論文発表
 

2016年
1. Yamashita H, Kato T, Oba M, Misawa T, Hattori T, Ohoka N, Tanaka M, Naito M, Kurihara M, Demizu Y: Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment. Sci. Rep. (Nature publishing group), 2016, in press.
2. Ueda A, Oba M, Izumi Y, Sueyoshi Y, Doi M, Demizu Y, Kurihara M, Tanaka M: Helical structures of homo-chiral isotope-labeled alpha-aminoisobutyric acid peptides. Tetrahedron, 2016, in press.
3. Ueda A, Umeno T, Doi M, Akagawa K, Kudo K, Tanaka M: Helical Peptide-Catalyzed Enantioselective Michael Addition Reactions and Their Mechanistic Insights. J. Org. Chem. 2016, in press.
4. Demizu Y, Doi M, Yamashita H, Misawa T, Oba M, Kurihara M, Suemune H, Tanaka M: The side-chain hydroxy groups of a cyclic alpha,alpha-disubstituted alpha-amino acid promote oligopeptide helix packing in the crystalline state, Biopolymers (Pept. Sci.), 2016, in press.
5. Koba Y, Hirata Y, Ueda A, Oba M, Doi M, Demizu Y, Kurihara M, Tanaka M: Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptide. Biopolymers (Pept. Sci.), 106, 555-562, 2016.
6. Oba M, Nonaka H, Doi M, Tanaka M: Conformational studies on peptides having dipropylglycine (Dpg) or 1-aminocycloheptanecarboxylic acid (Ac7c) within the sequence of L-leucine (Leu) residues. Biopolymers (Pept.Sci.), 106 (2), 210-218, 2016.
7. Demizu Y, Yamashita H, Misawa T, Doi M, Oba M, Tanaka M, Kurihara M: Handedness preferences of heterochiral helical peptides containing homochiral peptide segments. Eur. J. Org. Chem., 840–846, 2016.
8. Demizu Y, Okitsu K, Yamashita H, Doi M, Misawa T, Oba M, Tanaka M, Kurihara M: alpha-Helical structures of oligopeptides with alternating L-Leu-Aib segment. Eur. J. Org. Chem., 2815-2820, 2016.
9. Furukawa K, Oba M, Opiyo G O, Doi M, Tanaka M: Cyclic alpha,alpha-Disubstituted alpha-Amino Acids with Menthone in Their Side Chains through an Acetal Moiety and Helical Structures of Their Peptides, Eur. J. Org. Chem., 2988-2998, 2016.
10. Yamashita H, Oba M, Misawa T, Tanaka M, Hattori T, Naito M, Kurihara M, Demizu Y: A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular-Delivery Tool. ChemBioChem., 17, 137-140, 2016. (Cover picture).
11. Oba M, Kato T, Furukawa K, Tanaka M: A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery. Sci. Rep. (Nature publishing group), 2016, DOI: 10.1038/srep19913
12. Umeno T, Ueda A, Oba M, Doi M, Hirata T, Suemune H, Tanaka M: Helical structures of L-Leu-based peptides having chiral six-membered ring amino acids, Tetrahedron 3124-3131, 2016.
13. Kato T, Yamashita H, Misawa T, Nishida K, Kurihara M, Tanaka M, Demizu Y, Oba M: Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids, Bioorg. Med. Chem. 24, 2681-2687, 2016.

