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Selected Papers
| 1. | Ishida, Y., Sekine,Y., Oguchi, H., Chihara, T., Miura, M., Ichijo, H. and Takeda, K. Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster. |
| PLoS ONE 7, e30265 (2012)@ | |
| 2. | Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K. and Ichijo,H. p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. |
| J.Cell Sci124,3006-3016(2011) | |
| 3. | Nakagawa, H., Hirata, Y., Takeda, K., Hayakawa, Y., Sato, T., Kinoshita, H., Sakamoto, K., Nakata, W., Hikiba, Y., Omata, M., Yoshida, H., Koike, K. Ichijo, H. and Maeda, S. Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK. |
| Hepatology 54, 185-195 (2011) | |
| 4. | Hayakawa, T., Kato, K., Hayakawa, R., Hisamoto, N., Matsumoto, K., Takeda, K. and Ichijo, H. Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins. |
| Genetics 187, 785-792 (2011) | |
| 5. | Hayakawa, Y., Hirata, Y., Nakagawa, H., Sakamoto, K., Hikiba, Y., Kinoshita, H., Nakata, W., Takahashi, R., Tateishi, K., Tada, M., Akanuma, M., Yoshida, H., Takeda, K., Ichijo, H., Omata, M., Maeda, S. and Koike, K. Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer. |
| Proc. Natl. Acad. Sci. USA. 108, 780-785 (2011) | |
| 6. | Okamoto, M., Saito, N., Kojima, H., Okabe, T., Takeda, K., Ichijo, H., Furuya, T. and Nagano, T. Identification of novel ASK1 inhibitors using virtual screening. |
| Bioorg. Med. Chem. 19, 486-489 (2011) | |
| 7. | Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B. and Takahashi, R. The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. |
| PLoS Genet.6, e1001229 (2010) | |
| 8. | Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H. and Ichijo, H. CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. |
| EMBO J.29, 2501-2514 (2010) | |
| 9. | Kumakura, K., Nomura, H., Toyoda, T., Hashikawa, K., Noguchi, T., Takeda, K., Ichijo, H., Tsunoda, M., Funatsu, T., Ikegami, D., Narita, M., Suzuki, T. and Matsuki, N. Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice. |
| Neurosci. Res. 66, 313-320 (2010) | |
| 10. | Nagai, H., Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A. and Ichijo, H. Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. |
| Mol. Cell 36, 805-818 (2009) | |
| 11. | Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T. and Ichijo, H. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. |
| Proc. Natl. Acad. Sci. USA. 106, 12301-12305 (2009) | |
| 12. | Kundu, M., Pathak, S. K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S., Noguchi, T., Takeda, K., Ichijo, H., Thien, C. B. F., Langdon, W. Y. and Basu, J. A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. |
| Nat. Immunol. 10, 918-926 (2009) | |
| 13. | Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and Ichijo, H. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. |
| EMBO J. 28, 843-853 (2009) | |
| 14. | Nagai, A., Kadowaki, H., Maruyama, T., Takeda, K., Nishitoh, H. and Ichijo, H. USP14 inhibits ER-associated degradation via interaction with IREฟ. |
| Biochem. Biophys. Res. Commun. 379, 995-1000 (2009) | |
| 15. | Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K. and Ichijo, H. ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. |
| Genes Dev. 22, 1451-1464 (2008) | |
| 16. | 16. Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K. and Ichijo, H. Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracellular ATP-induced apoptosis in macrophage. |
| J. Biol. Chem. 283, 7657-7665 (2008) | |
| 17. | Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K. and Ichijo, H. Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. |
