Paper Archives

2011-2020 Articles

  1. Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system, Mariko Taniguchi, Hirotaka Miyamoto, Ayako Tokunaga, Shintaro Fumoto, Takashi Tanaka, Koyo Nishida, Xenobiotica 2020 Jun;50(6):654-662 DOI: 10.1080/00498254.2019.1683258 PMID: 31631733
  2. Influence of liver intoxication by carbon tetrachloride or D-galactosamine on absorption of fluorescein isothiocyanate-dextran-10 and other marker compounds with different molecular weights from the rat liver surface, Hirotaka Miyamoto, Kayoko Tsuda, Tomonori Honda, Ayako Tokunaga, Shintaro Fumoto, Koyo Nishida, Biol Pharm Bull, 43(2):319-324 (2020) doi: 10.1248/bpb.b19-00686 PMID: 32009118
  3. Yoshikawa N, Fumoto S, Yoshikawa K, Hu D, Okami K, Kato R, Nakashima M, Miyamoto H, Nishida K. Pharmaceutics. 2020 Apr 10;12(4). pii: E341. doi: 10.3390/pharmaceutics12040341 Interaction of Lipoplex with Albumin Enhances Gene Expression in Hepatitis Mice. PMID: 32290201
  4. Foreword: Recent Progress in Drug Delivery System for Cancer Therapy, Koyo Nishida, Chem Pharm Bull (Tokyo). 2020;68(7):559. doi: 10.1248/cpb.c20-ctf6807 PMID: 32611992
  5. Co-delivery Systems of Multiple Drugs Using Nanotechnology for Future Cancer Therapy, Shintaro Fumoto, Koyo Nishida, Chem Pharm Bull (Tokyo). 2020;68(7):603-612. doi: 10.1248/cpb.c20-00008 PMID: 32611997
  6. Effect of Chronic Kidney Disease on Hepatic Clearance of Drugs in Rats, A Tokunaga, H Miyamoto, S Fumoto, K Nishida, Biol Pharm Bull. 2020;43(9):1324-1330. doi: 10.1248/bpb.b20-00124 PMID: 32879206
  7. Peng JQ, Fumoto S, Suga T, Miyamoto H, Kuroda N, Kawakami S, Nishida K. Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles. J Control Release. 2019 May 28;302:42-53. doi: 10.1016/j.jconrel.2019.03.021 Epub 2019 Mar 26. PubMed PMID: 30926479 IF: 7.901
  8. Tokunaga A, Miyamoto H, Fumoto S, Nishida K. Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats. J Pharm Pharmacol. 2019 Dec;71(12):1792-1799. doi: 10.1111/jphp.13167 PubMed PMID: 31579949 IF: 2.390
  9. Kinoshita E, Fumoto S, Hori Y, Yoshikawa N, Miyamoto H, Sasaki H, Nakamura J, Tanaka T, Nishida K. Monitoring method for transgene expression in target tissue by blood sampling. Biotechnol Rep (Amst). 2019 Nov 15;24:e00401. doi: 10.1016/j.btre.2019.e00401 eCollection 2019 Dec. PubMed PMID: 31788440 PubMed Central PMCID: PMC6880019.
  10. Wang S, Fumoto S, Miyamoto H, Tanaka M, Nishida K, Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice, Int J Pharm. 548(1): 173-181, 2018 (IF: 3.862) doi: 10.1016/j.ijpharm.2018.06.068 PMID:29969708
  11. Koyo Nishida, Shintaro Fumoto: Organ surface application method-new DDS for digestive diseases, Drug Delivery System, 33(5): 270-276 (2018)https://doi.org/10.2745/dds.33.390
  12. Kodama Y, Horishita M, Tokunaga A, Miyamoto H, Fumoto S, Sasaki H, Nakamura J, Nishida K, Influence of vasomodulators and tumor transplantation on the disposition of 5-fluorouracil after application to the liver surface in rats, Biopharm Drug Dispos. 38 (6): 367-372, 2017 (IF: 2.091)　doi: 10.1002/bdd.2073 PMID: 28239866
  13. Peng J, Fumoto S, Miyamoto H, Chen Y, Kuroda N, Nishida K, One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin, J Drug Target. 25 (8): 704-714, 2017 (IF: 3.068) doi: 10.1080/1061186X.2017.1315687 PMID: 28368667
  14. Fumoto S, Nishida K: Methods for evaluating the stimuli-responsive delivery of nucleic acid and gene medicines, Chem Pharm Bull (Tokyo) 65 (7): 642-648, 2017 (IF: 1.133) doi: 10.1248/cpb.c17-00096 PMID: 28674337
