ページ一覧

研究会主旨

メンバー表

活動報告

環境ホルモンの発生源

長崎大学ホームページへ

リンク集

植田関連研究活動報告

受賞歴・研究費取得状況

 

図表のページ

 

学会発表要旨集

 

大学内教官紹介ページ

 

吉田関連研究活動報告

 

受賞歴・研究費取得状況

 

図表のページ

 

学会発表要旨集

 

1999年北米神経科学会要旨英文

NOCICEPTION INDUCED BY SIGMA RECEPTOR AGONISTS THROUGH A NOVEL METABOTROPIC SIGMA RECEPTOR INSENSITIVE TO NEUROSTEROIDS.
Makoto Inoue, Genta Kurosu, Kiyoshi Matsuno, Shiro Mita and Hiroshi Ueda.

We have proposed the presence of metabotropic sigma receptors and their identity to metabotropic neurosteroid receptors using brain synaptic membranes including reconstitution experiments with recombinant Gi1 (SFN abstract #627.8, 1998). In the peripheral nociception test in mice (PNAS 95,10949-10953,1998), various sigma agonists such as (+) pentazocine and SA4503 which were given intraplantarly into the hind limb of mice, elicited nociceptive flexor responses in a dose-dependent manner between 1 pmol and 1 nmol. The intraplantar injection of dehydroepiandrosterone sulfate (DHEAS), a neurosteroid, also elicited a nociception in doses of as low as 1 fmol, which was blocked by 1 fmol of progesterone. Although DHEAS-induced nociception was also blocked by 10 fmol of several endocrine disruptors, such as 1,3-diphenylpropane, methoxychlor, 4,4ユ-DDE, and 1 nmol of NE-100, the (+)pentazocine-one was not blocked by 100 fmol of progesterone. (+)Pentazocine-induced nociception was blocked by pertussis toxin. All these findings suggest that there is a novel metabotropic sigma receptor in the peripheral nervous system which is insensitive to neuropeptides.