8389 since 2008.05
Last updated 07/25/17

薬剤学研究室HPへ戻る

2017 Research article
  1. Biopharm Drug Dispos. 2017 Feb 27. doi: 10.1002/bdd.2073. Influence of vasomodulators and tumor transplantation on the disposition of 5-fluorouracil after application to the liver surface in rats., Kodama Y, Horishita M, Tokunaga A, Miyamoto H, Fumoto S, Sasaki H, Nakamura J, Nishida K.
    PMID:28239866
  2. J Drug Target. 2017 Apr 3:1-24. doi: 10.1080/1061186X.2017.1315687. One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin, Peng J, Fumoto S, Miyamoto H, Chen Y, Kuroda N, Nishida K.
    PMID:28368667
  3. Drug Delivery, accepted (2017), Effective Intraperitoneal Gene Transfection System Using Nanobubbles and Ultrasound Irradiation, Koyo Nishimura, Shintaro Fumoto, Yuki Fuchigami, Masayori Hagimori, Kazuo Maruyama, Shigeru Kawakami
  4. Drug Delivery, accepted (2017). Natsuko Oyama, Yuki Fuchigami, Shintaro Fumoto, Megumu Sato, Masayori Hagimori, Kazunori Shimizu, Shigeru Kawakami, Characterization of transgene expression and pDNA distribution of the suctioned kidney in mice
  5. Fumoto S, Nishida K. Chem Pharm Bull (Tokyo). 2017;65(7):642-648. doi: 10.1248/cpb.c17-00096. Methods for Evaluating the Stimuli-Responsive Delivery of Nucleic Acid and Gene Medicines
  6. 麓伸太郎: DDS先端技術の製剤への応用開発 第4章第9節 「非ウイルスベクターによる遺伝子導入技術の開発」, 技術情報協会, p.221-232 (2017) 邦文 著書

2016 Research article
  1. Fumoto S, Nishimura K, Nishida K, Kawakami S: Three-Dimensional Imaging of the Intracellular Fate of Plasmid DNA and Transgene Expression: ZsGreen1 and Tissue Clearing Method CUBIC are an Optimal Combination for Multicolor Deep Imaging in Murine Tissues, PLOS ONE 11(1): e0148233, 2016 (IF: 3.057)
    PMID:26824850
  2. Shimokawa K, Wakasugi K, Tomonaga R, Utsunomiya K, Miyamoto H, Fumoto S, Nishida K: Effect of metabolic inhibitors on the hepatic disposition of 5-fluorouracil after application to the rat liver surface, Biol Pharm Bull. 39 (3) :361-367, 2016 (IF: 1.574)
    PMID:26934928
  3. Fumoto S, Taniguchi N, Ikai Y, Yoshikawa N, Miyamoto H, Sasaki H, Hashida M, Kawakami S, Nishida K: The Insertion Timing of PEGylated Lipids to Galactosylated Lipoplexes is Important for Liver-Selective Transfection in Mice, Gene and Cell Therapy 1(1): 1-11, 2016
  4. Kato T, Yamashita H, Misawa T, Nishida K, Kurihara M, Tanaka M, Demizu Y, Oba M., Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids, Bioorg Med Chem. 24 (12): 2681-2687, 2016 (IF: 2.923)
  5. Hirata H, Fumoto S, Miyamoto H, Nakashima M, Nakayama M, Nishida K: Evaluation for Peritoneal Injury at an Early Stage Using Dual Macromolecular Markers, Biol Pharm Bull 39 (10): 1581-1587, 2016 (IF: 1.574)
    PMID:27725434

2015 Research article
  1. Kodama Y, Ohkubo C, Kurosaki T, Egashira K, Sato K, Fumoto S, Nishida K, Higuchi N, Kitahara T, Nakamura T, Sasaki H: Secure and effective gene delivery system of plasmid DNA coated by polynucleotide. J Drug Target 23 (1): 43-51, 2015 (IF: 2.741)
  2. Miyamoto H, Matsueda S, Moritsuka A, Shimokawa K, Hirata H, Nakashima M, Sasaki H, Fumoto S, Nishida Koyo: Evaluation of hypothermia on the in vitro metabolism and binding and in vivo disposition of midazolam in rats, Biopharmaceutics & Drug Disposition 36 (7): 481-489 (2015) (IF: 2.340)
    PMID:26037413
  3. 西田孝洋: 薬物速度論, 生物薬剤学 改訂3版, 南江堂, 第9章, p.229-247 (2015) 邦文 著書

