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2017

Stereoselective Construction of Entire Diastereomeric Stereotetrads Based on an Asymmetric Morita–Baylis–Hillman Reaction
Yoshimura, Hikaru; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Eur. J. Org. Chem. 2017, 19, 2719–2729.

Ionic Liquid-Mediated Hydrofluorination of o-Azaxylylenes Derived from 3-Bromooxindoles
Mizuta, Satoshi; Otaki, Hiroki; Kitagawa, Ayako; Kitamura, Kanami; Morii, Yuki; Ishihara, Jun; Nishi, Kodai; Hashimoto, Ryo; Usui, Toshiya; Chiba, Kenya
Org. Lett., 2017, 19 (10), pp 2572–2575.

Concise Formation of Spirocyclic Compounds for Marine Phycotoxins
Ishihara, Jun; Tojo, Shingo; Makino, Takuya; Sekiya, Hiroshi; Tanabe, Akiko, Shiraishi, Mitsutaka, Murai, Akio; Hatakeyama, Susumi 
Heterocycles, 2017, 95 (1), 422-444.

Enantioselective Protecting-Group-Free Synthesis of (+)-9,10-Dihydroecklonialactone B
Yasser, Asmaa Said Ali; Ishihara, Jun; Hatakeyama, Susumi
Heterocycles, 2017, 94 (1), 59-63.

2015

Unified Synthesis of Tirandamycins and Streptolydigins
Yoshimura, Hikaru; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Chemical Communications, 2015, (51), 17004–17007.

Total Synthesis of (−)-N-Methylwelwitindolinone C Isothiocyanate Based on a Pd-Catalyzed Tandem Enolate Coupling Strategy
Komine, Keita; Nomura, Yusuke; Ishihara, Jun; Hatakeyama, Susumi
Organic Letters, 2015, 17 (15), 3918–3921.

Unified Synthesis of Tirandamycins and Streptolydigins
Yoshimura, Hikaru; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Chemical Communications, 2015, (51), 17004–17007.

Total Synthesis of (−)-N-Methylwelwitindolinone C Isothiocyanate Based on a Pd-Catalyzed Tandem Enolate Coupling Strategy
Komine, Keita; Nomura, Yusuke; Ishihara, Jun; Hatakeyama, Susumi
Organic Letters, 2015, 17 (15), 3918–3921.

Acid Template-Catalyzed Asymmetric Diels-Alder Reaction
Ishihara, Jun; Nakadachi, Shino; Watanabe, Yuki; Hatakeyama, Susumi
Journal of Organic Chemistry, 2015, 80 (4), 2037-2041.

Stereoselective Approach toward Ophiodilactones Based on an Intramolecular [2+2] Cycloaddition Reaction
Matsubara, Takaaki; Ishihara, Jun; Hatakeyama, Susumi
Heterocycles, 2015, 90 (1), 405-424.

2014

Total Synthesis of Biologically Active Natural Products Based on Highly Selective Synthetic Methodologies
Hatakeyama, Susumi
Chemical & Pharmaceutical Bulletin, 2014, 62 (11), 1045-1061.

Total Synthesis of Marinomycin A Based on a Direct Dimerization Strategy
Nishimaru, Tatsuya; Kondo, Masashi; Takeshita, Kimito; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Angewandte Chemie, International Edition, 2014, 53, 8459-8462.

Total Synthesis of Oxazolomycins
Jun Ishihara; Susumi Hatakeyama
The Chemical Record, 2014, 14 (4), 663-677.

The Absolute Configuration for Inthomycin C: Revision of Previously Published Work with a Reinstatement of the (3R)-Configuration for (-)-Inthomycin C
Hale, Karl J.; Hatakeyama, Susumi; Urabe, Fumiya; Ishihara, Jun; Manaviazar, Soraya; Grabski, Milosz; Maczka, Maciej
Organic Letters, 2014, 16 (13), 3536-3539.

Total Synthesis of (-)-Dihydrosporothriolide Utilizing an Indium-Mediated Reformatsky-Claisen Rearrangement
Ishihara, Jun; Tsuru, Hiroaki; Hatakeyama, Susumi
Journal of Organic Chemistry, 2014, 79 (12), 5908-5913.

