A Comprehensive Analysis of Selenium-Binding Proteins in the Brain Using Its Reactive Metabolite.
ABSTRACT
In this chapter, the speciation analysis of the fish-specific selenoproteins
and low molecular mass organoselenium compounds from fish was described.
Selenium is essential to fish as well as mammals. The selenoproteomes (sets
of seleno-L-cysteine (SeCys)-containing proteins) of fish are greater in
number than those of mammals (25 selenoproteins in humans); at 41 selenoproteins,
the selenoproteomes of fish are among the largest known. Fish have several
species-specific selenoproteins (fish 15 kDa selenoprotein-like protein,
selenoprotein J and selenoprotein L). Many low-mass organoselenium species
are detected in fish samples other than seleno-L-methionine and SeCys derivatives.
Although the selenium contents in fish are higher than in terrestrial foodstuffs,
little is known about the chemical forms of such organoselenium species
in fish. Fish appear to contain nutritionally effective organoselenium
compounds that have not yet been chemically identified.