Push-pull benzothiazole derivatives as probes for detecting ƒÀ-amyloid plaques
in Alzheimer's brains.
ABSTRACT
We synthesized push-pull benzothiazole derivatives and evaluated their
potential as ƒÀ-amyloid imaging probes. In binding experiments in vitro,
the benzothiazoles showed excellent affinity for synthetic AƒÀ(1-42) aggregates.
ƒÀ-Amyloid plaques in the mouse and human brain were clearly visualized
with the benzothiazoles, reflecting the results in vitro. These compounds
may be a useful scaffold for the development of novel PET/SPECT and fluorescent
tracers for detecting ƒÀ-amyloid in Alzheimer's brains.