Formal [4+1]-Cycloaddition of homopropargyl alcohols to diazo dicarbonyl compounds giving substituted tetrahydrofurans
Urabe, Fumiya; Miyamoto, Shohei; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Organic Letters, 2014, 16 (3), 1004–1007.

Total Synthesis of (-)-Ophiodilactone A and (-)-Ophiodilactone B
Matsubara, Takaaki; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Angewandte Chemie - International Edition, 2014, 53 (3), 757–760.

Synthesis of Heterocycles Based on Rhodium-Catalyzed C-H Amination
Takahashi, Keisuke; Yamaguchi, Daisuke; Ishihara, Jun; Hatakeyama, Susumi
Synlett, 2014, 25 (1), 133–137.

2013

α-Isocupreine, an enantiocomplementary catalyst of β-isocupreidine
Nakamoto, Yoshito; Urabe, Fumiya; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Chemistry - A European Journal, 2013, 19 (38), 12653–12656.

Total synthesis of (-)-cinatrin C1 based on an In(OTf)3-catalyzed Conia-ene reaction
Urabe, Fumiya; Nagashima, Shunsuke; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Journal of Organic Chemistry, 2013, 78 (8), 3847–3857.

2012

A new method for the protection of carboxylic acids with a triisopropylsiloxymethyl group
Yoshimura, Hikaru; Eto, Kohei; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Chemical & Pharmaceutical Bulletin, 2012, 60 (10), 1334-1339.

Development of an advanced education program for community medicine by Nagasaki Pharmacy and Nursing Science Union Consortium
Teshima, Mugen; Nakashima, Mikiro; Hatakeyama, Susumi
Yakugaku Zasshi, 2012, 132 (1), 11-15.

Organocatalytic asymmetric syntheses of inthomycins A, B and C
Yoshino, Madoka; Eto, Kohei; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Organic & Biomolecular Chemistry, 2012, 10 (40), 8164-8174.

Process development for the practical production of eldecalcitol by linear, convergent and biomimetic syntheses
Kubodera, Noboru; Hatakeyama, Susumi
Anticancer Research, 2012, 32 (1), 303-310.

Recent developments in the Reformatsky-Claisen rearrangement
Ishihara, Jun; Hatakeyama, Susumi
Molecules, 2012, 17, 14249-14259.

Stereocontrolled Total Synthesis of (-)-Englerin A
Takahashi, Keisuke; Komine, Keita; Yokoi, Yuichi; Ishihara, Jun; Hatakeyama, Susumi
Journal of Organic Chemistry, 2012, 77 (17), 7364-7370.

Stereoselective synthesis of the fused γ-lactone/δ-lactone core of ophiodilactones
Matsubara, Takaaki; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Heterocycles, 2012, 86 (1), 155-158.

Total Synthesis of (-)-Kaitocephalin Based on a Rh-Catalyzed C-H Amination
Takahashi, Keisuke; Yamaguchi, Daisuke; Ishihara, Jun; Hatakeyama, Susumi
Organic Letters, 2012, 14 (6), 1644-1647.

2011

Indium-mediated Reformatsky-Claisen rearrangement
Ishihara, Jun; Watanabe, Yuki; Koyama, Noriko; Nishino, Yukihiro; Takahashi, Keisuke; Hatakeyama, Susumi
Tetrahedron, 2011, 67 (20), 3659-3667.

Organocatalytic asymmetric synthesis of quinine and quinidine
Sarkar, Shaheen M.; Taira, Yuko; Nakano, Ayako; Takahashi, Keisuske; Ishihara, Jun; Hatakeyama, Susumi
Tetrahedron Letters, 2011, 52 (8), 923-927.

Synthetic studies on vitamin D analogs. Part 39. Synthesis of 1-deoxyeldecalcitol, a biologically interesting analog of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (eldecalcitol)
Sasaki, Hirotaka; Eto, Kohei; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi; Kubodera, Noboru
Heterocycles, 2011, 83 (6), 1385-1394.

Total synthesis of NW-G01, a cyclic hexapeptide antibiotic, and 34-epi-NW-G01
Shibahara, Setsuya; Matsubara, Takaaki; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Organic Letters, 2011, 13 (17), 4700-4703.

