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1995
  1. Misawa H, UEDA H, Katada T, Ui M and Satoh M
    A subtype of opioid kappa-receptor is coupled to inhibition of Gi1-mediated
    phospholipase C activity in the guinea pig cerebellum
    FEBS  Lett. 361(1): 106-110, 1995
  2. UEDA H, Sato K, Okumura F, Inoue A, Nakata Y, Ozaki N, Yue J-L and Misu Y
    Supersensitization of neurochemical responses by L-DOPA and dopamine
    receptor agonists in the striatum of experimental Parkinson's disease model
    rats
    Biomed and Pharmacother. 49(4): 169-177, 1995
  3. Yue J.-L, Okumura Y, Miyamae T, UEDA H and Misu Y
    Altered tonic L-3,4-dihydroxyphenylalanine systems in the nucleus tractus
    solitarii and the rostral ventrolateral medulla of spontaneously
    hypertensive rats
    Neuroscience 67(1): 95-106, 1995
  4. UEDA H, and Hieber V
    Down-regulation of AMPA-type glutamate receptor gene expression during
    goldfish optic nerve regeneration
    Mol. Brain Res. 32(1): 151-155, 1995
  5. UEDA H, Miyamae T, Fukushima N, Takeshima H, Fukuda K, Sasaki Y and Misu Y
    "Opioid mu - and kappa -receptor mediate phospholipase C activation through
    Gi1 in@Xenopus oocytes "
    Mol. Brain Res. 32(1): 166-170, 1995
  6. Hayashi C, UEDA H, Fukushima N, Katayama T and Misu Y
    Protein kinase C inhibitor potentiates the agonist-induced GTPase activity
    in COS cell membranes expressing delta -opioid receptor
    Mol. Brain Res. 33(2): 347-350, 1995
  7. UEDA H, Sato K, Okumura F and Misu Y
    L-DOPA inhibits spontaneous acetylcholine release from the striatum of
    experimental Parkinson's model rats
    Brain Res. 698(1-2): 213-216, 1995
  8. UEDA H, Miyamae T, Hayashi C, Watanabe S, Fukushima N, Sasaki Y, Iwamura T
    and Misu Y
    Protein kinase C involvement in homologous desensitization of delta -opioid
    receptor coupled to Gi1- phospholipase C activation in Xenopus oocytes
    J. Neurosci. 15(11): 7485-7499, 1995
  9. UEDA H, Miyamae T, Fukushima N, Watanabe S and Misu Y
    Evidence for a metabostatic opioid kappa-receptor inhibiting pertussis toxin-
    sensitive metabotropic glutamate receptor-currents in Xenopus oocytes
    FEBS Lett. 375(3):201-205, 1995

