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Original Articles


Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H
ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.
Cell Death Differ in press [NEW]

Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S
Structures of PGAM5 provide insight into active site plasticity and multimeric assembly.
Structure 25, 1089-1099 (2017)

Honda S, Sadatomi D, Yamamura Y, Nakashioya K, Tanimura S, Takeda K
WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3.
Cancer Sci 108, 520-527 (2017)

Sadatomi D, Nakashioya K, Mamiya S, Honda S, Kameyama Y, Yamamura Y, Tanimura S, Takeda K
Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation.
J Biochem 161, 503-512 (2017)


Tanimura S, Hashizume J, Arichika N, Watanabe K, Ohyama K, Takeda K, Kohno M
ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips.
J Cell Biol 214, 475-489 (2016)

Furuoka M, Ozaki K, Sadatomi D, Mamiya S, Yonezawa T, Tanimura S, Takeda K
TNF-α induces caspase-1 activation independently of simultaneously induced NLRP3 in 3T3-L1 cells.
J Cell Physiol 231, 2761-2727 (2016)

Ozaki KI, Awazu M, Tamiya M, Iwasaki Y, Harada A, Kugisaki S, Tanimura S, Kohno M
Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes.
Am J Physiol Endocrinol Metab 310, E643-E651 (2016)

Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
ASK1 signaling regulates brown and beige adipocyte function.
Nat Commun 7, 11158 (2016)

Sekine S, Yao A, Hattori K, Sugawara S, Naguro I, Koike M, Uchiyama Y, Takeda K, Ichijo H
The ablation of mitochondrial protein phosphatase PGAM5 confers resistance against metabolic stress.
EBioMedicine 5, 82-92 (2016)

Maruyama J, Kobayashi Y, Umeda T, Vandewalle A, Takeda K, Ichijo H, Naguro I
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.
Sci Rep 6, 18710 (2016)


Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Sci Signal 8, ra78 (2015)


Mosallanejad K, Sekine Y, Ishikura-Kinoshita S, Kumagai K, Nagano T, Matsuzawa A, Takeda K, Naguro I, Ichijo H
DHX15, a DEAH-box RNA helicase, activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.
Sci Signal 7, ra40 (2014)

Mizukami J, Sato T, Camps M, Ji H, Rueckle T, Swinnen D, Tsuboi R, Takeda K, Ichijo H
ASK1 promotes the contact hypersensitivity response through IL-17 production.
Sci Rep 4, 4714 (2014)

Matsui H, Fukuno N, Kanda Y, Kantoh Y, Chida T, Nagaura Y, Suzuki O, Nishitoh H, Takeda K, Ichijo H, Sawada Y, Sasaki K, Kobayashi T, Tamura S
The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.
J Biol Chem 289, 6438-6450 (2014)


Homma K., Fujisawa T, Tsuburaya N, Yamaguchi N, Kadowaki H, Takeda K, Nishitoh H, Matsuzawa A, Naguro I, Ichijo H
SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.
Mol Cell 52, 75-86 (2013)

Sakamoto T, Ozaki K, Fujio K, Kajikawa S, Uesato S, Watanabe K, Tanimura S, Koji T, Kohno M
Blockade of the ERK pathway enhances the therapeutic efficacy of the histone deacetylase inhibitor MS-275 in human tumor xenograft models.
Biochem Biophys Res Commun 433, 456–462 (2013)

Yamaguchi K, Takeda K, Kadowaki H, Ueda I, Namba Y, Ouchi Y, Nishitoh H, Ichijo H
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic beta cell exhaustion.
Biochim Biophys Acta 1830, 3656-3663 (2013)

Waheed F, Dan Q, Amoozadeh Y, Zhang Y, Tanimura S, Speight P, Kapus A, Szászi K
Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.
Mol Biol Cell 24, 1068-1082 (2013)


Naguro I, Umeda T, Kobayashi Y, Maruyama J, Hattori K, Shimizu Y, Kataoka K, Kim-Mitsuyama S, Uchida S, Vandewalle A, Noguchi T, Nishitoh H, Matsuzawa A, Takeda K, Ichijo H
ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.
Nat Commun 3, 1285 (2012)

Sekine Y, Hatanaka R, Watanabe T, Sono N, Iemura S, Natsume T, Kuranaga E, Miura M, Takeda K, Ichijo H
The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
Mol Cell 48, 692-704 (2012)

Hayakawa Y, Hirata Y, Sakitani K, Nakagawa H, Nakata W, Kinoshita H, Takahashi R, Takeda K, Ichijo H, Maeda S, Koike K
Apoptosis signal-regulating kinase -1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.
Cancer Sci 103, 2181-2185 (2012)