Total synthesis of oxazolomycin A
Eto, Kohei; Yoshino, Madoka; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Organic Letters, 2011, 13 (19), 5398-5401.

2010

Indium-catalyzed conia-ene reaction and total syntheses of biologically active alkaloids
Takahashi, Keisuke; Hatakeyama, Susumi
Yuki Gosei Kagaku Kyokaishi, 2010, 68 (9), 951-961.

Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]
Hatakeyama, Susumi; Yoshino, Madoka; Eto, Kohei; Takahashi, Keisuke; Ishihara, Jun; Ono, Yoshiyuki; Saito, Hitoshi; Kubodera, Noboru
Journal of Steroid Biochemistry and Molecular Biology,
2010, 121 (1-2), 25-28.

Synthetic studies on vitamin D analogs. 37. Synthesis of 20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ed-71]
Yoshino, Madoka; Eto, Kohei; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi; Ono, Yoshiyuki; Saito, Hitoshi; Kubodera, Noboru
Heterocycles, 2010, 81 (2), 381-394.

Synthetic study on clutiolide based on a remote chelation controlled Ireland-Claisen rearrangement
Ishihara, Jun; Tokuda, Okihisa; Shiraishi, Kazunori; Nishino, Yukihiro; Takahashi, Keisuke; Hatakeyama, Susumi
Heterocycles, 2010, 80 (2), 1067-1079.

2009

A new variant of Reformatsky-Claisen rearrangement mediated by indium chloride
Ishihara, Jun; Koyama, Noriko; Nishino, Yukihiro; Takahashi, Keisuke; Hatakeyama, Susumi
Synlett, 2009, (14), 2351-2355.

Enantio- and stereoselective route to the phoslactomycin family of antibiotics: formal synthesis of (+)-fostriecin and (+)-phoslactomycin B
Sarkar, Shaheen M.; Wanzala, Everlyne N.; Shibahara, Setsuya; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Chemical Communications, 2009, (39), 5907-5909.

Enantioselective route to aryl(1,3-butadien-2-yl)methanols: formal synthesis of (-)-sporochnol A
Yanagimoto, Daisuke; Kawano, Kazuyuki; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Heterocycles, 2009, 77 (1), 249-253.

Indium-catalyzed Conia-ene reaction for alkaloid synthesis
Hatakeyama, Susumi
Pure and Applied Chemistry, 2009, 81 (2), 217-226.

Synthesis of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (eldecalcitol) and related compounds by the Trost convergent methodology
Kubodera, Noboru; Hatakeyama, Susumi
Heterocycles, 2009, 79, 145-162.

Synthesis of all possible A-ring diastereomers at the 1- and 3-positions of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) using C2-symmetrical epoxide as a common starting material
Kubodera, Noboru; Hatakeyama, Susumi
Anticancer Research, 2009, 29 (9), 3571-3578.

Synthetic studies of vitamin D analogs. Part 35. An improved synthesis of 1-epi-ED-71, a biologically interesting diastereomer of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)
Eto, Kohei; Fujiyama, Ayako; Kaneko, Mai; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi; Ono, Yoshiyuki; Kubodera, Noboru
Heterocycles, 2009, 77 (1), 323-331.

Total synthesis of (+)-fostriecin and (+)-phoslactomycin B
Shibahara, Setsuya; Fujino, Masataka; Tashiro, Yasumasa; Okamoto, Nanako; Esumi, Tomoyuki; Takahashi, Keisuske; Ishihara, Jun; Hatakeyama, Susumi
Synthesis, 2009, (17), 2935-2953.

2008

Asymmetric synthesis of (+)-trachyspic acid
Morokuma, Kenji; Taira, Yuko; Uehara, Yumiko; Shibahara, Setsuya; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Tetrahedron
Letters, 2008, 49 (42), 6043-6045.

Asymmetric Total Synthesis of (+)-Phoslactomycin B
Shibahara, Setsuya; Fujino, Masataka; Tashiro, Yasumasa; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Organic Letters, 2008, 10 (11), 2139-2142.

