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研究内容

    医薬品の開発は、21世紀において生命科学研究の進歩に伴った技術革新が起こっています。従来の低分子やペプチド、タンパク質医薬開発は成熟化し、現在では、抗体医薬が全盛期を迎えています。現在、核酸医薬、遺伝子医薬、細胞医薬、微粒子医薬、微生物医薬などの多様化・複雑化したモダリティが医薬品として開発されています。

    複雑な次世代モダリティ（薬物）を薬剤から医薬品へと開発を進めるためには、医薬品の3要素である有効性・安全性・品質の諸問題を解析し、その問題点を論理的・総合的に克服・制御化するための技術に関する「情報」の創出する新たな学問体系の構築が必要です。一方、上市された医薬品については、適正使用のための「情報」の創出が必要です。

    このような現状を踏まえ、医薬品情報学分野では、多様化・複雑化した次世代モダリティの問題点を収集・評価・解析し、薬物、薬剤を経て「医薬品」として開発していく上での様々な問題を克服・制御化する新規技術を創りこむ「創薬研究」や医薬品の適正使用における問題を収集・評価・解析する「育薬研究」に取り組んでいます。

    　
  • 超音波照射を利用した外部刺激応答性DDSの開発
  • マイクロ流体デバイスを用いた高機能・高品質脂質ナノ粒子の製造体系の構築
  • 抗体修飾核酸封入脂質ナノ粒子（LNP）を用いた有効かつ安全なmRNAワクチン開発
  • 脳腫瘍治療に向けた脳指向型抗体修飾核酸封入脂質ナノ粒子（LNP）の開発
  • 組織内環境の多色深部イメージングによる空間分布制御型DDSの開発
  • 標的指向型細胞外小胞（エクソソーム）医薬の開発
  • 免疫細胞の新規制御技術の開発と革新的がん免疫療法への展開
  • 難治性がん治療用デザイナー細菌医薬の開発に関する研究
  • 新規PETプローブの開発と新規体内動態解析法の開発
  • 人工冬眠マウスモデルを用いた新規がん治療標的の探索

2023年, 2022年, 2021年, 2020年, 2019年
2018年, 2017年, 2016年, 2015年以前

2023年

論文・特許等

    　　
  1. Sayuri Nakamae, Satoshi Miyagawa, Koki Ogawa, Mariko Kamiya, Mayumi Taniguchi, Akari Ono, Maho Kawaguchi, Awet Alem Teklemichael, Jiun-Yu Jian, Tamasa Araki, Yukimi Katagami, Hidefumi Mukai, Takeshi Annoura, Katsuyuki Yui, Kenji Hirayama, Shigeru Kawakami, and Shusaku Mizukami: Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles, Frontiers in Immunology, 14, 1116299 (2023)
    2. 　　
  2. Longjian Geng, Naoya Kato, Yukinobu Kodama, Hidefumi Mukai, and Shigeru Kawakami*: Influence of lipid composition of messenger RNA-loaded lipid nanoparticles on the protein expression via intratracheal administration in mice, International Journal of Pharmaceutics, 637, 122896 (2023)
  3. Yuri Sugimoto, Tadaharu Suga, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai, and Shigeru Kawakami*: Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives, Drug Delivery, 30(1), 2191891 (2023)
  4. Masayori Hagimori*, Naoya Kato, Akira Orimoto, Tadaharu Suga, and Shigeru Kawakami: Development of triple-negative breast cancer-targeted liposomes with MUC16 binding peptide ligand in triple-negative breast cancer cells, Journal of Pharmaceutical Sciences, 112(6), 1740-1745 (2023)
  5. Maho Kawaguchi, Marin Noda, Akari Ono, Mariko Kamiya, Makoto Matsumoto, Masako Tsurumaru, Shusaku Mizukami, Hidefumi Mukai, and Shigeru Kawakami*: Effect of cholesterol content of lipid composition in mRNA-LNPs on the protein expression in the injected site and liver after local administration in mice, Journal of Pharmaceutical Sciences, 112 (5), 1401-1410 (2023)
  6. Naoya Kato, Sakura Yamada, Rino Suzuki, Yoshiki Iida, Makoto Matsumoto, Shintaro Fumoto, Hidetoshi Arima, Hidefumi Mukai, and Shigeru Kawakami*: Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes, Drug Delivery, 30(1), 217333 (2023)
  7. Jun Miyata, Hirotomo Yamanashi, Shin-Ya Kawashiri, Sakiko Soutome, Kazuhiko Arima, Mami Tamai, Fumiaki Nonaka, Yukiko Honda, Masayasu Kitamura, Koji Yoshida, Yuji Shimizu, Naomi Hayashida, Shigeru Kawakami, Noboru Takamura, Takashi Sawase, Atsutoshi Yoshimura, Yasuhiro Nagata, Mayumi Ohnishi, Kiyoshi Aoyagi, Atsushi Kawakami, Toshiyuki Saito, and Takahiro Maeda: Profile of Nagasaki Islands Study (NaIS): A Population-Based Prospective Cohort Study on Multi-disease, Journal of Epidemiology, 14, 1116299 (2023)
  8. Sachiko Horie, Yasuhiro Suzuki, Tsuyoshi Yamamoto, Satoshi Obika, Kohta Mohri, Chizuru Kiyota, Qin Ren, Shota Warashina, Yasuhiro Wada, Yasuyoshi Watanabe, Hidefumi Mukai, and Yasufumi Sato: Novel strategy of liver cancer treatment with modified antisense oligonucleotides targeting human vasohibin-2, Cancer Sci, 114(9):3740-3749 (2023)
  9. Shota Warashina, Hiroki Sato, Maki Zouda, Maiko Takahashi, Yasuhiro Wada, Toby Passioura, Hiroaki Suga, Yasuyoshi Watanabe, Kunio Matsumoto, and Hidefumi Mukai*: Two-Chain Mature Hepatocyte Growth Factor-Specific Positron Emission Tomography Imaging in Tumors Using 64Cu-Labeled HiP-8, a Nonstandard Macrocyclic Peptide Probe, Mol Pharm, 20(4):2029-2038 (2023)
  10. Kohta Mohri, Kim Phuong Huynh Nhat, Maki Zouda, Shota Warashina, Yasuhiro Wada, Yasuyoshi Watanabe, Shunsuke Tagami, and Hidefumi Mukai*: Lasso peptide microcin J25 variant containing RGD motif as a PET probe for integrin avb 3 in tumor imaging, Eur J Pharm Sci, 180:106339 (2023)
    11. 　　
  11. Maiko Takahashi, Erike Widyasari Sukowati, Shoko Nomura, Akari Kato, Kenji Mizuseki, Yasuyoshi Watanabe, and Hidefumi Mukai*: Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours, J Drug Target, 31(2):194-205 (2023)
    12. 　　
  12. 神谷万里子, 田中義正, 川上 茂：脂質ナノ粒子（LNP）製剤の設計理論、「PHARMSTAGE」 特集１ 脂質ベースのナノ DDS（リポソーム・脂質ナノ粒子）の設計時の考え方，調製方法)、情報技術協会（2023）