  15. Fumoto S, Nishimura K, Nishida K, Kawakami S: Three-Dimensional Imaging of the Intracellular Fate of Plasmid DNA and Transgene Expression: ZsGreen1 and Tissue Clearing Method CUBIC are an Optimal Combination for Multicolor Deep Imaging in Murine Tissues, PLOS ONE 11(1): e0148233, 2016 (IF: 3.057) doi: 10.1371/journal.pone.0148233 PMID: 26824850
  16. Shimokawa K, Wakasugi K, Tomonaga R, Utsunomiya K, Miyamoto H, Fumoto S, Nishida K: Effect of metabolic inhibitors on the hepatic disposition of 5-fluorouracil after application to the rat liver surface, Biol Pharm Bull. 39 (3) :361-367, 2016 (IF: 1.574) doi: 10.1248/bpb.b15-00757 PMID: 26934928
  17. Hirata H, Fumoto S, Miyamoto H, Nakashima M, Nakayama M, Nishida K: Evaluation for Peritoneal Injury at an Early Stage Using Dual Macromolecular Markers, Biol Pharm Bull 39 (10): 1581-1587, 2016 (IF: 1.574) doi: 10.1248/bpb.b15-01042 PMID: 27725434
  18. Fumoto S, Taniguchi N, Ikai Y, Yoshikawa N, Miyamoto H, Sasaki H, Hashida M, Kawakami S, Nishida K: The Insertion Timing of PEGylated Lipids to Galactosylated Lipoplexes is Important for Liver-Selective Transfection in Mice, Gene and Cell Therapy 1(1): 1-11, 2016
  19. Miyamoto H, Matsueda S, Moritsuka A, Shimokawa K, Hirata H, Nakashima M, Sasaki H, Fumoto S, Nishida Koyo: Evaluation of hypothermia on the in vitro metabolism and binding and in vivo disposition of midazolam in rats, Biopharmaceutics & Drug Disposition 36 (7): 481-489 (2015) (IF: 2.340) doi: 10.1002/bdd.1960 PMID: 26037413
  20. Mine T, Miyamoto H, Yoshikawa N, Fumoto S, Sasaki H, Nakamura J, Nishida K: Effect of absorption enhancers on the absorption of FD-4 as a poorly absorbable marker macromolecule from the liver surface in rats. J Drug Del Sci Tech 24 (4): 386-389, 2014 (IF: 0.734)
  21. Hirata H, Miyamoto H, Shimokawa K, Nakashima M, Nakayama M, Fumoto S, Nishida K: Novel diagnostic method of peritoneal injury using dual macromolecular markers. Biol Pharm Bull 37 (2): 262-267, 2014 (IF: 1.778) PMID:24492723
  22. INTECH "Novel Gene Therapy Approaches" Editor, Ming Wei; Co-editor, David Good, Section 1 Approached to Gene Therapy, Chapter 1 Targeted Gene Delivery: Importance of Administration Routes: Shintaro Fumoto, Shigeru Kawakami, Mitsuru Hashida, Koyo Nishida, pp. 3-31 (2013)
  23. Naoki Yoshikawa, Shintaro Fumoto, Mikiro Nakashima, Kenta Shimokawa, Hirotaka Miyamoto, Koyo Nishida:The role of fibronectin in pulmonary gene transfer following intravenous administration of lipoplex in mice. Biol Pharm Bull, 2013 36(11):1807-13 PMID:24189424
  24. Miyamoto H, Matsueda S, Komori K, Fumoto S, Nakashima M, Yoshikawa N, Hirata H, Shimokawa K, Ohwaki Y, Nishida K: Evaluation for effect of hypothermia on the disposition of 4-nitrophenol in rats by in vitro metabolism study and rat liver perfusion system. J Pharm Pharmacol, 2013 Oct;65(10):1536-40 PMID:24028621
  25. Fumoto S, Nakajima S, Mine T, Yoshikawa N, Kitahara T, Sasaki H, Miyamoto H, Nishida K: Efficient in vivo gene transfer by intraperitoneal injection of plasmid DNA and calcium carbonate microflowers in mice. Mol Pharm 9: 1962-1970, 2012 (IF: 4.782) PMID:22670625
  26. Kodama Y, Horishita M, Fumoto S, Mine T, Miyamoto H, Yoshikawa N, Hirata H, Sasaki H, Nakamura J, Nishida K: Effect of viscous additives on the absorption and hepatic disposition of 5-fluorouracil (5-FU) after application to liver surface in rats. J Pharm Pharmacol 64(10): 1438-1444, 2012 (IF: 2.175) PMID: 22943174
  27. Miyamoto H, Baba S, Nakajima S, Mine T, Yoshikawa N, Fumoto S, Nishida K: Pretreatment with epidermal growth factor enhances naked plasmid DNA transfer onto gastric serosal surface in mice. Biol Pharm Bull 35(6): 903-908, 2012 (IF: 1.657) PMID:22687482