Entry to heterocycles based on indium-catalyzed Conia-ene reactions: asymmetric synthesis of (-)-salinosporamide A
Takahashi, Keisuske; Midori, Michiko; Kawano, Kei; Ishihara, Jun; Hatakeyama, Susumi
Angewandte Chemie, International Edition, 2008, 47 (33), 6244-6246.

Synthetic studies directed toward kaitocephalin: a highly stereocontrolled route to the right-hand pyrrolidine core
Takahashi, Keisuke; Haraguchi, Natsumi; Ishihara, Jun; Hatakeyama, Susumi
Synlett, 2008, (5), 671-674.

2007

A highly stereocontrolled total synthesis of dysiherbaine
Takahashi, Keisuke; Matsumura, Takashi; Ishihara, Jun; Hatakeyama, Susumi
Chemical Communications, 2007, (40), 4158-4160.

Synthesis and biological evaluation of a 3-position epimer of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)
Hatakeyama, Susumi; Nagashima, Satoshi; Imai, Naoko; Takahashi, Keisuke; Ishihara, Jun; Sugita, Atsuko; Nihei, Takeshi; Saito, Hitoshi; Takahashi, Fumiaki; Kubodera, Noboru
Journal of Steroid Biochemistry and Molecular Biology, 2007, 103 (3-5), 222-226.

Synthesis of 1,3-diepi-ed-71, a biologically important diastereomer of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)
Fujiyama, Ayako; Kaneko, Mai; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi; Kubodera, Noboru
Heterocycles, 2007, 71 (10), 2263-2271.

Total synthesis of Citrafungin A
Amer, Mumen F. A.; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Heterocycles, 2007, 72, 181-185.

Total synthesis of neooxazolomycin
Onyango, Evans Otieno; Tsurumoto, Joji; Imai, Naoko; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Angewandte Chemie, International Edition, 2007, 46 (35), 6703-6705.

2006

β-Isocupreidine-Catalyzed Baylis-Hillman Reaction of Chiral N-Boc-α-Amino Aldehydes
Nakano, Ayako; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Organic Letters, 2006, 8 (23), 5357-5360.

A Highly Stereocontrolled Total Synthesis of (-)-Neodysiherbaine A
Takahashi, Keisuke; Matsumura, Takashi; Corbin, Graeme R. M.; Ishihara, Jun; Hatakeyama, Susumi
Journal of Organic Chemistry, 2006, 71 (11), 4227-4231.

Synthesis and evaluation of a 3-position diastereomer of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)
Hatakeyama, Susumi; Nagashima, Satoshi; Imai, Naoko; Takahashi, Keisuke; Ishihara, Jun; Sugita, Atsuko; Nihei, Takeshi; Saito, Hitoshi; Takahashi, Fumiaki; Kubodera, Noboru
Bioorganic & Medicinal Chemistry, 2006, 14 (23), 8050-8056.

Synthesis of putative metabolites of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)
Ono, Yoshiyuki; Watanabe, Hiroyoshi; Taira, Ikuo; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi; Kubodera, Noboru
Steroids, 2006, 71 (7), 529-540.

Total synthesis of (+)-β-erythroidine
Fukumoto, Hironori; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Angewandte Chemie, International Edition, 2006, 45 (17), 2731-2734.

Two convergent approaches to the synthesis of
1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) by the lythgoe and the trost coupling reactions
Maeyama, Junji; Hiyamizu, Hiroko; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi; Kubodera, Noboru
Heterocycles, 2006, 70, 295-307.

Unusual extra space at the active site and high activity for acetylated hydroxyproline of prolyl aminopeptidase from Serratia marcescens
Nakajima, Yoshitaka; Ito, Kiyoshi; Sakata, Makoto; Xu, Yue; Nakashima, Kanako; Matsubara, Futoshi; Hatakeyama, Susumi; Yoshimoto, Tadashi
Journal of Bacteriology, 2006, 188 (4), 1599-1606.

Two convergent approaches to the synthesis of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) by the lythgoe and the trost coupling reactions.
Maeyama, Junji; Hiyamizu, Hiroko; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi; Kubodera, Noboru.
Heterocycles, 2006, 70, 295-307.