受賞等

  1. パーティクルデザイン賞/新製剤技術とエンジニアリング振興基金（川上 茂）
    「ナノ粒子を用いた核酸医薬の標的指向化技術の開発に関する研究」
  2. 令和5年度長崎大学Highインパクト論文賞/長崎大学（川上 茂）、
    受賞対象論文、”Journal of Controlled Release, 348, 34-41 (2022)”
  3. 令和5年度長崎大学インパクト論文賞/長崎大学（向井英史）、
    受賞対象論文、”International Journal of Pharmaceutics, 624:121968 (2022)”
  4. 令和5年度長崎大学インパクト論文賞/長崎大学（神谷万里子）、
    受賞対象論文、”Pharmaceutics, 14(11), 2357 (2022)”
  5. 第39回日本DDS学会学術集会 優秀発表賞（海野水綺）
  6. 育薬研究教育センター 第7回若手シンポジウム 優秀発表賞（海野水綺）
  7. 育薬研究教育センター 第7回若手シンポジウム 優秀発表賞（松本 眞）
  8. 第40回日本薬学会九州山口支部大会 優秀発表賞（松本 眞）
  9. 令和５年度下村脩博士記念成績優秀者賞（大野海晴）

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2022年

論文・特許等

  1. Shota Warashina, Maki Zouda, Kohta Mohri, Yasuhiro Wada, Kazuya Maeda, Yasuyoshi Watanabe, Hidefumi Mukai: 64Cu-labeling of small extracellular vesicle surfaces via a cross-bridged macrocyclic chelator for pharmacokinetic study by positron emission tomography imaging, International Journal of Pharmaceutics, 624:121968 (2022) *令和５年度長崎大学インパクト論文
  2. Yuri Sugimoto, Tadaharu Suga, Naoya Kato, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai, and Shigeru Kawakami*: Microfluidic post-insertion method for the efficient preparation of PEGylated liposomes using high functionality and quality lipids, International Journal of Nanomedicine, 17, 6675-6686 (2022)
  3. Mariko Kamiya, Makoto Matsumoto, Kazuma Yamashita, Tatsunori Izumi, Maho Kawaguchi, Shusaku Mizukami, Masako Tsurumaru, Hidefumi Mukai, and Shigeru Kawakami*: Stability study of mRNA-lipid nanoparticles exposed to various conditions based on the evaluation between physicochemical properties and their relation with protein expression ability, Pharmaceutics, 14(11), 2357 (2022) *令和５年度長崎大学インパクト論文
  4. Takayuki Fukuda, Hikaru Iwata, Naoya Kishikawa, Mahmoud H. El-Maghrabey, Kaname Ohyama, Shigeru Kawakami, Mitsuhiro Wada, and Naotaka Kuroda: Selective fluorescence labeling of myristicin using Mizoroki-Heck coupling reaction. Application to nutmeg powder, oil, and human plasma samples, Journal of Chromatography A, 463465 (2022)
  5. Naoya Kato, Takumi Sato, Yuki Fuchigami, Tadaharu Suga, Geng Longjian, Masako Tsurumaru, Masayori Hagimori, Hidefumi Mukai, and Shigeru Kawakami*: Synthesis and evaluation of a novel adapter lipid derivative for preparation of cyclic peptide-modified PEGylated liposomes: application of cyclic RGD peptide, European Journal of Pharmaceutical Sciences, 176, 106239-106239 (2022)
  6. Maiko Takahashi, Erike Widyasari Sukowati, Shoko Nomura, Akari Kato, Kenji Mizuseki, Yasuyoshi Watanabe, and Hidefumi Mukai*: Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours, Journal of Drug Targeting, 31(2), 194-205 (2022)
  7. Yusuke Okamoto, Naoya Kishikawa, Masayori Hagimori, Mahmoud El-Maghrabey, Shigeru Kawakami, and Naotaka Kuroda: A turn-on hydrazide oxidative decomposition-based fluorescence probe for highly selective detection of Cu2+ in tap water as well as cell imaging, Analytica Chimica Acta, 1217: 340024-340024 (2022)
  8. Koki Ogawa, Naoya Kato, Michiharu Yoshida, Takeshi Hiu, Takayuki Matsuo, Shusaku Mizukami, Daiki Omata, Ryo Suzuki, Kazuo Maruyama, Hidefumi Mukai, and Shigeru Kawakami*: Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain, Journal of Controlled Release, 348, 34-41 (2022) *令和５年度長崎大学Highインパクト論文
  9. Susumu Yamaguchi, Michiharu Yoshida, Nobutaka Horie, Katsuya Satoh, Yuutaka Fukuda, Shunsuke Ishizaka, Koki Ogawa, Yoichi Morofuji, Takeshi Hiu, Tsuyoshi Izumo, Shigeru Kawakami, Noriyuki Nishida, Takayuki Matsuo: Stem cell therapy for acute/subacute ischemic atroke with a focus on intraarterial stem cell transplantation: from basic research to clinical trials, Bioengineering, 10(1) 33-33 (2022)
  10. Hidefumi Mukai, Koki Ogawa, Naoya Kato, and Shigeru Kawakami*: Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics, Drug Metabolism and Pharmacokinetics, 44, 100450-100450 (2022)
  11. 川口真帆、加藤直也、神谷万里子、向井英史、川上 茂：腎臓に対するmRNAデリバリーの現状と今後の展望、Drug Delivery System, 37 (3), 102-111 (2022)
  12. PCT/JP2022/043546質性化合物、リポソーム、エクソソーム、脂質ナノ粒子及びドラッグデリバリーシステム、発明人：川上 茂, 向井英史, 杉本友里, 海野水綺, 神谷万里子, 出願人：長崎大学