    1994

  1. Sasaki-Yagi Y, Kimura S, UEDA H and Imanishi Y
    Binding of enkephalin/dextran conjugates to opioid receptors. Int.
    J. Pept. Protein Res. 43(3): 219-224, 1994
  2. Nakamura S, Yue J-L, Goshima Y, Miyamae T, UEDA H and Misu Y
    Non-effective dose of exogenously applied L-dopa itself stereoselectively
    potentiates postsynaptic D2 receptor-mediated locomotor activities of
    conscious rats
    Neurosci. Lett. 170(1):22-26, 1994
  3. Yue J-L, Nakamura S, UEDA H and Misu Y
    Endogenously released L-DOPA itself tonically functions to potentiate
    postsynaptic D2 receptor-mediated locomoter activities of conscious rats
    Neurosci. Lett. 170(1): 107-110, 1994
  4. Funada M Suzuki T, Sugano Y, Tsubai M, Misawa M, UEDA H and Misu Y
    Role of beta -adrenoceptors in the expression of morphine withdrawal signs
    Life Sci. 54(8): 113-118, 1994
  5. Yue J-L, UEDA H and Misu Y
    Evidence for a dopamine receptor subtype sensitive to combination of D1 with
    D2 antagonist in measurement of G-protein activity using rat striatal
    membranes
    Life Sci. 54(23): 413-418, 1994
  6. Sato K, UEDA H, Okumura F and Misu Y
    Supersensitization of intrastriatal dopamine receptors involved in opposite
    regulation of acetylcholine release in Parkinson's model rats
    Neurosci. Lett. 173(1-2): 59-62, 1994
  7. Inoue A, UEDA H, Nakata Y, and Misu Y
    Supersensitivity of quinpirole-evoked GTPase activation without changes in
    gene expression of D2 and Gi-protein in the striatum of hemi-dopaminergic
    lesiond rats
    Neurosci. Lett. 175(1-2), 107-110, 1994
  8. Fukushima N, UEDA H, Hayashi C, Katayama T, Miyamae T, and Misu Y
    Species and age-dependent differences of functional coupling between opioid
    "delta -receptor and G-proteins and possible involvement of protein kinase C
    in striatal membranes"
    Neurosci. Lett. 176(1), 55-58, 1994
  9. Sato K, UEDA H, Okumura F and Misu Y
    6-OHDA-induced lesion of the nigrostriatal dopaminergic neurons potentiates
    the inhibitory effect of 7-OHDPAT, a selective D3 agonist, on acetylcholine
    release during striatal microdialysis in conscious rats
    Brain Res. 655(1-2): 233-236, 1994
  10. UEDA H, Miyamae T, Fukushima N and Misu Y
    "Protein kinase inhibitor potentiates opioid delta -receptor-currents in
    Xenopus oocytes"
    Neuroreport 5(15): 1985-1988, 1994

1993

  1. Miyamae T, Fukushima N, Misu Y and UEDA H
    delta-Opioid receptor mediates phospholipase C activation via Gi in Xenopus
    oocytes
    FEBS Lett. 333(3): 311-314, 1993

1992

  1. Harada J, UEDA H, Iso Y and Satoh M
    "Affinity cross-linked delta-opioid receptor in NG108-15 cells is low
    molecular weight@(25kDa) and coupled to GTP-binding proteins"
    Eur. J. Pharmacol. 227(3): 301-307, 1992

1990

  1. UEDA H, Misawa H, Katada T, Ui M, Takagi H and Satoh M
    Functional reconstitution of purified Gi and Go with mu -opioid receptors in
    guinea pig striatal membranes pretreated with micromolar concentrations of
    N-ethylmaleimide
    J. Neurochem. 54(3): 841-848, 1990
  2. Yoshihara Y, UEDA H, Fujii H, Shide A, Yajima H and Satoh M
    Purification of a novel type of calcium-activated neutral protease from rat
    brain. Possible involvement in production of the neuropeptide kyotorphin
    from calpastatin fragments.
    J. Biol. Chem. 265(10):5809-5815, 1990
  3. Misawa H, UEDA H and Satoh M
    "kappa -Opioid agonist inhibits phospholipase C, possibly via an inhibition of
    G- protein activity"
    Neurosci. Lett. 112(2-3): 324-327, 1990
  4. Harada H, UEDA H, Katada T, Ui M and Satoh M
    "Phosphorylated mu -opioid receptor purified from rat brains lacks of
    functional coupling with Gi1, a GTP-binding protein in reconstituted lipid
    vesicles"
    Neurosci. Lett. 113(1): 47-49, 1990
  5. UEDA H, Uno S, Harada J, Kobayashi I, Katada T, Ui M and Satoh M
    Evidence for receptor-mediated inhibition of intrinsic activity of GTP-
    binding protein, Gi1 and Gi2, but not Go in reconstitution experiments
    FEBS. Lett. 266(1-2): 178-182, 1990