2015年
1. Hirata T, Ueda A, Oba M, Doi M, Demizu Y, Kurihara M, Nagano M, Suemune H, Tanaka M: Amino equatorial effect of a six-membered ring amino acid on its peptide 310- and alpha-helices. Tetrahedron, 71 (16): 2409-2420, 2015 (IF: 2.641).
2. Tanda K, Eto R, Kato K, Oba M, Ueda A, Suemune H, Doi M, Demizu Y, Kurihara M, Tanaka M: Peptide foldamers composed of six-membered ring alpha,alpha-disubstituted alpha-amino acids with two changeable chiral acetal moieties. Tetrahedron, 71 (23): 3909-3914, 2015 (IF: 2.641)
3. Demizu Y, Oba M, Okitsu K, Yamashita H, Misawa T, Tanaka M, Kurihara M, Gellman SH: A preorganized alpha-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides. Org Biomol Chem, 13: 5617-5620, 2015 (IF: 3.562).
4. Oba M, Demizu Y, Yamashita H, Kurihara M, Tanaka M: Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides. Bioorg Med Chem, 23 (15): 4911-4918, 2015 (IF: 2.793).
5. Demizu Y, Yamashita H, Doi M, Misawa T, Oba M, Tanaka M, Kurihara M: Topological study of the structures of heterochiral peptides containing equal amounts of L-Leu and D-Leu. J Org Chem, 80 (17): 8597-8603, 2015 (IF: 4.721).
6. Demizu Y, Yamashita H, Misawa T, Doi M, Tanaka M, Kurihara M: Effects of D-Leu residues on the helical secondary structures of L-Leu-based nonapeptides. Chem Pharm Bull, 63: 218-224, 2015 (IF: 1.164)

2014年
1. Yamashita H, Demizu Y, Shoda T, Yukik Sato, Oba M, Tanaka M, Kurihara M, Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability, Bioorg Med Chem 22(8): 2403-2408, 2014 (IF: 2.951)
2. Oba M, Takazaki H, Kawabe N, Doi M, Demizu Y, Kurihara M, Kawakubo H, Nagano M, Suemune H, Tanaka M, Helical peptide-foldamers having a chiral five-membered ring amino acid with two azido functional groups. J Org Chem 79(19): 9125-9140, 2014 (IF: 4.638)
3. Kato T, Oba M, Nishida K, Tanaka M, Cell-penetrating helical peptides having L-arginines and five-membered ring alpha,alpha-disubstituted alpha-amino acids. Bioconjugate Chem 25(10): 1761-1768, 2014 (IF: 4.821)
4. Oba M, Kawabe N, Takazaki H, Demizu Y, Doi M, Kurihara M, Suemune H, Tanaka M, Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues. Tetrahedron 70(46): 8900-8907, 2014 (IF: 2.817)
5. Ge Z, Chen Q, Osada K, Liu X, Tockary TA, Uchida S, Dirisala A, Ishii T, Nomoto T, Toh K, Matsumoto Y, Oba M, Kano MR, Itaka K, Kataoka K, Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials 35(10): 3416-3426, 2014 (IF: 8.312)
6. Nomoto T, Fukushima S, Kumagai M, Machitani K, Arnida, Matsumoto Y, Oba M, Miyata K, Osada K, Nishiyama N, Kataoka K, Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer. Nat Commun 5: 3545, 2014 (IF: 10.742)
7. Dirisala A, Osada K, Chen Q, Tockary TA, Machitani K, Osawa S, Liu X, Ishii T, Miyata K, Oba M, Uchida S, Itaka K, Kataoka K, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials 35(20): 5359-5368, 2014 (IF: 8.312)
8. Uchida H, Itaka K, Nomoto T, Ishii T, Suma T, Ikegami M, Miyata K, Oba M, Nishiyama N, Kataoka K, Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection. J Am Chem Soc 136(35): 12396-12405, 2014 (IF: 11.444)
9. Ueda A, Yamamoto A, Kato D, Kishi Y, Total synthesis of Halichondrin A, the missing member in the Halichondrin class of natural products. J Am Chem Soc 136(13): 5171-5176, 2014 (IF: 11.444)