受賞等

  1. 令和４年度長崎大学インパクト論文賞/長崎大学（川上 茂）
    受賞対象論文、Pharmaceutics, 1810, 13(11), 1810 (2021)
  2. 長崎大学薬学部令和４年度下村脩博士記念薬学部研究教育賞/長崎大学薬学部（向井英史）「PETに基づくニューモダリティの薬物動態研究とプレシジョン画像診断薬の開発」
  3. 日本薬剤学会第37年会最優秀発表賞（加藤直也）
  4. 日本薬剤学会第３回超分子薬剤学FGシンポジウム優秀発表賞（加藤直也）
  5. 第15回九州薬科学教育連合主催合宿研修　優秀者賞（山下和真）
  6. 長崎大学薬学部育薬研究教育センター第6回若手シンポジウム優秀発表賞（増田智成）
  7. 日本バイオマテリアル学会2022年度九州ブロック研究発表会優秀ポスター賞　　　（山田咲良）
  8. 長崎大学学長賞（研究）（加藤直也）

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2021年

論文・特許等

  1. Farid R El-Gamal, Mohamed A Akl, Hammam A Mowafy, Hidefumi Mukai, Shigeru Kawakami, and Mohsen I Afouna: Synthesis and evaluation of high functionality and quality cell-penetrating peptide conjugated lipid for octaarginine modified PEGylated liposomes in U251 and U87 glioma cells, Journal of Pharmaceutical Sciences, 111(6) 1719-1727 (2021)
  2. Natsuko Oyama, Maho Kawaguchi, Keiji Itaka, and Shigeru Kawakami*: Efficient messenger RNA delivery to the kidney using renal pelvis injection in mice, Pharmaceutics, 1810, 13(11), 1810 (2021) *令和4年度長崎大学インパクト論文
  3. Yukinobu Kodama, Ayako Tokunaga, Junya Hashizume, Hiroo Nakagawa, Hitomi Harasawa, Tomoaki Kurosaki, Tadahiro Nakamura, Koyo Nishida, Mikiro Nakashima, Mitsuru Hashida, Shigeru Kawakami, and Hitoshi Sasaki: Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice, Drug Delivery, 28(1), 542-549 (2021)
  4. Koyo Nishimura, Koki Ogawa, Maho Kawaguchi, Shintaro Fumoto, Hidefumi Mukai, and Shigeru Kawakami*: Suppression of peritoneal fibrosis by sonoporation of hepatocyte growth factor gene-encoding plasmid DNA in mice, Pharmaceutics, 13(1), 115 (2021)
  5. Masayori Hagimori, Yasushi Karimine, Naoko Mizuyama, Fumiko Hara, Takeshi Fujino, Hideo Saji, and Takahiro Mukai: Selective cadmium fluorescence probe based on bis-heterocyclic molecule and its imaging in cells, Journal of Fluorescence, 31(4) , 1161-1167 (2021)
  6. 山田咲良, 加藤直也, 川上 茂: 多色深部観察法を利用した超音波応答型の脳標的指向化DDS開発、神経超音波医学, 34(3) 135-137 (2021)
  7. 藁科翔太、佐藤拓輝、造田真希、酒井克也、Toby Passioura、和田 康弘、菅 裕明、松本邦夫、渡辺恭良、向井英史：プレシジョンがん診断を指向した活性型 HGF 分子イメージング用環状ペプチド PET プローブの開発、JSMI Report, 14(1), 26-30 (2021)
  8. 神谷万里子、川上 茂：mRNAワクチンの基幹技術：核酸デリバリーと脂質ナノ粒子、科学 91(12) 1118-1122 (2021)
  9. 西村光洋、小川昂輝、川口真帆、麓伸太郎、向井英史、川上 茂：マウスにおける肝細胞増殖因子遺伝子をコードする プラスミドDNA のソノポレーションによる 腹膜線維症の抑制、日本透析医会雑誌 36(2) 324-329 (2021)
  10. 山田咲良、加藤直也、川上 茂：多色深部観察法を利用した超音波応答型の脳標的指向化DDS開発、神経超音波医学, 34(3) 135-137 (2021)
  11. 加藤直也、増田智成、向井英史、川上 茂：創薬研究者・アカデミア研究者が知っておくべき最新の免疫学とその応用技術 (担当:分担執筆, 範囲:第6章第9節 がん深部を標的としたDDS技術の開発) (2021)
  12. 特願2021-190933：脂質性化合物、リポソーム、エクソソーム、脂質ナノ粒子及びドラッグデリバリーシステム、発明人：川上 茂, 向井英史, 杉本友里, 海野水綺, 神谷万里子, 出願人：長崎大学
    13. 　