2014 Research article
  1. Hirata H, Miyamoto H, Shimokawa K, Nakashima M, Nakayama M, Fumoto S, Nishida K: Novel diagnostic method of peritoneal injury using dual macromolecular markers. Biol Pharm Bull 37 (2): 262-267, 2014 (IF: 1.778)
    PMID:24492723
  2. Mine T, Miyamoto H, Yoshikawa N, Fumoto S, Sasaki H, Nakamura J, Nishida K: Effect of absorption enhancers on the absorption of FD-4 as a poorly absorbable marker macromolecule from the liver surface in rats. J Drug Del Sci Tech 24 (4): 386-389, 2014 (IF: 0.734)
  3. Kurosaki T, Kawanabe S, Kodama Y, Fumoto S, Nishida K, Nakagawa H, Higuchi N, Nakamura T, Kitahara T, Sasaki H: Hepatic gene delivery system electrostatically assembled with glycyrrhizin. Mol Pharm 11 (5): 1369-1377, 2014 (IF: 4.787). PMID:24673596
  4. Kato T, Oba M, Nishida K, Tanaka M: Cell-penetrating helical peptides having L-arginines and five-membered ring α,α-disubstituted α-amino acids. Bioconjugate Chemistry 25 (10): 1761-1768, 2014 (IF: 4.930)
  5. Fumoto S, Kawakami S: Combination of nanoparticles with physical stimuli toward cancer therapy. Biol Pharm Bull 37 (2), 212-216, 2014 (IF: 1.778) 欧文 Review
    PMID:24492718
  6. 西田孝洋: 内服・注射剤に代わる新規薬剤投与デバイスと簡便な投与経路の開発 第2部第1章第1節 「薬剤の経肺デリバリーのメカニズム」, 技術情報協会, p.81-85 (2014) 邦文 著書

2013 Research article
  1. Miyamoto H, Matsueda S, Komori K, Fumoto S, Nakashima M, Yoshikawa N, Hirata H, Shimokawa K, Ohwaki Y, Nishida K: Evaluation for effect of hypothermia on the disposition of 4-nitrophenol in rats by in vitro metabolism study and rat liver perfusion system. J Pharm Pharmacol 65 (10): 1536-1540, 2013 (IF: 2.033)
    PMID:24028621
  2. Yoshikawa N, Fumoto S, Nakashima M, Shimokawa K, Miyamoto H, Nishida K: The role of fibronectin in pulmonary gene transfer following intravenous administration of lipoplex in mice. Biol Pharm Bull 36 (11): 1807-1813, 2013 (IF: 1.849)
    PMID:24189424
  3. INTECH "Novel Gene Therapy Approaches" Editor, Ming Wei; Co-editor, David Good, Section 1 Approached to Gene Therapy, Chapter 1 Targeted Gene Delivery: Importance of Administration Routes: Shintaro Fumoto, Shigeru Kawakami, Mitsuru Hashida, Koyo Nishida, pp. 3-31 (2013) 欧文 著書
  4. Shintaro Fumoto: 臓器表面に適用する遺伝子導入剤の開発, Drug Delivery System, 28 (5), 464-465 (2013) 邦文 Review
  5. 西田孝洋: 非経口投与製剤の開発と応用第1編第8章「注射後の薬物吸収と注射剤の開発」, シーエムシー出版, p.48-54 (2013) 邦文 著書
  6. 麓伸太郎: DDS製剤の開発・評価と実用化手法 第1章第2節第4項 「肝臓への特異的DDS技術の動向」, 技術情報協会, p.60-64 (2013) 邦文 著書
  7. 特許公開、研磨剤を含有する核酸導入剤、発明者(長崎大学:麓伸太郎、西田孝洋)、特開2013-053125

