Profile: Koyo Nishida

Profile Information

Affiliation: Nagasaki University Graduate School of Biomedical Sciences
Position: Professor, Dean of School of Pharmaceutical Sciences, Nagasaki University
Degree: Ph.D. (Kyoto University)
Tel/Fax: +81-95-819-8566

Research Interests

drug delivery systems, peritoneal targeting, gene delivery, tissue clearing method, pharmacokinetics, drug absorption, controlled release

Recent Representative Publications (2018-2022)

  1. Flavonoids Enhance Lipofection Efficiency and Ameliorate Cytotoxicity in Colon26 and HepG2 Cells via Oxidative Stress Regulation, Die Hu, Shintaro Fumoto, Hirotaka Miyamoto, Masakazu Tanaka, Koyo Nishida, Pharmaceutics 2022, 14(6), 1203;
  2. In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs, S Fumoto, T Yamamoto, K Okami, Yuina Maemura, C Terada, A Yamayoshi, K Nishida, Pharmaceutics. 2021 Jan 26;13(2):159. doi: 10.3390/pharmaceutics13020159.
  3. Editorials: Recent Advances in Lipid-Based Drug Delivery., Nishida K. Pharmaceutics. 2021 Jun 22;13(7):926. doi: 10.3390/pharmaceutics13070926. PMID: 34206548
  4. Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system, Mariko Taniguchi, Hirotaka Miyamoto, Ayako Tokunaga, Shintaro Fumoto, Takashi Tanaka, Koyo Nishida, Xenobiotica 2020 Jun;50(6):654-662 DOI:10.1080/00498254.2019.1683258 PMID: 31631733
  5. Influence of liver intoxication by carbon tetrachloride or D-galactosamine on absorption of fluorescein isothiocyanate-dextran-10 and other marker compounds with different molecular weights from the rat liver surface, Hirotaka Miyamoto, Kayoko Tsuda, Tomonori Honda, Ayako Tokunaga, Shintaro Fumoto, Koyo Nishida, Biol Pharm Bull, 43(2):319-324 (2020) doi: 10.1248/bpb.b19-00686 PMID: 32009118
  6. Yoshikawa N, Fumoto S, Yoshikawa K, Hu D, Okami K, Kato R, Nakashima M, Miyamoto H, Nishida K. Pharmaceutics. 2020 Apr 10;12(4). pii: E341. doi: 10.3390/pharmaceutics12040341. Interaction of Lipoplex with Albumin Enhances Gene Expression in Hepatitis Mice. PMID: 32290201
  7. Foreword: Recent Progress in Drug Delivery System for Cancer Therapy, Nishida K. Chem Pharm Bull (Tokyo). 2020;68(7):559. doi: 10.1248/cpb.c20-ctf6807. PMID: 32611992
  8. Co-delivery Systems of Multiple Drugs Using Nanotechnology for Future Cancer Therapy. Fumoto S, Nishida K. Chem Pharm Bull (Tokyo). 2020;68(7):603-612. doi: 10.1248/cpb.c20-00008. PMID: 32611997
  9. Effect of Chronic Kidney Disease on Hepatic Clearance of Drugs in Rats. Tokunaga A, Miyamoto H, Fumoto S, Nishida K. Biol Pharm Bull. 2020;43(9):1324-1330. doi: 10.1248/bpb.b20-00124. PMID: 32879206
  10. A pH-adjustable tissue clearing solution that preserves lipid ultrastructures: Suitable tissue clearing method for DDS evaluation, S Fumoto, E Kinoshita, K Ohta, K Nakamura, T Hirayama, H Nagasawa, D Hu, K Okami, R Kato, S Shimokawa, N Ohira, K Nishimura, H Miyamoto, T Tanaka, S Kawakami, K Nishida, Pharmaceutics. 2020 Nov 9;12(11):E1070. doi: 10.3390/pharmaceutics12111070.
  11. Peng JQ, Fumoto S, Suga T, Miyamoto H, Kuroda N, Kawakami S, Nishida K. Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles. J Control Release. 2019 May 28;302:42-53. doi: 10.1016/j.jconrel.2019.03.021. Epub 2019 Mar 26. PubMed PMID: 30926479
  12. Tokunaga A, Miyamoto H, Fumoto S, Nishida K. Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats. J Pharm Pharmacol. 2019 Dec;71(12):1792-1799. doi:10.1111/jphp.13167. PubMed PMID: 31579949
  13. Kinoshita E, Fumoto S, Hori Y, Yoshikawa N, Miyamoto H, Sasaki H, Nakamura J, Tanaka T, Nishida K. Monitoring method for transgene expression in target tissue by blood sampling. Biotechnol Rep (Amst). 2019 Nov 15;24:e00401. doi:10.1016/j.btre.2019.e00401. eCollection 2019 Dec. PubMed PMID: 31788440
  14. Wang S, Fumoto S, Miyamoto H, Tanaka M, Nishida K, Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice, Int J Pharm. 548(1): 173-181, 2018 (IF: 3.862) doi:10.1016/j.ijpharm.2018.06.068. PMID:29969708
  15. Koyo Nishida, Shintaro Fumoto: Organ surface application method-new DDS for digestive diseases, Drug Delivery System, 33(5): 270-276 (2018)