受賞等

  1. 日本薬剤学会第36年会最優秀発表賞（小川昂輝）
  2. 日本薬剤学会第36年会「薬と健康の週間」懸賞論文第3席（山田咲良）
  3. 日本薬剤学会第36年会永井財団大学院学生スカラシップ（加藤直也）
  4. 長崎大学薬学部育薬研究教育センター第5回若手シンポジウム優秀発表賞　　　　（小野亜佳莉）
  5. 長崎大学薬学部育薬研究教育センター第5回若手シンポジウム優秀発表賞　　　　（神谷万里子）
  6. 日本薬剤学会第2回超分子薬剤学FGシンポジウム優秀発表賞（神谷万里子）
  7. Postdoctoral Presentation Award 2021（小川昂輝）

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2020年

論文・特許等

  1. Shintaro Fumoto, Eriko Kinoshita, Keisuke Ohta, Kei-ichiro Nakamura, Tasuku Hirayama, Hideko Nagasawa, Die Hu, Kazuya Okami, Riku Kato, Shojiro Shimokawa, Naho Ohira, Koyo Nishimura, Hirotaka Miyamoto, Takashi Tanaka, Shigeru Kawakami, Koyo Nishida: A pH-adjustable tissue clearing solution that preserves lipid ultrastructures: Suitable tissue clearing method for DDS evaluation, Pharmaceutics, 1070 (2020)
  2. Yukinobu Kodama, Mikiro Nakashima, Tadayuki Nagahara, Natsuko Oyama, Junya Hashizume, Hiroo Nakagawa, Hitomi Harasawa, Takahiro Muro, Tomoaki Kurosaki, Chikamasa Yamashita, Mitsuru Hashida, Takashi Kitahara, Hitoshi Sasaki, Shigeru Kawakami, and Tadahiro Nakamura: Development of a DNA vaccine for melanoma metastasis by inhalation based on an analysis of transgene expression characteristics of naked pDNA and ternary complex in mouse lung tissues, Pharmaceutics, 12, e540 (2020)
  3. Hiroshi Kida, Koyo Nishimura, Koki Ogawa, Akiko Watanabe, Loreto B Feril, Yutaka Irie, Hitomi Endo, Shigeru Kawakami, and Katsuro Tachibana: Nanobubble mediated gene delivery in conjunction with a hand-held ultrasound scanner, Frontiers in Pharmacology,11, e363 (2020)
  4. Natsuko Oyama, Haruyuki Takahashi, Maho Kawaguchi, Hirotaka Miyamoto, Koyo Nishida, Masako Tsurumaru, Mikiro Nakashima, Fumiyoshi Yamashita, Mitsuru Hashida, and Shigeru Kawakami*: Effects of tissue pressure on transgene expression characteristics via renal local administration routes from ureter or renal artery in the rat kidney, Pharmaceutics, 12(2) e114 (2020)
  5. Yota Taniguchi, Natsuko Oyama, Shintaro Fumoto, Hideyuki Kinoshita, Fumiyoshi Yamashita, Kazunori Shimizu, Mitsuru Hashida, and Shigeru Kawakami*: Tissue suction-mediated gene transfer to the beating heart in mice, PLoS ONE, 15(2) e0228203 (2020)
  6. Koki Ogawa, Naoya Kato, and Shigeru Kawakami*: Recent strategies for targeted brain drug delivery, Chemical and Pharmaceutical Bulletin, 68(7), 562-582 (2020)
  7. 川上 茂、菅 忠明：多色深部イメージングを利用した空間分布制御型ナノDDS の開発、薬学雑誌, 140(5), 633-640 (2020)
  8. 特許7033795：生体由来材料の透明化試薬、発明人：麓伸太郎、川上 茂、西田孝洋、出願人：長崎大学、登録日：2022年3月3日

受賞等

  1. 長崎大学薬学部育薬研究教育センター第4回若手シンポジウム優秀発表賞（小川昂輝）
  2. 日本薬剤学会第35年会日本薬剤学会永井財団学部学生七つ星薬師奨励賞（山田咲良）
  3. 第35回日本薬物動態学会年会優秀口頭発表賞（野田健太）
  4. 長崎大学学長賞（研究）（小川昂輝）
  5. 長崎大学学長賞（学業）（山田咲良）
  6. 下村脩博士記念成績優秀者賞（山田咲良）

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2019年

論文・特許等

  1. Koyo Nishimura, Keita Yonezawa, Shintaro Fumoto, Yusuke Miura, Masayori Hagimori, Koyo Nishida, and Shigeru Kawakami*: Application of direct sonoporation from a defined surface area of the peritoneum: evaluation of transfection characteristics in mice, Pharmaceutics, 11(5), e244 (2019)
  2. Masayori Hagimori, Mana Taniura, Naoko Mizuyama, Yasushi Karimine, Shigeru Kawakami, Hideo Saji, and Takahiro Mukai: Synthesis of a novel pyrazine-pyridone biheteroaryl-based fluorescence sensor and detection of endogenous labile zinc ions in lung cancer cells, Sensors, 19(9), 2049 (2019)
  3. Jian Qing Peng, Shintaro Fumoto, Tadaharu Suga, Hirotaka Miyamoto, Naotaka Kuroda, Shigeru Kawakami, and Koyo Nishida: Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles, Journal of Controlled Release, 302, 42-53 (2019)
  4. Koki Ogawa, Yuki Fuchigami, Masayori Hagimori, Shintaro Fumoto, Kazuo Maruyama, and Shigeru Kawakami*: Ultrasound-responsive nanobubble-mediated gene transfection in the cerebroventricular region by intracerebroventricular administration in mice, European Journal of Pharmaceutics and Biopharmaceutics, 137, 1-8 (2019)
  5. Kaname Ohyama, Yuka Ikeshita, Yuki Fuchigami, Shigeru Kawakami, Mihoko N. Nakashima, and Mikiro Nakashima: Proteomic analysis and ATP assay reveal a positive effect of artificial cerebral spinal fluid perfusion following microdialysis sampling on repair of probe-induced brain damage, Journal of Neuroscience Methods, 315, 1-5 (2019)
  6. Tadaharu Suga, Masanori Watanabe, Yuri Sugimoto, Tomonari Masuda, Naotaka Kuroda, Masayori Hagimori, and Shigeru Kawakami*: Synthesis of a high functionality and quality lipid with gp130 binding hydrophobic peptide for the preparation of human glioma cell-targeted PEGylated liposomes, Journal of Drug Delivery Science and Technology, 49, 668-673 (2019)
  7. Yusuke Miura, Yuki Fuchigami, Sakiko Nomura, Koyo Nishimura, Masayori Hagimori, and Shigeru Kawakami*: Brain microdialysis study of vancomycin in the cerebrospinal fluid after intracerebroventricular administration in mice, AAPS PharmSciTech, 20, 5 (2019)
  8. 清水一憲、川上 茂：組織吸引デバイスによる生体組織変形をトリガーとする臓器への遺伝子導入技術、化学工業、83(7) 402-404 (2019)
  9. 特願2019-099112：経肺投与用薬物送達体、発明人：佐々木 均、兒玉 幸修、川上 茂
  10. 特願2019-098677：肺指向性薬物送達体、発明人：佐々木 均、兒玉 幸修、川上 茂

