Push-pull benzothiazole derivatives as probes for detecting ƒÀ-amyloid plaques
in Alzheimer's brains.
We synthesized push-pull benzothiazole derivatives and evaluated their potential as ƒÀ-amyloid imaging probes. In binding experiments in vitro, the benzothiazoles showed excellent affinity for synthetic AƒÀ(1-42) aggregates. ƒÀ-Amyloid plaques in the mouse and human brain were clearly visualized with the benzothiazoles, reflecting the results in vitro. These compounds may be a useful scaffold for the development of novel PET/SPECT and fluorescent tracers for detecting ƒÀ-amyloid in Alzheimer's brains.