研究業績

2025年

1. Makoto Oba, Hikaru Nonaka, Tomohiro Umeno, Takuma Kato, Mitsunobu Doi, Atsushi Ueda, Masakazu Tanaka
   Redox-responsive side chain structural changes in a seven-membered cyclic α,α-disubstituted α-amino acid with a disulfide bond enable reversible conformational changes in peptides.
   ChemPlusChem 2025, 90, e202400772. （selected as a front cover）
   DOI: 10.1002/cplu.202400772
2. Yiming Hu, Akihiro Iyoshi, Yui Makura, Masakazu Tanaka, Atsushi Ueda
   1,3,4,5-Tetra-O-benzoyl-α-D-tagatopyranose.
   Molbank 2025, 2025, M2041.
   DOI: 10.3390/M2041
3. Yiming Hu, Akihiro Iyoshi, Masakazu Tanaka, Atsushi Ueda
   Methyl α-D-tagatopyranoside.
   Molbank 2025, 2025, M2046.
   DOI: 10.3390/M2046
4. Yui Makura, Akihiro Iyoshi, Makito Horiuchi, Yiming Hu, Masakazu Tanaka, Atsushi Ueda
   α-Selective glycosidation of the rare sugar D-tagatofuranose and the synthesis of α-D-tagatofuranosylceramide
   International Journal of Molecular Sciences 2025, 26, 8549.
   DOI: 10.3390/ijms26178459

2024年

1. Akihiro Iyoshi, Atsushi Ueda, Tomohiro Umeno, Takuma Kato, Kazuhiro Hirayama, Mitsunobu Doi, Masakazu Tanaka
   Conformational analysis and organocatalytic activity of helical stapled peptides containing α-carbocyclic α,α-disubstituted α-amino acids.
   Molecules 2024, 29, 4340.
   DOI: 10.3390/molecules29184340
2. Motoki Naka, Tomohiro Umeno, Mika Shibuya, Yuto Yamaberi, Atsushi Ueda, Masakazu Tanaka, Hiroyasu Takemoto, Makoto Oba
   Intracellular delivery of plasmid DNA using amphipathic helical cell-penetrating peptides containing dipropylglycine.
   Chemical and Pharmaceutical Bulletin 2024, 72, 512–517.
   DOI: 10.1248/cpb.c24-00221
3. Akihiro Iyoshi, Yui Makura, Masakazu Tanaka, Atsushi Ueda
   Stereocontrolled synthesis of α-D-allulofuranosides using α-selective D-fructofuranosidation reaction.
   Carbohydrate Research 2024, 536, 109044.
   DOI: 10.1016/j.carres.2024.109044
4. Akihiro Iyoshi, Yo Miyazaki, Masakazu Tanaka, Atsushi Ueda
   (S,Z)-1,4-Bis(benzyloxy)hexa-3,5-dien-2-ol.
   Molbank, 2024, 2024, M1848.
   DOI: 10.3390/M1848

2023年

1. Makoto Oba, Mika Shibuya, Yuto Yamaberi, Hidetomo Yokoo, Satoshi Uchida, Atsushi Ueda, Masakazu Tanaka
   An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery.
   Chemical and Pharmaceutical Bulletin 2023, 71, 250-256.
   DOI: 10.1248/cpb.c22-00852
2. Makoto Oba, Shun Nakajima, Kurumi Misao, Hidetomo Yokoo, Masakazu Tanaka
   Effect of helicity and hydrophobicity on cell-penetrating ability of arginine-rich peptides.
   Bioorganic & Medicinal Chemistry 2023, 91, 117409.
   DOI: 10.1016/j.bmc.2023.117409
3. Die Hu, Shintaro Fumoto, Naoki Yoshikawa, Jianqing Peng, Hirotaka Miyamoto, Masakazu Tanaka, Koyo Nishida
   Diffusion coefficient of cationic liposomes during lipoplex formation determines transfection efficiency in HepG2 cells.
   International Journal of Pharmaceutics 2023, 637, 122881.
   DOI: 10.1016/j.ijpharm.2023.122881