1989

  1. Amano H, Goshima Y, Akema N, UEDA H, Kubo T and Misu Y
    Effects of acute nicotine on catecholamine turnover in various rat brain
    regions
    J. Pharmacobiodyn. 12(1): 18-23, 1989
  2. UEDA H, Yoshihara Y, Misawa H, Fukushima N, Katada T, Ui M, Takagi H and
    Satoh M
    The kyotorphin (tyrosine-arginine) receptor and a selective reconstitution
    with purified Gi, measured with GTPase and phospholipase C Assays
    J. Biol. Chem. 264(7): 3732-3741, 1989
  3. Sakane T, Tanaka C, Yamamoto A, Hashida M, Sezaki H, UEDA H and Takagi H
    The effect of polysorbate 80 on brain uptake and analgesic effect of D-
    kyotorphin
    Int. J. Pharm. 57: 77-83, 1989
  4. Harada H, UEDA H, Wada Y, Katada T, Ui M and Satoh M
    Phosphorylation of mu -opioid receptors - a putative mechanism of selective
    uncoupling of receptor - Gi interaction, measured with low Km GTPase and
    guanine nucleotide-sensitive agonist binding
    Neurosci. Lett. 100(1-3): 221-226, 1989

1988

  1. UEDA H, Harada H, Nozaki M, Katada T, Ui M, Satoh M and Takagi H
    Reconstitution of rat@brain mu opioid receptors with purified guanine
    nucleotide-binding regulatory proteins, Gi and Go
    Proc. Natl. Acad. Sci. USA 85(18): 7013-7017, 1988
  2. Ge M, UEDA H and Satoh M
    Endogenous GABA released into the fourth ventricle of the rat brain in vivo
    is enhanced by noxious stimuli
    Neurosci. Lett. 92(1): 76-81, 1988
  3. Yoshihara Y, UEDA H, Imajoh S, Takagi H and Satoh M
    Calcium-activated neutral protease (CANP), a putative processing enzyme of
    the neuropeptide, kyotorphin, in the brain
    Biochem. Biophys. Res. Commun. 155(2): 546-553, 1988

 

1987

  1. UEDA H, Fukushima N and Takagi H
    A novel proenkephalin processing carboxypeptidase and its activation by
    cyclic AMP dependent protein kinase
    Biochem. Biophys. Res. Commun. 142(2): 595-602, 1987
  2. UEDA H, Harada H, Misawa H, Nozaki M and Takagi H
    "Purified@opioid mu -receptor is of a different molecular size than delta -
    and kappa]receptors"
    Neurosci. Lett. 75(3): 339-344, 1987
  3. Kitabatake S, Tsurutani R, Nakajima H, Tomita K, Yoshihara Y, UEDA H,
    Takagi H and Imahori K
    A novel method for the synthesis of kyotorphin, Tyr-Arg and 3H-Tyr-Arg,
    catalyzed by tyrosyl-tRNA synthetase from Bacillus Stearothermophilus
    Pharm. Res. 4(2): 154-157, 1987
  4. UEDA H, Ge M, Satoh M and Takagi H
    Subconvulsive doses of intracisternal bicuculline medthiodide, a GABAA
    receptor antagonist, produce a potent analgesia as measured in the tail
    pinch test in mice
    Eur. J. Pharmacol. 136(1): 129-131, 1987
  5. UEDA H, Tamura S, Satoh M and Takagi H
    Excess release of substance P from the spinal cord of mice during morphine
    withdrawal and involvement of the enhancement of presynaptic Ca2+ entry
    Brain Res. 425(1), 101-105, 1987
  6. UEDA H, Misawa H, Fukushima N and Takagi H
    The specific opioid k -agonist, U-50,488H inhibits low Km GTPase
    Eur. J. Pharmacol. 138(1): 129-132, 1987
  7. UEDA H, Yoshihara Y, Fukushima N, Shiomi H, Nakamura A and Takagi H
    Kyotorphin (tyrosine-arginine) synthetase in rat brain synaptosomes
    J. Biol. Chem. 262(17): 8165-8173, 1987
  8. UEDA H, Fukushima N, Yoshihara Y and Takagi H
    A met-enkephalin releaser, (kyotorphin)-induced release of plasma membrane-
    bound Ca2+ from rat brain synaptosomes
    Brain Res.419(1-2): 197-200, 1987
  9. UEDA H, Ge M, Satoh H and Takagi H
    Non-opioid analgesia of the neuropeptide, neo-kyotorphin and possible
    mediation by inhibition of GABA release in the mouse brain
    Peptides 8(5): 905-909, 1987
  10. UEDA H, Fukushima N, Ge M, Takagi H and Satoh M
    Presynaptic opioid kappa -receptor and regulation of the release of Met-
    enkephalin in the rat brainstem
    Neurosci. Lett. 81(3): 309-313, 1987