2005

β-Isocupreidine-hexafluoroisopropyl acrylate method for asymmetric Baylis-Hillman reactions
Nakano, Ayako; Kawahara, Sakie; Akamatsu, Saori; Morokuma, Kenji; Nakatani, Mari; Iwabuchi, Yoshiharu; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Tetrahedron, 2005, 62 (2-3), 381-389.

Measurement and characterization of C-3 epimerization activity toward vitamin D3
Kamao, Maya; Hatakeyama, Susumi; Sakaki, Toshiyuki; Sawada, Natsumi; Inouye, Kuniyo; Kubodera, Noboru; Reddy, G. Satyanarayana; Okano, Toshio
Archives of Biochemistry and Biophysics, 2005, 436 (1), 196-205.

Synthesis of a pseudoenantiomer of β-isocupreidine (β-ICD), a chiral amine catalyst for asymmetric Baylis-Hillman reactions
Nakano, Ayako; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Heterocycles, 2005, 66, 371-383.

Synthesis of an enantiocomplementary catalyst of β-isocupreidine (β-ICD) from quinine
Nakano, Ayako; Ushiyama, Mina; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Advanced Synthesis & Catalysis, 2005, 347 (14), 1790-1796.

Total synthesis of viridiofungin A
Morokuma, Kenji; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi
Chemical Communications, 2005, (17), 2265-2267.

2004

A Concise Route to (+)-Lactacystin
Ooi, Hidenori; Ishibashi, Norihisa; Iwabuchi, Yoshiharu; Ishihara, Jun; Hatakeyama, Susumi
Journal of Organic Chemistry, 2004, 69 (22), 7765-7768.

C-3 Epimerization of Vitamin D3 Metabolites and Further Metabolism of C-3 Epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1α or C-24 hydroxylation
Kamao, Maya; Tatematsu, Syuichiro; Hatakeyama, Susumi; Sakaki, Toshiyuki; Sawada, Natsumi; Inouye, Kuniyo; Ozono, Keiichi; Kubodera, Noboru; Reddy, G. Satyanarayana; Okano, Toshio
Journal of Biological Chemistry, 2004, 279 (16), 15897-15907.

Cell specificity and properties of the C-3 epimerization of Vitamin D3 metabolites
Kamao, Maya; Tatematsu, Syuichiro; Sawada, Natsumi; Sakaki, Toshiyuki; Hatakeyama, Susumi; Kubodera, Noboru; Okano, Toshio
Journal of Steroid Biochemistry and Molecular Biology, 2004, 89-90 (1-5), 39-42.

Enantio- and stereocontrolled formation of the bisspiroacetal core of spirolide B
Ishihara, Jun; Ishizaka, Tomoko; Suzuki, Takanori; Hatakeyama, Susumi
Tetrahedron Letters, 2004, 45 (42), 7855-7858.

Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 by CYP24A1
Kusudo, Tatsuya; Sakaki, Toshiyuki; Abe, Daisuke; Fujishima, Toshie; Kittaka, Atsushi; Takayama, Hiroaki; Hatakeyama, Susumi; Ohta, Miho; Inouye, Kuniyo
Biochemical and Biophysical Research Communications, 2004, 321 (4), 774-782.

Novel Metabolism of 1α,25-Dihydroxyvitamin D3 with C24-C25 Bond Cleavage Catalyzed by Human CYP24A1
Sawada, Natsumi; Kusudo, Tatsuya; Sakaki, Toshiyuki; Hatakeyama, Susumi; Hanada, Makoto; Abe, Daisuke; Kamao, Maya; Okano, Toshio; Ohta, Miho; Inouye, Kuniyo
Biochemistry, 2004, 43 (15), 4530-4537.

2003

β-Isocupreidine-Catalyzed Asymmetric Baylis-Hillman Reaction of Imines
Kawahara, Sakie; Nakano, Ayako; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Organic Letters, 2003, 5 (17), 3103-3105.

Novel inhibitor for prolyl aminopeptidase from Serratia marcescens and studies on the mechanism of substrate recognition of the enzyme using the inhibitor
Inoue, Takahiko; Ito, Kiyoshi; Tozaka, Tomohiro; Hatakeyama, Susumi; Tanaka, Nobutada; Nakamura, Kazuo T.; Yoshimoto, Tadashi
Archives of Biochemistry and Biophysics, 2003, 416 (2), 147-154.