受賞等

  1. 日本バイオマテリアル学会 九州ブロック第9回講演会学生優秀ポスター賞（加藤直也）
  2. 日本薬剤学会第34回年会永井財団大学院学生スカラシップ（川口真帆）
  3. 長崎大学学長賞（研究）（大山奈津子）
  4. 長崎大学学長賞（研究）（西村光洋）

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2018年

論文・特許等

  1. Tadaharu Suga, Naoya Kato, Masayori Hagimori, Yuki Fuchigami, Naotaka Kuroda, Yukinobu Kodama, Hitoshi Sasaki, and Shigeru Kawakami*: Development of high functionality and quality lipids with RGD peptide ligands: application for PEGylated liposomes and analysis of intratumoral distribution in a murine colon cancer model, Molecular Pharmaceutics, 15 (10), 4481-4490 (2018)
  2. Chie Munakata, Yuki Fuchigami, Shu Hiroishi, Ayana Haraguchi, Masayori Hagimori, Hatsune Enomoto, Hidehisa Tachiki, Yukinobu Kodama, Hitoshi Sasaki, and Shigeru Kawakami*: Evaluation of miR-122 to predict high dose acetaminophen-induced liver injury in mice: the combination uses of 5-fluorouracil, Biological & Pharmaceutical Bulletin, 41(11), 1732-1735 (2018)
  3. Wei Wang, Tadaharu Suga, Masayori Hagimori, Naotaka Kuroda, Yuki Fuchigami, and Shigeru Kawakami*: Investigation of intracellular delivery of NuBCP-9 by conjugation with oligoarginines peptides in MDA-MB-231 cells, Biological and Pharmaceutical Bulletin, 41(9),1448-1455 (2018)
  4. Masayori Hagimori, Yorinao Chinda, Tadaharu Suga, Kazuo Yamanami, Naoya Kato, Tatsuo Inamine, Yuki Fuchigami, and Shigeru Kawakami*: Synthesis of high functionality and quality mannose-grafted lipids to produce macrophage-targeted liposomes, European Journal of Pharmaceutical Sciences, 123, 153-161 (2018)
  5. Ayana Haraguchi, Yuki Fuchigami, Maho Kawaguchi, Shintaro Fumoto, Kaname Ohyama, Kazunori Shimizu, Masayori Hagimori, and Shigeru Kawakami*: Determining transgene expression characteristics using a suction device with multiple hole adjusting a left lateral lobe of the mouse liver, Biological and Pharmaceutical Bulletin, 41 (6), 944-950 (2018)
  6. Chie Munakata, Yuki Fuchigami, Takayuki Makizoe, Yusuke Miura, Mariko Yamaoka, Satomi Sasahara, Katsutomo Hata, Hidehisa Tachiki, Hitoshi Sasaki, Masayori Hagimori, and Shigeru Kawakami*: Effect of pH and additives on the compatibility between vancomycin and furosemide injections, Yakugaku Zasshi, 138 (6), 853-860 (2018)
  7. Koki Ogawa, Yuki Fuchigami, Masayori Hagimori, Shintaro Fumoto, Yusuke Miura, and Shigeru Kawakami*: Efficient gene transfection of the brain with ultrasound irradiation in mice using stabilized bubble lipopolyplexes prepared by the surface charge regulation method, International Journal of Nanomedicine, 13, 2309-2320 (2018)
  8. Yusuke Miura, Yuki Fuchigami, Masayori Hagimori, Hiroki Sato, Koki Ogawa, Chie Munakata, Mitsuhiro Wada, Kazuo Maruyama, and Shigeru Kawakami*: Evaluation of the targeted delivery of 5-fluorouracil and ascorbic acid into the brain with ultrasound-responsive nanobubbles, Journal of Drug Targeting, 26 (8), 684-691 (2018)
  9. Yukinobu Kodama, Hiroki Hanamura, Takahiro Muro, Hiroo Nakagawa, Tomoaki Kurosaki, Tadahiro Nakamura, Takashi Kitahara, Shigeru Kawakami, Mikiro Nakashima, and Hitoshi Sasaki: Gene delivery system of pDNA using the blood glycoprotein fetuin, Journal of Drug Targeting, 26 (7), 604-609 (2018)
  10. 萩森政頼、川上 茂、向 高弘：生体内遊離亜鉛イオンを可視化する蛍光プロープの開発(共著)、ファルマシア、54(7), 688-692 (2018)
  11. 川上 茂： 分布、生物薬剤学（薬学テキストシリーズ）、朝倉書店、第4章、p.40-56 (2018)