2022年

1. Atsushi Ueda, Yui Makura, Sana Kakazu, Takuma Kato, Tomohiro Umeno, Kazuhiro Hirayama, Mitsunobu Doi, Makoto Oba, Masakazu Tanaka
   E-Selective Ring-Closing Metathesis in α-Helical Stapled Peptides Using Carbocyclic α,α-Disubstituted α-Amino Acids.
   Organic Letters 2022, 24, 1049-1054.
   DOI: 10.1021/acs.orglett.1c04256
2. Hidetomo Yokoo, Takashi Misawa, Takuma Kato, Masakazu Tanaka, Yosuke Demizu, Makoto Oba
   Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine.
   Bioorganic & Medicinal Chemistry 2022, 72, 116997.
   DOI: 10.1016/j.bmc.2022.116997
3. Die Hu, Shintaro Fumoto, Hirotaka Miyamoto, Masakazu Tanaka, Koyo Nishida
   Flavonoids Enhance Lipofection Efficiency and Ameliorate Cytotoxicity in Colon26 and HepG2 Cells via Oxidative Stress Regulation.
   Pharmaceutics 2022, 14, 1203.
   DOI: 10.3390/pharmaceutics14061203
4. 岸川直哉, 沼田 翔, 梅野智大, Mahmoud EL-MAGHRABEY, 大山 要, 田中正一, 黒田直敬
   非天然型アミノ酸を含むペプチドにより修飾したHPLC固定相の調製とその評価.
   分析化学 2022, 71, 351-356.
   DOI: 10.2116/bunsekikagaku.71.351

2021年

1. Kazuki Sato, Tomohiro Umeno, Atsushi Ueda, Takuma Kato, Mitsunobu Doi, Masakazu Tanaka
   Asymmetric 1,4‐Addition Reactions Catalyzed by N‐Terminal Thiourea‐Modified Helical L‐Leu Peptide with Cyclic Amino Acids.
   Chemistry – A European Journal 2021, 27, 11216-11220.
   DOI: 10.1002/chem.202101252
2. Yuto Yamaberi, Ryo Eto, Tomohiro Umeno, Takuma Kato, Mitsunobu Doi, Hidetomo Yokoo, Makoto Oba, Masakazu Tanaka
   Synthesis of (S)-(-)-Cucurbitine and Conformation of Its Homopeptides.
   Organic Letters 2021, 23, 4358-4362.
   DOI: 10.1021/acs.orglett.1c01291
3. Yui Makura, Atsushi Ueda, Takuma Kato, Akihiro Iyoshi, Mei Higuchi, Mitsunobu Doi, Masakazu Tanaka
   X-ray Crystallographic Structure of α-Helical Peptide Stabilized by Hydrocarbon Stapling at i,i + 1 Positions.
   International Journal of Molecular Sciences 2021, 22, 5364.
   DOI: 10.3390/ijms22105364
4. Takuma Kato, Yuki Kita, Kazuki Iwanari, Akiko Asano, Makoto Oba, Masakazu Tanaka, Mitsunobu Doi
   Synthesis of six-membered carbocyclic ring α,α-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide.
   Bioorganic & Medicinal Chemistry 2021, 38, 116111.
   DOI: 10.1016/j.bmc.2021.116111
5. Satoshi Uchida, Yuto Yamaberi, Masakazu Tanaka, Makoto Oba
   A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA.
   Nanoscale 2021, 13, 18941-18946.
   DOI: 10.1039/D1NR03600A