  28. Miyamoto H, Miyake H, Yoshikawa N, Hirata H, Ohwaki Y, Fumoto S, Sasaki H, Nakamura J, Nishida K: Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system. J Pharm Pharmacol 64(6): 848-854, 2012 (IF: 2.175) PMID:22571263
  29. Koyo Nishida: Development of useful basic research for clinical application of DDS, Drug Delivery System, 27(2): 106-115 (2012)
  30. Yoshikawa N, Sakamoto K, Mizuno S, Sakaguchi J, Miyamoto H, Mine T, Sasaki H, Fumoto S, Nishida K: Multiple components in serum contribute to hepatic transgene expression by lipoplex in mice. J Gene Med 13(11): 632-643, 2011 (IF: 3.079) PMID: 22002583
  31. Fumoto S, Furukawa H, Nakamura J, Nishida K: Safety of liver surface instillation of plasmid DNA in normal and carbon tetrachloride-induced hepatitis mice. J Pharm Pharm Sci 14(2): 274-282, 2011 (IF: 1.914) PMID: 21733415.
  32. Mine T, Ishii H, Nakajima S, Yoshikawa N, Miyamoto H, Nakashima M, Nakamura J, Fumoto S, Nishida K: Rubbing gastric serosal surface enhances naked plasmid DNA transfer in rats and mice. Biol Pharm Bull 34(9): 1514-1517, 2011 (IF: 1.811) PMID: 21881243.
  33. Nishida K, Kobayashi M, Miyamoto H, Yoshikawa N, Fumoto S, Sasaki H, Nakamura J: Relationship between lipophilicity and absorption from the liver surface of paraben derivatives and antipyrine in rats. J Pharm Pharmacol 63(5): 736-740, 2011 (IF: 1.918) PMID:21492176

2001-2010 Articles

  1. Koyo Nishida, Development of drug delivery system by utilizing absorption from liver surface and its application, YAKUGAKU ZASSHI, 129: 925-932, 2009 PMID: 19652498
  2. Fumoto S, Nishi J, Ishii H, Wang X, Miyamoto H, Yoshikawa N, Nakashima M, Nakamura J, Nishida K, Rac-mediated macropinocytosis is a critical route for naked plasmid DNA transfer in mice. Molecular Pharmaceutics. 6:1170-1179, 2009. (IF: 4.565) PMID: 19492848
  3. Fumoto S, Tsuchimochi M, Nishi J, Ishii H, Kodama Y, Nakashima M, Sasaki H, Nakamura J, Nishida K, Liver- and lobe-specific gene transfer following the continuous microinstillation of plasmid DNA onto the liver surface in mice: effect of instillation speed. Biol. Pharm. Bull. 32: 1298-1302, 2009 (IF: 1.765) PMID: 19571403
  4. S. Fumoto, J. Nishi, J. Nakamura, K. Nishida: Gene therapy for gastric diseases, Curr. Gene Ther. 8(3):187-200 (2008). PMID: 18537593
  5. J. Nishi, S. Fumoto, H. Ishii, Y. Kodama, M. Nakashima, H. Sasaki, J. Nakamura, K. Nishida: Highly stomach-selective gene transfer following gastric serosal surface instillation of naked plasmid DNA in rats, J. Gastroenterol. 43(12): 912-919 (2008). PMID: 19107334
  6. J. Nishi, S. Fumoto, H. Ishii, Y. Kodama, M. Nakashima, H. Sasaki, J. Nakamura, K. Nishida: Improved stomach selectivity of gene expression following microinstillation of plasmid DNA onto the gastric serosal surface in mice, Eur. J. Pharm. Biopharm. 69(2): 633-639 (2008) Jun PMID: 18222072
  7. Y. Kodama, S. Fumoto, J. Nishi, M. Nakashima, H. Sasaki, J. Nakamura, K. Nishida: Absorption and distribution characteristics of 5-fluorouracil (5-FU) after an application to the liver surface in rats in order to reduce systemic side effects, Biol. Pharm. Bull. 31(5): 1049-1052 (2008) PMID: 18451546
  8. Koyo Nishida, Madoka Okazaki, Ryuichi Sakamoto, Natsuko Inaoka, Hideaki Miyake, Shintaro Fumoto, Junzo Nakamura, Mikiro Nakashima, Hitoshi Sasaki, Mikio Kakumoto and Toshiyuki Sakaeda, Change in pharmacokinetics of model compounds with different elimination processes in rats during hypothermia, Biological & Pharmaceutical Bulletin, 30 (9), 1763-1767, 2007 PMID: 17827736
  9. Shintaro Fumoto, Yukiko Nakashima, Koyo Nishida, Yukinobu Kodama, Junya Nishi, Mikiro Nakashima, Hitoshi Sasaki, Noboru Otsuka and Junzo Nakamura, Evaluation of Enhanced Peritoneum Permeability in Methylglyoxal-treated Rats as a Diagnostic Method for Peritoneal Damage, Pharmaceutical Research, 24 (10), 1891-1896, 2007 PMID: 17476464