2012 Research article
  1. Kurosaki T, Kitahara T, Nakamura T, Nishida K, Fumoto S, Kodama Y, Nakagawa H, Higuchi N, Sasaki H: Development of effective cancer vaccine using targeting system of antigen protein to APCs. Pharm Res 29 (2): 483-489, 2012 (IF: 4.093) PMID:21887598
  2. Miyamoto H, Miyake H, Yoshikawa N, Hirata H, Ohwaki Y, Fumoto S, Sasaki H, Nakamura J, Nishida K: Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system. J Pharm Pharmacol 64(6): 848-854, 2012 (IF: 2.175)
    PMID:22571263
  3. Miyamoto H, Baba S, Nakajima S, Mine T, Yoshikawa N, Fumoto S, Nishida K: Pretreatment with epidermal growth factor enhances naked plasmid DNA transfer onto gastric serosal surface in mice. Biol Pharm Bull 35(6): 903-908, 2012 (IF: 1.657)
    PMID:22687482
  4. Kodama Y, Horishita M, Fumoto S, Mine T, Miyamoto H, Yoshikawa N, Hirata H, Sasaki H, Nakamura J, Nishida K: Effect of viscous additives on the absorption and hepatic disposition of 5-fluorouracil (5-FU) after application to liver surface in rats. J Pharm Pharmacol 64(10): 1438-1444, 2012 (IF: 2.175)
    PMID: 22943174
  5. Fumoto S, Nakajima S, Mine T, Yoshikawa N, Kitahara T, Sasaki H, Miyamoto H, Nishida K: Efficient in vivo gene transfer by intraperitoneal injection of plasmid DNA and calcium carbonate microflowers in mice. Mol Pharm 9: 1962-1970, 2012 (IF: 4.782)
    PMID:22670625
  6. Koyo Nishida: 臨床応用に有用な基礎研究の進歩(Development of useful basic research for clinical application of DDS), Drug Delivery System, 27(2): 106-115 (2012) 邦文 Review
  7. 西田孝洋: 薬物代謝, 図解薬剤学 改訂5版, 南山堂, 第2編4章, p355-410 (2012) 邦文 著書
  8. 西田孝洋: 薬物送達システム(DDS)の必要性/放出制御型製剤/ターゲティング/プロドラッグ/その他のDDS, 薬剤学(第2版), 化学同人, 第7-11章, p.165-220 (2012) 邦文 著書

2011 Research article
  1. Nishida K, Kobayashi M, Miyamoto H, Yoshikawa N, Fumoto S, Sasaki H, Nakamura J: Relationship between lipophilicity and absorption from the liver surface of paraben derivatives and antipyrine in rats. J Pharm Pharmacol 63(5): 736-740, 2011 (IF: 1.918)
    PMID:21492176
  2. Ueki T, Nagai K, Ooe N, Nakashima MN, Nishida K, Nakamura J, Nakashima M: Case-controlled study on risk factors for the development of constipation in hospitalized patients. Yakugaku Zasshi 131(3): 469-476, 2011 (IF: 0.427) PMID:21372545
  3. Mine T, Ishii H, Nakajima S, Yoshikawa N, Miyamoto H, Nakashima M, Nakamura J, Fumoto S, Nishida K: Rubbing gastric serosal surface enhances naked plasmid DNA transfer in rats and mice. Biol Pharm Bull 34(9): 1514-1517, 2011 (IF: 1.811)
    PMID:21881243
  4. Fumoto S, Furukawa H, Nakamura J, Nishida K: Safety of liver surface instillation of plasmid DNA in normal and carbon tetrachloride-induced hepatitis mice. J Pharm Pharm Sci 14(2): 274-282, 2011 (IF: 1.914)
    PMID:21733415
  5. Ueki T, Nagai K, Mizukami Y, Takahashi A, Ooe N, Nakashima MN, Nishida K, Nakamura J, Nakashima M: Cross-sectional study on relationship between constipation and medication in consideration of sleep disorder. Yakugaku Zasshi 131(8): 1225-1232, 2011 (IF: 0.427) PMID:21804327
  6. Yoshikawa N, Sakamoto K, Mizuno S, Sakaguchi J, Miyamoto H, Mine T, Sasaki H, Fumoto S, Nishida K: Multiple components in serum contribute to hepatic transgene expression by lipoplex in mice. J Gene Med 13(11): 632-643, 2011 (IF: 3.079)
    PMID:22002583

