Activity
Publication (論文)
- Besse S., Sakaguchi T., Gauthier L., Sahaf Z., Ravindran R., Gonzalez L., Castellanos-Girouard X., Clairmeont C., Koçatug N., Péloquin O., Matta C., Hussin J.G., Michnick S.W., and Serohijos A.W.R.
Genetic landscape of an in vivo protein interactome.
Nat. Genet., in press. - Honda T., Kondo Y., Sakaguchi T., Higashimoto Y., Yano H., and Koga H.
Claudin-2 extracellular loop 1-mimetic peptides functionally inhibit combined hepatocellular-cholangiocarcinoma cells.
Sci. Rep., 2026, early access.
https://doi.org/10.1038/s41598-026-59784-1 - Honda T., Sakaguchi T., and Kuramasu A.
Cystamine is a redox-dependent inverse agonist of the histamine H4 receptor.
Am. J. Physiol.-Cell Physiol., 2026, 330(2), C390-C395.
https://doi.org/10.1152/ajpcell.00891.2025 - Takatani-Nakase T., Ikushima C., Sakitani M., and Nakase I.
Regulatory mechanisms for triple-negative breast cancer through cystine transporters and new therapeutic strategies.
Medical Science Digest, 2026. - Sakaguchi T., Irifune Y., Kamada R., and Sakaguchi K.
Bacterial Systematic Genetics and Integrated Multi-Omics: Beyond Static Genomics Toward Predictive Models.
Int. J. Mol. Sci., 2025, 26(19), 9326.
https://doi.org/10.3390/ijms26199326 - Matsui T., Sakaguchi T., Higashimoto Y., Nishino Y., Sotokawauchi A., Koga Y., and Yamagishi S.I.
Sulforaphane inhibits cardiac fibrosis induced by advanced glycation end product-receptor axis through its anti-oxidative property.
Acta Diabetol, 2025, 62(9), 1569-1572.
https://doi.org/10.1007/s00592-025-02545-9 - Kamada R., Sakaguchi S., Kanno M., Ozawa T., Nakagawa N., Omichinski J.G., and Sakaguchi K.
Dominant-Negative Effects of p53 R337 Variants in Li-Fraumeni Syndrome: Impact on Tetramer Formation and Transcriptional Activity.
ChemBioChem, 2025.
https://doi.org/10.1002/cbic.202500330 - Takatani-Nakase T., Ikushima C., Sakitani M., and Nakase I.
Regulatory mechanisms for triple-negative breast cancer through transporters and development of new treatment strategies.
Bio Clinica, 2025. - Takatani-Nakase T., Ikushima C., Sakitani M., and Nakase I.
Regulatory mechanisms for triple-negative breast cancer through transporters and development of new therapeutic strategies.
The Cell (Monthly Cell), 2025. - Takatani-Nakase T., Matsui C., Sakitani M., Nakao K., and Nakase I.
Roles of Zinc and Zinc Transporters in Breast Cancer.
Molecular Structures, Cellular Processes and Living Systems, Royal Society of Chemistry, 2025.
https://doi.org/10.1039/9781837676583-00245 - Peng Y., Huang Q., Liu D., Kong S., Kamada R., Ozato K., Zhang Y., and Zhu J.
A single-cell genomic strategy for alternative transcript start sites identification.
Biotechnol. J., 2024, 19, 2300516.
https://doi.org/10.1002/biot.202300516 - Takatani-Nakase T., Ikushima C., Sakitani M., and Nakase I.
Regulatory mechanisms for triple-negative breast cancer through transporters and new therapeutic strategies.
The Cell (Monthly Cell), 2024. - Takatani-Nakase T., Ikushima C., Sakitani M., and Nakase I.
Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer.
Life Sciences, 2024.
https://doi.org/10.1016/j.lfs.2023.122411 - Sakaguchi T., Nakagawa N., Mine K., Janairo J.I.B., Kamada R., Omichinski J.G., and Sakaguchi K.
Biomineralization through a Symmetry-Controlled Oligomeric Peptide.
Biomimetics, 2023, 8, 606.
https://doi.org/10.3390/biomimetics8080606 - Sakaguchi S., Nakagawa N., Wahba H.M., Wada J., Kamada R., Omichinski J.G., and Sakaguchi K.
Highly Similar Tetramerization Domains from the p53 Protein of Different Mammalian Species Possess Varying Biophysical, Functional and Structural Properties.
Int. J. Mol. Sci., 2023, 24, 16620.
https://doi.org/10.3390/ijms242316620 - Kamada R., Miyazaki H., Janairo J.I.B., Chuman Y., and Sakaguchi K.
Bilayer Hydrogel composed of elastin-mimetic polypeptides as a bio-actuator with bidirectional and reversible bending behaviors.
Molecules, 2023, 28, 5274.
https://doi.org/10.3390/molecules28135274 - Tsuruoka T., Nakayama E., Endo T., Harashima S., Kamada R., Sakaguchi K., and Imagawa T.
Development of a fluorescence reporter system to quantify transcriptional activity of endogenous p53 in living cells.
J. Cell Sci., 2023, 136, jcs260918.
https://journals.biologists.com/jcs/article/doi/10.1242/jcs.260918/310593 - Tani I., Oikawa Y., Doi S., Janairo J.I.B., Kamada R., and Sakaguchi K.
Ribosomal protein uL30 undergoes phase separation with nucleophosmin and regulates nucleolar formation in the absence of RNA.
Biochem. Biophys. Res. Commun., 2023, 642, 35-40. - Kamada R., Uno S., Kimura N., Yoshimura F., Tanino K., and Sakaguchi K.