  10. Junzo Nakamura, Shintaro Fumoto, Rie Kawanami, Yukinobu Kodama, Junya Nishi, Mikiro Nakashima, Hitoshi Sasaki and Koyo Nishida, Spleen-selective gene transfer following the administration of naked plasmid DNA onto the spleen surface in mice, Biological & Pharmaceutical Bulletin, 30 (5), 941-945, 2007 PMID: 17473439
  11. Junzo Nakamura, Shintaro Fumoto, Kimiyo Ariyoshi, Yukinobu Kodama, Junya Nishi, Mikiro Nakashima, Hitoshi Sasaki and Koyo Nishida, Unilateral lung-selective gene transfer following the administration of naked plasmid DNA onto the pulmonary pleural surface in mice, Biological & Pharmaceutical Bulletin, 30 (4), 729-732, 2007 PMID: 17409511
  12. Junzo Nakamura, Shintaro Fumoto, Keiko Shoji, Yukinobu Kodama, Junya Nishi, Mikiro Nakashima, Hitoshi Sasaki and Koyo Nishida, Stomach-selective gene transfer following the administration of naked plasmid DNA onto the gastric serosal surface in mice, Biological & Pharmaceutical Bulletin, 29 (10), 2082-2086, 2006 PMID: 17015955
  13. Ryu Hirayama, Shintaro Fumoto, Koyo Nishida, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura, Effect of solution composition of plasmid DNA on gene transfection following liver surface administration in mice, Biological & Pharmaceutical Bulletin, 28 (11), 2166-2169, 2005 PMID: 16272713
  14. Koyo Nishida, Rie Fujiwara, Yukinobu Kodama, Shintaro Fumoto, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Regional delivery of model compounds and 5-Fluorouracil to the liver by their application to the liver surface in rats: its implication for clinical use, Pharmaceutical Research, 22 (8), 1331-1337, 2005 PMID: 16078143
  15. Koyo Nishida, Akiko Kuma, Shintaro Fumoto, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Absorption characteristics of model compounds from the small intestinal serosal surface and a comparison with other organ surfaces, Journal of Pharmacy and Pharmacology, 57 (8), 1073-1077, 2005 PMID: 16102265
  16. Junzo Nakamura, Kazuko Kobayashi, Shintaro Fumoto, Junya Nishi, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki and Koyo Nishida: Stomach- and site-selective delivery of 5-fluorouracil following its application on the gastric serosal surface in rats, Biological & Pharmaceutical Bulletin, 28 (6): 1049-1053, 2005 PMID: 15930743
  17. Koyo Nishida, Manabu Kamenosono, Akiko Kuma, Shintaro Fumoto, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Delivery advantage to the unilateral kidney by direct drug application to the kidney surface in rats and pharmacokinetic verification based on a physiological model, Journal of Drug Targeting, 13 (4), 215-223, 2005 PMID: 16051533
  18. Ryu Hirayama, Koyo Nishida, Shintaro Fumoto, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Unilateral kidney-selective gene transfer following the administration of naked plasmid DNA to the kidney surface in mice, Biological & Pharmaceutical Bulletin, 28 (1), 181-184, 2005 PMID: 15635189
  19. Koyo Nishida, Naoki Tomiyama, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Absorption characteristics of compounds with different molecular weights after application to the unilateral kidney surface in rats. European Journal of Pharmaceutics and Biopharmaceutics, 58 (3), 705-711 (2004) PMID: 15451548
  20. Ryu Hirayama, Koyo Nishida, Shintaro Fumoto, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Liver site-specific gene transfer following the administration of naked plasmid DNA to the liver surface in mice, Biological & Pharmaceutical Bulletin, 27 (10): 1697-1699 (2004) PMID: 15467224