Synthesis of the tricyclic dihydrofuran moiety of azadirachtin: efficient transformation of the Claisen rearrangement intermediate into a functionalized tricyclic dihydrofuran core
Ishihara, Jun; Ikuma, Yohei; Hatakeyama, Susumi; Suzuki, Takanori; Murai, Akio
Tetrahedron, 2003, 59 (51), 10287-10294.

Total synthesis of (α)-erythravine based on ring closing dienyne metathesis
Fukumoto, Hironori; Esumi, Tomoyuki; Ishihara, Jun; Hatakeyama, Susumi
Tetrahedron Letters, 2003, 44 (44), 8047-8049.

Total Synthesis of (±)-Trachyspic Acid and Determination of the Relative Configuration
Hirai, Kanako; Ooi, Hidenori; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Organic Letters, 2003, 5 (6), 857-859.

Two novel metabolic pathways of 22-oxacalcitriol (OCT)
Kamao, Maya; Tatematsu, Syuichiro; Hatakeyama, Susumi; Ozono, Keiichi; Kubodera, Noboru; Reddy, G. Satyanarayana; Okano, Toshio
Journal of Biological Chemistry, 2003, 278 (3), 1463-1471.

2002

Potent Antimalarial Febrifugine Analogues against the Plasmodium Malaria Parasite
Kikuchi, Haruhisa; Tasaka, Hidehisa; Hirai, Shingo; Takaya, Yoshiaki; Iwabuchi, Yoshiharu; Ooi, Hidenori; Hatakeyama, Susumi; Kim, Hye-Sook; Wataya, Yusuke; Oshima, Yoshiteru
Journal of Medicinal Chemistry, 2002, 45 (12), 2563-2570.

Versatile enantiocontrolled synthesis of (+)-fostriecin
Esumi, Tomoyuki; Okamoto, Nanako; Hatakeyama, Susumi
Chemical Communications, 2002, (24), 3042-3043.

2001

1,1,1,3,3,3-Hexafluoroisopropyl Acrylate (HFIPA)
Ishihara, Jun; Hatakeyama, Susumi
e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001.

A Concise Enantioselective Synthesis of a Key A-Ring Synthon for 1α-Hydroxyvitamin D3 Compounds
Hiyamizu, Hiroko; Ooi, Hidenori; Inomoto, Yoko; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Organic Letters, 2001, 3 (3), 473-475.

A Concise Enantioselective Synthesis of Antimalarial Febrifugine Alkaloids
Ooi, Hidenori; Urushibara, Ayumi; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Organic Letters, 2001, 3 (6), 953-955.

An enantio- and stereocontrolled synthesis of (-)-mycestericin E via cinchona alkaloid-catalyzed asymmetric Baylis-Hillman reaction
Iwabuchi, Yoshiharu; Furukawa, Mariko; Esumi, Tomoyuki; Hatakeyama, Susumi
Chemical Communications, 2001, (19), 2030-2031.

Concise synthesis of (3R,4S)-3-hydroxy-4-methyl-γ-butyrolactone
Nishiyama, Takashi; Nishioka, Toshiko; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Heterocycles, 2001, 54 (1), 69-72.

Isolation, identification and biological activity of 24R,25-dihydroxy-3-epi-vitamin D3: a novel metabolite of 24R,25-dihydroxyvitamin D3 produced in rat osteosarcoma cells (UMR 106)
Kamao, Maya; Tatematsu, Syuichiro; Reddy, G. Satyanarayana; Hatakeyama, Susumi; Sugiura, Makiko; Ohashi, Noriko; Kubodera, Noboru; Okano, Toshio
Journal of Nutritional Science and Vitaminology,
2001, 47 (2), 108-115.

Life-threatening mediastinal teratoma in a neonate
Kuroiwa M; Suzuki N; Takahashi A; Ikeda H; Hatakeyama S I; Matsuyama S; Tsuchida Y
Pediatric surgery international, 2001, 17 (2-3), 235-238.