2010 Research article
  1. 2. Nakamura T, Teshima M, Kitahara T, Sasaki H, Uematsu M, Kitaoka T, Nakashima M, Nishida K, Nakamura J, Higuchi S: Sensitive and real-time method for evaluating corneal barrier considering tear flow. Biol Pharm Bull 33(1): 107-110, 2010 (IF:1.765) PMID: 20045945
  2. 1. Kurosaki T, Kitahara T, Fumoto S, Nishida K, Yamamoto K, Nakagawa H, Kodama Y, Higuchi N, Nakamura T, Sasaki H: Chondroitin sulfate capsule system for efficient and secure gene delivery. J Pharm Pharm Sci 13(3): 351-61, 2010 (IF: 2.042) PMID:21092708
  3. 西田孝洋: 薬物代謝, 薬物動態学 第1版, 化学同人, 第4章, p81-111 (2010) 邦文 著書

2009 Research article
  1. Yoshioka T, Yoshida S, Kurosaki T, Teshima M, Nishida K, Nakamura J, Nakashima M, To H, Kitahara T, Sasaki H., Cationic liposomes-mediated plasmid DNA delivery in murine hepatitis induced by carbon tetrachloride., J Liposome Res. 2009 Feb 23:1-7 PMID: 19235544
  2. Kurosaki T, Kitahara T, Fumoto S, Nishida K, Nakamura J, Niidome T, Kodama Y, Nakagawa H, To H, Sasaki H. Ternary complexes of pDNA, polyethylenimine, and gamma-polyglutamic acid for gene delivery systems. Biomaterials. 2009 May;30(14):2846-2853. PMID: 19232715
  3. Kurosaki T, Kitahara T, Kawakami S, Nishida K, Nakamura J, Teshima M, Nakagawa H, Kodama Y, To H, Sasaki H.. The development of a gene vector electrostatically assembled with a polysaccharide capsule. Biomaterials. 2009 Sep;30(26): 4427-34. PMID: 19473696
  4. Shintaro Fumoto, Mayumi Tsuchimochi, Junya Nishi, Hiroki Ishii, Yukinobu Kodama, Mikiro Nakashima, Hitoshi Sasaki, Junzo Nakamura, Koyo Nishida, Liver- and Lobe-Specific Gene Transfer Following the Continuous Microinstillation of Plasmid DNA onto the Liver Surface in Mice: Effect of Instillation Speed. Biol. Pharm. Bull. 32(7): 1298-1302 (2009)
    PMID:19571403
  5. Shintaro Fumoto, Junya Nishi, Hiroki Ishii, Xuan Wang, Hirotaka Miyamoto, Naoki Yoshikawa, Mikiro Nakashima, Junzo Nakamura, Koyo Nishida, Rac-Mediated Macropinocytosis Is a Critical Route for Naked Plasmid DNA Transfer in Mice. Molecular Pharmaceutics. (2009) 6(4):1170-1179.
    PMID:19492848
  6. Koyo Nishida: 肝臓表面からの吸収を利用した薬物送達システムの開発とその展開(Development of drug delivery system by utilizing absorption from liver surface and its application), YAKUGAKU ZASSHI, 129(8): 925-932 (2009) 邦文Review
    PMID: 19652498
  7. Shintaro Fumoto: 非ウイルス性ベクターによる臓器・部位・細胞選択的遺伝子導入法に関する研究 (Organ-, Region- and Cell-Selective Gene Transfer Using Non-Viral Vectors), YAKUGAKU ZASSHI, 129(9): 1055-1061 (2009) 邦文 Review
    PMID:19721381
  8. Koyo Nishida: 腹腔を利用した薬物デリバリー(Drug delivery by utilizing abdominal cavity), PHARM TECH JAPAN, 25(13): 2651-2654 (2009) 邦文 Review
  9. 西田孝洋: 薬物代謝, 新しい図解薬剤学 改訂4版, 南山堂, 第2編4章, p355-410 (2009) 邦文 著書