  21. Koyo Nishida, Seiichi Nose, Akiko Kuma, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Absorption of phenolsulfonphthalein as a model across the mesenteric surface in rats to determine the drug absorption route after intraperitoneal administration. Journal of Pharmacy and Pharmacology, 56 (5): 683-687 (2004) PMID: 15142348
  22. Takahiro Mukai, Kunihiro Mera, Koyo Nishida, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Pharmacokinetics of phenol red in rat models of liver damage prepared by liver targeting of carbon tetrachloride, Biological & Pharmaceutical Bulletin, 27 (4): 595-597 (2004) PMID: 15056875
  23. Koyo Nishida:Development of drug delivery system based on a new administration route for targeting to the specific region in the liver, YAKUGAKU ZASSHI, 123 (8): 681-689 (2003) PMID: 12931664
  24. Junzo Nakamura, Tomomi Horimoto, Ryu Hirayama, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki and Koyo Nishida: Further studies on the kidney- and site-selective delivery of 5-fluorouracil following kidney surface application in rats, Biological & Pharmaceutical Bulletin, 26 (12): 1761-1764 (2003) PMID: 14646186
  25. Junzo Nakamura, Tomomi Horimoto, Ryu Hirayama, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki and Koyo Nishida: Effect of the absorption enhancer saponin on the intrarenal distribution of 5-fluorouracil following its kidney surface application in rats, Biological & Pharmaceutical Bulletin, 26 (7): 1049-1051 (2003) PMID: 12843639
  26. Koyo Nishida, Tominori Honda, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Influence of liver disease on phenolsulfonphthalein absorption from liver surface to examine possibility of direct liver surface application for drug targeting, Biological & Pharmaceutical Bulletin, 26 (7): 988-993 (2003) PMID: 12843624
  27. Ryu Hirayama, Shigeru Kawakami, Koyo Nishida, Mikiro Nakashima, Hitoshi Sasaki, Toshiyuki Sakaeda and Junzo Nakamura: Development of the liver- and lobe-selective nonviral gene transfer following the instillation of naked plasmid DNA using catheter on the liver surface in mice, Pharmaceutical Research, 20 (2): 328-332 (2003) PMID: 12636176
  28. Takahiro Mukai, Kunihiro Mera, Koyo Nishida, Mikiro Nakashima, Hitoshi Sasaki, Toshiyuki Sakaeda and Junzo Nakamura: A novel method for preparation of animal models of liver damage: liver targeting of carbon tetrachloride in rats, Biological & Pharmaceutical Bulletin, 25 (11): 1494-1497 (2002) PMID: 12419969
  29. Koyo Nishida, Seiichi Nose, Akiko Kuma, Takahiro Mukai, Shigeru Kawakami, Mikiro Nakashima, Hitoshi Sasaki, Toshiyuki Sakaeda and Junzo Nakamura: Absorption characteristics of model compounds with different molecular weights from the serosal caecal surface in rats. Journal of Pharmacy and Pharmacology, 54 (7): 1005-1009 (2002) PMID: 12162704
  30. Shigeru Kawakami, Tomomi Horimoto, Koyo Nishida, Ryu Hirayama, Takahiro Mukai, Toshiyuki Sakaeda, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Kidney- and site-selective delivery of 5-fluorouracil utilizing the absorption on the kidney surface in rats, Biological & Pharmaceutical Bulletin, 25 (7): 928-930 (2002) PMID: 12132672
  31. Shigeru Kawakami, Ryu Hirayama, Keiko Shoji, Rie Kawanami, Koyo Nishida, Mikiro Nakashima, Hitoshi Sasaki, Toshiyuki Sakaeda and Junzo Nakamura: Liver- and lobe-selective gene transfection following the instillation of plasmid DNA to the liver surface in mice, Biochemical and Biophysical Research Communications, 294 (1): 46-50 (2002) PMID: 12054738