Sekine S, Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda K, Ichijo H
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
J Biol Chem 287, 34635-34645 (2012)

Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, Matsuzawa A, Takeda K, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Ichijo H
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Ann Neurol 72, 739-749 (2012)

Ishida Y, Sekine Y, Oguchi H, Chihara T, Miura M, Ichijo H, Takeda K
Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
PLoS ONE 7, e30265 (2012)

Kawabata T, Tanimura S, Asai K, Kawasaki R, Matsumaru Y, Kohno M
Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death Induced by the combination of ERK Kinase (MEK) Inhibitor and microtubule Inhibitor.
J Biol Chem 287, 10289-10300 (2012)


Sekine Y, Takagahara S, Hatanaka R, Watanabe T, Oguchi H, Noguchi T, Naguro I, Kobayashi K, Tsunoda M, Funatsu T, Nomura H, Toyoda T, Matsuki N, Kuranaga E, Miura M, Takeda K, Ichijo H
p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
J Cell Sci 124, 3006-3016 (2011)

Nakagawa H, Hirata Y, Takeda K, Hayakawa Y, Sato T, Kinoshita H, Sakamoto K, Nakata W, Hikiba Y, Omata M, Yoshida H, Koike K, Ichijo H, Maeda S
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK.
Hepatology 54, 185-195 (2011)

Hayakawa T, Kato K, Hayakawa R, Hisamoto N, Matsumoto K, Takeda K, Ichijo H
Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins.
Genetics 187, 785-792 (2011)

Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Kinoshita H, Nakata W, Takahashi R, Tateishi K, Tada M, Akanuma M, Yoshida H, Takeda K, Ichijo H, Omata M, Maeda S. Koike K
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
Proc Natl Acad Sci USA 108, 780-785 (2011)

Okamoto M, Saito N, Kojima H, Okabe T, Takeda K, Ichijo H, Furuya T, Nagano T
Identification of novel ASK1 inhibitors using virtual screening.
Bioorg Med Chem 19, 486-489 (2011)

Tanimura S, Hashizume J, Kurosaki Y, Sei K, Gotoh A, Ohtake R, Kawano M, Watanabe K, Kohno M
SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase-mediated phosphorylation.
Genes Cells 16, 514-526 (2011)


Imai Y, Kanao T, Sawada T, Kobayashi Y, Moriwaki Y, Ishida Y, Takeda K, Ichijo H, Lu B, Takahashi R
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
PLoS Genet 6, e1001229 (2010)

Maruyama T, Kadowaki H, Okamoto N, Nagai A, Naguro I, Matsuzawa A, Shibuya H, Tanaka K, Murata S, Takeda K, Nishitoh H, Ichijo H
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
EMBO J 29, 2501-2514 (2010)

Kumakura K, Nomura H, Toyoda T, Hashikawa K, Noguchi T, Takeda K, Ichijo H, Tsunoda M, Funatsu T, Ikegami D, Narita M, Suzuki T, Matsuki N
Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.
Neurosci Res 66, 313-320 (2010)


Nagai H, Noguchi T, Homma K, Katagiri K, Takeda K, Matsuzawa A, Ichijo H
Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.
Mol Cell 36, 805-818 (2009)

Takeda K, Komuro Y, Hayakawa T, Oguchi H, Ishida Y, Murakami S, Noguchi T, Kinoshita H, Sekine Y, Iemura S, Natsume T, Ichijo H
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
Proc Natl Acad Sci USA 106, 12301-12305 (2009)

Kundu M, Pathak SK, Kumawat K, Basu S, Chatterjee G, Pathak S, Noguchi T, Takeda K, Ichijo H, Thien CBF, Langdon WY, Basu J
A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
Nat Immunol 10, 918-926 (2009)

Iriyama T, Takeda K, Nakamura H, Morimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto I, Inazawa J, Chida K, Kamei Y, Kozuma S, Taketani Y, Matsuzawa A, Ichijo H
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
EMBO J 28, 843-853 (2009)

Nagai A, Kadowaki H, Maruyama T, Takeda K, Nishitoh H, Ichijo H
USP14 inhibits ER-associated degradation via interaction with IREα.
Biochem Biophys Res Commun 379, 995-1000 (2009)


Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, Ichijo H
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
Genes Dev 22, 1451-1464 (2008)

Noguchi T, Ishii K, Fukutomi H, Naguro I, Matsuzawa A, Takeda K, Ichijo H
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracellular ATP-induced apoptosis in macrophage.
J Biol Chem 283, 7657-7665 (2008)

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