The mechanism of substrate recognition of pyroglutamyl-peptidase I from Bacillus amyloliquefaciens as determined by X-ray crystallography and site-directed mutagenesis
Ito, Kiyoshi; Inoue, Takahiko; Takahashi, Tomoyuki; Huang, Hua-Shan; Esumi, Tomoyuki; Hatakeyama, Susumi; Tanaka, Nobutada; Nakamura, Kazuo T.; Yoshimoto, Tadashi
Journal of Biological Chemistry, 2001, 276 (21), 18557-18562.

2000

Concise synthesis of anolignan A
Luo, Meiming; Matsui, Akiko; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Tetrahedron Letters, 2000, 41 (22), 4401-4402.

Enantioselective synthesis of (+)-decarestrictine L from (2E,5E)-dibenzyloxy-2,5-heptadien-4-ol
Esumi, Tomoyuki; Kimura, Rieko; Mori, Masako; Iwabuchi, Yoshiharu; Irie, Hiroshi; Hatakeyama, Susumi
Heterocycles, 2000, 52 (2), 525-528.

Techniques for combination of molecules and synthesis of natural products
Hatakeyama, Susumi
Farumashia, 2000, 36 (12), 1033-1035.

Total Synthesis of (-)-Dysiherbaine
Masaki, Hidekazu; Maeyama, Junji; Kamada, Kazuko; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Journal of the American Chemical Society, 2000, 122 (21), 5216-5217.

1999

Buta-2,3-dienylstannanes, effective reagents for regioselective buta-1,3-dienylation of aldehydes and acetals
Luo, Meiming; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Chemical Communications, 1999, (3), 267-268.

Chiral Amine-Catalyzed Asymmetric Baylis-Hillman Reaction: A Reliable Route to Highly Enantiomerically Enriched (α-Methylene-β-hydroxy)esters
Iwabuchi, Yoshiharu; Nakatani, Mari; Yokoyama, Nobiko; Hatakeyama, Susumi
Journal of the American Chemical Society, 1999, 121 (43), 10219-10220.

Efficient route to functionalized eight-membered lactones based on intramolecular silicon-directed acylative ring-opening reactions of 3-(tetrahydro-2-furyl)propanoic acid derivatives
Ohi, Hidenori; Inoue, Susumu; Iwabuchi, Yoshiharu; Irie, Hiroshi; Hatakeyama, Susumi
Synlett, 1999, (11), 1757-1759.

New metabolic pathway of (24R)-24,25-dihydroxyvitamin D3: epimerization of the 3-hydroxy group
Higashi, Tatsuya; Kikuchi, Ryuta; Miura, Kanako; Shimada, Kazutake; Hiyamizu, Hiroko; Ooi, Hidenori; Iwabuchi, Yoshiharu; Hatakeyama, Susumi; Kubodera, Noboru
Biological & Pharmaceutical Bulletin, 1999, 22 (7), 767-769.

Preparation of 24-hydroxyvitamin D derivatives as antitumors and calcium metabolism regulators
Hatakeyama, Susumi; Watanabe, Hiroyoshi; Kawase, Akira
PCT Int. Appl. 1999, WO 9943645 A1 19990902.

Regioselective buta-1,3-dienylation of aldehydes via transmetalation of 2-(tributylstannyl)buta-1,3-diene
Luo, Meiming; Iwabuchi, Yoshiharu; Hatakeyama, Susumi
Synlett, 1999, (7), 1109-1111.

Vitamin D derivatives and process for producing the same
Hatakeyama, Susumi; Iwabuchi, Yoshiharu
PCT Int. Appl. 1999, WO 9915499 A1 19990401.

1998

A new stereoselective route to (-)-octalactin A based on intramolecular SmI2-promoted Reformatskii reaction
Inoue, Susumu; Iwabuchi, Yoshiharu; Irie, Hiroshi; Hatakeyama, Susumi
Synlett, 1998, (7), 735-736.

Concise enantioselective synthesis of (+)-aspicilin based on a ruthenium catalyzed olefin metathesis reaction
Nishioka, Toshiko; Iwabuchi, Yoshiharu; Irie, Hiroshi; Hatakeyama, Susumi
Tetrahedron Letters, 1998, 39 (31), 5597-5600.