受賞等

  1. 平成29年度笹川科学研究奨励賞（大山奈津子）
  2. 日本薬剤学会第33回年会永井財団大学院学生スカラシップ（菅 忠明）
  3. 第34回日本DDS学会学術集会優秀発表賞（加藤直也）
  4. 第12回九州薬科学研究教育連合合宿研修 優秀賞（杉本友里）
  5. 第1回超分子薬剤学FGシンポジウムポスター賞（菅 忠明）
  6. 第1回超分子薬剤学FGシンポジウム学生発表賞（三浦雄介）
  7. 長崎大学薬学部育薬研究教育センター第2回若手シンポジウム優秀発表賞（植木郁花）
  8. 長崎大学薬学部育薬研究教育センター第2回若手シンポジウム優秀発表賞（原口綾奈）
  9. 第40回日本バイオマテリアル学会大会優秀研究ポスター賞（菅 忠明）
  10. APSTJ Global Education Seminar Presentation Award 2018（菅 忠明）
  11. 平成30年度薬科学科分野横断型卒業研究ポスター発表会優秀ポスター賞（野田健太）
  12. 長崎大学学長賞（研究）（大山奈津子）
  13. 長崎大学学長賞（学業）（加藤直也）

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2017年

論文・特許等

  1. Natsuko Oyama, Yuki Fuchigami, Shintaro Fumoto, Megumu Sato, Masayori Hagimori, Kazunori Shimizu, and Shigeru Kawakami*: Characterization of transgene expression and pDNA distribution of the suctioned kidney in mice, Drug Delivery, 24 (1), 906-917 (2017)
  2. Koyo Nishimura, Shintaro Fumoto, Yuki Fuchigami, Masayori Hagimori, Kazuo Maruyama, Shigeru Kawakami*: Effective intraperitoneal gene transfection system using nanobubbles and ultrasound irradiation, Drug Delivery, 24 (1), 737-744 (2017)
  3. Chanikarn Chantarasrivong, Akiharu Ueki, Ryutaro Ohyama, Johan Unga, Shinya Nakamura, Isao Nakanishi, Yuriko Higuchi, Shigeru Kawakami, Hiromune Ando, Akihiro Imamura, Hideharu Ishida, Fumiyoshi Yamashita, Makoto Kiso, and Mitsuru Hashida: Synthesis and functional characterization of novel sialyl LewisX mimic-decorated liposomes for E-selectin-mediated targeting to inflamed endothelial cells, Molecular Pharmaceutics, 14(5), 1528-1537 (2017)
  4. Tadaharu Suga, Yuki Fuchigami, Masayori Hagimori, and Shigeru Kawakami*: Ligand peptide grafted PEGylated liposomes using HER2 targeted peptide-lipid derivatives for targeted delivery in breast cancer cells: the effect of serine-glycine repeated peptides as a spacer, International Journal of Pharmaceutics, 521 (1-2), 361-364 (2017)
  5. Rodi Abdalkader, Shigeru Kawakami*, Johan Unga, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita, and Mitsuru Hashida: The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection, Drug Delivery, 24 (1), 320-327 (2017)
  6. Mitsuhiro Wada, Akiko Yamaguchi, Akihiro Ogawa, Hirotsugu Kido, Shinichi Nakamura, Makoto Takada, Shigeru Kawakami, Naotaka Kuroda, and Kenichiro Nakashima: Luminol Chemiluminescence profile of O/W emulsions during thermal oxidation, Analytical Sciences, 33, 249-252 (2017)
  7. Tomonori Matsumoto, Ken Takahashi, Tadashi Inuzuka, Soo Ki Kim, Tomoaki Kurosaki, Shigeru Kawakami, Tsutomu Chiba, Hiroshi Seno, and Hiroyuki Marusawa: Activation of TNF-α-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B, Antiviral Research, 139, 138-145 (2017)
  8. Masayori Hagimori, Yuki Fuchigami, and Shigeru Kawakami*: Peptide-based cancer targeting DDS and molecular imaging, Chemical and Pharmaceutical Bulletin, 65 (7): 618-24 (2017)
  9. 萩森政頼、水山奈央子、小川昂輝、川上 茂、向 高弘、佐治英郎：亜鉛検出用蛍光プローブの開発とその応用、亜鉛栄養治療、8(1) 12-18 (2017)
  10. 渕上由貴、川上 茂：遺伝子導入試薬、Drug Delivery System 32(1), 66-68 (2017)

受賞等

  1. 日本薬剤学会永井財団大学院学生スカラシップ受賞（小川昂輝）
  2. 長崎大学薬学部育薬研究教育センター第1回若手シンポジウム優秀発表賞（米澤敬大）
  3. 第7回日本バイオマテリアル学会九州ブロック講演会優秀研究ポスター賞（加藤直也）
  4. 平成29年度薬科学科分野横断型卒業研究ポスター発表会優秀ポスター賞（杉本友里）
  5. 長崎大学学長賞（社会貢献）（野村紗希子）