| Mol. Cell. Biol. 27, 8152-8163 (2007) | |
| 18. | Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K. and Ichijo, H. ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds. |
| J. Cell Biol. 176, 903-909 (2007) | |
| 19. | Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A. and Ichijo, H. Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1. |
| J. Biol. Chem. 282, 7522-7531 (2007) | |
| 20. | Mizumura, K., Takeda, K., Hashimoto, S., Horie, T. and Ichijo, H. Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade. |
| J. Cell. Physiol. 206, 363-370 (2006) | |
| 21. | Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J. and Ichijo, H. Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death. |
| J. Biol. Chem. 280, 37033-37040 (2005) | |
| 22. | Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K. and Ichijo, H. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. |
| Nat. Immunol. 6, 587-592 (2005) | |
| 23. | Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K. and Ichijo, H. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. |
| Nat. Immunol. 6, 587-592 (2005) | |
| 24. | Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Yodoi, J., Urano, Y., Nagano, T. and Ichijo, H. Amyloid ภ induces neuronal cell death through ROS-mediated ASK1 activation. |
| Cell Death Differ. 12, 19-24 (2005) | |
| 25. | Takeda, K., Matsuzawa, A., Nishitoh, H., Tobiume, K., Kishida, S., Ninomiya-Tsuji, J., Matsumoto, K. and Ichijo, H. Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. |
| EMBO Rep. 5, 161-166 (2004) | |
| 26. | Inoshita, S., Takeda, K., Hatai, T., Terada, Y., Sano, M., Hata, J., Umezawa, A. and Ichijo, H.@Phosphorylation and inactivation of Mcl-1 by c-Jun N-terminal kinase (JNK) in response to oxidative stress. |
| J. Biol. Chem. 277, 43730-43734 (2002) | |
| 27. | Matsuura, H., Nishitoh, H., Takeda, K., Matsuzawa, A., Amagasa, T., Ito, M., Yoshioka, K. and Ichijo, H. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway: a new mode of regulation of the MAP kinase cascade. |
| J. Biol. Chem. 277, 40703-40709 (2002) | |
| 28. | Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A. and Ichijo, H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. |
| Genes Dev. 16, 1345-1355 (2002) | |
| 29. | Geleziunas, R., Xu, W., Takeda, K., Ichijo, H. and Greene W.C. HIV-1 Nef inhibits ASK1-dependent death signaling providing a potential mechanism for protecting the infected host cell. |
| Nature 410, 834-838 (2001) | |
| 30. | Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T. and Ichijo, H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. |
| EMBO Rep. 2, 222-228 (2001) | |
| 31. | Sawada, Y., Nakamura, K., Doi, K., Takeda, K., Tobiume, K., Saitoh, M., Morita, K., Komuro, I., De Vos, K., Sheetz, M. and Ichijo, H. Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase. |
| J. Cell Sci. 114, 1221-1227 (2001) | |
| 32. | Mochida, Y., Takeda, K., Saitoh, M., Nishitoh, H., Amagasa, T., Ninomiya-Tsuji, J., Matsumoto, K. and Ichijo, H. ASK1 inhibits Interleukin-1-induced NF-kB activity through disruption of TRAF6-TAK1 interaction. |
| J. Biol. Chem.275, 32747-32752 (2000) | |
| 33. | Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H. and Takeda, K. Execution of ASK1-induced apoptosis by the mitochondria-dependent caspase activation. |
| J. Biol. Chem. 275, 26576-26581 (2000) | |
| 34. | Takeda, K., Hatai, T., Hamazaki, T. S., Nishitoh, H., Saitoh, M. and Ichijo, H. Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells. |
| J. Biol. Chem. 275, 9805-9813 (2000) | |
| 35. | ๖Kanamoto, T., ๖Mota, M., ๖Takeda, K., Rubin, L. L., Miyazono, K., Ichijo, H. and Bazenet, C. E. Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons. (๖ Equally contributed authors). |
