99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging
cerebral ƒÀ-amyloid plaques.
Two 99mTc/Re complexes based on flavone and aurone were tested as potential probes for imaging ƒÀ-amyloid plaques using single photon emission computed tomography. Both 99mTc-labeled derivatives showed higher affinity for AƒÀ(1-42) aggregates than did 99mTc-BAT. In sections of brain tissue from an animal model of AD, the Re-flavone derivative 9 and Re-aurone derivative 19 intensely stained ƒÀ-amyloid plaques. In biodistribution experiments using normal mice, 99mTc-labeled flavone and aurone displayed similar radioactivity pharmacokinetics. With additional modifications to improve their brain uptake, 99mTc complexes based on the flavone or aurone scaffold may serve as probes for imaging cerebral ƒÀ-amyloid plaques.