2013年
1. Oba, M., Shimabukuro, A., Ono, M., Doi, M., Tanaka, M.: Synthesis of both enantiomers of cyclic methionine analogue: (R)- and (S)-3-aminotetrahydrothiophene-3-carboxylic acids. Tetrahedron Asymmetry, 24, 464-467 (2013) (IF: 2.652).
2. Oba M, Ishikawa N, Demizu Y, Kurihara M, Suemune H, Tanaka M: Helical oligomer with changeable chiral acetal moiety. Eur J Org Chem 34 pp.7679-7682, 2013 (IF: 3.344).
3. Kato T, Tanaka M, Oba M: Protein transfection study using multicellular spheroids of human hepatoma Huh-7 cells. PLoS ONE 8(12): e82876, 2013 (IF: 3.730).
4. Demizu Y, Yamashita H, Yamazaki N, Sato Y, Doi M, Tanaka M, Kurihara M: Oligopeptides with equal amounts of L- and D-amino acids may prefer a helix screw sense. J Org Chem 78(23): 12106-12113, 2013 (IF: 4.564).
5. Oba M: Study on development of polymeric micellar gene carrier and evaluation of its functionality. Biol Pharm Bull 36(7): 1045-1051, 2013 (IF: 1.849).

2012年
1. Demizu, Y., Doi, M., Kurihara, M., Maruyama, T., Suemune, H., Tanaka, M.: One-handed helical-screw direction of homopeptide-foldamer exclusively induced by cyclic alpha-amino acid side-chain chiral centers. Chem. Eur. J., 18, 2430-2439 (2012) (IF: 5.925)
2. Oba, M., Tanaka, M.: Intracellular internalization mechanism of protein transfection reagents. Biol. Pharm. Bull., 35(7), 1064-1068 (2012) (IF: 1.657)
3. Demizu, Y., Yabuki, Y., Doi, M., Sato, Y., Tanaka, M., Kurihara, M.: Conformations of helical Aib peptides containing a pair of L-amino acid and D-amino acid. J. Pept. Sci. 18, 466-475 (2012) (IF: 1.799)
4. Anan, K., Demizu, Y., Oba, M., Kurihara, M., Doi, M., Suemune, H., Tanaka, M.: Helical structures of bicyclic alpha-amino acid Homo-chiral oligomers with the chiral centers at the side-chain fused-ring junctions. Helv. Chim. Acta, 95(10), 1694-1713 (2012) (IF: 1.478)
5. Demizu, Y., Nagoya, S., Doi, M., Sato, Y., Tanaka, M., Kurihara, M.: Twisted structure of a cyclic hexapeptide containing a combination of alternating L-Leu-D-Leu-Aib segments. J. Org. Chem., 77, 9361-9365 (2012) (IF: 4.450)
6. Kagaya, H., Oba, M., Miura, Y., Koyama, H., Ishii, T., Shimada, T., Takato, T., Kataoka, K., Miyata, T., Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions. Gene Ther., 19, 61-69 (2012) (IF: 3.710)
7. Kim, H. J., Oba, M., Pittella, F., Nomoto, T., Cabral, H., Matsumoto, Y., Miyata, K., Nishiyama, N., Kataoka, K., PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor. J. Drug Target., 20, 33-42 (2012) (IF: 2.696)
8. Chen, Q., Osada, K., Ishii, T., Oba, M., Uchida, S., Tockary, T. A., Endo, T., Ge, Z., Kinoh, H., Kano, M. R., Itaka, K., Kataoka, K., Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic antiangiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials, 33, 4722-4730 (2012) (IF: 7.404)
9. 大庭 誠,田中正一:α,α-ジ置換アミノ酸の設計・合成とそのペプチドの二次構造解析・機能化.(木曽良明(編):遺伝子医学MOOK21 最新ペプチド合成技術とその創薬研究への応用,メディカルドゥ,大阪,205-210 (2012)

