganic and Medicinal Chemistry, 20(17), 5071-5076 (2012)

Preparation of Cationic Comb-Type Copolymer Having Tetra-Alkylammonium Groups and its Interaction with DNA
Rui Moriyama, Junji Mochida, Asako Yamayoshi, Naohiko Shimada, Arihiro Kano and Atsushi Maruyama
Current Nanoscience, 7(6), 979-983 (2011)

Real-time Imaging of RNA Expression in Living Cells Using Bispyrene-modified RNA Probes
Reiko Waki, Asako Yamayoshi, Akio Kobori and Akira Murakami*
Chemistry Letters, 40(11), 1247-1248 (2011)

Decoy-DNA against SATB1 inhibits the growth and invasive ability of human breast cancer
Asako Yamayoshi, Mariko Yasuhara, Sanjeev Galande, Akio Kobori and Akira Murakami
Oligonucleotides, 21(2), 115-121 (2011)

Development of a system to sensitively and specifically visualize c-fos mRNA in living cells using bispyrene-modified RNA probes
Reiko Waki, Asako Yamayoshi, Akio Kobori and Akira Murakami*
Chemical Communications, 47(14), 4204-4206 (2011)

Specific regulation of point-mutated K-ras-immortalized cell proliferation by a photo-dynamic antisense strategy
Maiko Higuchi, Asako Yamayoshi (First), Akio Kobori and Akira Murakami*
Oligonucleotides, 20(1), 37-44 (2010)

Real-time monitoring of mRNAs with fluorescence-modified RNA probes in living cells
Reiko Waki, Takako Ueda, Asako Yamayoshi, Akio Kobori and Akira Murakami
Nucleic Acids Symposium Series, 53(1), 153-154 (2009)

Development of peptide-oligonucleotide conjugates for regulation of small RNA function
Asako Yamayoshi*, Daiki Momokawa, Akio Kobori and Akira Murakami
Nucleic Acids Symposium Series, 53(1), 53-54 (2009)

Sequence selective formation of 1,N6-ethenoadenine in DNA by furan-conjugated probe
Akio Kobori*, Jumpei Morita, Masato Ikeda, Asako Yamayoshi and Akira Murakami
Bioorganic Medicinal Chemistry Letters, 19(13), 3657-3660 (2009)

Synthesis and photo-induced cross-linking reactions of 4,5',8-trimethyl-psoralen- incorporated oligodeoxyribonucleotide
Akio Kobori*, Kazutaka Takaya, Maiko Higuchi, Asako Yamayoshi and Akira Murakami
Chemistry Letters, 38(3), 272-273 (2009)

Synthesis of antisense oligonucleotides containing 2'-O-psoralenylmethoxyalkyl adenosine for photodynamic regulation of point mutations in RNA
Maiko Higuchi, Akio Kobori, Asako Yamayoshi and Akira Murakami*
Bioorganic Medicinal Chemistry, 17(2), 475-483 (2009)

Photodynamic antisense regulation of mRNA having a point mutation with psoralen-conjugated oligonucleotide
Maiko Higuchi, Asako Yamayoshi, Akio Kobori and Akira Murakami
Nucleic Acids Symposium Series, 52(1), 515-516 (2008)

Sequence-selective fluorophore formation by furan-conjugated oligodeoxyribonucleotides
Akio kobori, Jumpei Morita, Masato Ikeda, Asako Yamayoshi and Akira Murakami
Nucleic Acids Symposium Series, 52(1), 235-236 (2008)

Synthesis of naphthyridine-conjugated DNA probes and their application to SNPs typing
Akio kobori, Takashi Mori, Asako Yamayoshi and Akira Murakami
Nucleic Acids Symposium Series, 51(1), 309-310 (2007)

Selective regulation of mutant K-ras mRNA expression by photo-cross-linking antisense oligonucleotide
Maiko Higuchi, Asako Yamayoshi, Akio Kobori and Akira Murakami
Nucleic Acids Symposium Series, 51(1), 443-444 (2007)

Gene regulation by decoy approach (II): Development of photo-cross-linked oligonucleotides duplex as a decoy DNA for estrogen receptor
Asako Yamayoshi, Noriko Shimazu, Maiko Higuchi, Akio Kobori and Akira Murakami*
Nucleic Acids Symposium Series, 51(1), 91-92 (2007)

Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life
Ayumi Sato, Somg Wong Choi, Miwa Hirai, Asako Yamayoshi, Rui Moriyama, Takeshi Yamano, Motoki Takagi, Arihiro Kano, Akira Shimamoto and Atsushi Maruyama*
Journal of Controlled Release, 122(3), 209-216 (2007)

Characterization of side population cells (SP cells) in human normal endometrial cells, Human Reproduction
Kiyoko Kato*, Momoko Yoshimoto, Keiji Kato, Sawako Adachi, Asako Yamayoshi, Takahiro Arima, Kazuo Asanoma, Satoru Kyo, Tatsutoshi Nakahata and Norio Wake
Huma Reproduction, 22(5), 1214-1223 (2007)

An inhibitory effect on cell proliferation by blockage of the MAPK/estrogen receptor/MDM2 signal pathway in gynecologic cancer
Shin Suga, Kiyoko Kato*, Tatsuhiro Ohgami, Asako Yamayoshi, Sawako Adachi, Kazuo Asanoma, Shinichiro Yamaguchi, Takahiro Arima, Katsuyuki Kinoshita and Norio Wake
Gynecol Oncology, 105(2), 341-350 (2007)