  32. Koyo Nishida, Yayoi Yoshida, Takahiro Mukai, Shigeru Kawakami, Toshiyuki Sakaeda, Mikiro Nakashima, Hitoshi Sasaki and Junzo Nakamura: Effect of instillation method on the absorption of phenolsulphonphthalein as a model drug from the liver and small intestinal serosal surface in rats. Journal of Pharmacy and Pharmacology, 53 (10) Oct, 1341-1346 (2001) PMID: 11697541

1991-2000 Articles

  1. Koyo Nishida, Yuki Nakakoga, Norihito Sato, Shigeru Kawakami, Takahiro Mukai, Hitoshi Sasaki, Toshiyuki Sakaeda and Junzo Nakamura: Effect of viscous additives on drug absorption from the liver surface in rats using phenol red as a model. European Journal of Pharmaceutics and Biopharmaceutics, 50 (3), 397-402 (2000) PMID: 11072197
  2. Hitoshi Sasaki, Kenzo Yamamura, Takahiro Mukai, Koyo Nishida, Junzo Nakamura, Mikiro Nakashima and Masataka Ichikawa: Enhancement of ocular drug penetration, Critical Reviews in Therapeutic Drug Carrier Systems, 16: 85-146 (1999) PMID: 10099899
  3. Kenzo Yamamura, Hitoshi Sasaki, Mikiro Nakashima, Masataka Ichikawa, Takahiro Mukai, Koyo Nishida, Junzo Nakamura: Characterization of ocular pharmacokinetics of beta-blockers using a diffusion model after instillation, Pharmaceutical Research, 16: 1596-1601 (1999) PMID: 10554103
  4. Takahiro Mukai, Atsuko Tsurumaru, Kunihiro Mera, Koyo Nishida, Junzo Nakamura, Hitoshi Sasaki and Toshiyuki Sakaeda: Absorption characteristics of model drugs from the gastric serosal surface in rats, Pharmacy Pharmacology Communications, 5: 609-614 (1999)
  5. Junzo Nakamura, Atsuko Tsurumaru, Kunihiro Mera, Takahiro Mukai, Koyo Nishida and Hitoshi Sasaki: Absorption of drugs applied to the gastric serosal surface in rats, Pharmacy Pharmacology Communications, 5: 519-522 (1999)
  6. Junzo Nakamura, Yayoi Yoshida, Kunihiro Mera, Takahiro Mukai, Koyo Nishida and Hitoshi Sasaki: Continuous microinstillation of phenol red on liver surface for liver site-selective delivery, Biological & Pharmaceutical Bulletin 22: 713-715 (1999) PMID: 10443468
  7. Takahiro Mukai, Yasushi Arano, Koyo Nishida, Hitoshi Sasaki, Hiromichi Akizawa, Kazuma Ogawa, Masahiro Ono, Hideo Saji and Junzo Nakamura: Species difference in radioactivity elimination from liver parenchymal cells after injection of radiolabeled proteins. Nuclear Medicine & Biology 26: 281-289 (1999) PMID: 10363799
  8. Takahiro Mukai, Yasushi Arano, Koyo Nishida, Hitoshi Sasaki, Hideo Saji and Junzo Nakamura: In-vivo evaluation of Indium-111-diethylenetriaminepentaacetic acid-labelling for determining the sites and rates of protein catabolism. Journal of Pharmacy and Pharmacology 51: 15-20 (1999) PMID: 10197412
  9. Koyo Nishida, Norihito Sato, Yuki Nakakoga, Takahiro Mukai, Hitoshi Sasaki and Junzo Nakamura: Effect of application volume and area on the absorption of phenol red, as a model drug, from the liver surface in rats. Journal of Pharmacy and Pharmacology 49: 976-980 (1997) PMID: 9364405
  10. Hitoshi Sasaki, Masataka Ichikawa, Shigeru Kawakami, Kenzo Yamamura, Takahiro Mukai, Koyo Nishida and Junzo Nakamura, In-situ ocular absorption of ophthalmic beta-blockers through ocular membranes in albino rabbits. Journal of Pharmacy and Pharmacology 49: 140-144 (1997) PMID: 9055184
  11. Hitoshi Sasaki, Masataka Ichikawa, Kenzo Yamamura, Koyo Nishida and Junzo Nakamura, Ocular membrane permeability of hydrophilic drugs for ocular peptide delivery. Journal of Pharmacy and Pharmacology 49: 135-139 (1997) PMID: 9055183
  12. Koyo Nishida, Norihito Sato, Hitoshi Sasaki and Junzo Nakamura, Absorption characteristics of dextrans with different molecular weights from the liver surface membrane in rats: implications for targeting to the liver. Journal of Drug Targeting 4: 141-150 (1996) PMID: 8959486