Preparation of 2-iodo-1,3-butadienes from 1-(trimethylsilyl)-2,3-butadienes and their functionalizations
Nishiyama, Takashi; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Irie, Hiroshi; Hatakeyama, Susumi
Tetrahedron Letters, 1998, 39 (1/2), 43-46.

Synthesis of viridiofungin A trimethyl ester and determination of the absolute structure of viridiofungin A
Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Irie, Hiroshi; Hatakeyama, Susumi
Tetrahedron Letters,
1998, 39 (8), 877-880.

1997

A novel enantioselective synthesis of (+)-myriocin based on the chemistry of 1-trimethylsilylbuta-2,3-dienes
Hatakeyama, Susumi; Yoshida, Masashi; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Irie, Hiroshi; Kawamoto, Toshiki; Yamada, Hidetoshi; Nishizawa, Mugio
Tetrahedron Letters, 1997, 38 (45), 7887-7890.

Enantioselective preparation of 1-benzyloxy-3-methyl-6-heptene-2,4-idols: total synthesis of (+)-prelactone C
Esumi, Tomoyuki; Fukuyama, Hiroko; Oribe, Reiko; Kawazoe, Kaori; Iwabuchi, Yoshiharu; Irie, Hiroshi; Hatakeyama, Susumi
Tetrahedron Letters, 1997, 38 (27), 4823-4826.

Et2AlCl-Catalyzed Cyclization of Epoxytrichloroacetimidates for the Synthesis of α-Substituted Serines
Hatakeyama, Susumi; Matsumoto, Hiromitsu; Fukuyama, Hiroko; Mukugi, Yasuko; Irie, Hiroshi
Journal of Organic Chemistry, 1997, 62 (7), 2275-2279.

New synthetic reagents, allenylmethylsilanes and their utilization for natural product synthesis
Hatakeyama, Susumi
Yuki Gosei Kagaku Kyokaishi, 1997, 55 (9), 793-802.

Synthetic studies of vitamin D analogs. 25. Convergent synthesis of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)
Hatakeyama, Susumi; Ikeda, Tatsuhiko; Maeyama, Junji; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Irie, Hiroshi; Kawase, Akira; Kubodera, Noboru
Bioorganic & Medicinal Chemistry Letters, 1997, 7 (22), 2871-2874.

The efficient and regioselective synthesis of the naphthoquinone core of streptovaricin U
Miyashita, Masaaki; Yamasaki, Takahiro; Shiratani, Tomonori; Hatakeyama, Susumi; Miyazawa, Masahiro; Irie, Hiroshi
Chemical Communications, 1997, (18), 1787-1788.

1996

A stereocontrolled enantiospecific route to tirandamycin B
Shiratani, Tomonori; Kimura, kiyoshi; Yoshihara, Kousei; Hatakeyama, Susumi; Irie, Hiroshi; Miyashita, Masaaki
Chemical Communications, 1996, (1), 21-2.

Synthetic studies of vitamin D analogs. XXII. Synthesis and antiproliferation activity of putative metabolites of 1α,25-dihydroxy-22-oxavitamin D3
Watanabe, Hiroyoshi; Hatakeyama, Susumi; Tazumi, Kazuki; Takano, Seiichi; Masuda, Sonoko; Okano, Toshio; Kobayashi, Tadashi; Kubodera, Noboru
Chemical & Pharmaceutical Bulletin, 1996, 44 (12), 2280-2286.

Tandem synthesis of polypropionate chains-highly stereoselective synthesis of the ansa chain of streptovaricin U and protostreptovaricins based on stereospecific methylation of γ,δ-epoxy acrylates by trimethylaluminium
Miyashita, Masaaki; Shiratani, Tomonori; Kawamine, Katsumi; Hatakeyama, Susumi; Irie, Hiroshi
Chemical Communications, 1996, (9), 1027-1028.

Total synthesis of (+)-conagenin
Hatakeyama, Susumi; Fukuyama, Hiroko; Mukugi, Yasuko; Irie, Hiroshi
Tetrahedron Letters, 1996, 37 (23), 4047-4050.