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2016年

論文・特許等

  1. Mitsuhiro Wada, Yutaro Yamasaki, Shinichi Nakamura, Makoto Takada, Shigeru Kawakami, and Kenichiro Nakashima: Determination of asperulosidic acid and deacetylasperulosidic acid in rat plasma after administration of morinda citrifolia juice, Chromatography, 37, 141-145 (2016)
  2. Marie Masuda, Shigeru Kawakami*, Wassana Wijagkanalan, Tadaharu Suga, Yuki Fuchigami, Fumiyoshi Yamashita, and Mitsuru Hashida: Anti-MUC1 aptamer/negatively charged amino acid dendrimer conjugates for targeted delivery to human lung adenocarcinoma A549 cells, Biological and Pharmaceutical Bulletin, 39 (10), 1734-1738 (2016)
  3. Hidemasa Katsumi, Makiya Nishikawa, Rikiya Hirosaki, Tatsuya Okuda, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida, Toshiyasu Sakane, and Akira Yamamoto: Development of PEGylated cysteine-modified lysine dendrimers with multiple reduced thiols to prevent hepatic ischemia/reperfusion injury, Molecular Pharmaceutics, 13 (8), 2867-2873 (2016)
  4. Shintaro Fumoto, Naoki Taniguchi, Yuri Ikai, Naoki Yoshikawa, Hirotaka Miyamoto, Hitoshi Sasaki, Mitsuru Hashida, Shigeru Kawakami, and Koyo Nishida: The insertion timing of PEGylated lipids to galactosylated lipoplexes is important for liver-selective transfection in mice, Gene and Cell Therapy, 1(1), 1-11 (2016)
  5. Yota Taniguchi, Shigeru Kawakami*, Yuki Fuchigami, Natsuko Oyama, Fumiyoshi Yamashita, Satoshi Konishi, Kazunori Shimizu, and Mitsuru Hashida: Optimization of renal transfection using a renal suction-mediated transfection method in mice, Journal of Drug Targeting, 24 (5), 450-456 (2016)
  6. Ryo Suzuki, Yusuke Oda, Daiki Omata, Norihito Nishiie, Risa Koshima, Yasuyuki Shiono, Yoshikazu Sawaguchi, Johan Unga, Tomoyuki Naoi, Yoichi Negishi, Shigeru Kawakami, Mitsuru Hashida, and Kazuo Maruyama: Tumor growth suppression by the combination of nanobubbles and ultrasound, Cancer Science, 107(3):217-223 (2016)
  7. Mitsuhiro Wada, Misato Wada, Rie Ikeda, Yuki Fuchigami, Hironari Koyama, Susumu Ohkawara, Shigeru Kawakami, Naotaka Kuroda, and Kenichiro Nakashima: Quantitative and antioxidative behavior of Trolox in rats' blood and brain by HPLC-UV and SMFIA-CL methods, Luminescence, 31(2), 414-418 (2016)
  8. Shintaro Fumoto, Koyo Nishimura, Koyo Nishida, and Shigeru Kawakami*: Three-dimensional imaging of the intracellular fate of plasmid DNA and transgene expression: ZsGreen1 and tissue clearing method CUBIC are an optimal combination for multicolor deep imaging in murine tissues, PLoS One, 11 (1), e0148233 (2016)

受賞等

  1. コニカミノルタ画像科学奨励賞/コニカミノルタ科学技術振興財団（萩森政頼）「神経細胞における亜鉛シグナリングを可視化する分子内電荷移動制御型蛍光センサー分子の開発」
  2. 第27回日本微量元素学会学術集会優秀演題賞/日本微量元素学会（萩森政頼）
  3. 日本薬剤学会永井財団大学院学生スカラシップ（大山奈津子）
  4. APSTJ Global English Education Award 2016（三浦雄介）
  5. 平成28年度薬科学科分野横断型卒業研究ポスター発表会優秀発表賞（加藤直也）