2020年

1. Atsushi Ueda, Misuzu Ikeda, Takuya Kasae, Mitsunobu Doi, Yosuke Demizu, Makoto Oba, Masakazu Tanaka
   Synthesis of Chiral α‐Trifluoromethyl α,α‐Disubstituted α‐Amino Acids and Conformational Analysis of L‐Leu‐Based Peptides with ( R )‐ or ( S )‐α‐Trifluoromethylalanine.
   ChemistrySelect 2020, 5, 10882-10886.
   DOI: 10.1002/slct.202002888
2. Kaori Furukawa, Masakazu Tanaka, Makoto Oba
   siRNA delivery using amphipathic cell-penetrating peptides into human hepatoma cells.
   Bioorganic & Medicinal Chemistry 2020, 28, 115402.
   DOI: 10.1016/j.bmc.2020.115402
3. Atsushi Ueda, Mei Higuchi, Kazuki Sato, Tomohiro Umeno, Masakazu Tanaka
   Design and Synthesis of Helical N-Terminal L-Prolyl Oligopeptides Possessing Hydrocarbon Stapling.
   Molecules 2020, 25, 4667.
   DOI: 10.3390/molecules25204667
4. Atsushi Ueda, Jinhong Pi, Yui Makura, Masakazu Tanaka, Jun'ichi Uenishi
   Stereoselective synthesis of (+)-5-thiosucrose and (+)-5-thioisosucrose.
   RSC Advances 2020, 10, 9730-9735.
   DOI: 10.1039/d0ra01033b
5. Keisuke Tsuchiya, Tomohiro Umeno, Genichiro Tsuji, Hidetomo Yokoo, Masakazu Tanaka, Kiyoshi Fukuhara, Yosuke Demizu, Takashi Misawa
   Development of Photoswitchable Estrogen Receptor Ligands.
   Chemical & Pharmaceutical Bulletin 2020, 68, 398-402.
   DOI: 10.1248/cpb.c19-01108

2019年

1. Makoto Oba, Yu Nagano, Takuma Kato, Masakazu Tanaka
   Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers.
   Scientific Reports 2019, 9, 1349.
   DOI: 10.1038/s41598-018-38063-8
2. Makoto Oba, Yurika Ito, Tomohiro Umeno, Takuma Kato, Masakazu Tanaka
   Plasmid DNA delivery using cell-penetrating peptide foldamers composed of Arg-Arg-Aib repeating sequences.
   ACS Biomaterials Science & Engineering 2019, 5, 5660-5668.
   DOI: 10.1021/acsbiomaterials.8b01451
3. Takashi Misawa, Nobumichi Ohoka, Makoto Oba, Hiroko Yamashita, Masakazu Tanaka, Mikihiko Naito, Yosuke Demizu
   Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers (CPFs) for efficient siRNA delivery.
   Chemical Communications 2019, 55, 7792-7795.
   DOI: 10.1039/C9CC02203A
4. Tomohiro Umeno, Atsushi Ueda, Mitsunobu Doi, Takuma Kato, Makoto Oba, Masakazu Tanaka
   Helical foldamer-catalyzed enantioselective 1,4-addition reaction of dialkyl malonates to cyclic enones.
   Tetrahedron Letters 2019, 60, 151301.
   DOI: 10.1016/j.tetlet.2019.151301
5. Atsushi Ueda, Mei Higuchi, Tomohiro Umeno, Masakazu Tanaka
   Enantioselective synthesis of 2,4,5-trisubstituted tetrahydropyrans via peptide-catalyzed Michael addition followed by Kishi’s reductive cyclization.
   Heterocycles 2019, 99, 989-1002.
   DOI: 10.3987/com-18-s(f)63
6. Yui Makura, Atsushi Ueda, Takashi Matsuzaki, Tetsuo Minamino, Masakazu Tanaka
   α-Selective glycosidation of D-tagatofuranose with a 3,4-O-isopropylidene protection.
   Tetrahedron 2019, 75, 3758-3766.
   DOI: 10.1016/j.tet.2019.05.052
7. Makoto Oba
   Cell-penetrating peptide foldamers: Drug delivery tools.
   ChemBioChem 2019, 20, 2041-2045.
   DOI: 10.1002/cbic.201900204
8. 大庭 誠, 梅澤直樹, 出水庸介
   フォルダマーの魅力–設計・構造・機能–.
   薬学雑誌 2019, 139, 579-580.
   DOI: 10.1248/yakushi.18-00179-F
9. 大庭 誠
   ペプチドフォルダマーの構造制御と膜透過機能.
   薬学雑誌 2019, 139, 599-608.
   DOI: 10.1248/yakushi.18-00179-3