Lipid Droplet Formation Is Regulated by Ser/Thr Phosphatase PPM1D via Dephosphorylation of Perilipin 1.
Int. J. Mol. Sci., 2022, 23(19), 12046. - Kamada R., Sakaguchi S., Kura S., Takamatsu K., Yamamoto T., Imagawa T., and Sakaguchi K.
Stereoselective Interaction of Helix-Hairpin-Helix Motif Peptides with DNA Structure.
Chem. Lett., 2022, 51(10), 1029-1032.
https://doi.org/10.1246/cl.220340 - Takatani-Nakase T., Sakitani M., and Matsui C.
Regulation of breast cancer cell behaviors by zinc and zinc transporters.
The Cell (Monthly Cell), 2022. - Sakitani M. and Takatani-Nakase T.
Zinc and zinc transporter ZIP6 regulate the anticancer efficacy of targeted drug therapy.
Journal of Zinc Nutritional Therapy, 2022. - Takatani-Nakase T. and Sakitani M.
Mechanisms for breast cancer malignant progression via zinc and zinc transporters.
Agricultural Biotechnology, 2022. - Takatani-Nakase T., Matsui C., Sakitani M., and Nakase I.
ZIP6-centered zinc regulatory and malignant characteristics of breast cancer cells.
Metallomics Research, 2022.
https://doi.org/10.11299/metallomicsresearch.MR202113 - Tani I., Ito S., Shirahata Y., Matsuyama Y., Omichinski J.G., Shimohigashi Y., Kamada R., and Sakaguchi K.
Role of active site arginine residues in substrate recognition by PPM1A.
Biochem. Biophys. Res. Commun., 2021, 581, 1-5. - Kamada R., Kudoh F., Ito S., Tani I., Janairo J.I.B., Omichinski J.G., and Sakaguchi K.
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.
Pharmacol. Ther., 2020, 215, 107622. - Lussier-Price M., Mascle X.H., Cappadocia L., Kamada R., Sakaguchi K., Wahba H.M., and Omichinski J.G.
Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins.
Structure, 2020, 28(5), 573-585. - Nakagawa N., Sakaguchi S., Nomura T., Kamada R., Omichinski J.G., and Sakaguchi K.
The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein.
Biochem. Biophys. Res. Commun., 2020, 521(3), 681-686. - Higashimoto Y., Tanaka K., Matsui T., Sakaguchi T., Yamagishi S.I., and Motomiya Y.
Fibroblast Growth Factor 23 Contributes to Regulation of Hepcidin/Ferroportin Axis.
Austin. J. Pharmacol. Ther., 2020, 8(1), 1118.
2019年以前の業績については、Researchmapをご参照ください： 鎌田 瑠泉 / 坂口 達也
Presentation (学会発表)
口頭発表- 第29回 ペプチドフォーラム（2026.3.7／北海道大学理学部, 北海道札幌市）
「PPM1D-Mediated Secreted CEACAM3 Drives Immune Regulation in Cancer and Inflammatory Disorders」
⚪︎Rui Kamada - 第29回 ペプチドフォーラム（2026.3.7／北海道大学理学部, 北海道札幌市）
「piQTL: An Approach to Individual Variation Focusing on Protein-Protein Interactions」
⚪︎Tatsuya Sakaguchi - 第29回 ペプチドフォーラム（2026.3.7／北海道大学理学部, 北海道札幌市）
「PPM1Dを標的とした膠芽腫治療に向けたプロドラッグ型PPM1D阻害剤の開発」
⚪︎Yuta Irifune, Sari Ogasawara, Keiji Tanino, Rui Kamada, Kazuyasu Sakaguchi - The 6th Taiwan-Japan Bilateral Symposium on Protein Phosphatases（2026.1.10／National Cheng Kung University, Tainan, Taiwan）
「Regulation of neutrophil differentiation and inflammatory responses by the Ser/Thr phosphatase PPM1D via CEACAM3 splicing」
⚪︎Rui Kamada - 第42回 日本薬学会九州山口支部大会（2025.11.15／長崎大学薬学部, 長崎県長崎市）
「発がん性Ser/ThrホスファターゼPPM1D特異的阻害剤におけるシリル基の役割とプロドラッグ化戦略」
⚪︎入船 佑太, 小笠原 紗里, 坂口 和靖, 鎌田 瑠泉
- The 6th Taiwan-Japan Bilateral Symposium on Protein Phosphatases（2026.1.10／National Cheng Kung University, Tainan, Taiwan）
「Ser/Thr Phosphatase PPM1D regulates glioblastoma growth via dephosphorylation of oncogenic Golgi protein GOLPH3」
⚪︎Yuta Irifune, Rui Kamada, Kazuyasu Sakaguchi
[Honorable Mention Award] - 第12回 日本プロテインホスファターゼ研究会 学術集会（2025.10.11／かめ福オンプレイス, 山口県山口市）
「Ser/ThrホスファターゼPPM1Dによる破骨細胞形成・骨吸収活性の制御機構解明」
⚪︎鎌田 瑠泉, 本下 壮太郎, 辻 葵衣, 入船 佑太, 黒須 大樹, 牛尾 小百合, 坂口 和靖 - 第12回 日本プロテインホスファターゼ研究会 学術集会（2025.10.11／かめ福オンプレイス, 山口県山口市）
「膠芽腫におけるSer/ThrホスファターゼPPM1Dの新規基質GOLPH3の同定」
⚪︎入船 佑太, 鎌田 瑠泉, 坂口 和靖