2008 Research article
  1. M. Nakashima, T. Nakamura, M. Teshima, H. To, M. Uematsu, T. Kitaoka, K. Taniyama, K. Nishida, J. Nakamura, H. Sasaki: Breakdown evaluation of corneal epithelial barrier caused by antiallergic eyedrops using an electrophysiologic method, J. Ocul. Pharmacol. Ther., 24(1):43-51 (2008) PMID: 18205544
  2. K. Sakanaka, K. Kawazu, M. Tomonari, T. Kitahara, M. Nakashima, K. Nishida, J. Nakamura, H. Sasaki, S. Higuchi: Ocular pharmacokinetic/pharmacodynamic modeling for timolol in rabbits using a telemetry system, Biol. Pharm. Bull. 31(5): 970-975 (2008) PMID: 18451528
  3. Y. Kodama, S. Fumoto, J. Nishi, M. Nakashima, H. Sasaki, J. Nakamura, K. Nishida: Absorption and distribution characteristics of 5-fluorouracil (5-FU) after an application to the liver surface in rats in order to reduce systemic side effects, Biol. Pharm. Bull. 31(5): 1049-1052 (2008)
    PMID:18451546
  4. J. Nishi, S. Fumoto, H. Ishii, Y. Kodama, M. Nakashima, H. Sasaki, J. Nakamura, K. Nishida: Improved stomach selectivity of gene expression following microinstillation of plasmid DNA onto the gastric serosal surface in mice, Eur. J. Pharm. Biopharm. 69(2): 633-639 (2008) Jun
    PMID:18222072
  5. K. Miyanaga, T. Yoshioka, H. Nakagawa, T. Kitahara, H. To, N. Ichikawa, M. Nakashima, K. Nishida, J. Nakamura, H. Sasaki: Influence of murine hepatitis induced by D-(+)-galactosamine hydrochloride and lipopolysaccharide on gene expression of polyethylenimine/plasmid DNA polyplex, Biol. Pharm. Bull. 31(8): 1585-1589 (2008) PMID: 18670093
  6. K. Sakanaka, K. Kawazu, M. Tomonari, T. Kitahara, M. Nakashima, K. Nishida, J. Nakamura, H. Sasaki, S. Higuchi: Ocular pharmacokinetic/pharmacodynamic modeling for multiple anti-glaucoma drugs, Biol. Pharm. Bull. 31(8): 1590-1595 (2008). PMID: 18670094
  7. J. Nishi, S. Fumoto, H. Ishii, Y. Kodama, M. Nakashima, H. Sasaki, J. Nakamura, K. Nishida: Highly stomach-selective gene transfer following gastric serosal surface instillation of naked plasmid DNA in rats, J. Gastroenterol. 43(12): 912-919 (2008).
    PMID:19107334
  8. T. Kurosaki, T. Kitahara, M. Teshima, K. Nishida, J. Nakamura, M. Nakashima, H. To, H. Fukuchi, T. Hamamoto and H. Sasaki: Exploitation of de novo helper-lipids for effective gene delivery, J. Pharm. Pharm. Sci. 11: 56-67 (2008).
  9. S. Fumoto, J. Nishi, J. Nakamura, K. Nishida: Gene therapy for gastric diseases, Curr. Gene Ther. 8(3):187-200 (2008). Review
    PMID:18537593
  10. T. Ueki, N. Tasaki, T. Yoshida, N. Ooe, K. Nishida, J. Nakamura, M. Nakashima: Cross‐sectional study on relationship between constipation and medication, 医療薬学, 34 (9): 865-870 (2008) 邦文
  11. 濱本知之, 樋口則英, 三宅秀明, 清水和宏, 佐藤伸一, 稲岡奈津子, 森田光貴, 西田孝洋, 中村純三, 藤秀人, 北原隆志, 佐々木均: 院内製剤5%ハイドロキノン軟膏の使用状況とその有用性に関する調査, 日本病院薬剤師会雑誌, 44 (10): 1495-1498 (2008) 邦文
  12. 西田孝洋, 和田光弘, 伊藤 潔, 丸田英徳, 鈴木 斉, 黒川不二雄: 系統的な情報処理教育による薬物動態の理解向上の試み, IT活用教育方法研究, 11(1), 11月, 1-5 (2008) 邦文