 

1986

  1. Kubo T, Goshima Y, UEDA H and Misu Y
    Diminished@a 2- adrenoceptor-mediated modulation of noradrenergic
    neurotransmission in the posterior hypothalamus of spontaneously
    hypertensive rats
    Neurosci. Lett. 65(1): 29-34, 1986
  2. Hazato T, Kase R, UEDA H, Takagi H and Katayama T
    Inhibitory effects of the analgesic neuropeptides kyotorphin and neo-
    kyotorphin on enkephalin-degrading enzymes from monkey brain
    Biochem. Int. 12(3):379-383, 1986
  3. UEDA H, Fukushima N, Kitao T, Ge M and Takagi H
    Low doses of naloxone produce analgesia in the mouse brain by blocking
    presynaptic autoinhibition of enkephalin release
    Neurosci. Lett. 65(3): 247-252, 1986
  4. UEDA H, Tamura S, Fukushima N and Takagi H
    Pertussis toxin (IAP) enhances maitotoxin (a putative Ca2+ channel agonist)-
    induced Ca2+ entry into synaptosomes
    Eur. J. Pharmacol. 122(3): 379-380, 1986
  5. UEDA H, Tamura S, Harada H, Yasumoto T and Takagi H
    The maitotoxin-evoked Ca2+ entry into synaptosomes is enhanced by cholera
    toxin
    Neurosci. Lett. 67(2): 141-146, 1986
  6. UEDA H, Matsumoto S, Yoshihara Y, Fukushima N and Takagi H
    Uptake and release of kyotorphin in rat brain synaptosomes
    Life Sci. 38(26): 2405-2411, 1986
  7. UEDA H, Yoshihara Y and Takagi H
    A putative met-enkephalin releaser, kyotorphin enhances intracellular Ca2+
    in the synaptosomes
    Biochem. Biophys. Res. Comm. 137(2): 897-902, 1986

1985

  1. Kitagawa K, Kawai N, Kiyama S, Akita T, Kiso Y, UEDA H, Ge M and Takagi H
    Synthesis and analgesic activity of neo-kyotorphin analogs
    Chem. Pharm. Bull. 33(1): 377-382, 1985
  2. UEDA H, Goshima Y, Kubo T and Misu Y
    Involvement of epinephrine in the presynaptic beta adrenoceptor mechanism of
    norepinephrine release from rat hypothalamic slices.
    J. Pharmacol. Exp. Ther. 232(2): 507-512, 1985
  3. UEDA H, Yoshihara Y, Nakamura A, Shiomi H, Satoh M and Takagi H
    How is kyotorphin (Tyr-Arg) generated in the brain?
    Neuropeptides 5(4-6): 525-528, 1985
  4. UEDA H, Ge M, Hazato T, Katayama T and Takagi H
    Degradation of kyotorphin@by a@purified membrane-bound-aminopeptidase from
    monkey brain: potentiation of kyotorphin-induced analgesia by a highly
    effective inhibitor, bestatin
    Life Sci.36(19):1865-1871, 1985
  5. Misu Y, Goshima Y, UEDA H and Kubo T
    Presynaptic inhibitory@dopamine receptors on noradrenergic nerve terminals:
    analysis of biphasic actions of dopamine and apomorphine on the release of
    endogenous norepinephrine in rat hypothalamic slices
    J. Pharmacol. Exp. Ther. 235(3): 771-777, 1985