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2015年以前

論文・特許等

  1. Mohamed A. EL Hamd, Mitsuhiro Wada, Rie Ikeda, Shigeru Kawakami, and Kenichiro Nakashima:　Validation of an LC-MS/MS method for the determination of propofol, midazolam, and carbamazepine in rat plasma: effect of drug-drug interactions on their pharmacokinetics, Biological and Pharmaceutical Bulletin, 38 (8), 1250-1253 (2015)
  2. Yusuke Oda, Ryo Suzuki, Tatsuya Mori, Hideyo Takahashi, Hideaki Natsugari, Daiki Omata, Johan Unga, Hitoshi Uruga, Mutsumi Sugii, Shigeru Kawakami, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida, and Kazuo Maruyama: Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane, International Journal of Pharmaceutics, 487(1-2), 64-71 (2015)
  3. Rodi Abdalkader, Shigeru Kawakami*, Johan Unga, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita, and Mitsuru Hashida: Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model, Acta Biomaterialia, 19, 112-118 (2015)
  4. Yuki Fuchigami, Xunsing Fu, Rie Ikeda, Shigeru Kawakami, Mitsuhiro Wada, Ruri Kikura-Hanajiri, Naotaka Kuroda, and Kenichiro Nakashima: Evaluation of the neurochemical effects of methoxetamine using brain microdialysis in mice, Forensic Toxicology, 33 (2), 374-379 (2015)
  5. Yuki Otani, Shigeru Kawakami*, Hidefumi Mukai, Yuki Fuchigami, Fumiyoshi Yamashita, and Mitsuru Hashida: Long-term in vivo gene expression in mouse kidney using fC31 integrase and electroporation, Journal of Drug Targeting, 23 (5), 427-435 (2015)
  6. Akiharu Ueki, Keita Un, Yuka Mino, Mitsuru Yoshida, Shigeru Kawakami, Hiromune Ando, Hideharu Ishida, Fumiyoshi Yamashita, Mitsuru Hashida, and Makoto Kiso: Synthesis and evaluation of glycol-coated liposomes as drug carriers for active targeting in drug delivery systems, Carbohydrate Research, 405, 78-86 (2015)
  7. Mohamed A. EL Hamd, Mitsuhiro Wada, Rie Ikeda, Shigeru Kawakami, Naotaka Kuroda, and Kenichiro Nakashima: Simultaneous determination of propofol and remifentanil in rat plasma by liquid chromatography-tandem mass spectrometry: preclinical application to pharmacokinetic drug-drug interaction, Biomedical Chromatography, 29(3), 325-327 (2015)
  8. 川上 茂：医薬品情報学研究室の立ち上げと今後の抱負：薬剤学、75 (4), 21-220 (2015)
  9. 川上 茂：第1章リポソーム　2. 糖鎖修飾、DDSキャリア作製プロトコル集（シーエムシー出版）、pp9-15 (2015)
  10. 特願2015-4305：糖誘導体、またはその塩、セレクチン結合剤、糖結合体、粒子状キャリア、および輸送方法、発明人：橋田 充、山下富義、樋口ゆり子、チャニカーン・チャンタラスリウォン、川上　茂、ヨハン・ウンガ、木曽  真、植木章晴、安藤 弘宗、出願人：京都大学
  11. Tomoaki Kurosaki, Shigeru Kawakami*, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Hitoshi Sasaki, Fumiyoshi Yamashita, and Mitsuru Hashida: Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice, Nanomedicine-Nanotechnology, Biology, and Medicine, 10 (8), 1829-1838 (2014)
  12. Mitsuru Yoshida, Shigeru Kawakami*, Yusuke Kono, Keita Un, Yuriko Higuchi, Kazuo Maruyama, Fumiyoshi Yamashita, and Mitsuru Hashida: Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes, International Journal of Pharmaceutics, 475 (1-2), 401-407 (2014)
  13. Yusuke Kono, Shigeru Kawakami*, Yuriko Higuchi, Kazuo Maruyama, Fumiyoshi Yamashita, and Mitsuru Hashida: Anti-tumor effect of NF-kB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites, Cancer Science, 105(8), 1049-1055 (2014)
  14. Mitsuru Yoshida, Shigeru Kawakami*, Keita Un, Yusuke Kono, Yuriko Higuchi, Fumiyoshi Yamashita, and Mitsuru Hashida: Evaluation of inflammatory responses due to siRNA transfer using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophages, Journal of Drug Targeting, 22 (8), 732-738 (2014)
  15. Shuwen Zhou, Yasuhiko Hashida, Shigeru Kawakami, Junya Mihara, Tomokazu Umeyama, Hiroshi Imahori, Tastuya Murakami, Fumiyoshi Yamashita, and Mitsuru Hashida: Preparation of immunostimulatory single-walled carbon nanotube/CpG DNA complexes and evaluation of their potential in cancer immunotherapy, International Journal of Pharmaceutics, 471 (1-2), 214-223 (2014)
  16. Yusuke Kono, Shigeru Kawakami*, Yuriko Higuchi, Kazuo Maruyama, Fumiyoshi Yamashita, and Mitsuru Hashida: Tumour-associated macrophage targeted NF-kB decoy transfection with mannose-modified bubble lipoplexes inhibits tumour growth in tumour bearing mice, Journal of Drug Targeting, 22 (5), 439-449 (2014)
  17. Mitsuhiro Wada, Mana Kuroki, Yuu Minami, Rie Ikeda, Yui Sekitani, Noboru Takamura, Shigeru Kawakami, Naotaka Kuroda, and Kenichiro Nakashima: Quantitation of sulfur-containing amino acids, homocysteine, methionine and cysteine in dried blood spot from newborn baby by HPLC-fluorescence detection, Biomedical Chromatography, 28 (6), 810-814 (2014)
  18. Kazushi Matsumura, Chika Sakai, Shigeru Kawakami, Fumiyoshi Yamashita, and Mitsuru Hashida: Inhibition of cancer cell growth by GRP78 siRNA lipoplex via activation of unfolded protein response, Biological and Pharmaceutical Bulletin, 37 (4), 648-653 (2014)
  19. Kazunori Shimizu, Guangyuan Zhang, Shigeru Kawakami, Yota Taniguchi, Kouji Hayashi, Mitsuru Hashida, and Satoshi Konishi: Liver suction-mediated transfection in mice using a pressure-controlled computer system, Biological and Pharmaceutical Bulletin, 37 (4), 569-575 (2014) *Highlighted Paper 2014 Selected by Editor-in-Chief
  20. Tomoaki Kurosaki, Shigeru Kawakami*, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Hitoshi Sasaki, Fumiyoshi Yamashita, and Mitsuru Hashida: Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice, Journal of Controlled Release, 176, 24-34 (2014)
  21. Yasuhiko Hashida, Hironori Tanaka, Shuwen Zhou, Shigeru Kawakami, Fumiyoshi Yamashita, Tatsuya Murakami, Tomokazu Umeyama, Hiroshi Imahori, and Mitsuru Hashida: Photothermal ablation of tumor cells using a single-walled carbon nanotubes-peptide composite, Journal of Controlled Release, 173, 59-66 (2014)
  22. Yusuke Kono, Shigeru Kawakami*, Yuriko Higuchi, Fumiyoshi Yamashita and Mitsuru Hashida: In vitro evaluation of inhibitory effects of NF-kB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages, Biological and Pharmaceutical Bulletin, 37, 137-144 (2014)
  23. Shigeru Kawakami, and Mitsuru Hashida: Glycosylation-mediated targeting of carriers, Journal of Controlled Release, 190, 542-555 (2014)
  24. Shintaro Fumoto, and Shigeru Kawakami*: Combination of nanoparticles with physical stimuli toward cancer therapy, Biological and Pharmaceutical Bulletin, 37(2), 212-216 (2014)
  25. 川上 茂、渕上由貴：医薬工連携型DDSの開発、医薬ジャーナル、50(7)、103-107 (2014)
  26. Yoshimasa Takafuji, Yuriko Higuchi, Atsushi Muro, Kohei Oshiro, Shigeru Kawakami, Fumiyoshi Yamashita, and Mitsuru Hashida: Factors influencing the surface modification of mesenchymal stem cells with fluorescein-pegylated lipids, Biological and Pharmaceutical Bulletin, 36, 1731-1738 (2013)
  27. Shintaro Fumoto, Shigeru Kawakami, Mitsuru Hashida, Koyo Nishida: Novel Gene Therapy Approaches, IntechOpen (2013) DOI: 10.5772/54741
  28. 川上 茂：外部刺激を利用した in vivo 核酸デリバリー法の開発と評価、薬剤学、73(3) 、 153-160 (2013)

受賞等

  1. 第2回先導的薬剤師の未来像を考えるシンポジウム最優秀発表賞（山岡真理子）
  2. 平成26年度薬科学科分野横断型卒業研究ポスター発表会優秀発表賞（菅 忠明）
  3. 長崎大学学長賞（研究）（渕上由貴）
  4. 日本薬剤学会 永井財団学部学生七つ星薬師奨励賞（大山奈津子）
  5. 日本薬剤学会 最優秀発表者賞（西村光洋）
  6. APSTJ Global Education Seminar Award 2015（大山奈津子）
  7. 長崎大学学長賞（研究）（大山奈津子）
  8. 長崎大学学長賞（研究）（西村光洋）
  9. 平成25年度日本薬剤学会「薬と健康の週間」懸賞論文 第1席受賞（山崎裕太郎）
  10. 第1回先導的薬剤師の未来像を考えるシンポジウム最優秀発表賞（大山奈津子）

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医薬品情報学分野
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