論文発表

２０２１年

1.      Yamaberi Y, Eto R, Umeno T, Kato T, Doi M, Yokoo H, Oba M, Tanaka M: Synthesis of (S)-(-)-Cucurbitine and Conformation of Its Homopeptides.  Org. Lett. 2021, 23, 4358-4362 (Supplementary cover) .

2.      Makura Y, Ueda A, Kato T, Iyoshi A, Higuchi M, Doi M, Tanaka M: X-​ray crystallographic structure of α-​helical peptide stabilized by hydrocarbon stapling at i, i+1 positions.  Int. J. of Mol. Sci., 2021, 22, 5364. 

3.      Sato K, Umeno T, Ueda A, Kato T, Doi M, Tanaka M, Asymmetric 1,4-addition reactions catalyzed by N-terminal thiourea-modified helical L-Leu-peptide with cyclic amino acids.  Chem. Eur. J. 2021, 27, 11216-11220.

4.      Kato T, Kita Y, Iwanari K, Asano A, Oba M, Tanaka M, Doi M: Synthesis of six-membered carbocyclic ring α,α-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide. Bioorg. Med. Chem., 2021, 38, 116111/

5.      Uchida S, Yamaberi Y, Tanaka M, Oba M: A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of delivered mRNA. Nanoscale, 2021, in press.  

２０２０年

Furukawa K, Tanaka M, Oba M: siRNA delivery using amphipathic cell-​penetrating peptides into human hepatoma cells.  Bioorg Med Chem 28: 115402, 2020.

5.      Ueda A, Pi J, Makura Y, Tanaka M, Uenishi, J: Stereoselective synthesis of (+)​-​5-​thiosucrose and (+)​-​5-​thioisosucrose.  RSC Advances 10: 9730-9735, 2020.

6.      Tsuchiya K, Umeno T, Tsuji G, Yokoo H, Tanaka M, Fukuhara K, Demizu Y, Misawa T: Development of photoswitchable estrogen receptor ligands. Chem Pharm Bull,  68(4), 398-402, 2020. 　

7.      Ueda A, Ikeda M, Kasae T, Doi M, Demizu Y, Oba M, Tanaka M: Synthesis of chiral α-trifluoromethyl α,α-disubstituted α-amino acids and conformational analysis of L-Leu-based peptides with (R)- or (S)-α-trifluoromethylalanine.  ChemSelect 5: 10882-10886, 2020.

8.      Ueda A, Higuchi M, Sato K, Umeno T, Tanaka M: Design and synthesis of helical N-terminal L-prolyl oligopeptides possessing hydrocarbon stapling.  Molecule 25: 4667, 2020. 

２０１９年

9.      Oba M, Nagano Y, Kato T, Tanaka M: Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers. Sci Rep 9: 1349, 2019.

10.   Oba M, Ito Y, Umeno T, Kato T, Tanaka M: Plasmid DNA delivery using cell-penetrating peptide foldamers composed of Arg-Arg-Aib repeating sequences. ACS Biomater Sci Eng 5: 5660-5668, 2019.

11.   Misawa T, Ohoka N, Oba M, Yamashita H, Tanaka M, Naito M, Demizu Y: Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers (CPFs) for efficient siRNA delivery. Chem Commun 55: 7792-7795, 2019.

12.   Umeno T, Ueda A, Doi M, Kato T, Oba M, Tanaka M: Helical foldamer-catalyzed enantioselective 1,4-addition reaction of dialkyl malonates to cyclic enones. Tetrahedron Lett 60: 151301, 2019.

13.   Ueda A, Higuchi M, Umeno T, Tanaka M: Enantioselective synthesis of 2,4,5-trisubstituted tetrahydropyrans via peptide-catalyzed Michael addition followed by Kishi’s reductive cyclization. Heterocycles 99: 989-1002, 2019.

14.   Makura Y, Ueda A, Matsuzaki T, Minamino T, Tanaka M: α-Selective glycosidation of D-tagatofuranose with a 3,4-O-isopropylidene protection. Tetrahedron 75: 3758-3766, 2019.

２０１８年

15.   Oba M, Ito C, Tanaka M: Effects of five-membered ring amino acid incorporation into peptides for coiled coil formation. Bioorg Med Chem Lett 28 (5): 875-877, 2018.

16.   Kobayashi H, Misawa T, Oba M, Hirata N, Kanda Y, Tanaka M, Matsuno K, Demizu Y: Structural development of cell-penetrating peptides containing cationic proline derivatives. Chem Pharm Bull 66 (5): 575-580, 2018.

17.   Kato T, Oba M, Nishida K, Tanaka M: Cell-penetrating peptides using cyclic a,a-disubstituted a-amino acids with basic functional groups. ACS Biomat Sci Eng 4 (4): 1368-1376, 2018.

18.   Tanaka M, Yakabi H, Nakatani H, Ueda A, Doi M, Oba M: Helical structures of cyclopentene-based a,a-disubstituted a-amino acid homopeptides. Chimia 72 (12): 848-852, 2018.

19.   Koba Y, Ueda A, Oba M, Doi M, Kato T, Demizu Y, Tanaka M: Left-handed helix of three-membered ring amino acid homopeptide interrupted by an N–H···ethereal O type hydrogen bond. Org Lett 20 (24): 7830-7834, 2018.

20.   Ueda A, Nishimura Y, Makura Y, Tanaka M, Uenishi J: b-Selective D-psicofuranosylation of pyrimidine bases and thiols. Heterocycles 97 (2): 729-743, 2018.

21.   Wang S, Fumoto S, Miyamoto H, Tanaka M, and Nishida K: Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice. Int J Pharm 548 (1): 173-181, 2018.

２０１７年

22.   Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y: Development of helix-stabilized cell-penetrating peptides containing cationic a,a-disubstituted amino acids as helical promoters. Bioorg Med Chem 25(6): 1846-1851, 2017.

23.   Oba M, Kunitake M, Kato T, Ueda A, Tanaka M: Enhanced and prolonged cell-penetrating abilities of arginine-rich peptides by introducing cyclic a,a-disubstituted a-amino acids with stapling. Bioconjugate Chem 28(7): 1801-1806, 2017.

24.   Furukawa K, Oba M, Toyama K, Opiyo GO, Demizu Y, Kurihara M, Doi M, Tanaka M: Low pH-triggering changes in peptide secondary structures. Org Biomol Chem 15(30): 6302-6305, 2017 (Cover picture).

25.   Koba Y, Ueda A, Oba M, Doi M, Demizu Y, Kurihara M, Tanaka M: Helical L-Leu-based peptides having chiral five-membered carbocyclic ring amino acids with an ethylene acetal moiety. ChemistrySelect 2: 8108-8114, 2017.

26.   Eto R, Oba M, Ueda A, Uku T, Doi M, Matsuo Y, Tanaka T, Demizu Y, Kurihara M, Tanaka M: Diastereomeric right- and left-handed helical structures with fourteen (R)-chiral centers. Chem Eur J 23(72): 18120-18124, 2017.

27.   Chen Q, Osada K, Ge Z, Uchida S, Tockary TA, Dirisala A, Matsui A, Toh K, Takeda KM, Liu X, Nomoto T, Ishii T, Oba M, Matsumoto Y, Kataoka K: Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials 113: 253-265, 2017.