Shimomura Novel Laureate Memorial Center for Drug Discovery

Research projects
Cell Regulation

 

  • Mechanisms of mitochondrial sensing and stress response
  • Mechanisms of inflammatory death of macrophage lineage cells

 

Pharmacology and Therapeutic Innovation

 

  • Chronic pain and LPA or epigenetic regulation
  • Kyotorphin and opioid research

 

Pharmaceutical Chemistry

 

  • Synthesis of non-natural type amino acids and its application to medicinal chemistry
  • Design of cell-penetrating foldamers and their application to drug delivery system

 

Pharmaceutical Organic Chemistry

 

  • Synthesis of biologically active natural products
  • Development of innovative organic reactions and methodologies

 

Synthetic Chemistry for Pharmaceuticals

 

  • Selective molecular transformation of diols based on molecular recognition
  • Highly efficient synthesis of nitrogen heterocycles

 

Genome-based Drug Discovery

 

  • Analysis of molecular mechanisms underlying the pathogenesis of Alzheimer's disease
  • Analysis of endogenous molecules that modulate activities of neprilysin and secretases

 

Natural Product Chemistry

 

  • Studies on structure, metabolism, function, and application of plant polyphenols)
  • Investigation of intra-specific diversity of terpenoids in higher plants

 

Chemistry of Functional Molecules

 

  • Development of nucleic acid drugs for functional regulation of non-coding RNAs
  • Novel drug delivery system using circulating extracellular vehicles

 

Hygienic Chemistry

 

  • Analysis of selenium component and the effect in fish and shellfishes
  • Development of molecular probe for imaging infection in a prion disease

 

Analytical Chemistry for Pharmaceuticals

 

  • Development of sensitive analytical method for trace levels of biological substances and drugs and their application to clinical chemistry.
  • Development and application of specific detection for reactive oxygen species.

 

Pharmacotherapeutics

 

  • Research into association studies on susceptibility genes for diseases, progression, drug effectiveness, adverse effects, and prognosis using genetic polymorphic markers)
  • Research investigating interaction between gut microbiome and metabolic diseases

 

Pharmaceutical Informatics

 

  • Development of targeted gene delivery system using external stimuli
  • Development of nano-biotechnology for medical use

 

Pharmaceutics

 

  • Drug targeting to the liver utilizing the absorption from the liver surface
  • Cell specific gene delivery to the liver by non-viral vector

 

Pharmacy Practice

 

  • Propose use of PXB-mice® as a reliable tool for drug repositioning screening against liver disease
  • Screening disease-specific immune complex antigens for autoimmune diseases and cancers

 

Molecular Pharmacology of Infectious Agents

 

  • Analysis of mechanism of influenza virus replication
  • Analysis of microbial community structure for environmental assessment

 

Laboratory in Medical Plants Garden

 

  • Studies on the differentiation and material production of plant organization
  • Chemo-pharmaceutical studies on the biologically active compounds from marine invertebrates

 

Structure Analysis for Chemicals

 

  • Research into design and functions of molecular probes for molecular structure analysis
  • Exploitation of practical synthetic methodologies and their application for medicinal chemistry

 

Pharmaceutics and Therapeutics

 

  • Development of novel gene delivery system for clinical use
  • Development of vaccine against tropical disease using new delivery technique