  13. Hitoshi Sasaki, Masataka Ichikawa, Shigeru Kawakami, Kenzo Yamamura, Koyo Nishida and Junzo Nakamura, In situ ocular absorption of tilisolol through ocular membranes in albino rabbits. Journal of Pharmaceutical Sciences 85: 940-943 (1996) PMID: 8877883
  14. Hitoshi Sasaki, Kenzo Yamamura, Koyo Nishida, Junzo Nakamura and Masataka Ichikawa: Delivery of drugs to the eye by topical application, Progress in Retinal and Eye Research, 15, CHAPTER 11, p583-620 (1996)
  15. Hitoshi Sasaki, Koyo Nishida and Junzo Nakamura: Pyrrolidones as penetration enhancers "in Percutaneous Penetration Enhancers", Edited by Eric W. Smith and Howard I. Maibach, CRC Press Inc., Chapter 7.1, p211-220 (1995)
  16. Koyo Nishida, Hiroaki Amagishi, Hitoshi Sasaki and Junzo Nakamura, Absorption of phenol red and bromphenol blue as model drugs from the peritoneal cavity around the liver surface in rats. Journal of Pharmacy and Pharmacology 47: 1032-1035 (1995) PMID: 8932690
  17. Koyo Nishida, Norihito Sato, Hitoshi Sasaki and Junzo Nakamura, Effect of albumin on the absorption of phenol red, bromphenol blue and bromosulphonphthalein as model drugs from the liver surface membrane in rats. Biological & Pharmaceutical Bulletin 18: 1548-1550 (1995) PMID: 8593477
  18. Hitoshi Sasaki, Toshiaki Nagano, Kenzo Yamamura, Koyo Nishida and Junzo Nakamura, Ophthalmic preservatives as absorption promoters for ocular drug delivery. Journal of Pharmacy and Pharmacology 47: 703-707 (1995) PMID: 8583378
  19. Hitoshi Sasaki, Yoshiaki Igarashi, Toshiaki Nagano, Koyo Nishida and Junzo Nakamura, Different effects of absorption promoters on corneal and conjunctival penetration of ophthalmic beta-blockers. Pharmaceutical Research 12: 1146-1150 (1995) PMID: 7494826
  20. Hitoshi Sasaki, Kenzo Yamamura, Choyu Tei, Koyo Nishida and Junzo Nakamura, Ocular permeability of FITC-dextran with absorption promoter for ocular delivery of peptide drug. Journal of Drug Targeting 3: 129-135 (1995) PMID: 7496726
  21. Koyo Nishida, Norihito Sato, Hitoshi Sasaki and Junzo Nakamura, Mechanism for drug absorption from rat-liver surface membrane: Effect of dose and transport inhibitors on the pharmacokinetics of phenol red. Journal of Pharmacy and Pharmacology 47: 227-231 (1995) PMID: 7602486
  22. Hitoshi Sasaki, Yoshiaki Igarashi, Toshiaki Nagano, Kenzo Yamamura, Koyo Nishida and Junzo Nakamura, Penetration of beta-blockers through ocular membranes in albino rabbits. Journal of Pharmacy and Pharmacology 47: 17-21 (1995)
  23. Hitoshi Sasaki, Choyu Tei, Koyo Nishida and Junzo Nakamura, Effect of ophthalmic preservatives on serum concentration and local irritation of ocularly applied insulin. Biological & Pharmaceutical Bulletin 18: 169-171 (1995) PMID: 7735235
  24. Hitoshi Sasaki, Choyu Tei, Kenzo Yamamura, Koyo Nishida and Junzo Nakamura, Effect of preservatives on systemic delivery of insulin by ocular instillation in rabbits. Journal of Pharmacy and Pharmacology 46: 871-875 (1994) PMID: 7897590
  25. Koyo Nishida, Norihito Sato, Hitoshi Sasaki and Junzo Nakamura, Absorption of organic anions as model drugs following application to rat liver surface in-vivo. Journal of Pharmacy and Pharmacology 46: 867-870 (1994) PMID: 7897589
  26. Hitoshi Sasaki, Yoshiaki Igarashi, Koyo Nishida and Junzo Nakamura, Intestinal permeability of ophthalmic beta-blockers for predicting ocular permeability. Journal of Pharmaceutical Sciences 83: 1335-1338 (1994) PMID: 7830251
  27. Koyo Nishida, Mitsuhiko Kido, Hitoshi Sasaki and Junzo Nakamura, Pharmacokinetic analysis of in vivo metabolism of amino acid or dipeptide conjugates of salicylic acid in rabbit intestinal microorganisms. Pharmaceutical Research 11: 160-164 (1994) PMID: 8140048