Selective photo-cross-linking of 2'-O-psoralen-conjugated oligonucleotide with RNAs having point mutations
Maiko Higuchi, Asako Yamayoshi, Takasei Yamaguchi, Reiko Iwase, Tetsuji Yamaoka, Akio Kobori and Akira Murakami*
Nucleoside, Nucleotides & Nucleic Acids, 26(8-9), 3277-3290 (2007)

Effect of cationic comb-type copolymer on quadruplex folding of human telomeric DNA
Naoki Makita, Sung Wong Choi, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike and Atsushi Maruyama*
Nucleoside, Nucleotides & Nucleic Acids, 26(8-9), 1115-1119 (2007)

DNA nanomachine switching improved by cationic comb-type copolymer
Sung Wong Choi, Naoki Makita, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike and Atsushi Maruyama*
Macromolecular Symposia, 249, 317-321 (2007)

Cationic comb-type copolymers having high density of PEG graft chains for gene carriers
Sung Wong Choi, Asako Yamayoshi(First), Miwa Hirai, Takeshi Yamano, Motoki Takagi, Ayumi Sato, Arihiro Kano, Akira Shimamoto and Atsushi Maruyama*
Macromolecular Symposia, 249, 312-316 (2007)

Cationic comb-type copolymers for boosting DNA-fueled nanomachines
Sung Wong Choi, Naoki Makita, Satoru Inoue, Charle Lesoil, Asako Yamayoshi, Arihiro Kano, Toshihiro Akaike and Atsushi Maruyama*
Nano Letters, 7(1), 172-178 (2007)

Specific apoptosis induction in human papillomavirus-positive cervical carcinoma cells by photodynamic antisense regulation
Asako Yamayoshi, Kiyoko Kato*, Shin Shuga, Akimasa Ichinoe, Takahiro Arima, Takao Matsuda, Hidenori Kato, Akira Murakami and Norio Wake
Oligonucleotides, 17(1), 66-79 (2007)

Structural effect of cationic copolymers on nucleic acid-chaperoning activity
Kaoru Takada, Sung Wong Choi, Arihiro Kano, Asako Yamayoshi and Atsushi Maruyama
Nucleic Acids Symposium Series, 50(1), 27-28 (2006)

Single-base mismatch recognition using partially double-stranded probes having various lengths
Daisuke Ishii, Kentaro Muraki, Arihiro Kano, Asako Yamayoshi and Atsushi Maruyama
Nucleic Acids Symposium Series, 50(1), 325-326 (2006)

Hyaluronan conjugation of antigenic protein to modify immunogenic information
Shinichi Mochizuki, Arihiro Kano, Asako Yamayoshi and Atsushi Maruyama*
Science and Technology of Advanced Materials, 7(7), 685-691 (2006)

Synthesis and properties of photo-reactive antisense oligonucleotides containing 2'-O-psoralen-conjugated adenosine
Maiko Higuchi, Asako Yamayoshi, Akio Kobori, Tetsuji Yamaoka and Akira Murakami
Nucleic Acids Symposium Series, 49(1), 331-332 (2005)

Modulation of highly ordered structures of human telomeric sequence by cationic copolymers
Naoki Makita, Arihiro Kano, Asako Yamayoshi, Toshihide Akaike and Atsushi Maruyama
Nucleic Acids Symposium Series, 49(1), 53-54 (2005)

Discrimination of single nucleotide polymorphisms by strand exchange assay using partially double-stranded probes
Kazuya Hirata, Daisuke Ishii, Arihiro Kano, Asako Yamayoshi, Toshihide Akaike and Atsushi Maruyama
Nucleic Acids Symposium Series, 49(1), 223-224 (2005)

The molecular structure effect of cationic comb-type copolymers on nucleic acid chaperone activity
Sung Wong Choi, Kaoru Takada, Junichi Mochida, Asako Yamayoshi, Arihiro Kano, Toshihide Akaike and Atsushi Maruyama
Nucleic Acids Symposium Series, 49(1), 329-330 (2005)

Micro chamber for cellar analysis integrated with negligible dead volume sample injector
Masaki Kanai, Hirohisa Abe, Tatsuya Munaka, Yoichi Fujiyama, Daisuke Uchida, Asako Yamayoshi, Hiroaki Nakanishi, Akira Murakami and Shuichi Shoji*
Sensors and Actuators A, 114(2-3), 129-134 (2004)

Psoralen- conjugated oligonucleotide with hairpin structure as a novel photo-sensitive antisense molecule
Asako Yamayoshi, Reiko Iwase, Tetsuju Yamaoka and Akira Murakami*
Chemical Communications, 1(12), 1370-1371 (2003)

Photodynamic antisense therapy: regulation of cervical carcinoma cells by psoralen-conjugated oligonucleotides
Asako Yamayoshi, Kiyoko Kato, Reiko I wase, Tetsuji Yamaoka, Norio Wake and Akira Murakami
Nucleic Acids Symposium Series, 46(3), 75-76 (2003)

Photodynamic Antisense Regulation of Human Cervical Carcinoma Cell Growth using Psoralen-conjugated Oligo(nucleoside phosphorothioate)
Akira Murakami*, Asako Yamayoshi, Reiko Iwase, Jun-ichi Nishida, Tetsuju Yamaoka and Norio Wake
European Journal of Pharmaceutical Science, 13(1), 25-34 (2001)

Photodynamic Antisense Regulation Growth using Psoralen-conjugated Oligo-(nucleoside phosphorothioate)s (I) Growth Regulation of Cervical Carcinoma Cells
Reiko Iwase, Asako Yamayoshi, Jun-ichi Nishida, Tetsuji Yamaoka, Norio Wake and Akira Murakami*
Nucleic Acids Symposium Series, 42(1), 223-224 (1999)

* corresponding author