Here is a list of papers introduced in the recent seminar of our laboratory.
The lab undergraduate/graduate students choose from Alzheimer's disease-related and recently published papers with high impact.
・Apr. 1, 2017 - Mar. 31, 2018 □
・Apr. 1, 2015 - Mar. 31, 2016 □
・Apr. 1, 2014 - Mar. 31, 2015 □
・Apr. 1, 2013 - Mar. 31, 2014 □
・Apr. 1, 2012 - Mar. 31, 2013 □
*, corresponding author; #, equal contribution
Kuhn PH,* Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Muller U, Schweizer M, Saftig P, Brase S, Lichtenthaler SF*
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
Elife 2016;5:e12748
PMID: 26802628
Barr RK,# Verdile G,# Wijaya LK, Morici M, Taddei K, Gupta VB, Pedrini S, Jin L, Nicolazzo JA, Knock E, Fraser PE, Martins RN*
Validation and characterization of a novel peptide that binds monomeric and aggregated β-amyloid and inhibits the formation of neurotoxic oligomers
J Biol Chem 2016;291(2):547-559
PMID: 26538562
Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, Figueroa HY, Goldberg E, Hussaini SA, Duff KE*
Tau pathology induces excitatory neuron loss, grid cell dysfunction, and spatial memory deficits reminiscent of early Alzheimer's disease
Neuron 2017;93(3):533-541
PMID: 28111080
Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH*
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Nature 2016;540(7632):230-235
PMID: 27929004
Michetti C, Castroflorio E, Marchionni I, Forte N, Sterlini B, Binda F, Fruscione F, Baldelli P, Valtorta F, Zara F, Corradi A, Benfenati F*
The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations
Neurobiol Dis 2016;99:66-83
PMID: 28007585
Jay TR, Hirsch AM, Broihier ML, Miller CM, Neilson LE, Ransohoff RM, Lamb BT, Landreth GE*
Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease
J Neurosci 2017;37(3):637-647
PMID: 28100745
Chen PT, Chen ZT, Hou WC, Yu LC, Chen RP*
Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease
Sci Rep 2016;6:29760
PMID: 27407064
Li T,* Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C, Wong PC
The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model
Nat Commun 2016;7:12082
PMID: 27373369
Kobayashi M, Konishi H, Sayo A, Takai T, Kiyama H*
TREM2/DAP12 signal elicits proinflammatory response in microglia and exacerbates neuropathic pain
J Neurosci 36(43):11138-11150
PMID: 27798193
Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay J, Poljak A, Delerue F, Ke YD, Ittner LM*
Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice
Science 354(6314):904-908
PMID: 27856911
Zuhl AM,* Nolan CE, Brodney MA, Niessen S, Atchison K, Houle C, Karanian DA, Ambroise C, Brulet JW, Beck EM, Doran SD, O'Neill BT, Am Ende CW, Chang C, Geoghegan KF, West GM, Judkins JC, Hou X, Riddell DR, Johnson DS*
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors
Nat Commun 2016;7:13042
PMID: 27727204
Katsouri L, Lim YM, Blondrath K, Eleftheriadou I, Lombardero L, Birch AM, Mirzaei N, Irvine EE, Mazarakis ND,* Sastre M*
PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model
Proc Natl Acad Sci U S A 2016;113(43):12292-12297
PMID: 27791018
Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, Hansen DV, Atwal J, Lu Y, Bumbaca D, Pfeifer A, Watts RJ, Muhs A,* Scearce-Levie K,* Ayalon G*
Antibody-mediated targeting of tau in vivo does not require effector function and microglial engagement
Cell Rep 2016;16(6):1690-1700
PMID: 27475227
Brill MS,* Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T*
Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination
Neuron 2016;92(4):845-856
PMID: 27773584
Zhao X, Kotilinek LA, Smith B, Hlynialuk C, Zahs K, Ramsden M, Cleary J, Ashe KH*
Caspase-2 cleavage of tau reversibly impairs memory
Nat Med 2016;22(11):1268-1276
PMID: 27723722
Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, Fuhrmann M*
Dysfunction of somatostatin-positive interneurons associated with memory deficits in an Alzheimer's disease model
Neuron 2016;92(1):114-125
PMID: 27641495
Astorga C, Jorquera RA, Ramirez M, Kohler A, Lopez E, Delgado R, Cordova A, Olguin P, Sierralta J*
Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca2+ channels
Sci Rep 2016;6:32132
PMID: 27573697
Jackman SL, Turecek J, Belinsky JE, Regehr WG*
The calcium sensor synaptotagmin 7 is required for synaptic facilitation
Nature 2016;529(7584):88-91
PMID: 26738595
Sekine Y,* Zyryanova A, Crespillo-Casado A, Fischer PM, Harding HP, Ron D*
Mutations in a translation initiation factor identify the target of a memory-enhancing compound
Science 2015;348(6238):1027-1030
PMID: 25858979
Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM Jr, Dickey CA*
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins
EMBO J 2016;35(14):1537-1549
PMID: 27261198
Manocha GD, Floden AM, Rausch K, Kulas JA, McGregor BA, Rojanathammanee L, Puig KR, Puig KL, Karki S, Nichols MR, Darland DC, Porter JE, Combs CK*
APP regulates microglial phenotype in a mouse model of Alzheimer's disease
J Neurosci 2016;36(32):84718486
PMID: 27511018
Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E*
Reducing endogenous α-synuclein mitigates the degeneration of selective neuronal populations in an Alzheimer's disease transgenic mouse model
J Neurosci 2016;36(30):7971-7984
PMID: 27466341
Yeh FL, Wang Y, Tom I, Gonzalez LC,* Sheng M*
TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia
Neuron 2016;91(2):328-340
PMID: 27477018
Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, Clelland CL, Wray S, Duff KE*
Neuronal activity enhances tau propagation and tau pathology in vivo
Nat Neurosci 2016;19(8):1085-1092
PMID: 27322420
Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ*
Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis
J Cell Biol 2015;211(6):1157-1176
PMID: 26694839
Umeda T, Ono K, Sakai A, Yamashita M, Mizuguchi M, Klein WL, Yamada M, Mori H, Tomiyama T*
Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers
Brain 2016;139(Pt 5):1568-1586
PMID: 27020329
Schoch KM, DeVos SL, Miller RL, Chun SJ, Norrbom M, Wozniak DF, Dawson HN, Bennett CF, Rigo F, Miller TM*
Increased 4R-tau induces pathological changes in a human-tau mouse model
Neuron 2016;90(5):941-947
PMID: 27210553
Beglopoulos V, Tulloch J, Roe AD, Daumas S, Ferrington L, Watson R, Fan Z, Hyman BT, Kelly PA, Bard F, Morris RG*
Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice
Nat Commun 2016;7:11761
PMID: 27249364
Toledo JB,* Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, Adler CH, Beach TG, Trojanowski JQ
Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology
Acta Neuropathol 2016;131(3):393-409
PMID: 26721587
Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B*
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Science 2016;352(6286):712-716
PMID: 27033548
Nicholls RE,* Sontag JM, Zhang H, Staniszewski A, Yan S, Kim CY, Yim M, Woodruff CM, Arning E, Wasek B, Yin D, Bottiglieri T, Sontag E, Kandel ER,* Arancio O
PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments
Proc Natl Acad Sci U S A 2016;113(12):3347-3352
PMID: 26951658
Roy DS, Arons A, Mitchell TI, Pignatelli M, Ryan TJ, Tonegawa S*
Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease
Nature 2016;531(7595):508-512
PMID: 26982728
Ben Halima S, Mishra S, Raja KM, Willem M, Baici A, Simons K, Brustle O, Koch P, Haass C, Caflisch A, Rajendran L*
Specific inhibition of β-secretase processing of the Alzheimer disease amyloid precursor protein
Cell Rep 2016;14(9):2127-2141
PMID: 26923602
Olmos-Serrano JL,# Kang HJ,# Tyler WA,# Silbereis JC,# Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF,* Sestan N*
Down syndrome developmental brain transcriptome reveals defective oligodendrocyte differentiation and myelination
Neuron 2016;89(6):1208-1222
PMID: 26924435
Djelti F, Braudeau J,# Hudry E,# Dhenain M, Varin J, Bieche I, Marquer C, Chali F, Ayciriex S, Auzeil N, Alves S, Langui D, Potier MC, Laprevote O, Vidaud M, Duyckaerts C, Miles R, Aubourg P,# Cartier N*,#
CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease
Brain 2015;138(Pt 8):2383-2398
PMID: 26141492
Suarez-Calvet M, Kleinberger G, Araque Caballero MA, Brendel M, Rominger A, Alcolea D, Fortea J, Lleo A, Blesa R, Gispert JD, Sanchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, Traschutz A, Heneka MT, Struyfs H, Engelborghs S, Sleegers K, Van Broeckhoven C, Zetterberg H, Nellgard B, Blennow K, Crispin A, Ewers M,*,# Haass C*,#
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
EMBO Mol Med 2016;8(5):466-476
PMID: 26941262
Mei Y,# Monteiro P,# Zhou Y, Kim JA, Gao X, Fu Z, Feng G*
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes
Nature 2016;530(7591):481-484
PMID: 26886798
Yamamoto N,* Fujii Y, Kasahara R, Tanida M, Ohora K, Ono Y, Suzuki K, Sobue K
Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways
Glia 2016;64(6):952-962
PMID: 26875818
Moore KM, Girens RE, Larson SK, Jones MR, Restivo JL, Holtzman DM, Cirrito JR, Yuede CM, Zimmerman SD, Timson BF*
A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease
Neurobiol Dis 2016;85:218-224
PMID: 26563933
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