2011年
1. Yamagata, N., Demizu, Y., Sato, Y., Doi, M., Tanaka, M., Nagasawa, K., Okuda, H., Kurihara, M.: Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone. Tetrahedron Lett., 52 798-801 (2011) (IF: 2.618)
2. Demizu, Y., Doi, M., Kurihara, M., Okuda, H., Nagano, M., Suemune, H., Tanaka, M.: Conformational studies on peptides containing alpha,alpha-disubstituted alpha-amino acids: chiral cyclic a,a-disubstituted a-amino acid as an a-helical inducer. Org. Biomol. Chem., 9, 3303-3312 (2011) (IF: 3.451)
3. Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M.: Effect of one D-Leu residue on right-handed helical -L-Leu-Aib- peptides in the crystal state. J. Pept. Sci., 17, 420-426 (2011) (IF: 1.954)
4. Demizu, Y., Yamagata, N., Nagoya, S., Sato, Y., Doi, M., Tanaka, M., Nagasawa, K., Okuda, H., Kurihara, M.: Enantioselective epoxidation of alpha,beta-unsaturated ketones catalyzed by stapled helical L-Leu-based peptides. Tetrahedron, 67, 6155-6165 (2011) (IF: 3.011)
5. Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M.: Screw-sense control of helical oligopeptides containing equal amounts of L- and D-amino acids. Chem. Eur. J., 17, 11107-11109 (2011) (IF: 5.476)
6. Oba, M., Miyata, K., Osada, K., Christie, R. J., Sanjoh, M., Li, W., Fukushima, S., Ishii, T., Kano, M. R., Nishiyama, N., Koyama, H., Kataoka, K.: Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials, 32, 652-663 (2011) (IF: 7.883)
7. Vachutinsky, Y., Oba, M., Miyata, K., Hiki, S., Kano, M. R., Nishiyama, N., Koyama, H., Miyazono, K., Kataoka, K.: Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. J. Control. Release, 149, 51-57 (2011) (IF: 7.164)
8. Nomoto, T., Matsumoto, Y., Miyata, K., Oba, M., Fukushima, S., Nishiyama, N., Yamasoba, T., Kataoka, K.: In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy. J. Control. Release, 151, 104-109 (2011) (IF: 7.164)
9. Anraku, Y., Kishimura, A., Kobayashi, A., Oba, M., Kataoka, K.: Size-controlled long-circulating PICsome as ruler to measure critical cut-off disposition size into normal and tumor tissues. Chem. Comm., 47, 6054-6056 (2011) (IF: 5.787)
10. Herlambang, S., Kumagai, M., Nomoto, T., Horie, S., Fukushima, S., Oba, M., Miyazaki, K. Morimoto, Y., Nishiyama, N., Kataoka, K.: Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy. J. Control. Release, 155, 449-457 (2011) (IF: 7.164)
11. Konig, F. M., Vachutinsky, Y., Oba, M., Miyata, K., Nishiyama, N., Kataoka, K., Brauchle, C., Ruthardt, N.: Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging. J. Control. Release, 156, 364-373 (2011) (IF: 7.164)
12. Uchida, H., Miyata, K., Oba, M., Ishii, T., Suma, T., Itaka, K., Nishiyama, N., Kataoka, K.: Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles. J. Am. Chem. Soc., 133, 15524-15532 (2011) (IF: 9.023)
13. Kim, H. J., Oba, M., Pittella, F., Nomoto, T., Cabral, H., Matsumoto, Y., Miyata, K., Nishiyama, N., Kataoka, K.: PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery towrd subcutaneous BxPC3 pancreatic tumor. J. Drug Target., 20, 33-42 (2011) (IF: 2.491)
14. Iriyama, A., Usui, T., Yanagi, Y., Amano, S., Oba, M., Miyata, K., Nishiyama, N., Kataoka, K.: Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo. Cornea, 30, 1423-1427 (2011) (IF: 1.762)
15. Iriyama, A., Oba, M., Ishii, T., Nishiyama, N., Kataoka, K., Tamaki, Y., Yanagi, Y.: Gene transfer using micellar nanovectors inhibits choroidal neovascularization in vivo. PLos One, 6, e28560 (2011) (IF: 4.411)
16. 今井幹典,末宗 洋,田中正一:ロジウム錯体触媒によるヒドロアシル化反応-分子内反応から分子間反応への展開-.有機合成化学協会誌,69, 236-251 (2011)