  28. Hitoshi Sasaki, Choyu Tei, Koyo Nishida and Junzo Nakamura, Drug release from an ophthalmic insert of a beta-blocker as an ocular drug delivery system. Journal of Controlled Release 27: 127-137 (1993)
  29. Junzo Nakamura, Mitsuhiko Kido, Chieko Tagami, Koyo Nishida and Hitoshi Sasaki, Systemic and presystemic de-conjugation of salicylic acid-arginine conjugate as a prodrug of salicylic acid in rabbits. International Journal of Pharmaceutics 99: 189-195 (1993)
  30. Hitoshi Sasaki, Yoshiaki Igarashi, Koyo Nishida and Junzo Nakamura, Ocular delivery of the beta-blocker, tilisolol, through the prodrug approach. International Journal of Pharmaceutics 93: 49-60 (1993)
  31. Kanetoshi Washio, Osami Makaya, Hitoshi Sasaki, Koyo Nishida, Junzo Nakamura and Juichiro Shibasaki, A new aspect of tolbutamide metabolism in the rabbit: the role of 1-butyl-3-(p-formylphenyl)sulphonylurea. Journal of Pharmacy and Pharmacology 45: 231-233 (1993) PMID: 8483106
  32. Junzo Nakamura, Mitsuhiko Kido, Koyo Nishida and Hitoshi Sasaki, Effect of oral pretreatment with antibiotics on the hydrolysis of salicylic acid-tyrosine and salicylic acid-methionine prodrugs in rabbit intestinal microorganisms. Chemical & Pharmaceutical Bulletin 40: 2572-2575 (1992) PMID: 1446381
  33. Junzo Nakamura, Mitsuhiko Kido, Koyo Nishida and Hitoshi Sasaki, Hydrolysis of salicylic acid-tyrosine and salicylic acid-methionine prodrugs in the rabbit. International Journal of Pharmaceutics 87: 59-66 (1992)
  34. Junzo Nakamura, Kumiko Asai, Koyo Nishida and Hitoshi Sasaki, A novel prodrug of salicylic acid, salicylic acid-glycylglycine conjugate, utilizing the hydrolysis in rabbit intestinal microorganisms. Journal of Pharmacy and Pharmacology 44: 713-716 (1992) PMID: 1360520
  35. Junzo Nakamura, Kumiko Asai, Koyo Nishida and Hitoshi Sasaki, A novel prodrug of salicylic acid, salicylic acid-glutamic acid conjugate utilizing Hydrolysis in rabbit intestinal microorganisms. Chemical & Pharmaceutical Bulletin 40: 2164-2168 (1992) PMID: 1423774
  36. Junzo Nakamura, Michihiro Katayama, Koyo Nishida and Hitoshi Sasaki, An assessment of indomethacin-induced mucosal damage in vivo by measuring the metabolism of salicylamide in rabbit intestine. Chemical & Pharmaceutical Bulletin 40: 1261-1265 (1992) PMID: 1394644
  37. Junzo Nakamura, Michihiro Katayama, Koyo Nishida and Hitoshi Sasaki, An assessment of mucosal damage in vivo: Effect of oral pretreatment with 5-fluorouracil on the intestinal first-pass metabolism of salicylamide in rabbits. Chemical & Pharmaceutical Bulletin 40: 1011-1015 (1992) PMID: 1525929
  38. Junzo Nakamura, Chieko Tagami, Koyo Nishida and Hitoshi Sasaki, Development of a prodrug of salicylic acid, salicylic acid-L-alanine conjugate, utilizing hydrolysis by rabbit intestinal microorganisms. Journal of Pharmacy and Pharmacology 44: 295-299 (1992) PMID: 1355539
  39. Junzo Nakamura, Michihiro Katayama, Koyo Nishida and Hitoshi Sasaki, An assessment of salicylic acid-induced mucosal damage in vivo by measuring the metabolism of salicylamide in rabbit intestine. Chemical & Pharmaceutical Bulletin 40: 815-818 (1992) PubMed PMID: 1611698
  40. Junzo Nakamura, Chieko Tagami, Koyo Nishida and Hitoshi Sasaki, Unequal hydrolysis of salicylic acid-D-alanine and salicylic acid-L-alanine conjugate in rabbit intestinal microorganisms. Chemical & Pharmaceutical Bulletin 40: 547-549 (1992) PMID: 1606656
  41. Junzo Nakamura, Michihiro Katayama, Mitsuhiko Kido, Koyo Nishida and Hitoshi Sasaki, Decrease of gastrointestinal mucosal damage by salicyluric acid compared with salicylic acid in rabbits. Journal of Pharmacy and Pharmacology 43: 766-773 (1991) PMID: 1686904