 

1984

  1. UEDA H, Goshima Y, Kubo T and Misu Y
    Adrenaline involvement in the presynaptic b-adrenoceptor-mediated mechanism
    of dopamine release from slices of the rat hypothalamus
    Life Sci. 34(11): 1087-1093, 1984
  2. Matsubayashi K, Kojima C, Kawajiri S, Ono K, Takegoshi T, UEDA H and Takagi H
    Hydrolytic deactivation of kyotorphin by the rodent brain homogenates and
    sera
    J. Pharmacobiodyn. 7(7): 479-484, 1984
  3. Kubo T, Goshima Y, UEDA H and Misu Y
    Effects of yohimbine on endogenous noradrenaline release from hypothalamus
    and brainstem slices of spontaneously hypertensive rats
    Jpn. J. Pharmacol. 36(3): 416-418, 1984

1983

  1. UEDA H, Goshima Y and Misu Y
    Presynaptic mediation by a2-, b1-, and b2-adrenoceptors of endogenous
    noradrenaline and dopamine release from slices of rat hypothalamus
    Life Sci. 33(4):371-376, 1983
  2. UEDA H, Goshima Y and Misu Y
    Presynaptic a2- and dopamine-receptor-mediated inhibitory mechanisms and
    dopamine nerve terminals in the rat hypothalamus
    Neurosci. Lett. 40(2):157-162, 1983

1982

  1. UEDA H, Tatsumi K, Shiomi H and Takagi H
    Analgesic dipeptide, kyotorphin (Tyr-Arg) is highly concentrated in the
    synaptosomal fraction of the rat brain
    Brain Res. 231(1): 222-224, 1982
  2. Takagi H, Shiomi H, Kuraishi Y and UEDA H
    Analgesic dipeptide, L-Tyr-D-Arg (D-kyotorphin) induces met-enkephalin
    release from guinea pig striatal slices
    Experientia 38: 1344-1345, 1982

1981

  1. Shiomi H, UEDA H and Takagi H
    Isolation and identification of an analgesic opioid dipeptide kyotorphin
    (Tyr-Arg) from bovine brain
    Neuropharmacology 20(7): 633-638, 1981
  2. Shiomi H, Kuraishi Y, UEDA H, Harada Y, Amano H and Takagi H
    Mechanism of kyotorphin-induced release of met-enkephalin from guinea pig
    striatum and spinal cord
    Brain Res. 221(1): 161-169, 1981

1980

  1. Yajima H, Ogawa H, UEDA H and Takagi H
    Studies on peptides XCIV.@Synthesis and activity of kyotorphin and its
    analogs
    Chem. Pharm. Bull. 28(6): 1935-1938, 1980
  2. UEDA H, Shiomi H and Takagi H
    Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in
    the rat brain and spinal cord
    Brain Res. 198(2): 460-464, 1980

1979

  1. Takagi H, Shiomi H, UEDA H and Amano H
    A novel analgesic dipeptide from bovine brain is a possible met-enkephalin
    releaser
    Nature 282(5737): 410-412, 1979
  2. Takagi H, Shiomi H, Kuraishi Y, Fukui K and UEDA H
    Pain and the bulbospinal noradrenergic system: pain-induced increase in
    normetanephrine content in the spinal cord and its modification by morphine
    Eur. J. Pharmacol. 54(1-2): 99-107, 1979
  3. Takagi H, Shiomi H, UEDA H and Amano H
    Morphine-like analgesia by a new dipeptide, L-tyrosyl-L-arginine (kyotorphin)
    and its analogue
    Eur. J. Pharmacol. 55(1): 109-111, 1979
  4. UEDA H, Amano H, Shiomi H and Takagi H
    Comparison of the analgesic effects of various opioid peptides by a newly
    devised intracisternal injection technique in conscious mice
    Eur. J. Pharmacol. 56(3): 265-268, 1979

 

 
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