2010年
1. Nagano, M., Doi, M., Kurihara, M., Suemune, H., Tanaka, M.: Stabilized alpha-helix-catalyzed enantioselective epoxidation of alpha,beta-unsaturated ketones. Org. Lett., 12(15), 3564-3566, 2010. (IF: 5.420)
2. Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M.: Three-Dimensional Structure Control of Diastereomeric Leu-Leu-Aib-Leu-Leu-Aib Sequences in the Solid State. J. Org. Chem., 75(15), 5234-5239 (2010). (IF: 4.219)
3. Demizu, Y., Tanaka, M., Doi, M., Kurihara, M., Okuda, H., Suemune, H.: Conformations of peptides containing a chiral cyclic αlpha,αlpha-disubstituted αlpha-amino acid within the sequence of Aib residues. J. Pept. Sci., 16, 621-626 (2010). (IF: 1.807)
4. Demizu, Y., Yamagata, N., Sato, Y., Doi, M., Tanaka, M., Okuda, H., Kurihara, M.: Controlling the helical screw sense of peptides with C-terminal L-valine. J. Pept. Sci., 16(3) 153-158 (2010). (IF: 1.807)
5. Oba, M., Demizu, Y., Yamagata, N., Sato, Y., Doi, M., Tanaka, M., Suemune, H., Okuda, H., Kurihara, M.: Solid-state conformation of diastereomeric –Pro-Pro-(Aib)4 sequences. Tetrahedron, 66(13), 2293-2296 (2010). (IF: 3.219)
6. Shimizu, H., Hori, Y., Kaname, S., Yamada, K., Nishiyama, N., Matsumoto, S., Miyata, K., Oba, M., Yamada, A., Kataoka, K., Fujita, T.: siRNA-based therapy for glomerulonephritis. J. Am. Soc. Nephrol., 21(4), 622-633 (2010). (IF: 7.689)
7. Anraku, Y., Kishimura, A., Oba, M., Yamasaki, Y., Kataoka, K.: Spontaneous formation of nano-sized uni-lamellar polyion complex vesicles (nano-PICsomes) with tunable size and propeties. J. Am. Chem. Soc., 132(5), 1631-1636 (2010). (IF: 8.580)
8. Miyata, K., Gouda, N., Takemoto, H., Oba, M., Lee, Y., Koyama, H., Yamasaki, Y., Itaka, K., Nishiyama, N., Kataoka, K.: Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials, 31(17), 4764-4770 (2010). (IF: 7.365)
9. Oba, M., Vachutinsky, Y., Miyata, K., Kano, M. R., Ikeda, S., Nishiyama, N., Itaka, K., Miyazono, K., Koyama, H., Kataoka, K.: Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1. Mol. Pharmaceutics, 7(2), 501-509 (2010). (IF: 5.408)
10. Sanjoh, M., Hiki, S., Lee, Y., Oba, M., Miyata, K., Ishii, T., Kataoka, K.: pDNA/poly(L-lysine) polyplexes functionalized with a pH-sensitive charge-conversional poly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial cells. Macromol. Rapid Comm., 31(13), 1181-1186 (2010). (IF: 4.263)
11. Kim, H. J., Ishii, A., Miyata, K., Lee, Y., Wu, S., Oba, M., Nishiyama, N., Kataoka, K.: Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control. Release, 145(2), 141-148 (2010). (IF: 5.949)
12. Takemoto, H., Ishii, A., Miyata, K., Nakanishi, M., Oba, M., Ishii, T., Yamasaki, Y., Nishiyama, N., Kataoka, K.: Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system. Biomaterials, 31(31), 8097-8105 (2010). (IF: 7.365)
13. Matsumoto, Y., Nomoto, T., Cabral, H., Matsumoto, Y., Watanabe, S., Christie, R. J., Miyata, K., Oba, M., Ogura, T., Yamasaki, Y., Nishiyama, N., Yamasoba, T., Kataoka, K.: Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed. Opt. Exp., 1(4), 1209-1216 (2010). (IF: ---)

*教員の前所属での発表論文を含んでいます。


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