| Mol. Cell Biol.20, 196-204 (2000) | |
| 36. | Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K. and Ichijo, H. ASK1 is essential for JNK/SAPK activation by TRAF2. |
| Mol. Cell 2, 389-395 (1998) | |
| 37. | Takeda, K., Ichijo, H., Fujii, M., Mochida, Y., Saitoh, M., Nishitoh, H., Sampath, T. K. and Miyazono, K. Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA. |
| J. Biol. Chem. 273, 17079-17085 (1998) | |
| 38. | Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K. and Ichijo, H. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. |
| EMBO J. 17, 2596-2606 (1998) | |
| 39. | Tobiume, K., Inage, T., Takeda, K., Enomoto, S., Miyazono, K. and Ichijo, H. Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. |
| Biochem. Biophys.Res. Commun. 239, 905-910 (1997) |
Review Articles
| 1. | Takeda, K. PGAM5: a novel type of protein serine/threonine phosphatase that exists in the mitochondria. |
| J. Oral Biosci. 53, 122-127 (2011) | |
| 2. | Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H. Apoptosis signaling kinases: from stress response to health outcomes. |
| Antioxid. Redox Signal.15, 719-761 (2011) | |
| 3. | Matsuzawa, A., Takeda, K. and Ichijo, H. ASK1. |
| UCSD-Nature Molecule Pages (2010) (doi:10.1038/mp.a002816.01) | |
| 4. | Maruyama, J., Naguro, I., Takeda, K., and Ichijo, H. Stress-activated MAP kinase cascades in cellular senescence. |
| Curr. Med. Chem. (review article) 16, 1229-1235 (2009) | |
| 5. | Hatanaka, R., Sekine, Y., Hayakawa, T., Takeda, K. and Ichijo, H. Signaling pathways in invertebrate immune and stress response. |
| ISJ (Invertebrate Survival Journal) 6, 32-43 (2009) | |
| 6. | Takeda, K., Noguchi, T., Naguro, I. and Ichijo, H. Apoptosis signal-regulating kinase 1 in stress and immune response. |
| Annu. Rev. Pharmacol. Toxicol. 48, 199-225 (2008) | |
| 7. | Fujisawa, T., Takeda, K. and Ichijo, H. ASK family proteins in stress response and disease. |
| Mol. Biotechnol. 37, 13-18 (2007) | |
| 8. | Murakami, S., Noguchi, T., Takeda, K. and Ichijo, H. Stress signaling in cancer. |
| Cancer Sci. 98, 1521-1527 (2007) | |
| 9. | Nagai, H., Noguchi, T., Takeda, K. and Ichijo, H. Pathophysiological roles of ASK1-MAP kinase signaling pathways. |
| J. Biochem. Mol. Biol. 40, 1-6 (2007) | |
| 10. | Fujino, G., Noguchi, T., Takeda, K. and Ichijo, H. Thioredoxin and protein kinases in redox signaling. |
| Semin. Cancer Biol. 16, 427-435 (2006) | |
| 11. | Hayakawa, T., Matsuzawa, A., Noguchi, T., Takeda, K. and Ichijo, H. The ASK1-MAP kinase pathways in the immune and stress responses. |
| Microbes Infect. 8, 1098-1107 (2006) | |
| 12. | Sekine, Y., Takeda, K. and Ichijo, H. The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. |
| Curr. Mol. Med. 6, 87-97 (2006) | |
| 13. | Takeda, K., Noguchi, T. and Ichijo, H. ASK1 signalosome: a signaling complex essential for stress responses. |
| J. Oral Biosci. 48, 7-11 (2006) | |
| 14. | Matsukawa, J., Matsuzawa, A., Takeda, K. and Ichijo, H. The ASK1-MAP kinase cascades in mammalian stress response. |
| J. Biochem. 136, 261-265 (2004) | |
| 15. | Takeda, K., Matsuzawa, A., Nishitoh, H. and Ichijo, H. Roles of MAPKKK ASK1 in stress-induced cell death. |
| Cell Struct. Funct. 28, 23-29 (2003) | |
| 16. | Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K. and Ichijo, H. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. |
| Antioxid. Redox Signal. 4, 415-425 (2002) | |
| 17. | Takeda, K. and Ichijo, H. Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system. |
| Genes Cells7, 1099-1111 (2002) |